Disease

Obesity

About the Disease
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

Common Targets
cAMP Responsive Element Binding Protein (CREB) (nonspecified subtype) | BMPR2 | PDGFRA | LIPF | Soluble guanylyl cyclase | INPP5D | PCSK1 | ALOX5 | LIPG | KPTN | SLC6A3 | PLD5 | FGF2 | MXRA5 | NPY4R2 | OLFM2 | PTAFR | CCK receptor (nonspecified subtype) | INCA1 | MAOB | VHL | XBP1 | NRXN3 | SORBS1 | APEH | IFNG | Phosphodiesterase 6 (PDE6) (nonspecified subtype) | SH3PXD2A | CA4 | BBS9 | GLP1R | GRB2 | KLK15 | SLC27A2 | CDK1 | RARRES2 | APOE | TCF7L2 | TJP2 | G5743 | Monoamine oxidase (MAO) (nonspecified subtype) | PNMT | KSR2 | HTR3A | UCP3 | NPR3 | GCGR | PDIA5 | NLRP3 Inflammasome | SLC39A8 | ISLR | PM20D1 | KCNJ11 | TGFBR2 | NELL2 | ELOVL2 | EMC10 | RPS6KA4 | GSK3A | LINGO2 | RUNX1T1 | RASSF1 | FLT3 | PMM2 | IL4 | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | SREBF1 | CCL4 | ZNF321P | ASGR1 | TAS2R4 | TOMM40L | PTPN6 | Phosphodiesterase (nonspecified subtype) | GPR139 | TMEM186 | GSTP1 | CHEK2 | PLAAT4 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | CYBA | CUTC | TERF2IP | NADPH Oxidase (nonspecified subtype) | SCN5A | MTHFR | SIRT2 | PRDX1 | CD19 | CD36 | WDR5 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | CAT | PITRM1 | HMOX1 | SLC5A2 | CYP19A1 | Histone deacetylase (nonspecified subtype) | MLH1 | MMP1 | PASK | G238 | GPR55 | Prostaglandin EP Receptor (nonspecified subtype) | GPR88 | TNKS | KDM4A | ADK | SELE | INPPL1 | MAP2K4 | Glutamate Receptor Ionotropic AMPA Receptor | MIR133A1 | SEC16B | CSNK1E | TCF3 | RGS7 | CTR9 | TBC1D8 | MDM4 | DYSF | ENPP2 | IL6ST | DUSP3 | TLR5 | RUNX2 | CETP | Calcium/calmodulin-dependent protein kinase (nonspecified subtype) | FAIM2 | RPGRIP1L | TAS2R10 | PIK3CG | USP35 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | MIR133A2 | ABHD11 | PPIA | FADS2 | HSD17B2 | LPL | TNFSF14 | HRH3 | Proteasome Complex | Carnitine O-Palmitoyltransferase 1 (CPT-1) (nonspecified subtype) | GPR119 | CTNNB1 | GPBAR1 | RMST | G5599 | PTGR2 | EDNRA | MPO | ATP6V0A4 | FOLR2 | PTPN2 | Cyclin B (nonspecified subtype) | FFAR4 | JAK3 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G6647 | TACR3 | MOGAT2 | INTS5 | ACVR1C | Serum/glucocorticoid regulated kinase (Sgk) (nonspecified subtype) | TACR2 | NTRK2 | G5243 | CDH12 | GSR | NKX2-4 | PAX6-AS1 | CISD2 | ANGPTL4 | PDE4D | GHRL | GAPDH | LOC105373234 | G596 | CYP2A6 | TSC1 | TMPRSS15 | STIP1 | Kainate Receptor (GluR) (nonspecified subtype) | SNCA | AURKA | INVS | ALDH1A2 | LOC105373238 | FOXO1 | GDF15 | CA5A | CALD1 | GLI2 | LOC105375494 | CRY2 | MXD3 | PDK1 | G1026 | BANP | CERS1 | AVPR1A | LOC105373353 | RORC | CYP7A1 | FAP | VEGFB | FKBP4 | GRIN2C | BDNF | MLPH | HMGCLL1 | GRIK1 | MARK4 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | LDLR | SSTR2 | MC1R | F13A1 | SLC18A2 | MYT1L | OR12D3 | DAO | MAX | FER1L4 | ABL1 | MKNK2 | G114548 | IP6K2 | SH2B1 | DNA-Directed DNA Polymerase Complex | TFRC | DGAT1 | MIR488 | DDX10 | BSG | PAK2 | NR1I3 | KCNA3 | KDR | FH | CRBN | RXFP3 | GRM5 | PRDM16 | SFRP2 | GLIS3 | FFAR1 | FANK1 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | Serine/Threonine