Disease

Obesity

About the Disease
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

Common Targets
cAMP Responsive Element Binding Protein (CREB) (nonspecified subtype) | BMPR2 | PDGFRA | LIPF | Soluble guanylyl cyclase | INPP5D | PCSK1 | ALOX5 | LIPG | KPTN | SLC6A3 | PLD5 | FGF2 | MXRA5 | NPY4R2 | OLFM2 | PTAFR | CCK receptor (nonspecified subtype) | INCA1 | MAOB | VHL | XBP1 | NRXN3 | SORBS1 | APEH | IFNG | Phosphodiesterase 6 (PDE6) (nonspecified subtype) | SH3PXD2A | CA4 | BBS9 | GLP1R | GRB2 | KLK15 | SLC27A2 | CDK1 | RARRES2 | APOE | TCF7L2 | TJP2 | G5743 | Monoamine oxidase (MAO) (nonspecified subtype) | PNMT | KSR2 | HTR3A | UCP3 | NPR3 | GCGR | PDIA5 | NLRP3 Inflammasome | SLC39A8 | ISLR | PM20D1 | KCNJ11 | TGFBR2 | NELL2 | ELOVL2 | EMC10 | RPS6KA4 | GSK3A | LINGO2 | RUNX1T1 | RASSF1 | FLT3 | PMM2 | IL4 | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | SREBF1 | CCL4 | ZNF321P | ASGR1 | TAS2R4 | TOMM40L | PTPN6 | Phosphodiesterase (nonspecified subtype) | GPR139 | TMEM186 | GSTP1 | CHEK2 | PLAAT4 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | CYBA | CUTC | TERF2IP | NADPH Oxidase (nonspecified subtype) | SCN5A | MTHFR | SIRT2 | PRDX1 | CD19 | CD36 | WDR5 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | CAT | PITRM1 | HMOX1 | SLC5A2 | CYP19A1 | Histone deacetylase (nonspecified subtype) | MLH1 | MMP1 | PASK | G238 | GPR55 | Prostaglandin EP Receptor (nonspecified subtype) | GPR88 | TNKS | KDM4A | ADK | SELE | INPPL1 | MAP2K4 | Glutamate Receptor Ionotropic AMPA Receptor | MIR133A1 | SEC16B | CSNK1E | TCF3 | RGS7 | CTR9 | TBC1D8 | MDM4 | DYSF | ENPP2 | IL6ST | DUSP3 | TLR5 | RUNX2 | CETP | Calcium/calmodulin-dependent protein kinase (nonspecified subtype) | FAIM2 | RPGRIP1L | TAS2R10 | PIK3CG | USP35 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | MIR133A2 | ABHD11 | PPIA | FADS2 | HSD17B2 | LPL | TNFSF14 | HRH3 | Proteasome Complex | Carnitine O-Palmitoyltransferase 1 (CPT-1) (nonspecified subtype) | GPR119 | CTNNB1 | GPBAR1 | RMST | G5599 | PTGR2 | EDNRA | MPO | ATP6V0A4 | FOLR2 | PTPN2 | Cyclin B (nonspecified subtype) | FFAR4 | JAK3 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G6647 | TACR3 | MOGAT2 | INTS5 | ACVR1C | Serum/glucocorticoid regulated kinase (Sgk) (nonspecified subtype) | TACR2 | NTRK2 | G5243 | CDH12 | GSR | NKX2-4 | PAX6-AS1 | CISD2 | ANGPTL4 | PDE4D | GHRL | GAPDH | LOC105373234 | G596 | CYP2A6 | TSC1 | TMPRSS15 | STIP1 | Kainate Receptor (GluR) (nonspecified subtype) | SNCA | AURKA | INVS | ALDH1A2 | LOC105373238 | FOXO1 | GDF15 | CA5A | CALD1 | GLI2 | LOC105375494 | CRY2 | MXD3 | PDK1 | G1026 | BANP | CERS1 | AVPR1A | LOC105373353 | RORC | CYP7A1 | FAP | VEGFB | FKBP4 | GRIN2C | BDNF | MLPH | HMGCLL1 | GRIK1 | MARK4 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | LDLR | SSTR2 | MC1R | F13A1 | SLC18A2 | MYT1L | OR12D3 | DAO | MAX | FER1L4 | ABL1 | MKNK2 | G114548 | IP6K2 | SH2B1 | DNA-Directed DNA Polymerase Complex | TFRC | DGAT1 | MIR488 | DDX10 | BSG | PAK2 | NR1I3 | KCNA3 | KDR | FH | CRBN | RXFP3 | GRM5 | PRDM16 | SFRP2 | GLIS3 | FFAR1 | FANK1 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | Serine/Threonine