Spinocerebellar Ataxia Type 28
Spinocerebellar Ataxia Type 28
About the Disease
Spinocerebellar Ataxia 28, also known as spinocerebellar ataxia type 28, is related to hereditary ataxia and kearns-sayre syndrome, and has symptoms including muscle spasticity and gait ataxia. An important gene associated with Spinocerebellar Ataxia 28 is AFG3L2 (AFG3 Like Matrix AAA Peptidase Subunit 2), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Mitochondrial calcium ion transport. Affiliated tissues include spinal cord, eye and cerebellum, and related phenotypes are dysarthria and gait ataxia
Common Targets
HTT | AFG3L2
![疾病靶点研报](../img/disease-target-analysis-report.jpg)
Note: If you'd like to get a target analysis report for Spinocerebellar Ataxia Type 28, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Spinocerebellar Ataxia Type 28 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.
Other Diseases
Acute Motor Axonal Neuropathy | Hypohidrotic Ectodermal Dysplasia, X-linked | Episodic Ataxia Type 2 | Trigonocephaly | Postpoliomyelitis Syndrome | Sialidosis | Familial Thoracic Aortic Aneurysm | Porphyria | Familial Retinal Arterial Macroaneurysm | Bruck Syndrome | Adenylosuccinate Lyase Deficiency | Chylomicron Retention Disease | Hypersensitivity Pneumonitis | Amblyopia | Alveolar Capillary Dysplasia | Unverricht-Lundborg Syndrome | Thrombocythemia, Essential | Aplastic Anemia | Fanconi Anemia | Microphthalmia, Syndromic 7 | Chronic Beryllium Disease | Dysferlinopathy | Cholangiocarcinoma | Schistosomiasis | Mabry Syndrome | Seminoma | Paraplegia | Usher Syndrome Type III | Esotropia | Anemia | Allan-Herndon-Dudley Syndrome | Thrombophilia | Pitt-Hopkins Syndrome | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Mohr-Tranebjaerg Syndrome | Polymyalgia Rheumatica | Wagner Disease | Hyperthyroidism | Progressive Familial Intrahepatic Cholestasis Type 3 | Tumoral Calcinosis | Neuroblastoma | Retinoblastoma | Waardenburg Syndrome Type 2 | Gerodermia Osteodysplastica | Pulmonary Capillary Hemangiomatosis | Atelosteogenesis Type 1 | Fraser Syndrome | Stargardt Disease | Familial Hypobetalipoproteinemia | Small Lymphocytic Lymphoma | Hereditary Coproporphyria | IgA Nephropathy | PHARC Syndrome | Astrocytoma, Anaplastic | X-linked Creatine Transporter Deficiency | Hidradenitis Suppurativa | Ectodermal Dysplasia | Charcot-Marie-Tooth Disease, Type 1A | Overactive Bladder | Adrenoleukodystrophy, X-linked | Raine Syndrome | Tangier Disease | Congenital Dyserythropoietic Anemia Type 4 | Meier-Gorlin Syndrome | Tyrosinemia Type 1 | Congenital Mirror Movements | Treacher Collins Syndrome | AIDS | Adams-Oliver Syndrome | Congenital Poikiloderma | Nicolaides-Baraitser Syndrome | Cavitary Optic Disc Anomalies | Christianson Syndrome | Hyperkalemic Periodic Paralysis | Acquired Partial Lipodystrophy | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Nephritis, Interstitial | Sporadic Inclusion Body Myositis | Sarcoidosis, Pulmonary | Lipodystrophy | Autosomal Recessive Spastic Paraplegia Type 54 | Angiomyolipoma | Progressive Familial Intrahepatic Cholestasis Type 1 | Language Disorders | Asplenia | Hyperacusis | Atopy | Ophthalmia, Sympathetic | Smith-Kingsmore Syndrome | Currarino Syndrome | Nutrition Disorders | Membranous Nephropathy | PASLI Disease | Hyper IgE Syndrome | Charcot-Marie-Tooth Disease Type 2E | Hypogammaglobulinemia | Acute Tubular Necrosis | Autosomal Recessive Bestrophinopathy | Stroke, Hemorrhagic | Persistent Hyperplastic Primary Vitreous | Crigler-Najjar Syndrome | Acne Vulgaris | Delayed Sleep Phase Syndrome | Spinocerebellar Ataxia Type 40 | Hepatitis C, Chronic | Smoldering Myeloma | Sclerosteosis | Meesmann Corneal Dystrophy | Hyperlipidemia, Familial Combined | Familial