Vitamin A Deficiency

About the Disease
Keratomalacia, also known as vitamin a deficiency, is related to leber congenital amaurosis 2 and xerophthalmia, and has symptoms including other specified visual disturbances, photophobia and amaurosis fugax. An important gene associated with Keratomalacia is RBP4 (Retinol Binding Protein 4), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. The drugs BCG vaccine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
RBP4 | BCO1

Note: If you'd like to get a target analysis report for Vitamin A Deficiency, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Vitamin A Deficiency at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Endocarditis | Johanson-Blizzard Syndrome | Malnutrition | Pyruvate Kinase Deficiency | Cartilage Disorders | Raine Syndrome | Lattice Corneal Dystrophy | Hypersensitivity Pneumonitis | Sjogren Syndrome | Arthritis, Psoriatic | Mucolipidosis Type II | Chorea-acanthocytosis | Neutrophilia | Turner's Syndrome | Currarino Syndrome | Blepharo-cheilo-odontic Syndrome | Pontocerebellar Hypoplasia Type 2 | Gastritis, Atrophic | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Progressive External Ophthalmoplegia | Leukoplakia, Oral | Mabry Syndrome | Zellweger Syndrome | Craniometaphyseal Dysplasia | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Chordoma | Pulmonary Stenosis | Hodgkin Lymphoma | Prader-Willi Syndrome | Retinitis Pigmentosa 3 | Chronic Periodontitis | Hyperlipidemia | Colitis | Meckel-Gruber Syndrome | Osteoarthritis | Sclerosing Cholangitis | Behavioral Variant Of Frontotemporal Dementia | Bursitis | Gingivitis | X-linked Creatine Transporter Deficiency | Familial Hypobetalipoproteinemia | Sleep Apnea | Colorectal Adenoma | N-acetylglutamate Synthase Deficiency | Chronic Thromboembolic Pulmonary Hypertension | Sick Sinus Syndrome 1 | Amish Infantile Epilepsy Syndrome | Werner's Syndrome | Prune Belly Syndrome | Infantile Spasm | Tendinopathy | Vitiligo | Corneal Edema | Cryptosporidiosis | Sialoadenitis | Plasma Cell Dyscrasia | Long QT Syndrome Type 1 | Duane Retraction Syndrome | Exfoliative Dermatitis | Spinocerebellar Ataxia Type 28 | Steel Syndrome | Pemphigus | Poikiloderma With Neutropenia | Heart Block | Diffuse Mesangial Sclerosis | Hydrolethalus Syndrome | Pierson Syndrome | Adenosine Deaminase Deficiency | Triple A Syndrome | Gyrate Atrophy Of The Choroid And Retina | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Retinoschisis | Polymyositis | Agammaglobulinemia | Vitreoretinopathy, Proliferative | Congenital Lipoid Adrenal Hyperplasia | Pure Red Cell Aplasia | Localized Scleroderma | Meningitis | Primrose Syndrome | Meningococcal Infections | Spinocerebellar Ataxia Type 14 | Papilloma | Extramammary Paget's Disease | Ectodermal Dysplasia | Cholecystitis | Measles | Klippel-Feil Syndrome | Tibial Muscular Dystrophy | Cranial Nerve Disease | Myocardial Infarction | Pulmonary Tuberculosis | Early Infantile Epileptic Encephalopathy 1 | Chromosome 5q Deletion Syndrome | Transthyretin-related Amyloidosis | Polymyalgia Rheumatica | Nicolaides-Baraitser Syndrome | Arrhythmogenic Right Ventricular Cardiomyopathy | Heterotaxy | Acanthosis Nigricans | Congenital Dysfibrinogenemia | Chronic Beryllium Disease | Deafness, Dystonia, And Cerebral Hypomyelination | Porphyria | Gardner Syndrome | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Temtamy Preaxial Brachydactyly Syndrome | Majeed Syndrome | L-2-Hydroxyglutaric Aciduria | Zimmermann-Laband Syndrome | Micropenis | Palsy, Cerebral | PHARC Syndrome | Globozoospermia | Intestinal Hypomagnesemia 1 | Esophagitis, Eosinophilic | Pyloric Stenosis, Infantile Hypertrophic | Acute Coronary Syndrome | T-cell Prolymphocytic Leukemia | Fetal Alcohol Syndrome | Oculocutaneous Albinism Type 4 | Pheochromocytoma | Myofibromatosis | Teratozoospermia | Contact Dermatitis | Acute Anterior Uveitis | Malignant Peripheral Nerve Sheath Tumor | Asthma, Nocturnal | Hereditary Inclusion Body Myopathy | Charcot-Marie-Tooth Disease Type 4E | Amebiasis | Galloway-Mowat Syndrome | Vertebrobasilar Insufficiency | Macrophage Activation Syndrome | Endometriosis | Dysgerminoma | Paget's Disease Of The Breast | Obsessive-compulsive Disorder | Glutaric Aciduria Type 1 | Fukuyama Congenital Muscular Dystrophy | Becker Muscular Dystrophy | Encephalopathy | Lyme Disease | Diabetes Insipidus, Neurogenic | Hypertension, Pulmonary | Dysferlinopathy | Chronic Enteropathy Associated With SLCO2A1 Gene | Metaphyseal Chondrodysplasia, Schmid Type | Parkinson's Disease | Tenosynovial Giant Cell Tumor | Fraser Syndrome | Bare Lymphocyte Syndrome | Usher Syndrome Type IIC | Loeys-Dietz Syndrome Type 4 | Delayed Sleep Phase Syndrome | Neonatal Progeroid Syndrome | Neurodevelopmental Disorders | Acute Generalized Exanthematous Pustulosis | Cousin Syndrome | Tracheal Disorders | Hyperkeratosis | Polycystic Kidney, Autosomal Recessive | Tricho-hepato-enteric Syndrome | Primary Cutaneous Amyloidosis | Rolandic Epilepsy | McKusick Type Metaphyseal Chondrodysplasia | Pulverulent Zonular Cataract | Diabetes Type 1 | Pitt-Hopkins Syndrome | Prolidase Deficiency | Cancer, Kidney | Spinal Muscular Atrophy Type 2 | Corneal Dystrophy And Perceptive Deafness | Periodontitis | Loeys-Dietz Syndrome | Larsen Syndrome | Epithelioid Hemangioma | Vestibular Disease | Lymphopenia | Angioedema, Acquired | Acute Kidney Injury | Marfan Syndrome | Coronary Artery Disease | Carcinoma, Merkel Cell | Hemochromatosis | Neurofibroma, Plexiform | Mitochondrial Encephalomyopathy | Takenouchi-Kosaki Syndrome | Colitis, Collagenous | Early Infantile Epileptic Encephalopathy 4 | Lymphangioma | Blepharoconjunctivitis | Carpal Tunnel Syndrome | Headache | Stroke, Ischemic | Sarcoma, Alveolar Soft Part | Alopecia Areata | Myoclonic Epilepsy With Ragged Red Fibers | Polydactyly | DRESS Syndrome | Cabezas Syndrome | Acute Chest Syndrome | Oculocutaneous Albinism | Vitamin B12 Deficiency | Anti-glomerular Basement Membrane Disease | Hypertension, Essential | Dermatomyositis | Congenital Bilateral Absence Of Vas Deferens | Neuropathy | Vasculitis | Spinocerebellar Ataxia Type 20 | Blastoma, Pleuropulmonary | Analgesia | Cancer, Bladder | Anorchia | Neurogenic Bladder | Sertoli Cell-only Syndrome | Joubert Syndrome | Plasmacytoma | Schizencephaly | Sandhoff Disease | Torticollis | Peritonitis | Keratitis-ichthyosis-deafness Syndrome | Cancer, Colon | Crisponi Syndrome | Fetal And Neonatal Alloimmune Thrombocytopenia | Albinism | Phosphoglycerate Dehydrogenase Deficiency | Hyperthermia, Malignant | Chloridorrhea, Congenital | Protein S Deficiency | Cohen Syndrome | Cardiomyopathy, Peripartum | Abetalipoproteinemia | Multiple Hamartoma Syndrome | Oligoasthenoteratozoospermia | Monilethrix | Cutaneous Angiosarcoma | Peutz-Jeghers Syndrome | Epidermolytic Palmoplantar Keratoderma | Impulse Control Disorder | Fibronectin Glomerulopathy | Syphilis | Blau Syndrome | Corneal Neovascularization | Fibrodysplasia Ossificans Progressiva | Lipid Storage Diseases | Cutaneous Lupus Erythematosus | Acute Tubular Necrosis | Stomatitis | Poretti-Boltshauser Syndrome | Spondylocostal Dysostosis | Glycogen Storage Disease Type 6 | Multiple Sclerosis, Chronic Progressive | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Multicentric Carpotarsal Osteolysis Syndrome | Hypertriglyceridemia | Stiff-man Syndrome | Primary Hyperoxaluria Type 3 | Methylmalonic Acidemia | Glycogen Storage Disease Type 3 | Learning Disability | Primary Progressive Aphasia | Vertigo | Bone Marrow Necrosis | Chronic Kidney Disease | Bainbridge-Ropers Syndrome | Thrombasthenia | Peripheral T-cell Lymphoma | Cataplexy | Pituitary Dwarfism | Early Infantile Epileptic Encephalopathy | Smith-Lemli-Opitz Syndrome | Hereditary Coproporphyria | Macrodactyly | Choroiditis | Infantile Neuroaxonal Dystrophy | Dengue Hemorrhagic Fever | Seborrheic Dermatitis | Cavitary Optic Disc Anomalies | Xeroderma Pigmentosum Variant Type | Neurocutaneous Melanocytosis | Eating Disorder | Ophthalmoplegia | T-cell Chronic Lymphocytic Leukemia | Subcortical Band Heterotopia | Charcot-Marie-Tooth Disease Type 3 | Anemia | Multiple Myeloma | Antithrombin III Deficiency | Spinocerebellar Ataxia Type 6 | Heimler Syndrome | Glycogen Storage Disease Type 9 | Lamellar Ichthyosis | Distal Spinal Muscular Atrophy | Ollier Disease | Oguchi Disease-2 | Stromal Corneal Dystrophy | Combined Pituitary Hormone Deficiency | Cholera | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Hypertrophy | Skin Fragility-woolly Hair Syndrome | Cramp Fasciculation Syndrome | Microphthalmia, Syndromic 7 | Farber Disease | Glycogen Storage Disease Type 1b | HIBCH Deficiency | Encephalitis | Budd-Chiari Syndrome | Trichomegaly | Asthma | Mycosis Fungoides | Multiple Sclerosis, Relapsing-remitting | Exocrine Pancreatic Insufficiency | Chondrodysplasia Punctata 2, X-linked Dominant | Carcinoma, Small Cell | Raynaud Phenomenon | Spondyloperipheral Dysplasia | Acromicric Dysplasia | Sezary Syndrome | Acute Lymphocytic Leukemia | Fibrosarcoma | Omenn Syndrome | Myotonic Disorders | Cholelithiasis | Megaloblastic Anemia | Focal Dermal Hypoplasia | Perry Syndrome | Pelizaeus-Merzbacher Disease | Pneumococcal Meningitis | Hepatitis D | Lateral Meningocele Syndrome | Leprosy | Glycogen Storage Disease Type 4 | Leukemia | Neuroleptic Malignant Syndrome | Hypotonia-cystinuria Syndrome | Netherton Syndrome | Hyperkalemic Periodic Paralysis | Schindler Disease | Distal Myopathy | Bloom Syndrome | Schizotypal Personality Disorder | Carcinoma, Transitional Cell | Myopathy | Charcot-Marie-Tooth Disease Type 4B1 | Coma | Myositis, Focal | Usher Syndrome Type II | LEOPARD Syndrome | Noonan Syndrome-like Disorder With Loose Anagen Hair | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Bronchiectasis | Lysosomal Acid Lipase Deficiency | Neurocysticercosis | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Hydrocephalus | Anosmia, Congenital | Glycogen Storage Disease Type 0 | Unverricht-Lundborg Syndrome | Huntington's Disease-like 2 | Multifocal Motor Neuropathy | Acrodermatitis Enteropathica | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Okihiro Syndrome | Paternal Uniparental Disomy Of Chromosome 14 | Autosomal Recessive Spastic Paraplegia Type 75 | Low Phospholipid Associated Cholelithiasis | Tangier Disease | Congenital Poikiloderma | Keratosis, Seborrheic | Spasticity | Cannabis Abuse | Hypocalcemia | Sickle Cell Disease | Sialidosis | Donnai-Barrow Syndrome | Nephroblastoma | Acute Lung Injury | Blood Protein Disorders | Esotropia | Asplenia | Neurofibromatosis Type 1 | Motor Neuron Diseases | Shwachman-Bodian-Diamond Syndrome | Primary Progressive Nonfluent Aphasia | Patent Ductus Arteriosus | Traboulsi Syndrome | Huntington's Disease | Multiple Sclerosis, Secondary Progressive | Astrocytoma, Anaplastic | Angioimmunoblastic T-cell Lymphoma | Cerebrovascular Disorders | Basal Cell Nevus Syndrome | Melanoma, Malignant | Spinocerebellar Ataxia Type 13 | Hypermethioninemia