Kinase (nonspecified subtype) | G3576 | G1956 | CCDC171 | ADGRF5 | MORC2 | CADM2 | GHSR | GHRLOS | MGAT2 | IRX6 | LHX2 | IL12B | ZNF169 | Carbonic Anhydrase (nonspecified subtype) | MTNR1A | GTF3C2 | PRKCZ | PLAAT3 | Glycogen phosphorylase (nonspecified subtype) | SCLT1 | SFTPB | ZNF470 | CYP21A2 | COBLL1 | HOXD12 | MRAP2 | LanC-like proteins (nonspecified subtype) | AGRP | NPY1R | ARPIN-AP3S2 | CHP1 | PTPRE | C4orf33 | AKR1C2 | THRB | IRX3 | CDK2 | ATG9B | HNRNPA2B1 | BBS2 | CYP8B1 | NPSR1 | ACP1 | GNB3 | PLAAT2 | PROK2 | VPS13B | SMO | KLB | GFRAL | FCGRT | PNPLA3 | CES2 | NPC1L1 | Gamma-Aminobutyric acid type B receptor | Tyrosine-Protein Kinases Src (nonspecified subtype) | CRNDE | JAK2 | TRIP11 | LINC00470 | LRRK2 | CDK5/p25 | LGALS3 | MIR34A | GMPR2 | FNDC5 | IRX5 | PRMT5 | DRD4 | NR3C2 | ALDH3A1 | OPRK1 | KCTD21 | G5563 | COL1A1 | Interleukin-1 (nonspecified subtype) | ADRA2B | CYP2A7 | GIP | GPR18 | IKBKB | KCND3 | SLC5A3 | Thyroid hormone receptor (nonspecified subtype) | SLC7A5 | ADCY3 | NR1H2 | PDK2 | DUSP22 | CLN3 | G59272 | ITIH4 | FGFR2 | LRRK1 | TMC6 | CA6 | VKORC1 | RNF19A | AVPR1B | HMOX2 | ARNT2 | MGLL | ST6GAL1 | EGR1 | POMC | USP19 | Sodium-Glucose Cotransporter (SGLT) (nonspecified subtype) | PDE4B | ROPN1L | ANGPTL3 | TMEM67 | PTPRF | AREG | SUPT5H | DGAT2 | IRS2 | ADIPOQ | KIDINS220 | G1/S-specific cyclin-E (nonspecified subtype) | GCK | FFAR3 | EHD3 | HLA-DOA | AGT | G7124 | ALOX12 | PRKD1 | CPT1A | ZNF804B | SPZ1 | G3620 | EPHX2 | IL17RA | Hedgehog Protein (nonspecified subtype) | T-Type Calcium Channel | SCD | CTSS | NPM1 | PKLR | PACS1 | AMP-activated protein kinase (AMPK) | CYP17A1 | Phospholipase A2 (nonspecified subtype) | PDE1C | PRKCA | Cholesterol esterase (nonspecified subtype) | SGK1 | APLNR | G207 | CA1 | ANKK1 | ACSS2 | Casein kinase I (nonspecified subtype) | Mucin (nonspecified subtype) | BTK | OPRM1 | CEBPA | OR10P1 | TRPC5 | UGCG | Heat shock protein 90 (nonspecified subtype) | MAP3K5 | PEX11A | HRH2 | CIRBP | Phosphodiesterase IV (PDE4) (nonspecified subtype) | TAS2R31 | EXO1 | SCARB1 | SDCBP | LOX | CA12 | RUNX3 | CDK6 | HIF1A | ENTPD6 | ABCG1 | AMP-activated protein kinase alpha2beta1gamma1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | CDK5RAP1 | RAMP2 | G3479 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | SPTA1 | G6774 | NR1H3 | RPS6KB1 | SSTR3 | MAP3K11 | BACE2 | GALR3 | SLC22A12 | KHK | SNRPN | MMP3 | TPP2 | NGEF | GALNT2 | CCKBR | MACROH2A2 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | ELANE | ACKR1 | SLC22A6 | CFL1 | ACE | PAK3 | LOC105371268 | NR4A1 | Fibroblast growth factor (FGF) (nonspecified subtype) | G598 | BRD2 | AMP-activated protein kinase alpha1beta1gamma1 | JUNB | ARID4B | MKNK1 | GH1 | GRM2 | PTPN9 | DRD5 | ALDH2 | FKBP1A | THSD7B | MATN4 | LOC105371269 | HCRTR1 | AMP-activated protein kinase alpha2beta2gamma2 | LCK | EGR2 | MMP12 | TRAF6 | CASR | G5728 | GLIPR2 | MIR133B | PSD3 | LINC02183 | IDH1 | mTOR complex 1 | RBP4 | G1432 | HOXB-AS3 | MYOD1 | CERS6 | TAS2R30 | ITGBL1 | SCAND3 | TGFB1 | PPARA | HSF1 | G1385 | Calcium channel (nonspecified