Mediterranean Fever | Multiple Myeloma | Juvenile Polyposis | Neurocutaneous Syndromes | Glycogen Storage Disease Type 0 | Zellweger Syndrome | Granular Corneal Dystrophy | Esophagitis | Congenital Heart Block | GM2-gangliosidosis AB Variant | Early Infantile Epileptic Encephalopathy | Diastrophic Dysplasia | Cyclic Vomiting Syndrome | Mitochondrial Myopathy | Platelet Disorders | Palmoplantar Keratoderma | Acrodermatitis Enteropathica | X-linked Charcot-Marie-Tooth Disease | Limb Girdle Muscular Dystrophy | Colitis, Lymphocytic | Thalassemia | Trichotillomania | Zygomycosis | Frank-ter Haar Syndrome | Intermittent Explosive Disorder | Nephrosclerosis | Vogt-Koyanagi-Harada Syndrome | Portal Vein Thrombosis | Persistent Mullerian Duct Syndrome | Cataract | Speech Disorders | Glycogen Storage Disease Type 1 | Rhabdomyosarcoma, Embryonal | Atrioventricular Septal Defect | Peyronie's Disease | Infantile Liver Failure Syndrome 1 | Klippel-Feil Syndrome | Left Ventricular Noncompaction | Robinow Syndrome | Tinea Versicolor | Arthritis, Reactive | Shwachman-Bodian-Diamond Syndrome | Sleep Disorder | Alpha-mannosidosis | Chronic Mucocutaneous Candidiasis | Eclampsia | Light Chain Amyloidosis | Wieacker-Wolff Syndrome | Desbuquois Syndrome | Melanoma, Uveal | Torticollis | Dupuytren Disease | Sclerocornea | Hydrolethalus Syndrome | Varices | Polycythemia | Amish Infantile Epilepsy Syndrome | Hyperparathyroidism, Primary | Familial Glucocorticoid Deficiency | Cenani-Lenz Syndactyly Syndrome | Babesiosis | Precocious Puberty | Alopecia Totalis | Silicosis | Hyperglycemia | Progressive Myoclonic Epilepsy | Neuroendocrine Cancer | Bronchitis, Chronic | Hypertension, Pulmonary | Hepatitis B, Chronic | Triple A Syndrome | Gastrointestinal Disorders | Central Retinal Artery Occlusion | HIBCH Deficiency | Renal Tubular Dysgenesis | Lewy Body Dementia | Oligoastrocytoma | Leukoplakia, Oral | Niemann-Pick Disease, Type B | Autism Spectrum Disorders | 3-methylglutaconic Aciduria Type I | Pseudomyxoma Peritonei | Ocular Albinism Type 1 | McCune-Albright Syndrome | Sulfite Oxidase Deficiency | Alkaptonuria | Papilloma | Congenital Dyserythropoietic Anemia Type 1 | Arterial Tortuosity Syndrome | Sengers Syndrome | LRBA Deficiency | Bacterial Meningitis | Evans Syndrome | Craniosynostosis | Cirrhosis | Gastroenteritis, Eosinophilic | Congenital Central Hypoventilation Syndrome | Lattice Corneal Dystrophy | Fanconi Syndrome | Rhabdomyosarcoma, Alveolar | Oligoasthenoteratozoospermia | Persistent Truncus Arteriosus | Pemphigus Vulgaris | Malaria | Supravalvular Aortic Stenosis | Blepharitis | Weill-Marchesani Syndrome | Autonomic Nervous System Disorders | Diabetic Encephalopathy | Vitiligo | Dermatitis | Vascular Calcification | Ectrodactyly | Cerebral Cavernous Malformations | Cholera | Hodgkin Lymphoma | Urticaria | Cryoglobulinemia | Conjunctivitis, Allergic | Feingold Syndrome | Pyruvate Decarboxylase Deficiency | Central Pain Syndrome | Geleophysic Dysplasia | Cervicitis | Genitopatellar Syndrome | Lichen Planus | Sclerosteosis 2 | Myelitis | Follicular Dendritic Cell Sarcoma | Epidermolysis Bullosa | Barakat Syndrome | Alazami Syndrome | Benign Familial Neonatal Convulsions | Methylmalonic Aciduria And Homocystinuria, CblC Type | Smith-Magenis Syndrome | Menkes Disease | High Molecular Weight Kininogen Deficiency | Abetalipoproteinemia | Kabuki Syndrome | Von Willebrand Disease | Hemophagocytic Lymphohistiocytosis | T-cell Chronic Lymphocytic Leukemia | Familial Exudative Vitreoretinopathy | Dengue Shock Syndrome | Mountain Sickness | Corneal Dystrophy | WAGR Syndrome | Facioscapulohumeral Muscular Dystrophy Type 2 | Hepatitis A | Nephrotic Syndrome Type 1 | Blepharoconjunctivitis | Protein S Deficiency | Colitis, Collagenous | Diabetic Neuropathy | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Liver Failure, Acute Infantile | Glutaric Aciduria Type 1 | Argininosuccinic Aciduria | Hemolytic Uremic Syndrome, Atypical | Neurodevelopmental Disorders | Paroxysmal Nocturnal Hemoglobinuria | Retinitis Pigmentosa | Neurofibromatosis Type 1 | Mood Disorder | Contact Dermatitis | Chloridorrhea, Congenital | Dysequilibrium Syndrome | Histiocytosis | Pantothenate Kinase-associated Neurodegeneration | Walker-Warburg Syndrome | Alagille Syndrome | Osteoarthritis | Gastric Atrophy | Pleural Tuberculosis | Peeling Skin Syndrome Type B | Vaginitis | Gigantism | Polyneuropathy | Primary Hyperoxaluria Type 1 | Parvovirus B19 Infection | Heart Septal Defects | Multiple Sclerosis, Chronic Progressive | Hypertension, Renal | Seborrheic Dermatitis | Glycogen Storage Disease Type 0, Muscle | Hypotrichosis | Branchiootorenal Syndrome | Generalized Epilepsy With Febrile Seizures Plus | Orthostatic Intolerance | Lymphomatoid Granulomatosis | Carpal Tunnel Syndrome | Spinocerebellar Ataxia Type 13 | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Myopathy | Micropenis | Hyperparathyroidism, Secondary | Beta-Propeller Protein-associated Neurodegeneration | Muscular Dystrophy | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Multiple Sclerosis, Secondary Progressive | Vertigo | Reye Syndrome | Schwannoma | Pneumothorax | Crimean-Congo Hemorrhagic Fever | Poirier-Bienvenu Neurodevelopmental Syndrome | Congenital Dyserythropoietic Anemia | Vestibular Disease | Cervical Dystonia | Carotid Artery Disease | Hyperinsulinemic Hypoglycemia | Thromboembolism | Charcot-Marie-Tooth Disease Axonal Type 2N | Chondromyxoid Fibroma | Inflammatory Joint Disease | Arts Syndrome | Epidermolytic Palmoplantar Keratoderma | Lymphoma, B-cell | Periventricular Nodular Heterotopia | Pyruvate Carboxylase Deficiency Disease | Liebenberg Syndrome | Combined Malonic And Methylmalonic Acidemia | Rotor Syndrome | Amyotrophic Lateral Sclerosis | Clouston Hidrotic Ectodermal Dysplasia | Chondrodysplasia Punctata 2, X-linked Dominant | Corneal Ulcer | Glycogen Storage Disease Type 1a | Dermatitis Herpetiformis | Long QT Syndrome Type 2 | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Scapuloperoneal Spinal Muscular Atrophy | Mycosis Fungoides | Parkinson Disease 6, Autosomal Recessive Early-onset | Blepharophimosis Syndrome | Distal Myopathy | Basan Syndrome | Growth Hormone Excess | 3-methylcrotonyl-CoA Carboxylase Deficiency | Hydronephrosis | Aspartylglycosaminuria | Pemphigus | Diffuse Mesangial Sclerosis | Glycogen Storage Disease Type 9 | Lathosterolosis | Phenylketonuria II | Paternal Uniparental Disomy Of Chromosome 14 | Mevalonate Kinase Deficiency | Chronic Lymphocytic Leukemia | Eccrine Porocarcinoma | Persistent Fetal Circulation | Apraxia | Cockayne Syndrome | Asperger Syndrome | Coenzyme Q10 Deficiency | Globozoospermia | Snyder-Robinson Syndrome | Spondyloarthritis | Inflammatory Bowel Disease | Cysticercosis | Rett Syndrome | Heavy Chain Disease | Communication Disorders | Diverticulitis | Multiple Epiphyseal Dysplasia | Dengue Hemorrhagic Fever | Tonsillitis | Hereditary Elliptocytosis | Kearns-Sayre Syndrome | Colon Adenoma | Microvillus Inclusion Disease | Priapism | Meconium Ileus | Anxiety Disorders | Nance-Horan Syndrome | Diabetes Type 2 | Osteogenesis Imperfecta Type IV | Leukodystrophies | Carbonic Anhydrase VA Deficiency | Retinal Coloboma | Glaucoma | Chronic Granulomatous Disease | Maple Syrup Urine Disease | Basal Ganglia Disease | Dubin-Johnson Syndrome | Brugada Syndrome 1 | Chylothorax, Congenital | Shock, Cardiogenic | Vitamin K Deficiency | Imerslund-Grasbeck Syndrome | Pemphigus Foliaceus