Apparent Mineralocorticoid Excess Syndrome

About the Disease
Apparent Mineralocorticoid Excess, also known as cortisol 11-beta-ketoreductase deficiency, is related to hypertensive retinopathy and hypoaldosteronism. An important gene associated with Apparent Mineralocorticoid Excess is HSD11B2 (Hydroxysteroid 11-Beta Dehydrogenase 2), and among its related pathways/superpathways are Metabolism of steroids and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Licorice and Enoxolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, placenta and brain, and related phenotypes are hypertension and hypokalemia

Common Targets
HSD11B2

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