Microcephalic Primordial Dwarfism

About the Disease
Seckel Syndrome, also known as microcephalic primordial dwarfism, is related to microcephaly 10, primary, autosomal recessive and seckel syndrome 2, and has symptoms including seizures An important gene associated with Seckel Syndrome is ATRIP (ATR Interacting Protein), and among its related pathways/superpathways are Homology Directed Repair and EML4 and NUDC in mitotic spindle formation. Affiliated tissues include bone, bone marrow and olfactory bulb, and related phenotypes are intellectual disability and delayed skeletal maturation

Common Targets
ATRIP

Note: If you'd like to get a target analysis report for Microcephalic Primordial Dwarfism, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Microcephalic Primordial Dwarfism at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Charcot-Marie-Tooth Disease Type 2T | Sleep Disorder | Adenylosuccinate Lyase Deficiency | Seasonal Mood Disorder | Diabetic Neuropathy | Corneal Dystrophies, Hereditary | Hemangioma | Pulmonary Veno-occlusive Disease | Klippel-Feil Syndrome | Hypertensive Nephropathy | Alpers Syndrome | Bone Marrow Necrosis | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Actinomycetoma | Methylmalonic Acidemia | Thrombosis | Spondyloperipheral Dysplasia | Myocarditis | Acromicric Dysplasia | Acute Kidney Injury | Fahr Disease | Kindler Syndrome | Nemaline Myopathy 10 | Loeys-Dietz Syndrome | Anthrax | Renal Hypouricemia | Bronchiolitis | Eosinophilia | Avellino Corneal Dystrophy | Pemphigus Vulgaris | Progressive External Ophthalmoplegia | Crimean-Congo Hemorrhagic Fever | Fontaine Progeroid Syndrome | Central Retinal Artery Occlusion | Agammaglobulinemia | Leukoencephalopathy, Progressive Multifocal | Hyperphenylalaninemia | Smith-Kingsmore Syndrome | Acute Tubular Necrosis | Uremia | Menetrier Disease | Cancer, Prostate | Dyggve-Melchior-Clausen Disease | Peeling Skin Syndrome, Acral Type | Periodic Limb Movement Disorder | Polymyositis | Norrie Disease | Zellweger Syndrome | Split Hand-foot Malformation | Cerebral Cavernous Malformations | Pyoderma Gangrenosum | Sensory Neuropathy | Proctitis | Chronic Idiopathic Myelofibrosis | Opisthorchiasis | Creutzfeldt-Jakob Disease | Coma | Rash | Cardiomyopathy, Dilated, 1L | Leri Pleonosteosis | Adult Polyglucosan Body Disease | Nail Disorder, Nonsyndromic Congenital | Marshall-Smith Syndrome | Adenomatoid Tumor | Osteonecrosis | Hydrocephalus | Cervicitis | Usher Syndrome Type III | Thalassemia | Cancer, Bladder | Hemochromatosis Type 2 | Primary Carnitine Deficiency | Cone Dystrophy | Gerstmann-Straussler-Scheinker Syndrome | Acrodermatitis | Urofacial Syndrome | Bronchitis, Chronic | Hyperlipidemia Type V | Cherubism | IMAGe Syndrome | Atelosteogenesis Type 1 | Pfeiffer Syndrome | Borderline Personality Disorder | Erythromelalgia | Dysplastic Nevus | Farber Disease | Open-angle Glaucoma | Poretti-Boltshauser Syndrome | Peyronie's Disease | Vitiligo | ACTH-independent Macronodular Adrenal Hyperplasia | Basan Syndrome | Hemophagocytic Lymphohistiocytosis | Medulloblastoma | Posterior Polar Cataract | Supravalvular Aortic Stenosis | Esophageal Carcinoma | Spondyloarthritis | Carcinoma, Merkel Cell | Androgen Insensitivity | Fukuyama Congenital Muscular Dystrophy | Glycogen Storage Disease Type 5 | Epithelioid Hemangioma | Schizoaffective Disorder | Charcot-Marie-Tooth Disease, Type 2 | Albinism | Carney Triad | Retinoblastoma | Primary Progressive Aphasia | Mucolipidosis Type II | Pyloric Stenosis, Infantile Hypertrophic | Arthritis, Gouty | Keratitis | Genee-Wiedemann Syndrome | Hypercalciuria | Triple A Syndrome | Cardiofaciocutaneous Syndrome | Lactose Intolerance | Rubinstein-Taybi Syndrome | Polyarteritis Nodosa | Apraxia | Frontotemporal Dementia | Herpes Simplex Dermatitis | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Lichen Sclerosus | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Intestinal Obstruction | Sporadic Inclusion Body Myositis | Erythematotelangiectatic Rosacea | Dysfibrinogenemia | Abetalipoproteinemia | Protein C Deficiency | Marinesco-Sjogren Syndrome | Osteopathia Striata With Cranial Sclerosis | Moyamoya Disease | Autosomal Recessive Bestrophinopathy | Cushing Syndrome | Cellulitis | Lipid Metabolism Disorders | Spinocerebellar Ataxia Type 13 | Benign Familial Neonatal Convulsions | Lymphangioma | Sotos Syndrome | Osteogenesis Imperfecta Type V | Melanoma, Uveal | Rickets | Hermansky-Pudlak Syndrome | Paroxysmal Kinesigenic Dyskinesia | Leukocyte Adhesion Deficiency Type 1 | Haim-Munk Syndrome | Ellis-Van Creveld Syndrome | Insulin Resistance | Primary Sclerosing Cholangitis | Chloridorrhea, Congenital | Delirium | Congenital Tufting Enteropathy | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Pyruvate Kinase Deficiency | Inflammatory Linear Verrucous Epidermal Nevus | Cryopyrin-associated Periodic Syndromes | Thymoma, Malignant | Histiocytic Sarcoma | Glycogen Storage Disease Type 0 | Chronic Inflammatory Demyelinating Polyneuropathy | Congenital Ichthyosiform Erythroderma | Angioedema, Acquired | Vaginitis | Anterior Segment Dysgenesis | Tangier Disease | IgA Nephropathy | Microcephaly | Diabetes | Angiosarcoma | 3-methylglutaconic Aciduria | Hyperlipidemia, Familial Combined | Vitelliform Macular Dystrophy | Distal Spinal Muscular Atrophy | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Aspergillosis | Astrocytoma, Anaplastic | Parvovirus B19 Infection | Hemangioblastoma | Congenital Heart Block | Psoriasis | Plasmacytoma | Myeloid Leukemia | Burn-McKeown Syndrome | Gaucher Disease | Exostoses | Crouzon Syndrome With Acanthosis Nigricans | Niemann-Pick Disease, Type B | Walker-Warburg Syndrome | Keratoconus | Bloom Syndrome | Neurodermatitis | Large Granular Lymphocytic Leukemia | Pituitary Stalk Interruption Syndrome | Viral Meningitis | Malaria | Corneal Dystrophy And Perceptive Deafness | Pemphigoid | Angelman Syndrome | B-cell Prolymphocytic Leukemia | Tricho-hepato-enteric Syndrome | Primary Familial Brain Calcification | Congenital Bile Acid Synthesis Defect | Dystonia-parkinsonism, X-linked | Campomelic Dysplasia | Trichomegaly | Nijmegen Breakage Syndrome | Infantile Nephropathic Cystinosis | Wilson's Disease | Sarcoma, Ewing | X-linked Creatine Transporter Deficiency | Liver Failure | Polycythemia Vera | Progressive Familial Intrahepatic Cholestasis | Ophthalmoplegia | Okihiro Syndrome | Retinal Diseases | Glutathione Synthetase Deficiency | Porphyria | Sclerosteosis | Acromegaly | Meningitis | Spinocerebellar Ataxia Type 23 | Calcium Pyrophosphate Deposition Disease | Autosomal Recessive Spastic Paraplegia Type 35 | Pure Autonomic Failure | Arterial Tortuosity Syndrome | Lymphoproliferative Disorders | Meningococcal Meningitis | Down Syndrome | Schistosomiasis Mansoni | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Heart Block | Cranial Nerve Disease | Restrictive Dermopathy | Familial Advanced Sleep Phase Syndrome | Glycogen Storage Disease Type 3 | Ovarian Sex Cord-stromal Tumor | Brenner Tumor | Congenital Myopathy | Skin Carcinoma | Craniofrontonasal Syndrome | Duane Retraction Syndrome | Nephrocalcinosis | Diabetes Type 2 | Headache | Focal Segmental Glomerulosclerosis | Nestor-Guillermo Progeria Syndrome | Celiac Disease | Mitochondrial Disease | Neuropathy | Glaucomatocyclitic Crisis | Hypertrophy | Pilomatrix Carcinoma | Chronic Granulomatous Disease | Neuroectodermal Tumors, Primitive | Pulmonary Vein Stenosis | Osteonecrosis Of The Jaw | Hodgkin Lymphoma | Erythrokeratodermia Variabilis | Charcot-Marie-Tooth Disease, Type 2A | Addison Disease | Fetal Akinesia Deformation Sequence | Spinal And Bulbar Muscular Atrophy | Lymphangiomatosis | Pneumonia, Viral | Hypohidrotic Ectodermal Dysplasia, X-linked | Blomstrand Osteochondrodysplasia | Aldosteronism | Hereditary Elliptocytosis | Intracerebral Hemorrhage | Splenomegaly | KBG Syndrome | Cancer, Breast | Evans Syndrome | Congenital Dyserythropoietic Anemia Type 4 | Carcinoma, Small Cell | Erythema Multiforme | Basal Cell Nevus Syndrome | Sengers Syndrome | Tenosynovial Giant Cell Tumor | Familial Exudative Vitreoretinopathy | Dyskeratosis Congenita | Cerebrotendinous Xanthomatosis | Cardiomyopathy, Peripartum | Spinocerebellar Ataxia Type 8 | Congenital Hemolytic Anemia | Benign Hereditary Chorea | Infertility | Disseminated Intravascular Coagulation | Retinal Coloboma | Hemimegalencephaly | T-cell Chronic Lymphocytic Leukemia | Urethritis | Diabetes Insipidus, Neurogenic | Neuroma | Hypothalamic Obesity | Spondylocostal Dysostosis | Aplasia Cutis Congenita | Constipation | Rett Syndrome | Mixed Connective Tissue Disease | Juvenile Xanthogranuloma | Shprintzen-Goldberg Syndrome | Ectrodactyly | Gardner Syndrome | Myosin Storage Myopathy | Combined Malonic And Methylmalonic Acidemia | Myositis | Creatine Deficiency Syndrome Due To AGAT Deficiency | Encephalopathy, Ethylmalonic | Familial Dysautonomia | Charcot-Marie-Tooth Disease Type 4E | Goiter | Palsy, Cerebral | Lennox-Gastaut Syndrome | Basal Ganglia Cerebrovascular Disease | Mosaic Variegated Aneuploidy Syndrome 2 | Osteomalacia | Saethre-Chotzen Syndrome | Premenstrual Syndrome | Chronic Granulomatous Disease, X-linked | Thrombophlebitis | C3 Glomerulopathy | Huntington's Disease-like 2 | Inflammatory Myopathy | Corneal Dystrophy | Mast Cell Leukemia | Oligodendroglioma | Cystitis | AIDS Dementia Complex | Cartilage Disorders | Non-small Cell Lung Cancer | Babesiosis | Parkinson's Disease | Apert Syndrome | Stroke, Hemorrhagic | Williams Syndrome | Teratozoospermia | LRBA Deficiency | Meleda Disease | Spinal Muscular Atrophy Type 2 | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | TARP Syndrome | T-cell Lymphoma, Subcutaneous Panniculitis-like | Thyroid Dyshormonogenesis | Tyrosinemia Type 2 | Proopiomelanocortin Deficiency | Joubert Syndrome | Ichthyosis Hystrix, Curth-Macklin Type | Sporadic Hemiplegic Migraine | Beare-Stevenson Syndrome | Personality Disorders | Hereditary Mixed Polyposis Syndrome | Hyperinsulinemic Hypoglycemia | Lupus Erythematosus | Long QT Syndrome Type 3 | Early Infantile Epileptic Encephalopathy 13 | Kabuki Syndrome 2 | Beckwith-Wiedemann Syndrome | Orthostatic Intolerance | Enterocolitis, Necrotizing | Basal Ganglia Disease, Biotin-responsive | Fuchs Dystrophy | Maple Syrup Urine Disease | Nephroblastoma | Platelet Disorders | Muir-Torre Syndrome | N-acetylglutamate Synthase Deficiency | Disseminated Superficial Actinic Porokeratosis | Light Chain Amyloidosis | Peroxisomal Disorder | Toxic Epidermal Necrolysis | Hypoproteinemia, Hypercatabolic | T-cell Prolymphocytic Leukemia | Wolman Disease | Cholangiocarcinoma | Liebenberg Syndrome | Angiomyolipoma | Hyperthyroidism | Eosinophilic Asthma | Vertebrobasilar Insufficiency | Papillorenal Syndrome | Cyclic Vomiting Syndrome | Diabetes Type 1 | Osteochondrosis | Pyruvate Carboxylase Deficiency Disease | Lichen Planus | Chondromyxoid Fibroma | Pneumothorax | Hypertensive Retinopathy | Multicentric Carpotarsal Osteolysis Syndrome | Perivascular Epithelioid Cell Tumor | Familial Episodic Pain Syndrome | Hyperinsulinemia | Double Outlet Right Ventricle | Danon Disease