Kinase (nonspecified subtype) | G3576 | G1956 | CCDC171 | ADGRF5 | MORC2 | CADM2 | GHSR | GHRLOS | MGAT2 | IRX6 | LHX2 | IL12B | ZNF169 | Carbonic Anhydrase (nonspecified subtype) | MTNR1A | GTF3C2 | PRKCZ | PLAAT3 | Glycogen phosphorylase (nonspecified subtype) | SCLT1 | SFTPB | ZNF470 | CYP21A2 | COBLL1 | HOXD12 | MRAP2 | LanC-like proteins (nonspecified subtype) | AGRP | NPY1R | ARPIN-AP3S2 | CHP1 | PTPRE | C4orf33 | AKR1C2 | THRB | IRX3 | CDK2 | ATG9B | HNRNPA2B1 | BBS2 | CYP8B1 | NPSR1 | ACP1 | GNB3 | PLAAT2 | PROK2 | VPS13B | SMO | KLB | GFRAL | FCGRT | PNPLA3 | CES2 | NPC1L1 | Gamma-Aminobutyric acid type B receptor | Tyrosine-Protein Kinases Src (nonspecified subtype) | CRNDE | JAK2 | TRIP11 | LINC00470 | LRRK2 | CDK5/p25 | LGALS3 | MIR34A | GMPR2 | FNDC5 | IRX5 | PRMT5 | DRD4 | NR3C2 | ALDH3A1 | OPRK1 | KCTD21 | G5563 | COL1A1 | Interleukin-1 (nonspecified subtype) | ADRA2B | CYP2A7 | GIP | GPR18 | IKBKB | KCND3 | SLC5A3 | Thyroid hormone receptor (nonspecified subtype) | SLC7A5 | ADCY3 | NR1H2 | PDK2 | DUSP22 | CLN3 | G59272 | ITIH4 | FGFR2 | LRRK1 | TMC6 | CA6 | VKORC1 | RNF19A | AVPR1B | HMOX2 | ARNT2 | MGLL | ST6GAL1 | EGR1 | POMC | USP19 | Sodium-Glucose Cotransporter (SGLT) (nonspecified subtype) | PDE4B | ROPN1L | ANGPTL3 | TMEM67 | PTPRF | AREG | SUPT5H | DGAT2 | IRS2 | ADIPOQ | KIDINS220 | G1/S-specific cyclin-E (nonspecified subtype) | GCK | FFAR3 | EHD3 | HLA-DOA | AGT | G7124 | ALOX12 | PRKD1 | CPT1A | ZNF804B | SPZ1 | G3620 | EPHX2 | IL17RA | Hedgehog Protein (nonspecified subtype) | T-Type Calcium Channel | SCD | CTSS | NPM1 | PKLR | PACS1 | AMP-activated protein kinase (AMPK) | CYP17A1 | Phospholipase A2 (nonspecified subtype) | PDE1C | PRKCA | Cholesterol esterase (nonspecified subtype) | SGK1 | APLNR | G207 | CA1 | ANKK1 | ACSS2 | Casein kinase I (nonspecified subtype) | Mucin (nonspecified subtype) | BTK | OPRM1 | CEBPA | OR10P1 | TRPC5 | UGCG | Heat shock protein 90 (nonspecified subtype) | MAP3K5 | PEX11A | HRH2 | CIRBP | Phosphodiesterase IV (PDE4) (nonspecified subtype) | TAS2R31 | EXO1 | SCARB1 | SDCBP | LOX | CA12 | RUNX3 | CDK6 | HIF1A | ENTPD6 | ABCG1 | AMP-activated protein kinase alpha2beta1gamma1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | CDK5RAP1 | RAMP2 | G3479 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | SPTA1 | G6774 | NR1H3 | RPS6KB1 | SSTR3 | MAP3K11 | BACE2 | GALR3 | SLC22A12 | KHK | SNRPN | MMP3 | TPP2 | NGEF | GALNT2 | CCKBR | MACROH2A2 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | ELANE | ACKR1 | SLC22A6 | CFL1 | ACE | PAK3 | LOC105371268 | NR4A1 | Fibroblast growth factor (FGF) (nonspecified subtype) | G598 | BRD2 | AMP-activated protein kinase alpha1beta1gamma1 | JUNB | ARID4B | MKNK1 | GH1 | GRM2 | PTPN9 | DRD5 | ALDH2 | FKBP1A | THSD7B | MATN4 | LOC105371269 | HCRTR1 | AMP-activated protein kinase alpha2beta2gamma2 | LCK | EGR2 | MMP12 | TRAF6 | CASR | G5728 | GLIPR2 | MIR133B | PSD3 | LINC02183 | IDH1 | mTOR complex 1 | RBP4 | G1432 | HOXB-AS3 | MYOD1 | CERS6 | TAS2R30 | ITGBL1 | SCAND3 | TGFB1 | PPARA | HSF1 | G1385 | Calcium channel (nonspecified subtype) | Matrix Metalloproteinase (MMP) (nonspecified