Cholangiocarcinoma

About the Disease
Cholangiocarcinoma, also known as cholangiocarcinoma, susceptibility to, is related to klatskin's tumor and gallbladder cancer, and has symptoms including abdominal pain, malaise and constipation. An important gene associated with Cholangiocarcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is ncRNAs involved in STAT3 signaling in hepatocellular carcinoma. The drugs Celecoxib and Desflurane have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and lymph node, and related phenotypes are jaundice and biliary tract neoplasm

Common Targets
MAOA | G4851 | IDH1 | FKBP1A | SLC28A3 | Tubulin | HDAC1 | OGDH | CCND2 | G5743 | RUNX3 | Ribonucleoside-diphosphate reductase | FGFR1 | FLT4 | PNPLA3 | FLT1 | GNB3 | ZNF781 | ERBB3 | AURKB | Pyruvate Dehydrogenase Complex | G4609 | G4233 | LILRB4 | KDR | LCK | VIM | SPHK2 | BCR | RRM1 | G2064 | CDKN2B-AS1 | G3569 | G3845 | CDA | KAAG1 | SOX17 | OGG1 | JARID2 | ABCB4 | BMP3 | PLEC | CNRIP1 | APOBEC3A | ST8SIA1 | LOX | ROS1 | VSTM2B | SALL1 | GSTO1 | FRY | G7422 | FLT3 | DCK | NR5A2 | LBX2 | RET | DKK1 | CDO1 | CDH17 | SEPTIN9 | CTLA4 | G7015 | G4193 | RYR2 | MSLN | ASPH | Integrin alphavbeta5 receptor | NDRG4 | KLRK1-AS1 | KLRK1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | G7157 | APC | Casein kinase II (CKII) | SLC22A2 | TEK | FGFR4 | NDRG2 | LGALS9 | PDGFRA | INA | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | LOXL1 | PTGDR | PNMA8B | NRP1 | IDH2 | HOXA1 | CYP26C1 | G672 | ERBB4 | GNAS | KIT | EMX1 | CTNNB1 | CCNE1 | JAK1 | L1CAM | NLRP3 Inflammasome | MIR124-2 | PRKCB | BCL9 | MIR146A | G114548 | FGF19 | KLRC4-KLRK1 | PROM1 | LOXL2 | FOLR1 | PARP2 | STAB1 | WRAP53 | TGFB1 | APOBEC3B | MLH1 | IL6R | ZNF331 | G5133 | CD47 | MIR9-2 | DOT1L | SFRP1 | ARID1A | DCLK1 | XRCC1 | SP9 | CLDN1 | H1-3 | ABL1 | G6774 | G2146 | POLA1 | LOXL4 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | FGFR2 | G5728 | G1029 | TRIM36 | TGFBR2 | G29126 | KCNA1 | TACSTD2 | MSH6 | Sphingolipid delta(4)-desaturase (nonspecified subtype) | TWIST1 | LOXL3 | GRIN2B | HIF1A | MICA | G595 | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | MIR9-3 | SLC29A1 | NRAS | AURKA | PDGFRB | CSF1R | G6714 | KLHDC7B | DEGS2 | HDAC6 | SULF1 | DEGS1 | IFNAR2 | SNHG1 | HDAC2 | OPCML | G2475 | CDH13 | TNFRSF10B | G4089 | DNA-Directed DNA Polymerase Complex | PPT1 | BRCA2 | MIR129-2 | LINC00461 | ERCC1 | GPBAR1 | POLD1 | UNG | VTCN1 | PPARA | FGFR3 | PIK3CA | IL6ST-DT | Integrin alphavbeta3 (vitronectin) receptor | GAB1 | ZSCAN18 | TOP1 | G1956 | G142 | MAP3K4 | G5243 | G3309 | PIK3CD | IL6ST

Note: If you'd like to get a target analysis report for Cholangiocarcinoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Cholangiocarcinoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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