Woodhouse-Sakati Syndrome

About the Disease
Woodhouse-Sakati Syndrome, also known as diabetes-hypogonadism-deafness-intellectual disability syndrome, is related to dystonia and movement disease, and has symptoms including abnormality of extrapyramidal motor function An important gene associated with Woodhouse-Sakati Syndrome is DCAF17 (DDB1 And CUL4 Associated Factor 17), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Autophagy. The drug Iron has been mentioned in the context of this disorder. Affiliated tissues include uterus, testes and thyroid, and related phenotypes are dysarthria and hypothyroidism

Common Targets
DCAF17

Note: If you'd like to get a target analysis report for Woodhouse-Sakati Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Woodhouse-Sakati Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Multiple Sulfatase Deficiency | Progressive Encephalopathy-optic Atrophy Syndrome | Osteogenesis Imperfecta Type II | Motion Sickness | Axenfeld-Rieger Syndrome | Pituitary Dwarfism | Familial Pheochromocytoma-paraganglioma | Esotropia | Brenner Tumor | Glomerulonephritis, Membranoproliferative | Vitiligo | Lysosomal Acid Lipase Deficiency | DEND Syndrome | Lattice Corneal Dystrophy | Hypohidrotic Ectodermal Dysplasia, X-linked | Nicotine Dependence | Limb Girdle Muscular Dystrophy | Familial Digital Arthropathy-brachydactyly | Prolidase Deficiency | Hypertension, Portal | Hereditary Elliptocytosis | Cyclic Vomiting Syndrome | Lupus Erythematosus | Tetraplegia | Reticular Dysgenesis | Juvenile Myoclonic Epilepsy | Angiosarcoma | Bronchiolitis | Sickle Cell Disease | Chromosome 5q Deletion Syndrome | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Distal Myopathy | Meier-Gorlin Syndrome | Fanconi Syndrome | Fibrosis | Colitis, Microscopic | Urethritis | Cerebral Cavernous Malformations | Sick Sinus Syndrome 1 | Senior-Loken Syndrome | Pregnancy, Ectopic | Charcot-Marie-Tooth Disease Type 4 | Camptocormia | Autoimmune Polyendocrine Syndrome | Granular Corneal Dystrophy | Meningeal Melanocytoma | Glioblastoma | Vertigo | Ileitis | Macrodactyly | Encephalopathy, Hepatic | Acrodermatitis Enteropathica | Aldosteronism | Blood Protein Disorders | Gigantism | Enlarged Vestibular Aqueduct | Dementia | Dermatitis | Heart Septal Defects | Pseudohypoparathyroidism Type 1B | Xeroderma Pigmentosum | Becker Muscular Dystrophy | Anterior Segment Dysgenesis | Hereditary Folate Malabsorption | Perry Syndrome | Scleritis | Malaria, Cerebral | Cabezas Syndrome | Progressive Familial Intrahepatic Cholestasis | Pseudohypoaldosteronism | Cancer, Kidney | Ghosal Syndrome | Progressive Myoclonic Epilepsy | Fuchs Heterochromic Iridocyclitis | Idiopathic Pulmonary Fibrosis | GAPO Syndrome | Bloom Syndrome | C3 Glomerulonephritis | Cardiomyopathy, Peripartum | Cholesteryl Ester Storage Disease | Progressive Familial Intrahepatic Cholestasis Type 2 | Arteriosclerosis | Intestinal Hypomagnesemia 1 | Dystrophy, Cone-rod | Hydrops Fetalis | CHOPS Syndrome | Essential Fructosuria | Hypodontia | Carcinoma, Signet Ring Cell | Hypopigmentation | Alopecia Areata | Liddle Syndrome | Motor Neuron Diseases | Diffuse Palmoplantar Keratoderma | Lymphangioma | Methemoglobinemia | Distal Spinal Muscular Atrophy | Carcinoma, Transitional Cell | Congenital Fiber-type Disproportion Myopathy | Periodontitis | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Joubert Syndrome 2 | Temtamy Preaxial Brachydactyly Syndrome | Hypohidrotic Ectodermal Dysplasia | Congenital Nystagmus | Kernicterus | Varicocele | Rash | Overactive Bladder | IgA Nephropathy | Amebiasis | Creatine Deficiency Syndrome | Vestibular Disease | GLUT1 Deficiency