Glutathione Synthetase Deficiency

About the Disease
Glutathione Synthetase Deficiency, also known as pyroglutamic aciduria, is related to hemolytic anemia and bilirubin metabolic disorder, and has symptoms including abdominal pain, diarrhea and vomiting. An important gene associated with Glutathione Synthetase Deficiency is GSS (Glutathione Synthetase), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. Affiliated tissues include brain, neutrophil and bone marrow, and related phenotypes are hemolytic anemia and abnormality of immune system physiology

Common Targets
GSS

Note: If you'd like to get a target analysis report for Glutathione Synthetase Deficiency, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Glutathione Synthetase Deficiency at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Lattice Corneal Dystrophy Type 1 | Pyruvate Dehydrogenase Deficiency | Herpes Simplex Dermatitis | Smith-Lemli-Opitz Syndrome | Spinocerebellar Ataxia Type 12 | Schuurs-Hoeijmakers Syndrome | Malnutrition | Hypertensive Retinopathy | Gastrointestinal Disorders | Pseudohypoparathyroidism Type 1C | Hemangioendothelioma | Haim-Munk Syndrome | Lymphoma Lymphoblastic | Lymphoproliferative Disease, X-linked | Epidermodysplasia Verruciformis | Pulmonary Alveolar Microlithiasis | Insulin Resistance | Necrobiosis Lipoidica | Ileitis | Neural Tube Defect | Spinal Muscular Atrophy | Spinocerebellar Ataxia Type 20 | Vertebrobasilar Insufficiency | 3-M Syndrome | Thrombocytopenia | Myelitis | Infantile Spasm | Methylmalonic Aciduria And Homocystinuria, CblC Type | Granular Corneal Dystrophy | Stroke, Hemorrhagic | Periodic Limb Movement Disorder | Porphyria, Variegate | Extramammary Paget's Disease | Spinocerebellar Ataxia Type 5 | Fabry's Disease | Bone Marrow Necrosis | Majeed Syndrome | Hyperparathyroidism, Primary | Bullous Pemphigoid | Leukocyte Adhesion Deficiency | Rubeosis Iridis | Primary Biliary Cholangitis | Renal Medullary Carcinoma | Large Granular Lymphocytic Leukemia | Chronic Idiopathic Myelofibrosis | Hereditary Elliptocytosis | Distal Myopathy 2 | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Sclerocornea | Spastic Paraplegia Type 7 | Schindler Disease | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Transthyretin-related Amyloidosis | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Congenital Stromal Corneal Dystrophy | Familial Hyperaldosteronism | Acute Kidney Injury | Hereditary Spherocytosis | PASLI Disease | Progressive Osseous Heteroplasia | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Lymphoma | Prostatitis | Hyperkalemic Periodic Paralysis | Cardiomyopathy, Peripartum | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Spermatocele | ICF Syndrome | Measles | Uremic Pruritus | Combined Pituitary Hormone Deficiency | Paraganglioma | Connective Tissue Disorders | Cancer, Breast | Diabetes Insipidus, Neurogenic | Nephritis, Interstitial | Carcinoma, Transitional Cell | Charcot-Marie-Tooth Disease Type 3 | Presbyopia | Waldenstrom Macroglobulinemia | Transient Bullous Dermolysis Of The Newborn | Waardenburg Syndrome Type 2 | Barakat Syndrome | Carpenter Syndrome | Palmoplantar Keratoderma | Anorchia | Creutzfeldt-Jakob Disease | Niemann-Pick Disease, Type A | Autoimmune Polyendocrine Syndrome | Colitis, Lymphocytic | Idiopathic Pulmonary Fibrosis | Molybdenum Cofactor Deficiency | Turner's Syndrome | Burn-McKeown Syndrome | Tyrosine Hydroxylase Deficiency | Scleroderma | Glycogen Storage Disease | Cryoglobulinemia | Evans Syndrome | Myocarditis | Congenital Poikiloderma | Mast Cell Leukemia | Alstrom Syndrome | Spinal Muscular Atrophy Type 3 | Amyotrophic Lateral Sclerosis | Postpartum Depression | C3 Glomerulonephritis | Sarcoma, Endometrial