Disease

Basal Ganglia Disease

About the Disease
Basal Ganglia Disease, also known as basal ganglia diseases, is related to thiamine metabolism dysfunction syndrome 2 and basal ganglia calcification. An important gene associated with Basal Ganglia Disease is DNAH7 (Dynein Axonemal Heavy Chain 7), and among its related pathways/superpathways are S1P3 pathway and S1P1 pathway. The drugs Cysteine and Soy Bean have been mentioned in the context of this disorder. Affiliated tissues include basal ganglia, cortex and brain, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
SLC20A2

疾病靶点研报
Basal Ganglia Disease

Note: If you'd like to get a target analysis report for Basal Ganglia Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Basal Ganglia Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Hypersensitivity Pneumonitis | Dyggve-Melchior-Clausen Disease | Sturge-Weber Syndrome | Cataract | Hyperuricemic Nephropathy, Familial Juvenile | Tic Disorder | Charcot-Marie-Tooth Disease, Type 2A | Ileitis | Mannosidase Deficiency Diseases | Biotinidase Deficiency | Blastomycosis | Peripheral Neuropathy | Language Disorders | Pontocerebellar Hypoplasia Type 2 | Krabbe Disease | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Venous Insufficiency | Gaucher Disease | Takotsubo Cardiomyopathy | Autonomic Neuropathy | Borjeson-Forssman-Lehmann Syndrome | Congenital Mirror Movements | Left Ventricular Noncompaction | Erythema Multiforme | Corneal Ulcer | Obesity, Morbid | Wiskott-Aldrich Syndrome | Robinow Syndrome | Long QT Syndrome Type 3 | Chromosome 8q21.11 Deletion Syndrome | Vulvovaginitis | Sick Sinus Syndrome 1 | Heimler Syndrome | Ulcerative Colitis | Pycnodysostosis | Retinoblastoma | Sensorineural Hearing Loss | Odonto-onycho-dermal Dysplasia | Myopia | Spermatocele | Myelitis | Tenosynovial Giant Cell Tumor | Osteoporosis, Postmenopausal | Smith-Magenis Syndrome | Dysgerminoma | Coronary Heart Disease | Constipation | Acrodermatitis Enteropathica | Spondylosis | Angelman Syndrome | Partington Syndrome | Persistent Fetal Circulation | Gangliosidosis, GM1 | Primary Familial Brain Calcification | Axenfeld-Rieger Syndrome | Pupil Disorders | Progressive Familial Intrahepatic Cholestasis Type 1 | Potocki-Shaffer Syndrome | Greenberg Dysplasia | Hepatitis A | Tetanus | Pericarditis | Tyrosinemia Type 2 | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Hidradenitis | Acute Kidney Injury | Alpers Syndrome | Hypersomnia | Optic Neuropathy, Anterior Ischemic | Follicular Dendritic Cell Sarcoma | Gallstones | Basal Ganglia Disease, Biotin-responsive | Diabetic Neuropathy | Majeed Syndrome | Barakat Syndrome | Primary Hyperoxaluria Type 1 | Charcot-Marie-Tooth Disease, Type 2C | Infertility, Male | Thrombocytopenia | Focal Cortical Dysplasia Type 2 | Chronic Periodontitis | Bare Lymphocyte Syndrome | Peters-plus Syndrome | Centronuclear Myopathy | Familial Dysautonomia | Histiocytic Sarcoma | Multiple Sulfatase Deficiency | Diabetes Insipidus | Platelet Disorders | Osteoglophonic Dysplasia | MIRAGE Syndrome | Autoimmune Polyendocrinopathy Syndrome Type I | Hemangioendothelioma | Hypoalbuminemia | Precocious Puberty | Angiomyolipoma | Adenosine Deaminase Deficiency | Common Variable Immunodeficiency | Anthrax | Schizencephaly | Coronary Restenosis | Blau Syndrome | Esophageal Carcinoma | FG Syndrome | Empyema | Dwarfism | Pelvic Inflammatory Disease | Primary Hyperoxaluria Type 3 | Spinocerebellar Ataxia Type 17 | Chronic Granulomatous Disease | Cystitis, Interstitial | Ornithine Transcarbamylase Deficiency | Pseudohypoaldosteronism | Arterial Tortuosity Syndrome | Giant Cell Glioblastoma | Alcoholism | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Chondromyxoid Fibroma | L-2-Hydroxyglutaric Aciduria | Thrombasthenia | Osteochondrosis | Seizures | Osteogenesis Imperfecta Type I | Antithrombin III Deficiency | Polymyalgia Rheumatica | Episodic Ataxia | Gastritis | Cervicitis | Fontaine Progeroid Syndrome | Lupus Erythematosus | Oculopharyngeal Muscular Dystrophy | Hemorrhagic Disorders | Alzheimer Disease, Late Onset | Hypobetalipoproteinemias | Adenocarcinoma | Sulfite Oxidase Deficiency | Cardiomyopathy, Hypertrophic | Pachyonychia Congenita | Glycogen Storage Disease Type 9 | Werner's Syndrome | Hypogammaglobulinemia | IgA Deficiency | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Carcinoma, Merkel Cell | Glaucoma, Congenital | Anorectal Malformations | Neovascular Glaucoma | Early Infantile Epileptic Encephalopathy 13 | Non-proliferative Diabetic Retinopathy | Rhabdomyosarcoma | Ebstein Anomaly | Myotonia | Glycogen Storage Disease | Maternally Inherited Diabetes And Deafness | X-linked Creatine Transporter Deficiency | Cryopyrin-associated Periodic Syndromes | Viral Meningitis | Hereditary Spastic Paraplegia | Congenital Diaphragmatic Hernia | Hyperekplexia | Twin-to-twin Transfusion Syndrome | Bardet-Biedl Syndrome | Smoldering Myeloma | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Cocaine-Related Disorders | Pseudomyxoma Peritonei | Episodic Ataxia Type 1 | Myofibromatosis | DICER1 Syndrome | Parkinson Disease 6, Autosomal Recessive Early-onset | Cellulitis | Reye Syndrome | Periodic Limb Movement Disorder | Kearns-Sayre Syndrome | Persistent Truncus Arteriosus | Polydactyly | Brachial Plexus Neuropathy | Generalized Epilepsy And Paroxysmal Dyskinesia | Arteriosclerosis | Nephronophthisis | REM Sleep Behavior Disorder | Camptocormia | Glycogen Storage Disease Type 6 | Cerebrotendinous Xanthomatosis | Johanson-Blizzard Syndrome | Gigantism | Achromatopsia | Thalassemia | Neuropathy | Congenital Hypofibrinogenemia | Astrocytoma, Anaplastic | Fibrosarcoma | Glomerulonephritis | Costello Syndrome | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Nail-Patella Syndrome | Osteopetrosis | Adrenoleukodystrophy, X-linked | Colitis, Lymphocytic | Bernard-Soulier Syndrome | Albinism | Epidermal Nevus Syndrome | Histiocytosis | GM2-gangliosidosis AB Variant | Anemia | Avellino Corneal Dystrophy | Dysthymia | Scapuloperoneal Myopathy, X-linked Dominant | Optic Neuritis | Tinea | Amelanotic Melanoma | Acrodermatitis | Leukoplakia, Oral | Fibromuscular Dysplasia | Blepharo-cheilo-odontic Syndrome | Retinitis Pigmentosa | Adrenomyeloneuropathy | Giant Axonal Neuropathy | Pantothenate Kinase-associated Neurodegeneration | Smith-Lemli-Opitz Syndrome | Mosaic Variegated Aneuploidy Syndrome 2 | Hemophilia | Glutathione Synthetase Deficiency | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Hairy Cell Leukemia | Congenital Nystagmus | Proximal Symphalangism | Juvenile Hyaline Fibromatosis | Spinal Muscular Atrophy | Sarcoma | Schnyder Crystalline Corneal Dystrophy | Necrobiosis Lipoidica | Ocular Hypertension | Holt-Oram Syndrome | T-cell Leukemia | Vici Syndrome | Premature Ejaculation | Rothmund-Thomson Syndrome | Aplastic Anemia | TARP Syndrome | Budd-Chiari Syndrome | Hyperphenylalaninemia | Megaloblastic Anemia | Bronchiolitis | Vitamin B12 Deficiency | Cabezas Syndrome | Martsolf Syndrome | Pneumonia, Bacterial | Cavitary Optic Disc Anomalies | Pemphigus | Hodgkin Lymphoma | IMAGe Syndrome | Familial Hypobetalipoproteinemia | Branchiootorenal Syndrome | Usher Syndrome Type IIC | Conjunctivitis, Allergic | Methemoglobinemia | Pompe Disease | Dermatomyositis | Panic Disorder | Primary Sclerosing