subtype) | Matrix Metalloproteinase (MMP) (nonspecified subtype) | LEP | PDE9A | PRPF19 | LOC105371274 | PDE10A | CHRNA2 | AMP-activated protein kinase alpha2beta1gamma2 | RAMP1 | SELENOS | IL1B | MIR324 | POU5F1 | FLOT1 | LOC105371275 | Lipoxygenase (nonspecified subtype) | CNR2 | SMPD1 | TYR | OBI1 | ANGPTL2 | TAS1R2 | PDE6C | PPID | CDK5 | MAP3K14 | Nicotinic alpha3beta4 Receptor | G7295 | NR5A2 | PIP4K2B | LOC105371276 | BAD | NEK7 | MGAT5B | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CSF1R | SLC6A9 | TIAM1 | NPY2R | CREB3 | LOC105371278 | SHC1 | HDAC11 | BTF3L4 | JUND | CYP2E1 | ND2 | TM6SF2 | BBS7 | GRIA3 | LOC105371279 | IAPP | WEE1 | MTHFD2 | ADORA2B | AKTIP | KEAP1 | NADH dehydrogenase (Complex I) | PDK4 | CDK4 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | Opioid receptor (nonspecified subtype) | ADRB3 | TOP1 | ZFHX3 | DPP8 | VPS26A | HTR2B | APOC3 | COMT | CA13 | Neurotrophic Factor (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | GADD45A | TBX3 | IKZF1 | PCDHGA10 | HTR1A | PTPRJ | G3569 | Amylin receptor | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | MAP2K1 | ST6GALNAC6 | PYGL | TRAPPC11 | ADORA1 | ESR2 | VCAM1 | BBS5 | SLC6A2 | VIPR1 | CEP290 | FFAR2 | Nicotinic alpha4beta2 receptor | KIT | MAOA | CXXC5 | GPAM | PGAM5-KEAP1-NRF2 Complex | PDPK1 | PCSK9 | PRKAG3 | NEDD4 | HMGCR | DRD2 | NPPA | CA7 | ASPSCR1 | G23411 | MAP1LC3B | TTTY14 | CREG1 | GNPDA2 | NPPA-AS1 | GPX1 | HMG20A | SLC22A8 | TMEM106A | DAW1 | EDNRB | MTNR1B | G4780 | ZNF165 | CHRNA7 | C3AR1 | SIRPA | SHISA9 | NEDD8 | NR1I2 | RNPC3 | PIWIL4 | ADCY4 | ZAP70 | GATA2 | GIPR | ARHGEF3 | ABCA1 | BRD4 | QPCTL | PRKCH | ICAM1 | Histone acetyltransferase (HAT) (nonspecified subtype) | BCHE | ADRA2A | ASCL1 | OPRL1 | PGR | PIK3CD | REPIN1 | TRPV2 | LYPLAL1 | cAMP-Dependent protein kinase (PKA) | SOD2 | DYRK1A | MC3R | XPO1 | CDK9 | Orexin receptor (nonspecified subtype) | NF-kappaB (NFkB) | CYP24A1 | NPY4R | Casein kinase II (CKII) | SLC6A19 | DNA Topoisomerase II (nonspecified subtype) | MYH2 | GRK4 | SCTR | INSR | GABA(A) receptor | LSP1 | ANKRD26 | NTRK3 | GLRA3 | SDHC | MAF | TFAP2B | NPY | MTCH2 | CEBPB | CD38 | HPR | Taste receptor type 2 (nonspecified subtype) | ALDH1A1 | RIN3 | TOMM7 | ATP6AP2 | GUSB | MAPK9 | CNR1 | LCT | Na+/K+-ATPase (nonspecified subtype) | PIKFYVE | CCR2 | MAPKAPK2 | ABHD6 | Glucagon-like peptide receptor (GLP-R) (nonspecified subtype) | NMBR | PAX5 | IRAK4 | ABCC9 | RORA | Estrogen receptor (nonspecified subtype) | FABP5 | NPY5R | G2309 | KLF11 | LINC02516 | HEXB | CES1 | SUCNR1 | CD40 | MAP Kinase-Interacting Serine/Threonine-Protein Kinase (nonspecified subtype) | SOCS3 | PRKAB2 | PRL | PPARD | HSD11B1 | ACVR2B | HOXB3 | MMP7 | LMTK2 | ALMS1 | ZNF324 | KLF7 | NRP1 | PTCH1 | CPB2 | GANAB | ADIPOR1 | WWTR1 | GPD1 | PRKCD | SLC19A1 | OXT | INSIG2 | AKT2 | TULP2 | C16orf46 | POC5 | LHCGR | CEP19 | PLG | DPP4 | PDGFRB | NPFFR2 | K(ATP) Channel (nonspecified subtype) | G142 | HSD11B1L | CALCA | BCL9 | G4170 | GLUD1 | HLA-DRB1 | MTTP | TGFBR1 | BACE1 | CPD | KCNJ5 | TSPO | ESRRA | PDE3B | HCAR1 | TPH2 | Retinoid acid receptor (nonspecified subtype) | SPTBN1 | FGF11 | ACKR3 | TIMP1 | BDNF-AS | CXCL1 | Heme Oxygenase (HO) (nonspecified subtype) | Trypsin (nonspecified subtype) | ADORA2A | ADRB1 | CYP2J2 | SYK | MAP3K7 | TBX5 | G4609 | AKR1B1 | CROT | sigma Receptor (nonspecified subtype) | Voltage-Gated Sodium Channel Complex | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | SERPINE1 | CASP8 | AP3S2 | APOBR | HCRTR2 | PTBP2 | ELOVL5 | OPRD1 | GPR84 | HCG9 | PPP5C | PNPLA2 | CHRM3 | CHUK | G3605 | ADORA3 | STK33 | GPR6 | BCAT1 | DAPK1 | SULT1A2 | ATF3 | NDN | DENND1C | LOC101927169 | SOAT1 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | DLX4 | DRD1 | TRPV1 | G6PC1 | CALCRL | CDK1/Cyclin B | CXCL12 | PRKCI | HOXB5 | mTOR complex 2 | CMTM3 | LINC02210-CRHR1 | ACMSD | ESRRB | AKR1C3 | KLF15 | ZNF331 | LIPC | XDH | ABHD5 | C1D | OGA | ADP/ATP Translocase (nonspecified subtype) | CHIA | POU3F3 | CDC25A | TRIM21 | NTRK1 | CRTC1 | E2F Transcription Factor (nonspecified subtype) | RPL31 | DLX5 | BRS3 | STS | GSK3B | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | GHR | HIP1R | SGMS2 | MSC | HDAC4 | PTPN1 | CCR1 | FBP1 | MLYCD | PTGS1 | SNAP25 | ERCC2 | G9429 | Transforming growth factor beta (nonspecified subtype) | ACHE | ZBTB7B | AARSD1 | MCHR2 | HSD11B2 | DNA topoisomerase (nonspecified subtype) | Cytochrome P450 Enzymes (nonspecified subtype) | Dopamine receptor (nonspecified subtype) | EDNRB-AS1 | NR1H4 | Carbonic Anhydrase V (nonspecified subtype) | Vasopressin Receptor (nonspecified subtype) | LOXL2 | G2033 | FGF1 | PKM | PPARG | MAN1B1 | RXRA | LEPR | HNF1A | ZZZ3 | MIR92A1 | TAOK3 | LOC101929710 | PTPN4 | G3480 | NMUR1 | RUNDC1 | GPRC6A | PAPPA | COG8 | MSTN | TRIM36 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | CRHR1 | TPH1 | PCK1 | PLIN1 | MAGEL2 | GRK5 | Cytohesin (nonspecified subtype) | KDM1A | MMP2-AS1 | BDKRB1 | ALDOC | ALDH5A1 | G2475 | DOT1L | Adrenoceptor (nonspecified subtype) | SIM1 | FBXO48 | BCKDK | Fructose-Bisphosphate Aldolase (nonspecified subtype) | FAAH | ADIPOR2 | STK25 | GPR83 | CHI3L1 | HTR6 | RBL2 | TBX15 | BORCS5 | RORB | Neuropeptides B/W receptor (nonspecified subtype) | SIRT5 | CA14 | ENPP1 | NPBWR1 | KCTD1 | KCNJ8 | SORD | GABRA5 | LINC00578 | CCNE1 | RAB5A | CLK1 | CDK2/Cyclin A | KCNQ1 | KIF22 | FGFR1 | FGFR4 | PDE2A | ZSCAN30 | ACACB | LYPD1 | MIR92A2 | TFF1 | PIN1 | GJA1 | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | BLK | Cannabinoid receptor (nonspecified subtype) | TDO2 | PABPC4 | RPS10-NUDT3 | CCKAR | Sodium channel (nonspecified subtype) | NQO2 | ZIC3 | CDKN1B | RXRB | Heat shock protein 70 (nonspecified subtype) | SLC2A1 | CYP2C9 | G2099 | DRB sensitivity-inducing factor complex | FLT1 | TRIB3 | CIDEC | Adenosine receptor (nonspecified subtype) | DAGLA | KCNK4 | SGIP1 | CDC42BPA | HCAR3 | FAM3C | ZNF543 | IL12A | Mitochondrial pyruvate carrier complex (MPC) | G3630 | HIF3A | SLCO2A1 | TLR2 | CACNA1A | SIK2 | RNPC3-DT | SLC10A2 | ZNF717 | LINC02169 | P2RY14 | PRLHR | CERS5 | MAPK10 | FASN | PIM1 | DYRK1B | GLP2R | TEK | G836 | PON1 | EIF2AK3 | AKR1B10 | HTR1B | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | ESRRG | APOA1 