Syndrome | Sandhoff Disease | Menkes Disease | Noonan Syndrome-like Disorder With Loose Anagen Hair | Bethlem Myopathy | Majeed Syndrome | Early Infantile Epileptic Encephalopathy 1 | Mitochondrial Myopathy | Pseudoexfoliation Syndrome | Spinocerebellar Ataxia Type 28 | Pelvic Inflammatory Disease | Rubinstein-Taybi Syndrome | Renal Dysplasia | Familial Hypertrophic Cardiomyopathy | Necrotizing Autoimmune Myopathy | Hyperuricemic Nephropathy, Familial Juvenile | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Spinocerebellar Ataxia Type 6 | Muckle-Wells Syndrome | McCune-Albright Syndrome | Hermansky-Pudlak Syndrome | Hypogonadism | Micro Syndrome | Polycystic Liver | Weill-Marchesani Syndrome | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Familial Advanced Sleep Phase Syndrome | Stevens-Johnson Syndrome | Methylmalonic Aciduria And Homocystinuria, CblC Type | Schwannoma | Coronary Restenosis | Leber Hereditary Optic Neuropathy | Primary Progressive Aphasia | Neurocysticercosis | Hypotension, Orthostatic | T-cell Prolymphocytic Leukemia | Thyroiditis, Autoimmune | Neuroma | Reflex Epilepsy | HIBCH Deficiency | Cardiac Sarcoidosis | Rett Syndrome | Corneal Dystrophies, Hereditary | Cherubism | Primrose Syndrome | Alkaptonuria | Spinal Muscular Atrophy Type 2 | Early Infantile Epileptic Encephalopathy 4 | Autoimmune Polyendocrinopathy Syndrome Type I | Cirrhosis | Desmosterolosis | Hemangioendothelioma | Chronic Granulomatous Disease, X-linked | Autosomal Recessive Bestrophinopathy | Dowling-Degos Disease | Peutz-Jeghers Syndrome | Learning Disability | Nijmegen Breakage Syndrome | Azoospermia | Triple A Syndrome | Alpha-thalassemia Myelodysplasia Syndrome | Pneumonia, Mycoplasma | Plasmacytoma | Microcephaly | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Sengers Syndrome | Analgesia | Larsen Syndrome | Ocular Albinism Type 1 | Epidermolytic Ichthyosis, Annular | Pseudohypoparathyroidism Type 2 | Uveitis | Clouston Hidrotic Ectodermal Dysplasia | Microcephaly, Seizures, And Developmental Delay | Macrophage Activation Syndrome | Cardiospondylocarpofacial Syndrome | Usher Syndrome | Lentigo | Colitis | Kleine-Levin Syndrome | Corneal Ulcer | Basal Cell Nevus Syndrome | Congenital Dysfibrinogenemia | Onchocerciasis | Periventricular Leukomalacia | Nemaline Myopathy 8 | Diabetes Mellitus, Transient Neonatal | Early Infantile Epileptic Encephalopathy | Sarcoidosis, Pulmonary | Hypercalciuria | Richter's Syndrome | Schizoaffective Disorder | Noonan Syndrome | Epidermolysis Bullosa Dystrophica | Empyema | Microphthalmia, Syndromic 7 | Spitz Nevus | Zimmermann-Laband Syndrome | Behcet's Disease | Chitayat Syndrome | 5-oxoprolinase Deficiency | Adenoma, Pituitary | Sialidosis | Diabetes Type 2 | Wagner Disease | Angina Pectoris | Long QT Syndrome Type 1 | Hairy Cell Leukemia | Mitochondrial Cytopathy | Congenital Bile Acid Synthesis Defect | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Ollier Disease | Occipital Neuralgia | Vogt-Koyanagi-Harada Syndrome | Chudley-McCullough Syndrome | Obesity | Restrictive Dermopathy | Bronchitis, Chronic | Generalized Epilepsy And Paroxysmal Dyskinesia | Borderline Personality Disorder | Nance-Horan Syndrome | Arthrogryposis | Cockayne Syndrome | Combined Deficiency Of Factor V And Factor VIII | Keratosis, Seborrheic | Cancer, Breast | Carbamoyl Phosphate Synthetase I Deficiency | Transcobalamin Deficiency | Parkinsonism | Methemoglobinemia Type IV | Blomstrand Osteochondrodysplasia | Chondrodysplasia Punctata 2, X-linked Dominant | Fatty Aldehyde Dehydrogenase Deficiency | Myelitis, Transverse | Ataxia-ocular Apraxia 2 | Insulinoma | Spondylocostal