subtype) | LEP | PDE9A | PRPF19 | LOC105371274 | PDE10A | CHRNA2 | AMP-activated protein kinase alpha2beta1gamma2 | RAMP1 | SELENOS | IL1B | MIR324 | POU5F1 | FLOT1 | LOC105371275 | Lipoxygenase (nonspecified subtype) | CNR2 | SMPD1 | TYR | OBI1 | ANGPTL2 | TAS1R2 | PDE6C | PPID | CDK5 | MAP3K14 | Nicotinic alpha3beta4 Receptor | G7295 | NR5A2 | PIP4K2B | LOC105371276 | BAD | NEK7 | MGAT5B | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CSF1R | SLC6A9 | TIAM1 | NPY2R | CREB3 | LOC105371278 | SHC1 | HDAC11 | BTF3L4 | JUND | CYP2E1 | ND2 | TM6SF2 | BBS7 | GRIA3 | LOC105371279 | IAPP | WEE1 | MTHFD2 | ADORA2B | AKTIP | KEAP1 | NADH dehydrogenase (Complex I) | PDK4 | CDK4 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | Opioid receptor (nonspecified subtype) | ADRB3 | TOP1 | ZFHX3 | DPP8 | VPS26A | HTR2B | APOC3 | COMT | CA13 | Neurotrophic Factor (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | GADD45A | TBX3 | IKZF1 | PCDHGA10 | HTR1A | PTPRJ | G3569 | Amylin receptor | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | MAP2K1 | ST6GALNAC6 | PYGL | TRAPPC11 | ADORA1 | ESR2 | VCAM1 | BBS5 | SLC6A2 | VIPR1 | CEP290 | FFAR2 | Nicotinic alpha4beta2 receptor | KIT | MAOA | CXXC5 | GPAM | PGAM5-KEAP1-NRF2 Complex | PDPK1 | PCSK9 | PRKAG3 | NEDD4 | HMGCR | DRD2 | NPPA | CA7 | ASPSCR1 | G23411 | MAP1LC3B | TTTY14 | CREG1 | GNPDA2 | NPPA-AS1 | GPX1 | HMG20A | SLC22A8 | TMEM106A | DAW1 | EDNRB | MTNR1B | G4780 | ZNF165 | CHRNA7 | C3AR1 | SIRPA | SHISA9 | NEDD8 | NR1I2 | RNPC3 | PIWIL4 | ADCY4 | ZAP70 | GATA2 | GIPR | ARHGEF3 | ABCA1 | BRD4 | QPCTL | PRKCH | ICAM1 | Histone acetyltransferase (HAT) (nonspecified subtype) | BCHE | ADRA2A | ASCL1 | OPRL1 | PGR | PIK3CD | REPIN1 | TRPV2 | LYPLAL1 | cAMP-Dependent protein kinase (PKA) | SOD2 | DYRK1A | MC3R | XPO1 | CDK9 | Orexin receptor (nonspecified subtype) | NF-kappaB (NFkB) | CYP24A1 | NPY4R | Casein kinase II (CKII) | SLC6A19 | DNA Topoisomerase II (nonspecified subtype) | MYH2 | GRK4 | SCTR | INSR | GABA(A) receptor | LSP1 | ANKRD26 | NTRK3 | GLRA3 | SDHC | MAF | TFAP2B | NPY | MTCH2 | CEBPB | CD38 | HPR | Taste receptor type 2 (nonspecified subtype) | ALDH1A1 | RIN3 | TOMM7 | ATP6AP2 | GUSB | MAPK9 | CNR1 | LCT | Na+/K+-ATPase (nonspecified subtype) | PIKFYVE | CCR2 | MAPKAPK2 | ABHD6 | Glucagon-like peptide receptor (GLP-R) (nonspecified subtype) | NMBR | PAX5 | IRAK4 | ABCC9 | RORA | Estrogen receptor (nonspecified subtype) | FABP5 | NPY5R | G2309 | KLF11 | LINC02516 | HEXB | CES1 | SUCNR1 | CD40 | MAP Kinase-Interacting Serine/Threonine-Protein Kinase (nonspecified subtype) | SOCS3 | PRKAB2 | PRL | PPARD | HSD11B1 | ACVR2B | HOXB3 | MMP7 | LMTK2 | ALMS1 | ZNF324 | KLF7 | NRP1 | PTCH1 | CPB2 | GANAB | ADIPOR1 | WWTR1 | GPD1 | PRKCD | SLC19A1 | OXT | INSIG2 | AKT2 | TULP2 | C16orf46 | POC5 | LHCGR | CEP19 | PLG | DPP4 | PDGFRB | NPFFR2 | K(ATP) Channel (nonspecified subtype) | G142 | HSD11B1L | CALCA | BCL9 | G4170 | GLUD1 | HLA-DRB1 | MTTP | TGFBR1 | BACE1 | CPD | KCNJ5 | TSPO | ESRRA | PDE3B | HCAR1 | TPH2 | Retinoid acid receptor (nonspecified subtype) | SPTBN1 | FGF11 | ACKR3 | TIMP1 | BDNF-AS | CXCL1 | Heme Oxygenase (HO) (nonspecified subtype) | Trypsin (nonspecified subtype) | ADORA2A | ADRB1 | CYP2J2 | SYK | MAP3K7 | TBX5 | G4609 | AKR1B1 | CROT | sigma Receptor (nonspecified subtype) | Voltage-Gated Sodium Channel Complex | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | SERPINE1 | CASP8 | AP3S2 | APOBR | HCRTR2 | PTBP2 | ELOVL5 | OPRD1 | GPR84 | HCG9 | PPP5C | PNPLA2 | CHRM3 | CHUK | G3605 | ADORA3 | STK33 | GPR6 | BCAT1 | DAPK1 | SULT1A2 | ATF3 | NDN | DENND1C | LOC101927169 | SOAT1 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | DLX4 | DRD1 | TRPV1 | G6PC1 | CALCRL | CDK1/Cyclin B | CXCL12 | PRKCI | HOXB5 | mTOR complex 2 | CMTM3 | LINC02210-CRHR1 | ACMSD | ESRRB | AKR1C3 | KLF15 | ZNF331 | LIPC | XDH | ABHD5 | C1D | OGA | ADP/ATP Translocase (nonspecified subtype) | CHIA | POU3F3 | CDC25A | TRIM21 | NTRK1 | CRTC1 | E2F Transcription Factor (nonspecified subtype) | RPL31 | DLX5 | BRS3 | STS | GSK3B | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | GHR | HIP1R | SGMS2 | MSC | HDAC4 | PTPN1 | CCR1 | FBP1 | MLYCD | PTGS1 | SNAP25 | ERCC2 | G9429 | Transforming growth factor beta (nonspecified subtype) | ACHE | ZBTB7B | AARSD1 | MCHR2 | HSD11B2 | DNA topoisomerase (nonspecified subtype) | Cytochrome P450 Enzymes (nonspecified subtype) | Dopamine receptor (nonspecified subtype) | EDNRB-AS1 | NR1H4 | Carbonic Anhydrase V (nonspecified subtype) | Vasopressin Receptor (nonspecified subtype) | LOXL2 | G2033 | FGF1 | PKM | PPARG | MAN1B1 | RXRA | LEPR | HNF1A | ZZZ3 | MIR92A1 | TAOK3 | LOC101929710 | PTPN4 | G3480 | NMUR1 | RUNDC1 | GPRC6A | PAPPA | COG8 | MSTN | TRIM36 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | CRHR1 | TPH1 | PCK1 | PLIN1 | MAGEL2 | GRK5 | Cytohesin (nonspecified subtype) | KDM1A | MMP2-AS1 | BDKRB1 | ALDOC | ALDH5A1 | G2475 | DOT1L | Adrenoceptor (nonspecified subtype) | SIM1 | FBXO48 | BCKDK | Fructose-Bisphosphate Aldolase (nonspecified subtype) | FAAH | ADIPOR2 | STK25 | GPR83 | CHI3L1 | HTR6 | RBL2 | TBX15 | BORCS5 | RORB | Neuropeptides B/W receptor (nonspecified subtype) | SIRT5 | CA14 | ENPP1 | NPBWR1 | KCTD1 | KCNJ8 | SORD | GABRA5 | LINC00578 | CCNE1 | RAB5A | CLK1 | CDK2/Cyclin A | KCNQ1 | KIF22 | FGFR1 | FGFR4 | PDE2A | ZSCAN30 | ACACB | LYPD1 | MIR92A2 | TFF1 | PIN1 | GJA1 | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | BLK | Cannabinoid receptor (nonspecified subtype) | TDO2 | PABPC4 | RPS10-NUDT3 | CCKAR | Sodium channel (nonspecified subtype) | NQO2 | ZIC3 | CDKN1B | RXRB | Heat shock protein 70 (nonspecified subtype) | SLC2A1 | CYP2C9 | G2099 | DRB sensitivity-inducing factor complex | FLT1 | TRIB3 | CIDEC | Adenosine receptor (nonspecified subtype) | DAGLA | KCNK4 | SGIP1 | CDC42BPA | HCAR3 | FAM3C | ZNF543 | IL12A | Mitochondrial pyruvate carrier complex (MPC) | G3630 | HIF3A | SLCO2A1 | TLR2 | CACNA1A | SIK2 | RNPC3-DT | SLC10A2 | ZNF717 | LINC02169 | P2RY14 | PRLHR | CERS5 | MAPK10 | FASN | PIM1 | DYRK1B | GLP2R | TEK | G836 | PON1 | EIF2AK3 | AKR1B10 | HTR1B | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | ESRRG | APOA1 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | GBA2 | OR7D4 | FAAP20 | NPR1 | CA9 | CACNA1E | EGLN1 | SEMA6D | PLAU | GUCY2C | CA5B | SELENOP | SLC5A1 | CTSK | PLEKHG4B | SDK1 | IL1A | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | G4193 | BRD3 | MTIF3 | CA2 | CSRNP3 | GCG | RAPGEF3 | GGPS1 | SDC3 | C10orf55 | FOXO4 | HSD17B1 | Sphingomyelin synthase (nonspecified subtype) | G196 | ACLY | NOS3 | STK39 | METAP2 | HIVEP3 | CDK2/Cyclin E | SSTR5 | MIR127 | G4318 | SOAT2 | DNM3 | HNF4A | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | Cyclooxygenase (COX) (nonspecified subtype) | FGF14 | DDAH2 | SGMS1 | NR1D1 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CBX3 | Angiotensin receptor (AT) (nonspecified subtype) | GSX1 | MRAS | QRFPR | PIP4K2A | CREB5 | SCRN1 | TACR1 | UCP1 | GHRHR | G8678 | PRCP | HPSE | CMKLR1 | RXRG | PDF | ADRB2 | MC4R | AHSG | KIF16B | PRKCQ | RXFP4 | alpha1-Adrenoceptor (nonspecified subtype) | G7157 | NF1 | HYOU1 | RETN | HES3 | LBP | COX15 | Bombesin receptor (nonspecified subtype) | LYN | RUNX1 | GPR75 | HRH1 | LIPE | IDE | NARS2 | MKKS | CRY1 | CSNK1D | SLC6A4 | FABP4 | LRP1B | KCNQ1DN | MICOS13 | NUBP1 | ERP44 | PNLIP | GRM4 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | WT1 | TFEB | PARL | IGF2BP2 | GPR39 | HCAR2 | CTSB | AGTR2 | NOX3 | PDE5A | GRPR | Cyclin A (nonspecified subtype) | MBOAT4 | CXCL6 | alpha-Amylase (nonspecified subtype) | NNMT | CASP1 | GAA | GATA3 | GALR2 | ADCY9 | IL2 | Retinoid RXR receptor (nonspecified subtype) | DAGLB | CALCR | TXNDC12 | NEGR1 | ABAT | AGTR1 | NPC1 | HS6ST3 | APOB | NMDA receptor | TUB | RSPO3 | NAMPT | IP6K1 | Collagen (nonspecified subtype) | AGER | CA3 | MAP3K21 | GNAS | NOTO | COL6A3 | CRHR2 | SIRT3 | PLAAT5 | GRK2 | FTO | AKT3 | PYY | BBS1 | BRD9 | NQO1 | FABP2 | Nitric oxide synthase (NOS) (nonspecified subtype) | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | CYP1B1 | TBC1D1 | UGT1A1 | GSPT1 | ACACA | NMUR2 | Transcription Factor TCF (nonspecified subtype) | MCHR1 | WDR64 | TRIM40 | IRAK1 | SLC2A4 | NR3C1 | DLGAP2 | THRA | ALDH1A3 | FSHB | G8878 | GPR17 | CHRDL1 | CACNA2D3 | RARG | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | FKBP1B | BBS10 | PPARGC1A | CHGA | RAB21 | ZFR2 | GALR1 | NALCN | TBK1 | HTR2C | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | IRS1 | PRKCE | CX3CR1 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | CHRNB2 | TAAR1 | SLC8A1 | PRKN | CRP | G367 | CYP11B2 | ELOVL6 | PNLIPRP2 | IKBKE | CREBBP | Melanocortin receptor (nonspecified subtype) | SLC1A2 | FYN | PTPRC | CCL2 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | FADS1 | ARID1A | GAD2 | GNAT2 | CAMKK2 | PTPN11 | EN1 | PIK3CA | GAS6 | GSTM1 | HTR2A | NADPH Oxidase Complex | ATXN2 | TAS1R3 | LOC107986362 | HTR1D | MC5R | LY96 | HECTD4 | CLOCK | ECE2 | alpha-Mannosidase (nonspecified subtype) | DRD3 | RWDD4 | PDE3A | SIRT6 | L1TD1 | CHRM2 | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | CMA1 | TRPA1 | Epoxide Hydrolase (nonspecified subtype) | IL6R | EPAS1 | MASTL | H19 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | STING1 | IGF2 | Rho kinase (ROCK) (nonspecified subtype) | MIR22 | UCP2 | CD3G | HSD17B3 | HRH4 | MIF | NOS2 | FOXP3 | OXTR | MAP2K5 | MOK | CCR5 | RET | EXD1 | VDR

