Disease

Obesity

About the Disease
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

Common Targets
cAMP Responsive Element Binding Protein (CREB) (nonspecified subtype) | BMPR2 | PDGFRA | LIPF | Soluble guanylyl cyclase | INPP5D | PCSK1 | ALOX5 | LIPG | KPTN | SLC6A3 | PLD5 | FGF2 | MXRA5 | NPY4R2 | OLFM2 | PTAFR | CCK receptor (nonspecified subtype) | INCA1 | MAOB | VHL | XBP1 | NRXN3 | SORBS1 | APEH | IFNG | Phosphodiesterase 6 (PDE6) (nonspecified subtype) | SH3PXD2A | CA4 | BBS9 | GLP1R | GRB2 | KLK15 | SLC27A2 | CDK1 | RARRES2 | APOE | TCF7L2 | TJP2 | G5743 | Monoamine oxidase (MAO) (nonspecified subtype) | PNMT | KSR2 | HTR3A | UCP3 | NPR3 | GCGR | PDIA5 | NLRP3 Inflammasome | SLC39A8 | ISLR | PM20D1 | KCNJ11 | TGFBR2 | NELL2 | ELOVL2 | EMC10 | RPS6KA4 | GSK3A | LINGO2 | RUNX1T1 | RASSF1 | FLT3 | PMM2 | IL4 | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | SREBF1 | CCL4 | ZNF321P | ASGR1 | TAS2R4 | TOMM40L | PTPN6 | Phosphodiesterase (nonspecified subtype) | GPR139 | TMEM186 | GSTP1 | CHEK2 | PLAAT4 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | CYBA | CUTC | TERF2IP | NADPH Oxidase (nonspecified subtype) | SCN5A | MTHFR | SIRT2 | PRDX1 | CD19 | CD36 | WDR5 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | CAT | PITRM1 | HMOX1 | SLC5A2 | CYP19A1 | Histone deacetylase (nonspecified subtype) | MLH1 | MMP1 | PASK | G238 | GPR55 | Prostaglandin EP Receptor (nonspecified subtype) | GPR88 | TNKS | KDM4A | ADK | SELE | INPPL1 | MAP2K4 | Glutamate Receptor Ionotropic AMPA Receptor | MIR133A1 | SEC16B | CSNK1E | TCF3 | RGS7 | CTR9 | TBC1D8 | MDM4 | DYSF | ENPP2 | IL6ST | DUSP3 | TLR5 | RUNX2 | CETP | Calcium/calmodulin-dependent protein kinase (nonspecified subtype) | FAIM2 | RPGRIP1L | TAS2R10 | PIK3CG | USP35 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | MIR133A2 | ABHD11 | PPIA | FADS2 | HSD17B2 | LPL | TNFSF14 | HRH3 | Proteasome Complex | Carnitine O-Palmitoyltransferase 1 (CPT-1) (nonspecified subtype) | GPR119 | CTNNB1 | GPBAR1 | RMST | G5599 | PTGR2 | EDNRA | MPO | ATP6V0A4 | FOLR2 | PTPN2 | Cyclin B (nonspecified subtype) | FFAR4 | JAK3 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G6647 | TACR3 | MOGAT2 | INTS5 | ACVR1C | Serum/glucocorticoid regulated kinase (Sgk) (nonspecified subtype) | TACR2 | NTRK2 | G5243 | CDH12 | GSR | NKX2-4 | PAX6-AS1 | CISD2 | ANGPTL4 | PDE4D | GHRL | GAPDH | LOC105373234 | G596 | CYP2A6 | TSC1 | TMPRSS15 | STIP1 | Kainate Receptor (GluR) (nonspecified subtype) | SNCA | AURKA | INVS | ALDH1A2 | LOC105373238 | FOXO1 | GDF15 | CA5A | CALD1 | GLI2 | LOC105375494 | CRY2 | MXD3 | PDK1 | G1026 | BANP | CERS1 | AVPR1A | LOC105373353 | RORC | CYP7A1 | FAP | VEGFB | FKBP4 | GRIN2C | BDNF | MLPH | HMGCLL1 | GRIK1 | MARK4 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | LDLR | SSTR2 | MC1R | F13A1 | SLC18A2 | MYT1L | OR12D3 | DAO | MAX | FER1L4 | ABL1 | MKNK2 | G114548 | IP6K2 | SH2B1 | DNA-Directed DNA Polymerase Complex | TFRC | DGAT1 | MIR488 | DDX10 | BSG | PAK2 | NR1I3 | KCNA3 | KDR | FH | CRBN | RXFP3 | GRM5 | PRDM16 | SFRP2 | GLIS3 | FFAR1 | FANK1 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | Serine/Threonine