Sickle Cell Anemia

About the Disease
Sickle Cell Anemia, also known as hemoglobin sc disease, is related to hereditary persistence of fetal hemoglobin-sickle cell disease syndrome and deficiency anemia, and has symptoms including abdominal pain, angina pectoris and chest pain. An important gene associated with Sickle Cell Anemia is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Golgi-to-ER retrograde transport and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Deferoxamine and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include Blood, bone marrow and bone, and related phenotypes are chronic hemolytic anemia and recurrent infections

Common Targets
ADAR | Soluble guanylyl cyclase | SERPINF1 | NPRL3 | SELE | Histone deacetylase (nonspecified subtype) | DNA Methyltransferase (DNMT) (nonspecified subtype) | BCL11A | CRBN | SPHK2 | PRMT5 | CYSLTR1 | HDAC2 | EHMT1 | HDAC6 | G7124 | PKLR | Ribonucleoside-diphosphate reductase | GDF2 | KCNN4 | IL1B | ADORA2B | CYP2C8 | Chloride channel (nonspecified subtype) | G3569 | KIT | ADCY6 | POLL | NR1I2 | HDAC3 | QPCTL | GATAD2A | QPCT | LHCGR | P2RY12 | SLC40A1 | HDAC1 | HAGLR | HBB | ADORA2A | GSTT1 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | NTRK1 | NFIX | HBG1 | KDM1A | EHMT2 | HBG2 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | NOS3 | G1786 | GALR2 | MBD2 | Cytochrome b5 reductase (nonspecified subtype) | PTGFR | GSTM1 | Potassium Channels (nonspecified subtype) | STING1

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