Dysostosis | Mucolipidosis | Fibrillation, Atrial | Charcot-Marie-Tooth Disease Type 4E | Basal Ganglia Disease | Vertebrobasilar Insufficiency | Chordoid Glioma | Charcot-Marie-Tooth Disease, Type 2C | Microtia | Narcolepsy | Persistent Fetal Circulation | Sjogren Syndrome | Aneurysm, Abdominal Aortic | Nemaline Myopathy | Osteomyelitis | Peripheral Neuropathy | Spinocerebellar Ataxia Type 2 | Cysticercosis | Angioedema, Acquired | Hyperostosis | Liver Failure | Angiomyolipoma | Ebstein Anomaly | Encephalopathy | Shprintzen-Goldberg Syndrome | Gliosarcoma | Milk Allergy | Alstrom Syndrome | 3-methylglutaconic Aciduria Type IV | Sclerosteosis 2 | Retinal Detachment | Fabry's Disease | Ganglioglioma | Smith-Kingsmore Syndrome | Blue Nevus | Wiedemann-Steiner Syndrome | Lymphoproliferative Disorders | Sitosterolemia | Iron Deficiency Anemia | Primary Cutaneous Amyloidosis | Placenta Previa | Cardiomyopathy, Hypertrophic | Keratoconus | Coenzyme Q10 Deficiency | Uterine Leiomyoma | Adenomyosis | Congenital Ichthyosiform Erythroderma | Hereditary Inclusion Body Myopathy | Tracheal Disorders | Dysfibrinogenemia | Ovarian Hyperstimulation Syndrome | Vasculitis | Headache | Waardenburg Syndrome | Autism | Gangliosidosis | Congenital Myopathy | Neuroectodermal Tumors, Primitive | Primary Erythromelalgia | Megalencephaly | Vici Syndrome | Blepharo-cheilo-odontic Syndrome | Achondrogenesis | Androgenic Alopecia | Choriocarcinoma | Pemphigus | Avellino Corneal Dystrophy | Familial Hemiplegic Migraine | Immunoproliferative Disorders | Facioscapulohumeral Muscular Dystrophy Type 2 | Encephalocele | Proteasome-associated Autoinflammatory Syndrome 2 | Central Core Disease | Mitochondrial Disease | Dyslexia | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Orthostatic Intolerance | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Retinal Degeneration | MELAS Syndrome | Glaucoma, Congenital | Malaria | Papilledema | Diffuse Intrinsic Pontine Glioma | Fetal And Neonatal Alloimmune Thrombocytopenia | Anorectal Fistula | Craniopharyngioma | Miyoshi Myopathy | Sialoadenitis | Liver Failure, Acute Infantile | Myositis | Campomelic Dysplasia | Mumps | Hyperkeratosis | Mucormycosis | Epilepsy | Babesiosis | Pyruvate Carboxylase Deficiency Disease | Hereditary Mixed Polyposis Syndrome | Optic Atrophy 2 | Hypobetalipoproteinemias | Spinal Cord Diseases | Stuttering | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Platelet Disorders | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Spinocerebellar Ataxia Type 23 | Spinocerebellar Ataxia Type 12 | Syphilis | Zygomycosis | Adult Polyglucosan Body Disease | Cardiac Arrest | Beckwith-Wiedemann Syndrome | Neonatal Progeroid Syndrome | Osteonecrosis Of The Jaw | Esophageal Motility Disorders | Galloway-Mowat Syndrome | Klinefelter Syndrome | Ichthyosis Bullosa Of Siemens | Leukoencephalopathy, Progressive Multifocal | Duchenne Muscular Dystrophy | Wolfram Syndrome 2 | Exocrine Pancreatic Insufficiency | Juvenile Hyaline Fibromatosis | Herpes Simplex Dermatitis | Gerodermia Osteodysplastica | Argininosuccinic Aciduria | Patent Foramen Ovale | Anencephaly | Kawasaki Disease | Cerebellofaciodental Syndrome | Brooke-Spiegler Syndrome | Zellweger Syndrome | Atelosteogenesis Type 2 | Craniofrontonasal Syndrome | Metatropic Dysplasia | Multicystic Renal Dysplasia | Goiter, Nodular | Basan Syndrome | Sturge-Weber Syndrome | Preaxial Polydactyly | Schuurs-Hoeijmakers Syndrome | Lennox-Gastaut Syndrome | Aicardi-Goutieres Syndrome | Glycogen Storage Disease Type 9 | Proximal Symphalangism | Hyperprolactinemia | Huntington's Disease | Multiple Myeloma | Neuroblastoma | Diabetes