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | GBA2 | OR7D4 | FAAP20 | NPR1 | CA9 | CACNA1E | EGLN1 | SEMA6D | PLAU | GUCY2C | CA5B | SELENOP | SLC5A1 | CTSK | PLEKHG4B | SDK1 | IL1A | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | G4193 | BRD3 | MTIF3 | CA2 | CSRNP3 | GCG | RAPGEF3 | GGPS1 | SDC3 | C10orf55 | FOXO4 | HSD17B1 | Sphingomyelin synthase (nonspecified subtype) | G196 | ACLY | NOS3 | STK39 | METAP2 | HIVEP3 | CDK2/Cyclin E | SSTR5 | MIR127 | G4318 | SOAT2 | DNM3 | HNF4A | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | Cyclooxygenase (COX) (nonspecified subtype) | FGF14 | DDAH2 | SGMS1 | NR1D1 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CBX3 | Angiotensin receptor (AT) (nonspecified subtype) | GSX1 | MRAS | QRFPR | PIP4K2A | CREB5 | SCRN1 | TACR1 | UCP1 | GHRHR | G8678 | PRCP | HPSE | CMKLR1 | RXRG | PDF | ADRB2 | MC4R | AHSG | KIF16B | PRKCQ | RXFP4 | alpha1-Adrenoceptor (nonspecified subtype) | G7157 | NF1 | HYOU1 | RETN | HES3 | LBP | COX15 | Bombesin receptor (nonspecified subtype) | LYN | RUNX1 | GPR75 | HRH1 | LIPE | IDE | NARS2 | MKKS | CRY1 | CSNK1D | SLC6A4 | FABP4 | LRP1B | KCNQ1DN | MICOS13 | NUBP1 | ERP44 | PNLIP | GRM4 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | WT1 | TFEB | PARL | IGF2BP2 | GPR39 | HCAR2 | CTSB | AGTR2 | NOX3 | PDE5A | GRPR | Cyclin A (nonspecified subtype) | MBOAT4 | CXCL6 | alpha-Amylase (nonspecified subtype) | NNMT | CASP1 | GAA | GATA3 | GALR2 | ADCY9 | IL2 | Retinoid RXR receptor (nonspecified subtype) | DAGLB | CALCR | TXNDC12 | NEGR1 | ABAT | AGTR1 | NPC1 | HS6ST3 | APOB | NMDA receptor | TUB | RSPO3 | NAMPT | IP6K1 | Collagen (nonspecified subtype) | AGER | CA3 | MAP3K21 | GNAS | NOTO | COL6A3 | CRHR2 | SIRT3 | PLAAT5 | GRK2 | FTO | AKT3 | PYY | BBS1 | BRD9 | NQO1 | FABP2 | Nitric oxide synthase (NOS) (nonspecified subtype) | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | CYP1B1 | TBC1D1 | UGT1A1 | GSPT1 | ACACA | NMUR2 | Transcription Factor TCF (nonspecified subtype) | MCHR1 | WDR64 | TRIM40 | IRAK1 | SLC2A4 | NR3C1 | DLGAP2 | THRA | ALDH1A3 | FSHB | G8878 | GPR17 | CHRDL1 | CACNA2D3 | RARG | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | FKBP1B | BBS10 | PPARGC1A | CHGA | RAB21 | ZFR2 | GALR1 | NALCN | TBK1 | HTR2C | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | IRS1 | PRKCE | CX3CR1 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | CHRNB2 | TAAR1 | SLC8A1 | PRKN | CRP | G367 | CYP11B2 | ELOVL6 | PNLIPRP2 | IKBKE | CREBBP | Melanocortin receptor (nonspecified subtype) | SLC1A2 | FYN | PTPRC | CCL2 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | FADS1 | ARID1A | GAD2 | GNAT2 | CAMKK2 | PTPN11 | EN1 | PIK3CA | GAS6 | GSTM1 | HTR2A | NADPH Oxidase Complex | ATXN2 | TAS1R3 | LOC107986362 | HTR1D | MC5R | LY96 | HECTD4 | CLOCK | ECE2 | alpha-Mannosidase (nonspecified subtype) | DRD3 | RWDD4 | PDE3A | SIRT6 | L1TD1 | CHRM2 | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | CMA1 | TRPA1 | Epoxide Hydrolase (nonspecified subtype) | IL6R | EPAS1 | MASTL | H19 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | STING1 | IGF2 | Rho kinase (ROCK) (nonspecified subtype) | MIR22 | UCP2 | CD3G | HSD17B3 | HRH4 | MIF | NOS2 | FOXP3 | OXTR | MAP2K5 | MOK | CCR5 | RET | EXD1 | VDR