疾病靶点研报
Obesity

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Veno-occlusive Disease | Meningococcal Meningitis | Heavy Chain Disease | DRESS Syndrome | Congenital Primary Aphakia | Rheumatic Heart Disease | Bainbridge-Ropers Syndrome | Glutaric Aciduria Type 3 | Myeloid Leukemia | Imerslund-Grasbeck Syndrome | Myocarditis | Ischemia | Turner's Syndrome | Usher Syndrome | Nager Acrofacial Dysostosis | Macular Corneal Dystrophy Type 1 | Bronchiolitis | Polymyositis | Juvenile Xanthogranuloma | Dystonia | Early Infantile Epileptic Encephalopathy 28 | Oligoasthenoteratozoospermia | Paroxysmal Nocturnal Hemoglobinuria | Waardenburg Syndrome Type 2 | Maple Syrup Urine Disease | Huntington's Disease-like 2 | Alopecia | Gitelman Syndrome | Pterygium | Migraine | Dubin-Johnson Syndrome | Williams Syndrome | Neurodermatitis | Knobloch Syndrome | Charcot-Marie-Tooth Disease, Type 2C | Camptocormia | Precocious Puberty | Progressive Osseous Heteroplasia | Mucolipidosis Type II | Iron Overload | Malonyl-CoA Decarboxylase Deficiency | WAGR Syndrome | Hypertension, Essential | Acromesomelic Dysplasia | Pleural Tuberculosis | Congenital Torticollis | Nail-Patella Syndrome | Smith-Magenis Syndrome | Vascular Calcification | Porphyria Cutanea Tarda | 3-hydroxy-3-methylglutaric Aciduria | Pseudoexfoliation Syndrome | Microcephalic Primordial Dwarfism | Osteogenesis Imperfecta Type III | Multicentric Carpotarsal Osteolysis Syndrome | Lymphangioleiomyomatosis | Liver Diseases | Methylmalonic Aciduria And Homocystinuria, CblC Type | Crimean-Congo Hemorrhagic Fever | Lysosomal Acid Lipase Deficiency | Congenital Myopathy | Nevus | Pyelonephritis | Diabetes Insipidus, Nephrogenic | Hyperhomocysteinemia | Carey-Fineman-Ziter Syndrome | Rett Syndrome | Diffuse Palmoplantar Keratoderma | Infantile Spasm | Multicystic Renal Dysplasia | FG Syndrome | Adrenal Insufficiency | Ichthyosis, X-linked | Dent Disease | Hyperparathyroidism, Primary | Lateral Meningocele Syndrome | Paraplegia | Urea Cycle Disorder | Pantothenate Kinase-associated Neurodegeneration | Antenatal Bartter Syndrome Type 1 | Schuurs-Hoeijmakers Syndrome | Holt-Oram Syndrome | Encephalopathy, Glycine | Purpura, Thrombotic Thrombocytopenic | Blepharospasm | Orthostatic Intolerance | Mitochondrial DNA Depletion Syndrome | Bartter Syndrome | Okihiro Syndrome | Amenorrhea | Infantile Nephropathic Cystinosis | Aspartylglycosaminuria | Gerodermia Osteodysplastica | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Combined Deficiency Of Factor V And Factor VIII | Sorsby Fundus Dystrophy | Diamond-Blackfan Anemia | Paraganglioma, Carotid Body | Hydronephrosis | Congenital Nephrotic Syndrome | Extramammary Paget's Disease | Hermansky-Pudlak Syndrome | Panuveitis | LRBA Deficiency | Cholecystitis | Chronic Periodontitis | Vertebrobasilar Insufficiency | Lung Diseases | Waardenburg Syndrome Type 2A | Keratoconjunctivitis | Netherton Syndrome | Colitis, Collagenous | Chondroma | Richter's Syndrome | Behcet's Disease | Papillorenal Syndrome | Alpers Syndrome | Noonan Syndrome | Oral Lichen Planus | Epidermolysis Bullosa | Fanconi Syndrome | 