Kinase (nonspecified subtype) | G3576 | G1956 | CCDC171 | ADGRF5 | MORC2 | CADM2 | GHSR | GHRLOS | MGAT2 | IRX6 | LHX2 | IL12B | ZNF169 | Carbonic Anhydrase (nonspecified subtype) | MTNR1A | GTF3C2 | PRKCZ | PLAAT3 | Glycogen phosphorylase (nonspecified subtype) | SCLT1 | SFTPB | ZNF470 | CYP21A2 | COBLL1 | HOXD12 | MRAP2 | LanC-like proteins (nonspecified subtype) | AGRP | NPY1R | ARPIN-AP3S2 | CHP1 | PTPRE | C4orf33 | AKR1C2 | THRB | IRX3 | CDK2 | ATG9B | HNRNPA2B1 | BBS2 | CYP8B1 | NPSR1 | ACP1 | GNB3 | PLAAT2 | PROK2 | VPS13B | SMO | KLB | GFRAL | FCGRT | PNPLA3 | CES2 | NPC1L1 | Gamma-Aminobutyric acid type B receptor | Tyrosine-Protein Kinases Src (nonspecified subtype) | CRNDE | JAK2 | TRIP11 | LINC00470 | LRRK2 | CDK5/p25 | LGALS3 | MIR34A | GMPR2 | FNDC5 | IRX5 | PRMT5 | DRD4 | NR3C2 | ALDH3A1 | OPRK1 | KCTD21 | G5563 | COL1A1 | Interleukin-1 (nonspecified subtype) | ADRA2B | CYP2A7 | GIP | GPR18 | IKBKB | KCND3 | SLC5A3 | Thyroid hormone receptor (nonspecified subtype) | SLC7A5 | ADCY3 | NR1H2 | PDK2 | DUSP22 | CLN3 | G59272 | ITIH4 | FGFR2 | LRRK1 | TMC6 | CA6 | VKORC1 | RNF19A | AVPR1B | HMOX2 | ARNT2 | MGLL | ST6GAL1 | EGR1 | POMC | USP19 | Sodium-Glucose Cotransporter (SGLT) (nonspecified subtype) | PDE4B | ROPN1L | ANGPTL3 | TMEM67 | PTPRF | AREG | SUPT5H | DGAT2 | IRS2 | ADIPOQ | KIDINS220 | G1/S-specific cyclin-E (nonspecified subtype) | GCK | FFAR3 | EHD3 | HLA-DOA | AGT | G7124 | ALOX12 | PRKD1 | CPT1A | ZNF804B | SPZ1 | G3620 | EPHX2 | IL17RA | Hedgehog Protein (nonspecified subtype) | T-Type Calcium Channel | SCD | CTSS | NPM1 | PKLR | PACS1 | AMP-activated protein kinase (AMPK) | CYP17A1 | Phospholipase A2 (nonspecified subtype) | PDE1C | PRKCA | Cholesterol esterase (nonspecified subtype) | SGK1 | APLNR | G207 | CA1 | ANKK1 | ACSS2 | Casein kinase I (nonspecified subtype) | Mucin (nonspecified subtype) | BTK | OPRM1 | CEBPA | OR10P1 | TRPC5 | UGCG | Heat shock protein 90 (nonspecified subtype) | MAP3K5 | PEX11A | HRH2 | CIRBP | Phosphodiesterase IV (PDE4) (nonspecified subtype) | TAS2R31 | EXO1 | SCARB1 | SDCBP | LOX | CA12 | RUNX3 | CDK6 | HIF1A | ENTPD6 | ABCG1 | AMP-activated protein kinase alpha2beta1gamma1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | CDK5RAP1 | RAMP2 | G3479 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | SPTA1 | G6774 | NR1H3 | RPS6KB1 | SSTR3 | MAP3K11 | BACE2 | GALR3 | SLC22A12 | KHK | SNRPN | MMP3 | TPP2 | NGEF | GALNT2 | CCKBR | MACROH2A2 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | ELANE | ACKR1 | SLC22A6 | CFL1 | ACE | PAK3 | LOC105371268 | NR4A1 | Fibroblast growth factor (FGF) (nonspecified subtype) | G598 | BRD2 | AMP-activated protein kinase alpha1beta1gamma1 | JUNB | ARID4B | MKNK1 | GH1 | GRM2 | PTPN9 | DRD5 | ALDH2 | FKBP1A | THSD7B | MATN4 | LOC105371269 | HCRTR1 | AMP-activated protein kinase alpha2beta2gamma2 | LCK | EGR2 | MMP12 | TRAF6 | CASR | G5728 | GLIPR2 | MIR133B | PSD3 | LINC02183 | IDH1 | mTOR complex 1 | RBP4 | G1432 | HOXB-AS3 | MYOD1 | CERS6 | TAS2R30 | ITGBL1 | SCAND3 | TGFB1 | PPARA | HSF1 | G1385 | Calcium channel (nonspecified subtype) | Matrix Metalloproteinase (MMP) (nonspecified subtype) | LEP | PDE9A | PRPF19 | LOC105371274 | PDE10A | CHRNA2 | AMP-activated protein kinase alpha2beta1gamma2 | RAMP1 | SELENOS | IL1B | MIR324 | POU5F1 | FLOT1 | LOC105371275 | Lipoxygenase (nonspecified subtype) | CNR2 | SMPD1 | TYR | OBI1 | ANGPTL2 | TAS1R2 | PDE6C | PPID | CDK5 | MAP3K14 | Nicotinic alpha3beta4 Receptor | G7295 | NR5A2 | PIP4K2B | LOC105371276 | BAD | NEK7 | MGAT5B | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CSF1R | SLC6A9 | TIAM1 | NPY2R | CREB3 | LOC105371278 | SHC1 | HDAC11 | BTF3L4 | JUND | CYP2E1 | ND2 | TM6SF2 | BBS7 | GRIA3 | LOC105371279 | IAPP | WEE1 | MTHFD2 | ADORA2B | AKTIP | KEAP1 | NADH dehydrogenase (Complex I) | PDK4 | CDK4 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | Opioid receptor (nonspecified subtype) | ADRB3 | TOP1 | ZFHX3 | DPP8 | VPS26A | HTR2B | APOC3 | COMT | CA13 | Neurotrophic Factor (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | GADD45A | TBX3 | IKZF1 | PCDHGA10 | HTR1A | PTPRJ | G3569 | Amylin receptor | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | MAP2K1 | ST6GALNAC6 | PYGL | TRAPPC11 | ADORA1 | ESR2 | VCAM1 | BBS5 | SLC6A2 | VIPR1 | CEP290 | FFAR2 | Nicotinic alpha4beta2 receptor | KIT | MAOA | CXXC5 | GPAM | PGAM5-KEAP1-NRF2 Complex | PDPK1 | PCSK9 | PRKAG3 | NEDD4 | HMGCR | DRD2 | NPPA | CA7 | ASPSCR1 | G23411 | MAP1LC3B | TTTY14 | CREG1 | GNPDA2 | NPPA-AS1 | GPX1 | HMG20A | SLC22A8 | TMEM106A | DAW1 | EDNRB | MTNR1B | G4780 | ZNF165 | CHRNA7 | C3AR1 | SIRPA | SHISA9 | NEDD8 | NR1I2 | RNPC3 | PIWIL4 | ADCY4 | ZAP70 | GATA2 | GIPR | ARHGEF3 | ABCA1 | BRD4 | QPCTL | PRKCH | ICAM1 | Histone acetyltransferase (HAT) (nonspecified subtype) | BCHE | ADRA2A | ASCL1 | OPRL1 | PGR | PIK3CD | REPIN1 | TRPV2 | LYPLAL1 | cAMP-Dependent protein kinase (PKA) | SOD2 | DYRK1A | MC3R | XPO1 | CDK9 | Orexin receptor (nonspecified subtype) | NF-kappaB (NFkB) | CYP24A1 | NPY4R | Casein kinase II (CKII) | SLC6A19 | DNA Topoisomerase II (nonspecified subtype) | MYH2 | GRK4 | SCTR | INSR | GABA(A) receptor | LSP1 | ANKRD26 | NTRK3 | GLRA3 | SDHC | MAF | TFAP2B | NPY | MTCH2 | CEBPB | CD38 | HPR | Taste receptor type 2 (nonspecified subtype) | ALDH1A1 | RIN3 | TOMM7 | ATP6AP2 | GUSB | MAPK9 | CNR1 | LCT | Na+/K+-ATPase (nonspecified subtype) | PIKFYVE | CCR2 | MAPKAPK2 | ABHD6 | Glucagon-like peptide receptor (GLP-R) (nonspecified subtype) | NMBR | PAX5 | IRAK4 | ABCC9 | RORA | Estrogen receptor (nonspecified subtype) | FABP5 | NPY5R | G2309 | KLF11 | LINC02516 | HEXB | CES1 | SUCNR1 | CD40 | MAP Kinase-Interacting Serine/Threonine-Protein Kinase (nonspecified subtype) | SOCS3 | PRKAB2 | PRL | PPARD | HSD11B1 | ACVR2B | HOXB3 | MMP7 | LMTK2 | ALMS1 | ZNF324 | KLF7 | NRP1 | PTCH1 | CPB2 | GANAB | ADIPOR1 | WWTR1 | GPD1 | PRKCD | SLC19A1 | OXT | INSIG2 | AKT2 | TULP2 | C16orf46 | POC5 | LHCGR | CEP19 | PLG | DPP4 | PDGFRB | NPFFR2 | K(ATP) Channel (nonspecified subtype) | G142 | HSD11B1L | CALCA | BCL9 | G4170 | GLUD1 | HLA-DRB1 | MTTP | TGFBR1 | BACE1 | CPD | KCNJ5 | TSPO | ESRRA | PDE3B | HCAR1 | TPH2 | Retinoid acid receptor (nonspecified subtype) | SPTBN1 | FGF11 | ACKR3 | TIMP1 | BDNF-AS | CXCL1 | Heme Oxygenase (HO) (nonspecified subtype) | Trypsin (nonspecified subtype) | ADORA2A | ADRB1 | CYP2J2 | SYK | MAP3K7 | TBX5 | G4609 | AKR1B1 | CROT | sigma Receptor (nonspecified subtype) | Voltage-Gated Sodium Channel Complex | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | SERPINE1 | CASP8 | AP3S2 | APOBR | HCRTR2 | PTBP2 | ELOVL5 | OPRD1 | GPR84 | HCG9 | PPP5C | PNPLA2 | CHRM3 | CHUK | G3605 | ADORA3 | STK33 | GPR6 | BCAT1 | DAPK1 | SULT1A2 | ATF3 | NDN | DENND1C | LOC101927169 | SOAT1 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | DLX4 | DRD1 | TRPV1 | G6PC1 | CALCRL | CDK1/Cyclin B | CXCL12 | PRKCI | HOXB5 | mTOR complex 2 | CMTM3 | LINC02210-CRHR1 | ACMSD | ESRRB | AKR1C3 | KLF15 | ZNF331 | LIPC | XDH | ABHD5 | C1D | OGA | ADP/ATP Translocase (nonspecified subtype) | CHIA | POU3F3 | CDC25A | TRIM21 | NTRK1 | CRTC1 | E2F Transcription Factor (nonspecified subtype) | RPL31 | DLX5 | BRS3 | STS | GSK3B | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | GHR | HIP1R | SGMS2 | MSC | HDAC4 | PTPN1 | CCR1 | FBP1 | MLYCD | PTGS1 | SNAP25 | ERCC2 | G9429 | Transforming growth factor beta (nonspecified subtype) | ACHE | ZBTB7B | AARSD1 | MCHR2 | HSD11B2 | DNA topoisomerase (nonspecified subtype) | Cytochrome P450 Enzymes (nonspecified subtype) | Dopamine receptor (nonspecified subtype) | EDNRB-AS1 | NR1H4 | Carbonic Anhydrase V (nonspecified subtype) | Vasopressin Receptor (nonspecified subtype) | LOXL2 | G2033 | FGF1 | PKM | PPARG | MAN1B1 | RXRA | LEPR | HNF1A | ZZZ3 | MIR92A1 | TAOK3 | LOC101929710 | PTPN4 | G3480 | NMUR1 | RUNDC1 | GPRC6A | PAPPA | COG8 | MSTN | TRIM36 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | CRHR1 | TPH1 | PCK1 | PLIN1 | MAGEL2 | GRK5 | Cytohesin (nonspecified subtype) | KDM1A | MMP2-AS1 | BDKRB1 | ALDOC | ALDH5A1 | G2475 | DOT1L | Adrenoceptor (nonspecified subtype) | SIM1 | FBXO48 | BCKDK | Fructose-Bisphosphate Aldolase (nonspecified subtype) | FAAH | ADIPOR2 | STK25 | GPR83 | CHI3L1 | HTR6 | RBL2 | TBX15 | BORCS5 | RORB | Neuropeptides B/W receptor (nonspecified subtype) | SIRT5 | CA14 | ENPP1 | NPBWR1 | KCTD1 | KCNJ8 | SORD | GABRA5 | LINC00578 | CCNE1 | RAB5A | CLK1 | CDK2/Cyclin A | KCNQ1 | KIF22 | FGFR1 | FGFR4 | PDE2A | ZSCAN30 | ACACB | LYPD1 | MIR92A2 | TFF1 | PIN1 | GJA1 | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | BLK | Cannabinoid receptor (nonspecified subtype) | TDO2 | PABPC4 | RPS10-NUDT3 | CCKAR | Sodium channel (nonspecified subtype) | NQO2 | ZIC3 | CDKN1B | RXRB | Heat shock protein 70 (nonspecified subtype) | SLC2A1 | CYP2C9 | G2099 | DRB sensitivity-inducing factor complex | FLT1 | TRIB3 | CIDEC | Adenosine receptor (nonspecified subtype) | DAGLA | KCNK4 | SGIP1 | CDC42BPA | HCAR3 | FAM3C | ZNF543 | IL12A | Mitochondrial pyruvate carrier complex (MPC) | G3630 | HIF3A | SLCO2A1 | TLR2 | CACNA1A | SIK2 | RNPC3-DT | SLC10A2 | ZNF717 | LINC02169 | P2RY14 | PRLHR | CERS5 | MAPK10 | FASN | PIM1 | DYRK1B | GLP2R | TEK | G836 | PON1 | EIF2AK3 | AKR1B10 | HTR1B | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | ESRRG | APOA1 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | GBA2 | OR7D4 | FAAP20 | NPR1 | CA9 | CACNA1E | EGLN1 | SEMA6D | PLAU | GUCY2C | CA5B | SELENOP | SLC5A1 | CTSK | PLEKHG4B | SDK1 | IL1A | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | G4193 | BRD3 | MTIF3 | CA2 | CSRNP3 | GCG | RAPGEF3 | GGPS1 | SDC3 | C10orf55 | FOXO4 | HSD17B1 | Sphingomyelin synthase (nonspecified subtype) | G196 | ACLY | NOS3 | STK39 | METAP2 | HIVEP3 | CDK2/Cyclin E | SSTR5 | MIR127 | G4318 | SOAT2 | DNM3 | HNF4A | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | Cyclooxygenase (COX) (nonspecified subtype) | FGF14 | DDAH2 | SGMS1 | NR1D1 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CBX3 | Angiotensin receptor (AT) (nonspecified subtype) | GSX1 | MRAS | QRFPR | PIP4K2A | CREB5 | SCRN1 | TACR1 | UCP1 | GHRHR | G8678 | PRCP | HPSE | CMKLR1 | RXRG | PDF | ADRB2 | MC4R | AHSG | KIF16B | PRKCQ | RXFP4 | alpha1-Adrenoceptor (nonspecified subtype) | G7157 | NF1 | HYOU1 | RETN | HES3 | LBP | COX15 | Bombesin receptor (nonspecified subtype) | LYN | RUNX1 | GPR75 | HRH1 | LIPE | IDE | NARS2 | MKKS | CRY1 | CSNK1D | SLC6A4 | FABP4 | LRP1B | KCNQ1DN | MICOS13 | NUBP1 | ERP44 | PNLIP | GRM4 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | WT1 | TFEB | PARL | IGF2BP2 | GPR39 | HCAR2 | CTSB | AGTR2 | NOX3 | PDE5A | GRPR | Cyclin A (nonspecified subtype) | MBOAT4 | CXCL6 | alpha-Amylase (nonspecified subtype) | NNMT | CASP1 | GAA | GATA3 | GALR2 | ADCY9 | IL2 | Retinoid RXR receptor (nonspecified subtype) | DAGLB | CALCR | TXNDC12 | NEGR1 | ABAT | AGTR1 | NPC1 | HS6ST3 | APOB | NMDA receptor | TUB | RSPO3 | NAMPT | IP6K1 | Collagen (nonspecified subtype) | AGER | CA3 | MAP3K21 | GNAS | NOTO | COL6A3 | CRHR2 | SIRT3 | PLAAT5 | GRK2 | FTO | AKT3 | PYY | BBS1 | BRD9 | NQO1 | FABP2 | Nitric oxide synthase (NOS) (nonspecified subtype) | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | CYP1B1 | TBC1D1 | UGT1A1 | GSPT1 | ACACA | NMUR2 | Transcription Factor TCF (nonspecified subtype) | MCHR1 | WDR64 | TRIM40 | IRAK1 | SLC2A4 | NR3C1 | DLGAP2 | THRA | ALDH1A3 | FSHB | G8878 | GPR17 | CHRDL1 | CACNA2D3 | RARG | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | FKBP1B | BBS10 | PPARGC1A | CHGA | RAB21 | ZFR2 | GALR1 | NALCN | TBK1 | HTR2C | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | IRS1 | PRKCE | CX3CR1 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | CHRNB2 | TAAR1 | SLC8A1 | PRKN | CRP | G367 | CYP11B2 | ELOVL6 | PNLIPRP2 | IKBKE | CREBBP | Melanocortin receptor (nonspecified subtype) | SLC1A2 | FYN | PTPRC | CCL2 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | FADS1 | ARID1A | GAD2 | GNAT2 | CAMKK2 | PTPN11 | EN1 | PIK3CA | GAS6 | GSTM1 | HTR2A | NADPH Oxidase Complex | ATXN2 | TAS1R3 | LOC107986362 | HTR1D | MC5R | LY96 | HECTD4 | CLOCK | ECE2 | alpha-Mannosidase (nonspecified subtype) | DRD3 | RWDD4 | PDE3A | SIRT6 | L1TD1 | CHRM2 | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | CMA1 | TRPA1 | Epoxide Hydrolase (nonspecified subtype) | IL6R | EPAS1 | MASTL | H19 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | STING1 | IGF2 | Rho kinase (ROCK) (nonspecified subtype) | MIR22 | UCP2 | CD3G | HSD17B3 | HRH4 | MIF | NOS2 | FOXP3 | OXTR | MAP2K5 | MOK | CCR5 | RET | EXD1 | VDR

