Ophthalmoplegia

About the Disease
Kearns-Sayre Syndrome, also known as ophthalmoplegia, is related to chronic progressive external ophthalmoplegia and mitochondrial dna depletion syndrome 7, and has symptoms including cerebellar ataxia, seizures and muscle weakness. An important gene associated with Kearns-Sayre Syndrome is MT-TL1 (Mitochondrially Encoded TRNA-Leu (UUA/G) 1), and among its related pathways/superpathways are Metabolism and "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.". The drugs Dalfampridine and Clemastine have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and skeletal muscle, and related phenotypes are abnormality of retinal pigmentation and progressive external ophthalmoplegia

Common Targets
RYR1 | MYF5 | STAC3 | MYH2 | TRNL2 | TUBB3

Note: If you'd like to get a target analysis report for Ophthalmoplegia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Ophthalmoplegia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Atelosteogenesis Type 2 | Anemia | Mitochondrial Myopathy | Infantile Spasm | Keratoconjunctivitis | Autosomal Recessive Bestrophinopathy | Duane Retraction Syndrome | Binge Eating Disorder | Beta-Propeller Protein-associated Neurodegeneration | Pneumonia, Viral | Distal Myopathy 2 | Keratoacanthoma | Malaria | Perry Syndrome | Small Lymphocytic Lymphoma | Cold Agglutinin Disease | Anti-glomerular Basement Membrane Disease | Williams Syndrome | Multifocal Motor Neuropathy | Carcinoma, Merkel Cell | Botulism | Cholestasis, Intrahepatic | Hyperekplexia | Pendred Syndrome | Glycogen Storage Disease Type 1a | Familial Mediterranean Fever | Spondyloperipheral Dysplasia | Congenital Generalized Lipodystrophy | Hepatitis, Alcoholic | Lipodystrophy | Atrioventricular Septal Defect | Cone Dystrophy | Coenzyme Q10 Deficiency | Huntington's Disease | Adenocarcinoma | Lymphedema-distichiasis Syndrome | Cyst | Azoospermia | Lennox-Gastaut Syndrome | Orotic Aciduria | Hepatitis E | Parkinsonism | Androgen Insensitivity | Carcinoid Tumor | WAGR Syndrome | MIRAGE Syndrome | Membranous Nephropathy | Primary Pigmented Nodular Adrenocortical Disease | Saethre-Chotzen Syndrome | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Lafora Disease | Hyperbilirubinemia, Neonatal | Sarcoma, Ewing | NDH Syndrome | Takenouchi-Kosaki Syndrome | Hereditary Hemorrhagic Telangiectasia Type 2 | Hyperbilirubinemia | Epidermolytic Ichthyosis, Annular | Muscle Wasting | AIDS Dementia Complex | Leukemia | Narcolepsy | Cataract | Malnutrition | Pseudo-pseudohypoparathyroidism | Meningococcal Infections | Hypopigmentation | Hemophilia | Glycogen Storage Disease | Pleural Tuberculosis | Thyrotoxic Periodic Paralysis | Hypohidrotic Ectodermal Dysplasia, X-linked | Charcot-Marie-Tooth Disease Type 4B1 | Asthma, Exercise-induced | Tuberculous Meningitis | Rhabdoid Tumor | Charcot-Marie-Tooth Disease Type 2D | Waardenburg Syndrome Type 2A | Diffuse Palmoplantar Keratoderma | Juvenile Myoclonic Epilepsy | Craniosynostosis | Leukocyte Adhesion Deficiency | Nail-Patella Syndrome | LEOPARD Syndrome | POEMS Syndrome | LRBA Deficiency | VEXAS Syndrome | Shprintzen-Goldberg Syndrome | Globozoospermia | Rheumatic Heart Disease | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Acrodysostosis | Pure Autonomic Failure | Thyroiditis, Autoimmune | Autosomal Recessive Spastic Paraplegia Type 75 | Jawad Syndrome | Ectrodactyly | Neuroma | Schizophrenia | Cranioectodermal Dysplasia | Urea Cycle Disorder | Lattice Corneal Dystrophy | C3 Glomerulopathy | Rolandic Epilepsy | Spinocerebellar Ataxia Type 23 | Splenomegaly | Carbamoyl Phosphate Synthetase I Deficiency | Hydrops Fetalis | Insulinoma | Scabies | Erectile Dysfunction | IMAGe Syndrome | Hyperinsulinemic Hypoglycemia | Depression | Osteoporosis, Postmenopausal | AIDS | Spasticity | Hemosiderosis | Coloboma | Wolcott-Rallison Syndrome | Jaundice, Obstructive | Citrullinemia | Pseudohypoparathyroidism Type 1A | McLeod Syndrome | Dementia | Congenital Muscular Dystrophy | Heterotopic Ossification | Focal Facial Dermal Dysplasia | Babesiosis | Eclampsia | Spinal Muscular Atrophy | Leigh Syndrome | Von Willebrand Disease | Birk-Barel Syndrome | Nicotine Addiction | Hypodontia | Compartment Syndrome | ADNP Syndrome | Epicondylitis | Phosphoglycerate Dehydrogenase Deficiency | Patent Foramen Ovale | Basal Cell Nevus Syndrome | Nephroblastoma | Mitochondrial DNA Depletion Syndrome | Coronary Heart Disease | Lactose Intolerance | Duchenne Muscular Dystrophy | Inflammatory Bowel Disease | Epidermolytic Palmoplantar Keratoderma | Spinocerebellar Ataxia Type 6 | Common Cold | Deafness, Dystonia, And Cerebral Hypomyelination | Spondylocarpotarsal Synostosis Syndrome | Cancer, Brain | Prolymphocytic Leukemia | Carney Triad | Becker Muscular Dystrophy | Cushing Syndrome | Thrombotic Microangiopathy | Language Disorders | Congenital Central Hypoventilation Syndrome | Anthrax | Bethlem Myopathy | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Hypertrophy | 3-methylcrotonyl-CoA Carboxylase Deficiency | Cholangitis | Cerebrovascular Disorders | Acrocallosal Syndrome | Pleurisy | Hereditary Spherocytosis | Hyperuricemic Nephropathy, Familial Juvenile | Aplasia Cutis Congenita | Huntington's Disease-like 2 | Low Tension Glaucoma | Multiple Sclerosis, Chronic Progressive | Optic Nerve Diseases | Early Infantile Epileptic Encephalopathy 4 | Geleophysic Dysplasia | Gastric Atrophy | Pantothenate Kinase-associated Neurodegeneration | Leri Pleonosteosis | Acute Generalized Exanthematous Pustulosis | Vertigo | Retinal Dystrophy | Intracranial Hypertension | Plasma Cell Leukemia | Silver-Russell Syndrome | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Microcephaly, Seizures, And Developmental Delay | Aphasia | Colitis, Microscopic | Sarcoma | Wiedemann-Steiner Syndrome | Gastritis, Atrophic | Episodic Ataxia | Vestibular Disease | Axenfeld-Rieger Syndrome | Hereditary Sensory Neuropathy Type 1 | Arthropathy | Light Chain Amyloidosis | Larsen Syndrome | Mitochondrial DNA Depletion Syndrome 13 | Hypokalemic Periodic Paralysis | Glucagonoma | Bleeding Disorder Due To CalDAG-GEFI Deficiency | GM2-gangliosidosis AB Variant | Keratitis-ichthyosis-deafness Syndrome | Dementia, Vascular | Blood Protein Disorders | Cellulitis | Acquired Partial Lipodystrophy | Chordoid Glioma | Glaucoma | Familial Dysautonomia | Birt-Hogg-Dube Syndrome | Hyperlipidemia Type V | Xeroderma Pigmentosum Variant Type | Loeys-Dietz Syndrome | Charcot-Marie-Tooth Disease Type 4 | Esophageal Motility Disorders | Meningitis | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Thrombophlebitis | Glycogen Storage Disease Type 3 | Retinal Diseases | Thyroid Hormone Resistance | Lupus Erythematosus | Arthrogryposis | Lymphoma, Mantle Cell | Esophageal Carcinoma | Pseudohypoparathyroidism Type 1C | Gastroschisis | Lipid Storage Myopathy | Sickle Cell Anemia | Neuroleptic Malignant Syndrome | Congenital Poikiloderma | Fetal And Neonatal Alloimmune Thrombocytopenia | Polyradiculopathy | Myofibrillar Myopathy | Progressive Familial Intrahepatic Cholestasis Type 3 | Inflammatory Myofibroblastic Tumor | Varices | Hemochromatosis Type 1 | Osteogenesis Imperfecta Type III | Peeling Skin Syndrome Type B | Dermatitis Herpetiformis | Anxiety Disorders | Osteonecrosis Of The Jaw | Triple A Syndrome | Progressive Encephalopathy-optic Atrophy Syndrome | Gitelman Syndrome | Adams-Oliver Syndrome | Thymoma, Malignant | Prolidase Deficiency | Guillain-Barre Syndrome | Porphyria Cutanea Tarda | Chronic Mucocutaneous Candidiasis | Eosinophilia | Renal Failure | Supravalvular Aortic Stenosis | Connective Tissue Disorders | Extramammary Paget's Disease | Lymphoma, Follicular | Basan Syndrome | Congenital Stromal Corneal Dystrophy | Chromosome 9q34.3 Deletion Syndrome | MELAS Syndrome | Lymphoma, AIDS-related | Hemangioendothelioma | Calcium Pyrophosphate Deposition Disease | Asthma, Nocturnal | Hyperglycemia | Mood Disorder | Intestinal Hypomagnesemia 1 | Cancer, Kidney | Nephrotic Syndrome Type 1 | Cholecystitis | Cryoglobulinemia | Episodic Ataxia Type 2 | Pelizaeus-Merzbacher Disease | Ocular Surface Squamous Neoplasia | Hepatic Steatosis | Retinoblastoma | Sleep Apnea, Central | Platelet Disorders | Polydactyly | Chondrodysplasia Punctata 2, X-linked Dominant | Vasculitis | Actinomycetoma | Sclerosing Cholangitis | Delayed Sleep Phase Syndrome | Kaposi Sarcoma | Polyneuropathy | Hyperkeratosis | Neurofibromatosis Type 2 | Anodontia | Snyder-Robinson Syndrome | Cervicitis | Epidermolysis Bullosa Simplex, Localized | Bacterial Meningitis | Oligoasthenoteratozoospermia | Glycogen Storage Disease Type 0 | Liver Diseases | Melanoma, Malignant | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Renal Dysplasia | Primary Cutaneous Amyloidosis | Open-angle Glaucoma | Hereditary Elliptocytosis | Walker-Warburg Syndrome | Motion Sickness | Fraser Syndrome | Follicular Dendritic Cell Sarcoma | LMNA-related Congenital Muscular Dystrophy | Meningioma | Schuurs-Hoeijmakers Syndrome | Bruck Syndrome | Adrenoleukodystrophy, X-linked | Familial Episodic Pain Syndrome | Rotor Syndrome | Choroideremia | Spinal Muscular Atrophy Type 2 | Long QT Syndrome Type 2 | Spinocerebellar Ataxia Type 40 | Carbonic Anhydrase VA Deficiency | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Nephronophthisis | Charcot-Marie-Tooth Disease Type 3 | Osteogenesis Imperfecta Type V | Hepatitis A | Periventricular Nodular Heterotopia | Optic Neuritis | Otitis Externa | Chromosome 16p11.2 Deletion Syndrome | Stomatitis | H Syndrome | Inborn Errors Of Metabolism | Spitz Nevus | Lissencephaly 2 | Subacute Sclerosing Panencephalitis | Guttate Psoriasis | Vitamin B12 Deficiency | Seasonal Mood Disorder | Marfan Syndrome | Vitamin D Deficiency | Megalencephaly | Gallstones | Ameloblastic Carcinoma | Diabetes | Stickler Syndrome | Autoimmune Autonomic Ganglionopathy | Neurofibromatosis-Noonan Syndrome | Diamond-Blackfan Anemia | Myositis, Focal | Fowler's Syndrome | Alkaptonuria | Silicosis | Methylmalonic Acidemia | Exocrine Pancreatic Insufficiency | Epithelial-myoepithelial Carcinoma | Desmosterolosis | Tuberculosis | Liver Failure | Sclerosteosis | Basal Ganglia Disease, Biotin-responsive | Osteogenesis Imperfecta Type II | Pyloric Stenosis, Infantile Hypertrophic | Aceruloplasminemia | Yellow Fever | Hypoglycemia | Hyperinsulinemia | Reflex Epilepsy | Glutathione Synthetase Deficiency | Ligneous Conjunctivitis | Waardenburg Syndrome Type 2 | Acromesomelic Dysplasia | Persistent Fetal Circulation | Vitiligo | Malonyl-CoA Decarboxylase Deficiency | Epiphyseal Chondrodysplasia, Miura Type | Vici Syndrome | Stroke, Hemorrhagic | Combined Pituitary Hormone Deficiency | Juvenile Xanthogranuloma | Spondylolisthesis | Autoimmune Polyendocrine Syndrome | Oculocutaneous Albinism Type 1 | Sturge-Weber Syndrome | Tonsillitis | Fascioliasis | Neurodegeneration With Brain Iron Accumulation | Oligospermia | Thromboembolism | Argininosuccinic Aciduria | Hamartoma | Alagille Syndrome | Imerslund-Grasbeck Syndrome | Brenner Tumor