5-oxoprolinase Deficiency | Cole-Carpenter Syndrome | Congenital Bilateral Absence Of Vas Deferens | Chudley-McCullough Syndrome | Multiple Hamartoma Syndrome | Multiple System Atrophy | Werner's Syndrome | Chitayat Syndrome | Schizophrenia, Paranoid | Constipation | Osteogenesis Imperfecta Type I | Crigler-Najjar Syndrome | Mitochondrial Disease | Sclerosteosis 2 | Borjeson-Forssman-Lehmann Syndrome | Oligodendroglioma | Hypoplastic Left Heart Syndrome | Albinism | Thrombosis | Thalassemia | Sporadic Inclusion Body Myositis | Tremor | Micro Syndrome | Barrett Esophagus | Macular Corneal Dystrophy | Myelomeningocele | Necrotizing Autoimmune Myopathy | Acute Motor Axonal Neuropathy | X-linked Myotubular Myopathy | Amelanotic Melanoma | Congenital Dyserythropoietic Anemia Type 4 | Proximal Symphalangism | Epilepsy Of Infancy With Migrating Focal Seizures | Pituitary Dwarfism | Glioblastoma Multiforme | Amyloidosis | Episodic Ataxia | Stickler Syndrome | Anovulation | Hemophilia | Holoprosencephaly | Ectodermal Dysplasia | Nicotine Addiction | Myopathy | Renal Tubular Acidosis | Esthesioneuroblastoma | Charcot-Marie-Tooth Disease | Ichthyosis | Renpenning Syndrome | Bipolar Disorder | Congenital Hemolytic Anemia | Agranulocytosis | Trichotillomania | Epicondylitis | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Sick Sinus Syndrome | Neurodevelopmental Disorders | Alstrom Syndrome | Non-epidermolytic Palmoplantar Keratoderma | Hypoglycemia | Lennox-Gastaut Syndrome | Oculocutaneous Albinism Type 2 | Macrophagic Myofasciitis | Fibrosarcoma | Hereditary Xerocytosis | Blastomycosis | Optic Nerve Diseases | Senior-Loken Syndrome | Left Ventricular Noncompaction | Branchiootorenal Syndrome | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | GATA2 Deficiency | Glycogen Storage Disease | Dysplastic Nevus | Follicular Dendritic Cell Sarcoma | Tibial Muscular Dystrophy | Periodic Limb Movement Disorder | Down Syndrome | Ichthyosis Bullosa Of Siemens | Cataract | Hypertrophy | Christianson Syndrome | Hereditary Neuropathy With Liability To Pressure Palsies | Leukoplakia | Retinitis Pigmentosa | Benign Familial Pemphigus | Spinal Muscular Atrophy Type 2 | McLeod Syndrome | Seasonal Mood Disorder | Rhinitis | Odonto-onycho-dermal Dysplasia | Neuromyotonia | Amblyopia | Endocarditis | Otosclerosis | Cutaneous Mastocytosis | Potocki-Shaffer Syndrome | Irritable Bowel Syndrome | Multisystemic Smooth Muscle Dysfunction Syndrome | Pyruvate Kinase Deficiency | Primary Progressive Aphasia | Peutz-Jeghers Syndrome | Myoclonic Atonic Epilepsy | Angiosarcoma Of The Breast | Lipoma | Bietti Crystalline Dystrophy | Diabetic Neuropathy | Pure Red Cell Aplasia | Rift Valley Fever | Seizures-scoliosis-macrocephaly Syndrome | Glomerulonephritis, Membranous | Neuromuscular Disorders | Shock, Cardiogenic | Coffin-Siris Syndrome | Thrombocytopenia | Myelitis, Transverse | Infantile Refsum Disease | Keratosis, Actinic | Choriocarcinoma | Leukoencephalopathy, Progressive Multifocal | Saul-Wilson Syndrome | Auriculocondylar Syndrome | Acute Chest Syndrome | Hyperbilirubinemia | Chronic Idiopathic Myelofibrosis | Twin-to-twin Transfusion Syndrome | Wolcott-Rallison Syndrome | Thanatophoric Dysplasia | Conduct Disorder | Hereditary Hemorrhagic Telangiectasia Type 2 | Raynaud Phenomenon | Spinocerebellar Ataxia | Mitochondrial Encephalomyopathy | Cholangiocarcinoma | Carcinoma, Transitional Cell | Retinitis Pigmentosa 3 | Common Variable Immunodeficiency | Obesity | Cancer, Skin | Loeys-Dietz Syndrome | Hyper IgE Syndrome | Pulmonary Tuberculosis | Intestinal Pseudo-obstruction | Intellectual Disability, Autosomal Dominant 5 | Platelet Disorders | Teratozoospermia | Anterior Segment Dysgenesis | Hemolytic Uremic Syndrome, Atypical | Schwannomatosis | Hyperuricemic Nephropathy, Familial Juvenile | Tyrosinemia | Hyperprolactinemia | Alpha-1 Antitrypsin Deficiency | Cartilage Disorders | Globozoospermia | Spondyloperipheral Dysplasia | Glycogen Storage Disease Type 1b | Heart Failure | Multiple Myeloma | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | 3-methylglutaconic Aciduria Type IV | Charcot-Marie-Tooth Disease, Type 6 | Hypoproteinemia, Hypercatabolic | Hypohidrotic Ectodermal Dysplasia, X-linked | Autosomal Recessive Bestrophinopathy | Usher Syndrome Type IIC | Sarcosinemia | Myhre Syndrome | Spinocerebellar Ataxia Type 8 | Pericarditis | Acute Tubular Necrosis | Obsessive-compulsive Disorder | Arrhythmogenic Right Ventricular Cardiomyopathy | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Postpoliomyelitis Syndrome | Familial Mediterranean Fever | Bronchiectasis | Myelitis | Tumoral Calcinosis | Esophageal Motility Disorders | VEXAS Syndrome | Iron Deficiency Anemia | Pancreatitis, Chronic | Retinopathy Of Prematurity | Sclerosteosis | Preaxial Polydactyly | Mastitis | Atrioventricular Septal Defect | Autosomal Recessive Spastic Paraplegia Type 75 | Kabuki Syndrome 2 | Familial Hyperaldosteronism | Van Der Knaap Disease | Peters-plus Syndrome | Cramp Fasciculation Syndrome | Atherosclerosis | Trichothiodystrophy | Leri Pleonosteosis | Carbamoyl Phosphate Synthetase I Deficiency | Cutaneous T-cell Lymphoma | Osteogenesis Imperfecta Type VI | Gangliosidosis, GM1 | Neurocutaneous Syndromes | Loeys-Dietz Syndrome Type 4 | Charcot-Marie-Tooth Disease Type 4D | Acute Lymphocytic Leukemia | Majeed Syndrome | Choroiditis | Dysferlinopathy | Stroke, Ischemic | Renal Oncocytoma | Niemann-Pick Disease, Type B | Charcot-Marie-Tooth Disease Type 3 | Tyrosinemia Type 1 | Basal Ganglia Cerebrovascular Disease | Thin Basement Membrane Disease | Proteus Syndrome | Jacobsen Syndrome | Acne Vulgaris | Hepatopulmonary Syndrome | DICER1 Syndrome | Fowler's Syndrome | Hereditary Multiple Exostoses | Pseudohypoparathyroidism Type 1B | Carcinoma, Squamous Cell | Sandhoff Disease | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Essential Fructosuria | Mixed Connective Tissue Disease | Exotropia | Metabolic Diseases | Heart Block | Peeling Skin Syndrome Type B | Thrombasthenia | Gyrate Atrophy Of The Choroid And Retina | Skin Papilloma | Hairy Cell Leukemia | Spinal Muscular Atrophy Type 3 | Chronic Beryllium Disease | Stuttering | Xeroderma Pigmentosum Variant Type | Autosomal Recessive Congenital Ichthyosis