Cholangitis | Osteomalacia | Cutaneous T-cell Lymphoma | Familial Cerebral Amyloid Angiopathy | Glycogen Storage Disease Type 0, Muscle | T-cell Chronic Lymphocytic Leukemia | Lymphoma, B-cell | Intestinal Hypomagnesemia 1 | Von Willebrand Disease | Speech Disorders | Central Retinal Artery Occlusion | Angiodysplasia | Angiosarcoma | Mitochondrial Disease | Distal Spinal Muscular Atrophy | Acne | Encephalopathy, Hepatic | Familial Advanced Sleep Phase Syndrome | Spinocerebellar Ataxia Type 13 | Hyperthyroidism | Wagner Disease | Sialidosis | Membranous Nephropathy | Chronic Myelomonocytic Leukemia | Loeys-Dietz Syndrome | Blepharospasm | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Tay-Sachs Disease | Encephalocele | Neurodermatitis | Metatropic Dysplasia | Maple Syrup Urine Disease | Lissencephaly 2 | Cholangiocarcinoma | Pseudo-pseudohypoparathyroidism | Low Tension Glaucoma | Adenylosuccinate Lyase Deficiency | Congenital Afibrinogenemia | Acute Tubular Necrosis | Motion Sickness | Extramammary Paget's Disease | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Arthrogryposis | Cryptorchidism | Clouston Hidrotic Ectodermal Dysplasia | Teratozoospermia | Thyroiditis | Vitreoretinal Degeneration, Snowflake Type | Congenital Generalized Lipodystrophy | Oculodentodigital Dysplasia | Asplenia | Neuromuscular Disorders | Neuroectodermal Tumors, Primitive | Niemann-Pick Disease, Type B | Carbamoyl Phosphate Synthetase I Deficiency | Obsessive-compulsive Disorder | Li-Fraumeni Syndrome | Thyrotoxic Periodic Paralysis | Myocardial Infarction | Chronic Inflammatory Demyelinating Polyneuropathy | Microcephaly, Seizures, And Developmental Delay | Dysfibrinogenemia | Autosomal Recessive Spastic Paraplegia Type 75 | Metachondromatosis | Hidradenitis Suppurativa | Sertoli Cell-only Syndrome | Diabetic Nephropathy | Binge Eating Disorder | Craniosynostosis | Hypotonia-cystinuria Syndrome | Mevalonate Kinase Deficiency | Seasonal Mood Disorder | Panniculitis | Charcot-Marie-Tooth Disease Type 4 | Hyperinsulinemic Hypoglycemia | Sporadic Hemiplegic Migraine | Diabetes | Cholera | Leishmaniasis, Visceral | Alstrom Syndrome | Anorectal Fistula | Vascular Cognitive Impairment | Small Lymphocytic Lymphoma | Vitreoretinopathy, Proliferative | Esotropia | Mesothelioma, Malignant | Infantile Neuroaxonal Dystrophy | Polymicrogyria | Hypercholesterolemia | Nager Acrofacial Dysostosis | Granular Corneal Dystrophy | Neuronal Ceroid Lipofuscinosis | Neuromyelitis Optica | Brenner Tumor | Veno-occlusive Disease | Oligodendroglioma | Familial Partial Lipodystrophy | Presbycusis | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Fundus Albipunctatus | Neutrophilia | Glycogen Storage Disease Type 1a | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Hemolytic Uremic Syndrome | Harlequin Ichthyosis | Hereditary Hemorrhagic Telangiectasia | Exocrine Pancreatic Insufficiency | Osteonecrosis Of The Jaw | Galloway-Mowat Syndrome | Infantile Spasm | Hypertension, Essential | Sponastrime Dysplasia | Neuroendocrine Cancer | Zimmermann-Laband Syndrome | Hoyeraal-Hreidarsson Syndrome | Spinal Muscular Atrophy Type 3 | Insulin Resistance | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Nephrosclerosis | Muckle-Wells Syndrome | Silicosis | Cancer, Prostate | Lymphoma, Follicular | CEDNIK Syndrome | Botulism | Hereditary Mixed Polyposis Syndrome | Autism | Charcot-Marie-Tooth Disease, Type 6 | Lewy Body Dementia | Aldosteronism | Diverticulitis | Tracheal Disorders | Glomerulonephritis, Membranous | Periventricular Nodular Heterotopia | Granular Corneal Dystrophy Type 1 | Headache | LEOPARD Syndrome | Birk-Barel Syndrome | Endometritis