Autosomal Recessive Polycystic Kidney

About the Disease
Polycystic Kidney Disease 4 with or Without Polycystic Liver Disease, also known as autosomal recessive polycystic kidney disease, is related to polycystic kidney disease 3 with or without polycystic liver disease and polycystic kidney disease 4. An important gene associated with Polycystic Kidney Disease 4 with or Without Polycystic Liver Disease is PKHD1 (PKHD1 Ciliary IPT Domain Containing Fibrocystin/Polyductin), and among its related pathways/superpathways are Organelle biogenesis and maintenance and Cargo trafficking to the periciliary membrane. The drugs Tolvaptan and Arginine Vasopressin have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart, and related phenotypes are hypertension and polycystic kidney dysplasia

Common Targets
PKD1 | INVS | PKD2 | KIF7 | NPHP4 | FLT4 | G1956 | TMEM67 | KDR | EPHB4 | G2064 | ACTN4 | GLIS2 | PKHD1 | DZIP1L | WDR19 | NPHP3 | ZNF423 | HNF1B | NPR2 | HDAC6 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CSK

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