Stromal | Reye Syndrome | Hyperlipidemia Type V | Fuchs Heterochromic Iridocyclitis | Hyperferritinemia-cataract Syndrome | Eclampsia | Vaginitis | Zimmermann-Laband Syndrome | Diffuse Mesangial Sclerosis | Congenital Tufting Enteropathy | Mitochondrial Myopathy | Whipple's Disease | Metachondromatosis | Erythromelalgia | Schizoaffective Disorder | Motion Sickness | Osteogenesis Imperfecta Type IV | Asphyxia Neonatorum | Still Disease | Motor Neuron Diseases | DNA Ligase IV Deficiency | Sleep Apnea, Central | Hartsfield Syndrome | Nail-Patella Syndrome | Retinal Diseases | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Donnai-Barrow Syndrome | Sialoadenitis | Progressive External Ophthalmoplegia | Inflammatory Bowel Disease | Abetalipoproteinemia | Retinoblastoma | Tic Disorder | Dubin-Johnson Syndrome | Congenital Dyserythropoietic Anemia Type 1 | Cancer, Kidney | Arteriovenous Malformations | Mucolipidosis Type IV | Warsaw Breakage Syndrome | Craniopharyngioma | Kernicterus | Sezary Syndrome | Ocular Albinism Type 1 | Hyperuricemic Nephropathy, Familial Juvenile | Lymphoma, AIDS-related | Ghosal Syndrome | Facioscapulohumeral Muscular Dystrophy Type 1 | Thyroiditis | Peroxisomal Disorder | Cancer, Prostate | Crigler-Najjar Syndrome | Epidermolysis Bullosa Simplex, Localized | Richter's Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Greenberg Dysplasia | Cyst | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Hereditary Xerocytosis | Language Disorders | Rhabdomyosarcoma, Embryonal | Hepatitis B, Chronic | Neurofibroma | Congenital Myasthenic Syndrome | Lipoma | Long QT Syndrome Type 2 | Renpenning Syndrome | Urticaria | Hypohidrotic Ectodermal Dysplasia | Membranous Nephropathy | Combined Malonic And Methylmalonic Acidemia | Aldosterone Deficiency | Autosomal Recessive Congenital Ichthyosis | Neutrophilia | Polymyositis | Brugada Syndrome 1 | Microcephalic Primordial Dwarfism | Benign Familial Pemphigus | Allergic Contact Dermatitis | Lissencephaly 2 | McLeod Syndrome | Paroxysmal Nocturnal Hemoglobinuria | Thanatophoric Dysplasia Type 1 | Inflammatory Joint Disease | Adenomatoid Tumor | Rhinitis | Optic Neuropathy | Retinopathy Of Prematurity | Waardenburg Syndrome Type 4 | Sarcoma | Pigment Dispersion Syndrome | Primary Progressive Nonfluent Aphasia | Meningococcal Meningitis | Speech Disorders | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Alexander Disease | Myelomeningocele | Multiple Sclerosis, Relapsing-remitting | Loeys-Dietz Syndrome Type 4 | Meningeal Melanocytoma | Mohr-Tranebjaerg Syndrome | Barrett Esophagus | Alveolar Capillary Dysplasia | Encephalitis, Tick-borne | Cavitary Optic Disc Anomalies | POEMS Syndrome | Multiple Sclerosis, Primary Progressive | Giant Axonal Neuropathy | Lamellar Ichthyosis | Neurofibrosarcoma | Autoimmune Hemolytic Anemia | Spinocerebellar Ataxia Type 1 | Neurodevelopmental Disorders | Vici Syndrome | Erythrokeratodermia Variabilis | Congenital Dysfibrinogenemia | Cerebral Cavernous Malformations | Rift Valley Fever | Polyneuropathy | Enhanced S-cone Syndrome | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Cardiofaciocutaneous Syndrome | Skin Carcinoma | Intermittent Explosive Disorder | Epidermolytic Palmoplantar Keratoderma | Meningioma, Benign | Multiple Hamartoma Syndrome | Pelvic Inflammatory Disease | Blastomycosis | Knobloch Syndrome | T-cell Prolymphocytic Leukemia | Maternally Inherited Diabetes And Deafness | Skin Papilloma | Endometriosis | Diastrophic Dysplasia | Eccrine Porocarcinoma | Meckel-Gruber Syndrome | Xeroderma Pigmentosum Variant Type | Tyrosinemia Type 2 | Episodic Ataxia | Corneal Edema | Mixed Connective Tissue Disease | Aspergillosis | Usher Syndrome Type I | 3-hydroxy-3-methylglutaric