疾病靶点研报
Obesity

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Malnutrition | Pierson Syndrome | Apert Syndrome | Diabetes Mellitus, Transient Neonatal | Multiple Sclerosis, Secondary Progressive | Carney-Stratakis Syndrome | Fuchs Heterochromic Iridocyclitis | Transcobalamin Deficiency | Schistosomiasis | X-linked Sideroblastic Anemia | Retinal Vasculitis | Keratitis-ichthyosis-deafness Syndrome | Vitamin A Deficiency | Perivascular Epithelioid Cell Tumor | Blue Rubber Bleb Nevus Syndrome | Porphyria | Blau Syndrome | Mannosidase Deficiency Diseases | Pericarditis | Hydrocephalus | Multiple Sclerosis, Chronic Progressive | Hypodontia | Spinocerebellar Ataxia Type 42 | Lymphomatoid Granulomatosis | Whipple's Disease | Polycystic Kidney, Autosomal Recessive | Calcium Pyrophosphate Deposition Disease | Seasonal Mood Disorder | Pheochromocytoma | Klinefelter Syndrome | Cleidocranial Dysplasia | Retinal Dystrophy | Conduct Disorder | Spinocerebellar Ataxia Type 7 | Crouzon Syndrome With Acanthosis Nigricans | Tumoral Calcinosis | Parapsoriasis | Spinocerebellar Ataxia | Adenomyosis | Vici Syndrome | Coloboma | Myhre Syndrome | C3 Glomerulopathy | Tatton-Brown-Rahman Syndrome | Speech Disorders | Papilloma | Leishmaniasis, Visceral | Multiple Sclerosis, Relapsing-remitting | Lactose Intolerance | Progressive Encephalopathy-optic Atrophy Syndrome | Peroxisomal Disorder | Meconium Ileus | Best Macular Dystrophy | Fetal Akinesia Deformation Sequence | Rheumatoid Arthritis | Photosensitivity | Aphasia | Sclerosteosis 2 | Graft-versus-host Disease | Fibromyalgia | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Postpartum Depression | Lymphangioma | Disseminated Superficial Actinic Porokeratosis | Chromosome 5q Deletion Syndrome | Raine Syndrome | Congenital Dyserythropoietic Anemia Type 1 | Mucolipidosis Type III | DEND Syndrome | Hepatic Veno-occlusive Disease | Centronuclear Myopathy | Insulinoma | Blepharospasm | Haim-Munk Syndrome | Exocrine Pancreatic Insufficiency | Gaucher Disease | Hereditary Xerocytosis | Sulfite Oxidase Deficiency | Nijmegen Breakage Syndrome | 5-oxoprolinase Deficiency | Demyelinating Diseases | Pulmonary Vein Stenosis | Eosinophilic Asthma | VEXAS Syndrome | Tyrosine Hydroxylase Deficiency | Fraser Syndrome | Mitochondrial Disease | Osteogenesis Imperfecta Type IV | Malaria, Cerebral | Aspergillosis | Polydactyly | Onchocerciasis | Congenital Ichthyosiform Erythroderma | Urolithiasis | Spondylosis | Sialoadenitis | Aneurysm, Thoracic Aortic | Neurodermatitis | Dengue Shock Syndrome | Cerebrovascular Disorders | Herpes Simplex Dermatitis | Congenital Bilateral Absence Of Vas Deferens | Insulin Resistance | Carcinoma, Merkel Cell | Lennox-Gastaut Syndrome | Spinocerebellar Ataxia Type 14 | Hydrolethalus Syndrome | Birt-Hogg-Dube Syndrome | Congenital Dyserythropoietic Anemia Type 4 | Progressive Familial Intrahepatic Cholestasis Type 1 | Optic Atrophy 2 | Infertility, Male | Systemic Mastocytosis | Protein S Deficiency | Hypermethioninemia | Pneumoconiosis | Alpha-thalassemia Myelodysplasia