Disease

Muckle-Wells Syndrome

About the Disease
Muckle-Wells Syndrome, also known as urticaria-deafness-amyloidosis syndrome, is related to cryopyrin-associated periodic syndrome and familial cold autoinflammatory syndrome 1, and has symptoms including lower extremity pain An important gene associated with Muckle-Wells Syndrome is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Ginseng and Rilonacept have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and eye, and related phenotypes are splenomegaly and hepatomegaly

Common Targets
IL1B | G114548

疾病靶点研报
Muckle-Wells Syndrome

Note: If you'd like to get a target analysis report for Muckle-Wells Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Muckle-Wells Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Cryptosporidiosis | Exostoses | Methemoglobinemia | Megaloblastic Anemia | Pupil Disorders | Charcot-Marie-Tooth Disease, Type 2C | Primary Cutaneous Amyloidosis | Dentinogenesis Imperfecta | Lymphopenia | Erdheim-Chester Disease | Von Willebrand Disease | Waardenburg Syndrome Type 4 | Insulinoma | Varicocele | GATA2 Deficiency | Cold-induced Sweating Syndrome | Hereditary Elliptocytosis | Atopy | Schnitzler Syndrome | Glycogen Storage Disease Type 0, Muscle | Wolfram Syndrome 2 | Mixed Connective Tissue Disease | Bronchiolitis | Colon Adenoma | Primary Erythromelalgia | Scleroderma | Astigmatism | Macular Degeneration | Arthropathy | Cholelithiasis | Pyruvate Kinase Deficiency | Bartsocas-Papas Syndrome | Azoospermia | Chronic Myeloid Leukemia | Myofibromatosis | Hypertriglyceridemia | Dysfibrinogenemia | Fibrosarcoma | Skin Fragility-woolly Hair Syndrome | Congenital Stationary Night Blindness | Spitzoid Melanoma | Pontocerebellar Hypoplasia Type 7 | Peeling Skin Syndrome, Acral Type | Papilloma | Hypertension, Renal | Hemangioblastoma | Tinea | Withdrawal Syndrome | Sarcoma | Fanconi Anemia | Keratosis, Actinic | Vestibular Disease | Oculocutaneous Albinism Type 2 | Fraser Syndrome | Nephrocalcinosis | Spitz Nevus | GLUT1 Deficiency Syndrome | Pneumothorax | Meningococcal Infections | Guttate Psoriasis | Cholecystitis | Hypohidrotic Ectodermal Dysplasia, X-linked | Anorectal Malformations | Opisthorchiasis | Blepharoconjunctivitis | Hereditary Pyropoikilocytosis | Pulmonary Vein Stenosis | Alagille Syndrome | Aldosteronism | Congenital Dyserythropoietic Anemia | Fragile X Syndrome | 3C Syndrome | Tenosynovial Giant Cell Tumor | Stroke, Hemorrhagic | Prader-Willi Syndrome | Spondylocostal Dysostosis | T-cell Leukemia | Perry Syndrome | Thyrotoxic Periodic Paralysis | Antley-Bixler Syndrome | Encephalitis, Tick-borne | Pneumococcal Meningitis | Obesity | Encephalitis | Angiosarcoma Of The Breast | 3-methylglutaconic Aciduria | HANAC Syndrome | Spondyloperipheral Dysplasia | Cancer, Prostate | Schizophrenia | Pseudohypoparathyroidism Type 2 | Infectious Diarrhea | Agranulocytosis | Eosinophilic Asthma | Vitreoretinal Degeneration, Snowflake Type | Tuberculosis | Lewy Body Dementia | Angelman Syndrome | Hepatitis A | Congenital Poikiloderma | Spinocerebellar Ataxia Type 28 | Holt-Oram Syndrome | Retinoblastoma | Myasthenia | Perivascular Epithelioid Cell Tumor | Unverricht-Lundborg Syndrome | Meningitis | X-linked Sideroblastic Anemia | Burn-McKeown Syndrome | Metabolic Syndrome | Walker-Warburg Syndrome | Metachondromatosis | Fabry's Disease | Prediabetes | Retinal Degeneration | Pneumonia, Mycoplasma | Synpolydactyly | Spinal Muscular Atrophy Type 2 | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Dengue Shock Syndrome | Headache | Marinesco-Sjogren Syndrome | Cholangiocarcinoma | Protein S Deficiency | Ameloblastoma | Chronic Myelomonocytic Leukemia | Neurofibrosarcoma | Dystonia Musculorum Deformans | Tracheal Disorders | Asthma, Nocturnal | Encephalopathy, Ethylmalonic | Tietze Syndrome | Tremor | Dominant Optic Atrophy | Crohn's Disease | Craniofrontonasal Syndrome | Smith-Magenis Syndrome | Congenital Generalized Lipodystrophy | Adrenal Insufficiency | Pendred Syndrome | Mitochondrial Cytopathy | Malnutrition | Schaaf-Yang Syndrome | Smith-Kingsmore Syndrome | Inflammatory Linear Verrucous Epidermal Nevus | Ellis-Van Creveld Syndrome | Pemphigus Vulgaris | Primary Familial Brain Calcification | Central Pain Syndrome | Cervicitis | LRBA Deficiency | Epidermal Nevus Syndrome | Xeroderma Pigmentosum | Neurofibromatosis | Palmoplantar Keratoderma | Bursitis | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Acanthosis Nigricans | Colitis, Microscopic | Amelanotic Melanoma | Acute Tubular Necrosis | Stickler Syndrome | Polycystic Kidney, Autosomal Dominant | Anti-glomerular Basement Membrane Disease | Arteriosclerosis | Hyperglycemia | Spinocerebellar Ataxia Type 21 | Hodgkin Lymphoma | Von Hippel-Lindau Disease | Retinal Telangiectasia | Polycythemia | Birt-Hogg-Dube Syndrome | Cardiac Sarcoidosis | Polyradiculopathy | Thin Basement Membrane Disease | Vertebrobasilar Insufficiency | Omenn Syndrome | Cole-Carpenter Syndrome | Familial Exudative Vitreoretinopathy | Lichen Sclerosus | Charcot-Marie-Tooth Disease Type 4D | Gastritis | Early Infantile Epileptic Encephalopathy | Multiple Epiphyseal Dysplasia | Renal Hypomagnesemia 3 | Aldosterone Synthase Deficiency | Brugada Syndrome 1 | Epithelioid Hemangioma | Milk Allergy | Progressive Familial Intrahepatic Cholestasis Type 2 | Osteosclerosis | Pyruvate Dehydrogenase Deficiency | Anemia | Arthritis, Gouty | Lysosomal Acid Lipase Deficiency | Nutrition Disorders | Klinefelter Syndrome | Glycogen Storage Disease Type 6 | Canavan Disease | Anterior Segment Dysgenesis | CHOPS Syndrome | Pilomatrix Carcinoma | Hypermethioninemia | Cri-du-chat Syndrome | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Intellectual Disability, Autosomal Dominant 5 | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Arteriovenous Malformations | Non-Hodgkin Lymphoma | Lathosterolosis | Sclerosing Cholangitis | Goldenhar Syndrome | Carney Triad | Eiken Syndrome | Follicular Dendritic Cell Sarcoma | Primrose Syndrome | Hereditary Xerocytosis | Nemaline Myopathy | Renal Dysplasia | Retinal Diseases | Hyperphenylalaninemia | Martsolf Syndrome | Leukocyte Adhesion Deficiency Type 1 | Multiple System Atrophy | Melanocytic Nevus | Spondylolisthesis | Renal Hypouricemia | Paronychia | Brenner Tumor | IgA Nephropathy | Best Macular Dystrophy | Conjunctivitis | Metatropic Dysplasia | Premenstrual Syndrome | Dwarfism | Histiocytosis | Spinocerebellar Ataxia Type 42 | Hyperlipidemia Type V | Chronic Enteropathy Associated With SLCO2A1 Gene | Hemochromatosis | Maple Syrup Urine Disease | Muscular Dystrophy | Stevens-Johnson Syndrome | Lipid Metabolism Disorders | Lymphangioma | Diabetes Insipidus, Nephrogenic | Usher Syndrome | Uremic Pruritus | Asthma | Lung Diseases | Diffuse Mesangial Sclerosis | Iron Metabolism Disorders | GM2-gangliosidosis AB Variant | Gliosarcoma | Cohen Syndrome | Purpura, Thrombotic Thrombocytopenic | Triphalangeal Thumb-polysyndactyly Syndrome | Pathological Gambling | Ectodermal Dysplasia | Prolidase Deficiency | Growth Hormone Excess | Muscle Wasting | Autism | Panic Disorder | Neovascular Glaucoma | DRESS Syndrome | Pancreatitis | Schizotypal Personality Disorder | Keratopathy | Lipodystrophy | Anal Fissure | Polyneuropathy | Epilepsy Of Infancy With Migrating Focal Seizures | Papulopustular Rosacea | Apparent Mineralocorticoid Excess Syndrome | Leukemia | Methylmalonic Acidemia | Melnick-Needles Syndrome | Pheochromocytoma | Inflammatory Myopathy | Hyperparathyroidism, Primary | Cancer, Kidney | Combined Deficiency Of Factor V And Factor VIII | Huntington's Disease-like 2 | TARP Syndrome | Shock, Cardiogenic | Meleda Disease | Usher Syndrome Type IIC | Adult Polyglucosan Body Disease | Antenatal Bartter Syndrome Type 1 | Multiple Sulfatase Deficiency | Hereditary Hemorrhagic Telangiectasia | Meningioma, Benign | Restrictive Dermopathy | Acute Lung Injury | Neurodegeneration With Brain Iron Accumulation | Pituitary Dwarfism | Fanconi Syndrome | Supravalvular Aortic Stenosis | Non-Langerhans Cell Histiocytosis | Lymphedema | Epidermolysis Bullosa Dystrophica | Glaucomatocyclitic Crisis | Progressive Familial Intrahepatic Cholestasis Type 3 | Diabetes Insipidus | Corneal Dystrophy | Stomatitis | Lipid Storage Diseases | Osteogenesis Imperfecta Type III | Congenital Adrenal Hyperplasia 1 | Hyperparathyroidism | Hyperhomocysteinemia | Aarskog-Scott Syndrome | Krabbe Disease | Rheumatoid Arthritis | Ocular Albinism Type 1 | Basal Ganglia Disease | Osteochondroma | Cholestasis | Onchocerciasis | Renal Tubular Acidosis | Tyrosinemia Type 2 | Heterotaxy | Metachromatic Leukodystrophy | Williams Syndrome | Keratoacanthoma | Ischemia | Epidermolytic Hyperkeratosis | Blomstrand Osteochondrodysplasia | Demyelinating Diseases | Glycogen Storage Disease Type 4 | Diamond-Blackfan Anemia | Basal Ganglia Disease, Biotin-responsive | Klippel-Feil Syndrome | Periodontitis | Cardiomyopathy, Peripartum | Hepatic Veno-occlusive Disease | Pulmonary Alveolar Microlithiasis | Corneal Edema | Vulvovaginitis | Gangliosidosis | Chronic Idiopathic Myelofibrosis | Dysferlinopathy | Cataplexy | Pyoderma Gangrenosum | Meningeal Melanocytoma | Chediak-Higashi Syndrome | Hyperbilirubinemia, Neonatal | Congenital Nystagmus | Vitamin B12 Deficiency | Lymphedema-distichiasis Syndrome | Wolcott-Rallison Syndrome | Pneumonia, Bacterial | Evans Syndrome | Cockayne Syndrome | Early Infantile Epileptic Encephalopathy 28 | Glomerulonephritis, Membranous | Primary Progressive Aphasia | Keratitis-ichthyosis-deafness Syndrome | Pyloric Stenosis, Infantile Hypertrophic | Stromal Corneal Dystrophy | Sjogren Syndrome | Osteoporosis-pseudoglioma Syndrome | Glioma | Acromicric Dysplasia | Tatton-Brown-Rahman Syndrome | Swine Influenza | Farber Disease | Carcinoma In Situ | Cranioectodermal Dysplasia | Peripheral Neuropathy | Osteopetrosis | T-cell Chronic Lymphocytic Leukemia | Eczema | Plasma Cell Dyscrasia | Spondylocarpotarsal Synostosis Syndrome | Pseudohypoparathyroidism Type 1B | Congenital Absence Of Vas Deferens | Tangier Disease | Lymphoma Lymphoblastic | Rhabdomyosarcoma, Alveolar | Pyruvate Decarboxylase Deficiency | Ovarian Sex Cord-stromal Tumor | Sclerocornea | Urofacial Syndrome | Seizures | Myelofibrosis | Hemorrhoids | Partington Syndrome | Subacute Sclerosing Panencephalitis | Pemphigoid | Isobutyryl-CoA Dehydrogenase Deficiency | Usher Syndrome Type III | Hyperkalemic Periodic Paralysis | Hyperparathyroidism, Secondary | Leishmaniasis, Cutaneous | Cutaneous Angiosarcoma | Myoclonic Epilepsy With Ragged Red Fibers | Cataract | Familial Hypertrophic Cardiomyopathy