Proliferative Vitreoretinopathy

About the Disease
Vitreoretinopathy, Neovascular Inflammatory, also known as proliferative vitreoretinopathy, is related to retinal detachment and retinal perforation. An important gene associated with Vitreoretinopathy, Neovascular Inflammatory is CAPN5 (Calpain 5), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Bupivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and bone marrow, and related phenotypes are blindness and abnormal electroretinogram

Common Targets
Folate Receptor (nonspecified subtype) | LTA | NR3C1 | ADORA1 | ADORA2B | ADORA2A | Tyrosine Kinase (nonspecified subtype) | S1PR2 | SMAD7 | HSPA13 | IL10 | PLG | G4193 | G3569 | G7422 | IL2 | IL1A | TGFB2 | PDGFRA | CR1 | JAK3 | MIF | CCL2 | CAPN5 | DHFR | G7124 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | TGFB1 | FGF2 | G7157 | CNR2

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