Aciduria | Smith-Kingsmore Syndrome | Prader-Willi Syndrome | Leukoplakia | Non-proliferative Diabetic Retinopathy | Primary Carnitine Deficiency | Postaxial Polydactyly | Craniometaphyseal Dysplasia | Creatine Deficiency Syndrome | Preaxial Polydactyly | Hepatitis, Chronic | Vascular Cognitive Impairment | Progressive Familial Intrahepatic Cholestasis Type 1 | Chronic Leukemia | Low Phospholipid Associated Cholelithiasis | Dysferlinopathy | Craniofacial Dysostosis | Delirium | Intestinal Hypomagnesemia 1 | Osteogenesis Imperfecta Type VI | Woodhouse-Sakati Syndrome | Aplastic Anemia | Achondrogenesis | Diabetes Insipidus | Sleep Disorder | Toxic Epidermal Necrolysis | Cholesteryl Ester Storage Disease | Niemann-Pick Disease | Avellino Corneal Dystrophy | Fanconi Syndrome | Stroke, Ischemic | Lactose Intolerance | Insulinoma | Polyarteritis Nodosa | Schamberg Disease | Von Willebrand Disease | Hypervalinemia | Arteriosclerosis | Sepiapterin Reductase Deficiency | Vitreoretinal Degeneration, Snowflake Type | Retinal Dystrophy, Early-onset Severe | Congenital Stationary Night Blindness | Duodenal Atresia | Hypersomnia | Disseminated Intravascular Coagulation | Hyperthermia, Malignant | Spinocerebellar Ataxia Type 6 | Polyradiculopathy | Chromosome 5q Deletion Syndrome | Encephalitis | Autism Spectrum Disorders | Long QT Syndrome Type 3 | Hepatitis D | CDKL5 Deficiency Disorder | Triple A Syndrome | Sorsby Fundus Dystrophy | Polycystic Ovary Syndrome | Papulopustular Rosacea | Autism | Myocardial Infarction | Chronic Myelomonocytic Leukemia | Liebenberg Syndrome | Coffin-Lowry Syndrome | Proopiomelanocortin Deficiency | Torticollis | Hypermethioninemia | Hyperglycemia | Lymphangioleiomyomatosis | Spinocerebellar Ataxia Type 31 | Encephalocele | Methemoglobinemia Type IV | Syphilis | Panuveitis | Neurocysticercosis | Asthma | Lymphedema | Chondrosarcoma | Dystrophy, Cone-rod | Seborrheic Dermatitis | Spitzoid Melanoma | Hypersensitivity | Methemoglobinemia | Nanophthalmos | Neovascular Glaucoma | Immunoproliferative Disorders | Stromal Corneal Dystrophy | Waardenburg Syndrome Type 2A | Loeys-Dietz Syndrome | Johanson-Blizzard Syndrome | Hairy Cell Leukemia | Hereditary Pyropoikilocytosis | Primary Ovarian Insufficiency | Diffuse Intrinsic Pontine Glioma | Carcinoid Syndrome | Protein C Deficiency | Multiple Sclerosis, Chronic Progressive | Juvenile Myoclonic Epilepsy | Brooke-Spiegler Syndrome | Congenital Generalized Lipodystrophy | Uterine Leiomyoma | Acute Myeloid Leukemia | Erythropoietic Protoporphyria | Myofibromatosis | Glycogen Storage Disease Type 9 | Osteomyelitis | Japanese Encephalitis | Galloway-Mowat Syndrome | Aspartylglycosaminuria | Hypobetalipoproteinemias | Fibrosarcoma | Chromosome 17q21.31 Deletion Syndrome | Hypertension, Renal | Histiocytic Sarcoma | Congenital Hypofibrinogenemia | Vertigo | Porphyria | Kaposi Sarcoma | MELAS Syndrome | Infantile Refsum Disease | Tuberculosis | Chronic Thromboembolic Pulmonary Hypertension | Unverricht-Lundborg Syndrome | Fraser Syndrome | Methylmalonic Acidemia | Ocular Surface Squamous Neoplasia | Colorectal Adenoma | Hydrolethalus Syndrome | Lymphoma, Follicular | Alpha-thalassemia Myelodysplasia Syndrome | Anosmia, Congenital | Aromatic L-amino Acid Decarboxylase Deficiency | Galactosemia | Combined Deficiency Of Factor V And Factor VIII | Bainbridge-Ropers Syndrome | Encephalopathy, Glycine | Pseudohypoparathyroidism Type 1A | Presbycusis | Syndactyly | Pulmonary Sclerosing Hemangioma | Cholangitis | Kidney Stones | Erythema Nodosum | Moyamoya Disease | Primary Cutaneous Amyloidosis | N-acetylglutamate Synthase Deficiency | Holoprosencephaly | Schistosomiasis | Cryptosporidiosis | Gastroenteritis | Gout