疾病靶点研报
Obesity

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Purpura, Thrombotic Thrombocytopenic | Neurocutaneous Melanocytosis | Follicular Dendritic Cell Sarcoma | Polycystic Ovary Syndrome | Mandibuloacral Dysplasia With Type A Lipodystrophy | Pompe Disease | Vitamin B12 Deficiency | Spondylometaphyseal Dysplasia | Charcot-Marie-Tooth Disease, Type 2A | Cranioectodermal Dysplasia | Congenital Heart Defects | Pearson Syndrome | Hereditary Mixed Polyposis Syndrome | Multiple Hamartoma Syndrome | Angioedema, Hereditary | GATA2 Deficiency | Adenomyosis | Renal Failure | Non-bullous Congenital Ichthyosiform Erythroderma | Necrobiosis Lipoidica | Cenani-Lenz Syndactyly Syndrome | Benign Familial Neonatal Convulsions | Cheilitis | Perivascular Epithelioid Cell Tumor | Lipodystrophy | Epidermolysis Bullosa Dystrophica | Sclerosteosis | Osteogenesis Imperfecta Type VI | Acquired Partial Lipodystrophy | Autosomal Recessive Congenital Ichthyosis | Zygomycosis | Wolfram Syndrome | Hypopituitarism | Diarrhea | Peyronie's Disease | Hydrolethalus Syndrome | Smith-Lemli-Opitz Syndrome | Sleep Apnea | Hyperbilirubinemia | Myelofibrosis | Bronchiectasis | Congenital Dyserythropoietic Anemia | Fibrosis | Whipple's Disease | Persistent Fetal Circulation | Thyrotoxic Periodic Paralysis | Vulvovaginitis | Leishmaniasis, Cutaneous | Retinopathy Of Prematurity | Primary Torsion Dystonia | Juvenile Myoclonic Epilepsy | Ischemia | Toxoplasmosis | Orthostatic Intolerance | Vasculitis | Autism Spectrum Disorders | Bronchitis | Charcot-Marie-Tooth Disease Type 2D | Martsolf Syndrome | Fibrodysplasia Ossificans Progressiva | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Sleep Disorder | Myasthenia | Hepatorenal Syndrome | Giant Cell Arteritis | Vitamin A Deficiency | Essential Fructosuria | Norrie Disease | Anemia | Glycogen Storage Disease Type 9 | Cherubism | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Heavy Chain Disease | Schwartz-Jampel-Aberfeld Syndrome | Auriculocondylar Syndrome | Hypodontia | Spinocerebellar Ataxia Type 12 | Pneumonia, Mycoplasma | Charcot-Marie-Tooth Disease Type 3 | Takenouchi-Kosaki Syndrome | Cranial Nerve Disease | Schuurs-Hoeijmakers Syndrome | PASLI Disease | Spinocerebellar Ataxia Type 3 | Lafora Disease | Cocaine-Related Disorders | Myelodysplasia | Adenylosuccinate Lyase Deficiency | Leprosy | Retinoblastoma | Bainbridge-Ropers Syndrome | Sick Sinus Syndrome 1 | Hypoproteinemia, Hypercatabolic | Pheochromocytoma | Kabuki Syndrome | Alstrom Syndrome | Shock, Cardiogenic | Citrullinemia | Meier-Gorlin Syndrome | Lipoma | Diffuse Mesangial Sclerosis | Encephalopathy, Glycine | Nijmegen Breakage Syndrome | Ollier Disease | Rhabdomyosarcoma, Embryonal | Amyotrophic Lateral Sclerosis, Juvenile | Charcot-Marie-Tooth Disease Type 4E | Sezary Syndrome | Chorea-acanthocytosis | Brachydactyly | Hyperostosis | 3-methylcrotonyl-CoA Carboxylase Deficiency | Renal Hypomagnesemia 3 | Osteogenesis Imperfecta Type IV | Angioedema, Acquired | Mannosidase Deficiency Diseases | Nail Disorder, Nonsyndromic Congenital | Carbohydrate Metabolism Disorders | Macrophagic Myofasciitis | Glycogen Storage Disease Type 1 | Arthritis, Psoriatic | Lymphoproliferative Disorders | Rhabdoid Tumor | Impulse Control Disorder | Zellweger Syndrome | Polymyositis | Granuloma Annulare | Silver-Russell Syndrome | Omenn Syndrome | Micropenis | Persistent Hyperplastic Primary Vitreous | Usher Syndrome Type I | Spinal Muscular Atrophy | ACTH-independent Macronodular Adrenal Hyperplasia | Relapsing Polychondritis | C3 Glomerulopathy | Bethlem Myopathy | Beta-Propeller Protein-associated Neurodegeneration | Fibronectin Glomerulopathy | Glucagonoma | Papillon-Lefevre Syndrome | Aphasia | Mucormycosis | Tetanus | Polyarteritis Nodosa | Osteopathia Striata With Cranial Sclerosis | Wiskott-Aldrich Syndrome | Heterotaxy | Basal Ganglia Disease, Biotin-responsive | Papilloma | Optic Atrophy 2 | Arthritis, Gouty | Purpura | Lymphoma Lymphoblastic | Nasodigitoacoustic Syndrome | Cushing Syndrome | DiGeorge Syndrome | Progressive Familial Intrahepatic Cholestasis Type 2 | Chitayat Syndrome | Barakat Syndrome | Ectodermal Dysplasia | Vaginitis | Porencephaly | Osteogenesis Imperfecta Type I | Juvenile Myelomonocytic Leukemia | Spinocerebellar Ataxia | Aceruloplasminemia | Lathosterolosis | Retinal Telangiectasia | Multicystic Renal Dysplasia | Blepharo-cheilo-odontic Syndrome | Arthritis | Adenoma, Pleomorphic | Galactosialidosis | Anorexia Nervosa | Benign Hereditary Chorea | Scleritis | Angiodysplasia | Schizencephaly | Blau Syndrome | Saethre-Chotzen Syndrome | Canavan Disease | Familial Glucocorticoid Deficiency | LMNA-related Congenital Muscular Dystrophy | Hyperthermia, Malignant | POEMS Syndrome | Sotos Syndrome | Paronychia | Parkinsonism | Thyroid Hormone Resistance | Systemic Mastocytosis | Spinocerebellar Ataxia Type 14 | Diabetes Mellitus, Transient Neonatal | Keratitis | Seborrheic Dermatitis | Congenital Bilateral Absence Of Vas Deferens | Hyperglycemia | Shprintzen-Goldberg Syndrome | Sulfite Oxidase Deficiency | Histoplasmosis | Hypertriglyceridemia | Androgen Insensitivity | Epithelial-myoepithelial Carcinoma | Lactose Intolerance | Stromal Corneal Dystrophy | Leri-Weill Dyschondrosteosis | Charcot-Marie-Tooth Disease Type 4 | Ectopia Lentis, Isolated, Autosomal Recessive | Actinomycetoma | T-cell Chronic Lymphocytic Leukemia | Hyperacusis | Tuberculosis | Glycogen Storage Disease Type 1b | Choriocarcinoma | Chorioretinitis | Cluster Headache | Uremic Pruritus | Bietti Crystalline Dystrophy | Chromosome 9q34.3 Deletion Syndrome | Pierpont Syndrome | Non-Langerhans Cell Histiocytosis | Angioedema | Walker-Warburg Syndrome | Micro Syndrome | Reflex Epilepsy | Epidermal Nevus Syndrome | Proteasome-associated Autoinflammatory Syndrome 2 | Schistosomiasis Mansoni | Leri Pleonosteosis | Coloboma | Hyperparathyroidism, Primary | Pelvic Inflammatory Disease | High Molecular Weight Kininogen Deficiency | Craniopharyngioma | Polyneuropathy | Endocarditis | Congenital Nephrotic Syndrome | Obesity | Nephritis, Interstitial | Adrenoleukodystrophy, X-linked | Parvovirus B19 Infection | Pancytopenia | Hypertrophy | Hypogonadism | Familial Partial Lipodystrophy | Cataplexy | Colitis, Lymphocytic | Coma | Parkinson's Disease | Lymphomatoid Granulomatosis | Acute Myeloid Leukemia | Polydactyly | Twin-to-twin Transfusion Syndrome | Obesity, Morbid | Anterior Segment Dysgenesis | Epidermolysis Bullosa | Niemann-Pick Disease, Type B | Scapuloperoneal Spinal Muscular Atrophy | Porokeratosis | Autosomal Recessive Spastic Paraplegia Type 35 | Meleda Disease | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Hepatitis, Alcoholic | Myositis, Focal | Dupuytren Disease | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Hepatic Adenomatosis | Histiocytic Sarcoma | Chronic Thromboembolic Pulmonary Hypertension | Lamellar Ichthyosis | Tularemia | Hepatopulmonary Syndrome | Osteonecrosis Of The Jaw | Low Tension Glaucoma | Blepharophimosis Syndrome | Hemorrhagic Disorders | Anorectal Fistula | Reticular Dysgenesis | Schindler Disease | Hypokalemic Periodic Paralysis | Poikiloderma With Neutropenia | Olmsted Syndrome | Neurofibromatosis-Noonan Syndrome | Chorea | Carcinoma, Squamous Cell | Hairy Cell Leukemia | Leukoencephalopathy, Progressive Multifocal | Hereditary Spherocytosis | Plasma Cell Leukemia | Dystonia | Ovarian Hyperstimulation Syndrome | Epidermolytic Palmoplantar Keratoderma | Posterior Polar Cataract | Leiomyoma | Glioblastoma | Premenstrual Syndrome | Hypersensitivity Pneumonitis | Gyrate Atrophy Of The Choroid And Retina | Avellino Corneal Dystrophy | Rosacea | Kleine-Levin Syndrome | Syndactyly | Restrictive Dermopathy | Menetrier Disease | Myofibrillar Myopathy | Acute Anterior Uveitis | Split Hand-foot Malformation | Pemphigus | Allergic Contact Dermatitis | Trichuriasis | Myositis | Noonan Syndrome-like Disorder With Loose Anagen Hair | Amblyopia | Spinocerebellar Ataxia Type 40 | Infantile Refsum Disease | Spastic Paraplegia Type 7 | Hemangioendothelioma | Corneal Dystrophy | Hemimegalencephaly | Roberts Syndrome | Autosomal Recessive Spastic Paraplegia Type 54 | LRBA Deficiency | Anuria | Sweet Syndrome | Hypertension | Brachial Plexus Neuropathy | Hemorrhoids | Sick Sinus Syndrome | Transcobalamin Deficiency | Congenital Lipoid Adrenal Hyperplasia | Hypoparathyroidism | Localized Scleroderma | Malignant Peripheral Nerve Sheath Tumor | T-cell Lymphoma, Subcutaneous Panniculitis-like | GLUT1 Deficiency Syndrome | Carcinoma, Small Cell | Chronic Idiopathic Myelofibrosis | Coenzyme Q10 Deficiency | Greig Cephalopolysyndactyly Syndrome | Dyslexia | Carpenter Syndrome | Chronic Myeloid Leukemia | Asthma, Nocturnal | McLeod Syndrome | Mitochondrial Cytopathy | Neuromyotonia | CDKL5 Deficiency Disorder | Lymphangioleiomyomatosis | Johanson-Blizzard Syndrome | Vitelliform Macular Dystrophy | Cantu Syndrome | Encephalopathy | Graves Disease | Hypersomnia | Asperger Syndrome | Leber Congenital Amaurosis | Antisocial Personality Disorder | Dubin-Johnson Syndrome | Leukocyte Adhesion Deficiency | Optic Neuropathy, Anterior Ischemic | Measles | Carotid Artery Disease | Focal Facial Dermal Dysplasia