Syndrome | Majeed Syndrome | Bullous Pemphigoid | Porphyria Cutanea Tarda | Moyamoya Disease | Liver Diseases | Macrophagic Myofasciitis | Myelofibrosis | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Von Willebrand Disease | Bethlem Myopathy | Woodhouse-Sakati Syndrome | Proctitis | Macrodactyly | Greenberg Dysplasia | NGLY1 Deficiency | Neurocutaneous Melanocytosis | Alagille Syndrome | Osteitis | Primary Hyperoxaluria Type 1 | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Chronic Leukemia | Infantile Refsum Disease | Hyperammonemia | Leukocyte Adhesion Deficiency Type 1 | Postpoliomyelitis Syndrome | Bare Lymphocyte Syndrome | Angioedema, Acquired | Pseudohypoparathyroidism Type 2 | Ameloblastic Carcinoma | Waardenburg Syndrome Type 2 | Split Hand-foot Malformation | Bardet-Biedl Syndrome | Vitelliform Macular Dystrophy | Costello Syndrome | Tibial Muscular Dystrophy | Evans Syndrome | Acrocallosal Syndrome | Polycythemia Vera | Glutathione Synthetase Deficiency | Fibrosarcoma | Polyomavirus Nephropathy | Sclerosing Cholangitis | Hypertension, Renal | Hepatitis E | Occipital Neuralgia | Glycogen Storage Disease Type 1a | TARP Syndrome | Spinocerebellar Ataxia Type 21 | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Neuroleptic Malignant Syndrome | WAGR Syndrome | Silicosis | Dementia, Vascular | 3-methylglutaconic Aciduria Type I | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Diabetes Gestational | Encephalitis, Tick-borne | Otitis Media | Mood Disorder | Hemosiderosis | Lymphopenia | Amblyopia | DRESS Syndrome | Pancreatitis | Leri Pleonosteosis | Corneal Neovascularization | Neuromyotonia | Basal Ganglia Cerebrovascular Disease | Nutrition Disorders | Connective Tissue Disorders | Schamberg Disease | Obesity | Deafness, Dystonia, And Cerebral Hypomyelination | Aneurysm, Abdominal Aortic | Phenylketonuria | L-2-Hydroxyglutaric Aciduria | Thrombophilia | Microcephalic Primordial Dwarfism | Retinitis Pigmentosa 3 | Feingold Syndrome | Babesiosis | Chondrosarcoma | Fowler's Syndrome | Pseudoachondroplasia | Methemoglobinemia Type IV | Ocular Hypertension | Focal Segmental Glomerulosclerosis | Charcot-Marie-Tooth Disease Type 2D | Primary Familial Brain Calcification | Glutaric Aciduria Type 2 | Thrombocythemia, Essential | Pathological Gambling | Bacterial Meningitis | Persistent Fetal Circulation | Hyperacusis | Atrioventricular Septal Defect | Chondrodysplasia Punctata 2, X-linked Dominant | Oculocutaneous Albinism Type 4 | Myeloid Leukemia | Hydrops Fetalis | Intermittent Explosive Disorder | Opisthorchiasis | Hepatopulmonary Syndrome | Nail-Patella Syndrome | ACTH-independent Macronodular Adrenal Hyperplasia | Vulvovaginitis | Fragile X Syndrome | Bernard-Soulier Syndrome | Acute Lung Injury | Gangliosidosis, GM1 | Combined Deficiency Of Factor V And Factor VIII | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Duane Retraction Syndrome | Meningococcal Infections | Neutropenia | Intestinal Tuberculosis | Milk Allergy | Chanarin-Dorfman Syndrome | Leber Congenital Amaurosis | Prolactinoma | Netherton Syndrome | Rhabdomyosarcoma, Embryonal | Hepatitis, Alcoholic | Pure Autonomic Failure | Brooke-Spiegler Syndrome | POEMS Syndrome | Hartsfield Syndrome | Osteoporosis-pseudoglioma Syndrome | Infantile Spasm | Achondrogenesis | Peyronie's Disease | Distal Spinal Muscular Atrophy | Li-Fraumeni Syndrome | T-cell Prolymphocytic Leukemia | Discoid Lupus Erythematosus | Glycogen Storage Disease Type 3 | Olmsted Syndrome | Cranial Nerve Disease | Gastric Atrophy | Jacobsen Syndrome | Hypertension, Renovascular | Avellino Corneal Dystrophy | Emery-Dreifuss Muscular Dystrophy | Anti-NMDA Receptor Encephalitis | Hyperuricemia | Keratoacanthoma | Hypertrophy | Alzheimer Disease, Late Onset | Chorea | Wolman Disease | Myoclonus-dystonia Syndrome | Early Infantile Epileptic Encephalopathy 13 | Waardenburg Syndrome Type 4 | Idiopathic Pulmonary Fibrosis | Sickle Cell Anemia | Hypogammaglobulinemia | Crimean-Congo Hemorrhagic Fever | Schizoaffective Disorder | Temporal Lobe Epilepsy | Dermatitis Herpetiformis | Nephrotic Syndrome Type 1 | Cabezas Syndrome | Renal Tubular Acidosis | Fontaine Progeroid Syndrome | Wiedemann-Steiner Syndrome | Ameloblastoma | Paget's Disease Of The Breast | Episodic Ataxia Type 1 | Shwachman-Bodian-Diamond Syndrome | Pyruvate Dehydrogenase Deficiency | Hemangioendothelioma | Large Granular Lymphocytic Leukemia | Uterine Leiomyoma | Urethritis | Molybdenum Cofactor Deficiency | Crisponi Syndrome | Hypercholesterolemia, Familial | Glycogen Storage Disease Type 4 | Traboulsi Syndrome | Kaposi Sarcoma | Cluster Headache | Hyperinsulinemic Hypoglycemia | Heroin Dependence | Anorectal Fistula | Familial Partial Lipodystrophy | Hamartoma | Arthritis, Gouty | Argininosuccinic Aciduria | Bartter Syndrome | Acromesomelic Dysplasia | Hypercholesterolemia | Neurofibrosarcoma | Chondrodysplasia Punctata 1, X-linked Recessive | Early Infantile Epileptic Encephalopathy | Encephalopathy, Ethylmalonic | Cushing Syndrome | Zollinger-Ellison Syndrome | Sialidosis Type I | Heart Septal Defects | DOCK8 Immunodeficiency Syndrome | Macular Degeneration | Vitamin D Deficiency | Schaaf-Yang Syndrome | Tracheal Disorders | Uremic Pruritus | Leri-Weill Dyschondrosteosis | Dysequilibrium Syndrome | Hereditary Hemorrhagic Telangiectasia Type 2 | Hemochromatosis Type 2 | Xeroderma Pigmentosum Variant Type | Stroke, Ischemic | Spinocerebellar Ataxia Type 16 | Blepharophimosis Syndrome | Congenital Diaphragmatic Hernia | Charcot-Marie-Tooth Disease Type 2E | Chloridorrhea, Congenital | Priapism | Carey-Fineman-Ziter Syndrome | Spondylolisthesis | Chondromyxoid Fibroma | Alopecia | Viral Meningitis | Hereditary Sensory And Autonomic Neuropathy | DiGeorge Syndrome | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Spinocerebellar Ataxia Type 40 | Hairy Cell Leukemia | Endocarditis | Eczema | Cardiospondylocarpofacial Syndrome | Pseudohypoparathyroidism Type 1A | Leber Hereditary Optic Neuropathy | Spinocerebellar Ataxia Type 5 | Kawasaki Disease | Hypersensitivity Pneumonitis | Impetigo | Knobloch Syndrome | Osteoarthritis | Hyperlipidemia Type V | Urticaria | Fabry's Disease | Mitochondrial Encephalomyopathy | Panic Disorder | Blastomycosis