Systemic Mastocytosis

About the Disease
Systemic Mastocytosis, also known as systemic mast cell disease, is related to systemic mastocytosis with associated hematologic neoplasm and indolent systemic mastocytosis. An important gene associated with Systemic Mastocytosis is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Protein Kinase Inhibitors and Imatinib Mesylate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and spleen, and related phenotypes are Decreased viability and Decreased viability

Common Targets
BCR | G598 | BMX | TLR2 | HSP90AB1 | Tyrosine Kinase (nonspecified subtype) | ETNK1 | FLT3 | SIGLEC8 | FCGR3A | RAF1 | PDGFRA | TLR9 | JAK2 | SIRPA | ADA | G673 | Adenosine deaminase (nonspecified subtype) | KIT | BCL2A1 | BLK | G7099 | LYN | Immunoglobulin E (IgE) | PDE6D | PROM1 | G596 | ABL1 | IL6R | IL13 | G2146 | PDGFRB | CSF1R | G6776 | BTK | G2475 | CMA1 | LINC01412 | G5243 | FGFR3 | Heat shock protein 90 (nonspecified subtype) | Protein kinase C (nonspecified subtype) | GPR35 | G3320 | FKBP1A | G9429

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