Richter's Syndrome

About the Disease
Richter's Syndrome, also known as richter syndrome, is related to leukemia, chronic lymphocytic 2 and lymphoma, hodgkin, classic. An important gene associated with Richter's Syndrome is IGHV4-38-2 (Immunoglobulin Heavy Variable 4-38-2), and among its related pathways/superpathways are Innate Immune System and PI3K-Akt signaling pathway. The drugs Nivolumab and Ofatumumab have been mentioned in the context of this disorder. Affiliated tissues include myeloid, spleen and liver, and related phenotypes are Reduced mammosphere formation and cellular

Common Targets
GPR35 | BRD7 | TRIM66 | ARHGEF38 | NELL2 | COL12A1 | ZNF219 | PLD3 | G7157 | CD3 Complex (T Cell Receptor Complex) | NFS1 | ZNF74 | TSGA10IP | GPR37L1 | NRK | NAALADL1 | PPP4R3A | C17orf98 | MTCL1 | ZNF76 | SLC26A9 | SH2D4A | AP1B1 | ADNP | B3GNT7 | CEP85 | GNPAT | ARMH4 | PCM1 | MBTPS1 | NAGPA | SMTN | AMBRA1 | FAM161B | KCNQ4 | F13A1 | FGFR3 | CACNA1S | FAT4 | GREB1 | PLA2G4A | ABHD13 | DNAH3 | SIGLEC10 | IKZF1 | CLSTN2 | AMACR | DHX16 | PMS1 | LZTS1 | SNU13 | ZFYVE26 | TJP3 | C14orf178 | G4851 | SUPT7L | LZTR1 | FANK1 | RNF32 | HOXD12 | BMX | WDR90 | CAMK2G | RIMBP2 | C8orf58 | GASK1B | PSMD8 | CHRNG | CDK9/Cyclin T1 | FAM53A | NUDT8 | BEND3 | ASXL3 | TBX21 | G4609 | BOD1L1 | NOD2 | C6orf120 | SASH1 | ENG | FRY | ZNF99 | ANGEL1 | FBN2 | NID1 | CDK9 | FZD6 | MCM3AP | APOH | Tubulin | IGLL5 | SEC16A | KMT2E | PTPN9 | EGR2 | CRTAC1 | PDE6C | XPO1 | IRF4 | G4170 | PCNX2 | MASP2 | SEMA4F | CCNT1 | MCPH1 | CCDC113 | FAM200B | UPF3A | TBL1XR1 | RIMS2 | PYGL | PCNX1 | CDC123 | HSPG2 | SYNM | PZP | BACH2 | GBP5 | PRR5-ARHGAP8 | DNAH8 | MS4A1 | RYR2 | HEXA | ALOX12B | SPTB | SLC6A19 | ABRA | CD300LD-AS1 | PIK3C2G | GRM8 | G1956 | NOS3 | EYS | SIGLEC1 | KMT2A | OSBPL6 | FASN | DLGAP5 | CFAP141 | MYOM1 | SPATA31D1 | PHC3 | ZFPM2 | AXDND1 | BLK | ARMS2 | ACTN3 | MARK3 | NTN1 | G3845 | TNS1 | POU4F2 | KRTAP20-3 | ROR1 | DACT1 | ADH7 | POLH | ZIM3 | VWC2 | USH2A | AXIN2 | SEC63 | SLC16A11 | ACO1 | PPP1R3B | FHIP1B | POU2AF3 | ADAMTS17 | DDX54 | ARHGAP23 | ABCF1 | ZNF469 | GABRD | PANK4 | ZSCAN29 | COG3 | TGM6 | TRIO | NOTCH2 | PARD3 | OSMR | PRR12 | LFNG | CFAP20DC | ABCC1 | AKT3 | UBA6 | CRAMP1 | PLEKHD1 | LOXL3 | NPAS3 | NUP62 | NME7 | STRC | SIPA1L3 | TTLL12 | HLA-DQB1 | G596 | UTRN | PLEKHG4B | PATL1 | CD72 | BAP1 | LRRFIP1 | CD19 | CSRNP3 | MUS81 | TBK1 | SLC25A44 | KIF1A | G5133 | USP33 | GALNT9 | TRUB2 | SLC2A8 | IL22RA1 | CCDC186 | ARMC1 | HELZ2 | CXXC1 | DPYD | DOP1A | FYCO1 | NPAP1 | EFCAB7 | THSD7A | CTIF | ONECUT1 | IGFBP7 | FKBPL | LSG1 | CCRL2 | SEC31A | MED12 | LIG4 | L1TD1 | JMJD7-PLA2G4B | EXOC8 | SELE | CARMIL2 | TGFBI | BTK | GOLGB1 | NEURL4 | SIGLEC11 | MST1R | IDO2 | PRAMEF4 | ZNF514 | MPPED1 | ANKRD12

Note: If you'd like to get a target analysis report for Richter's Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Richter's Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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