Paroxysmal Nocturnal Hemoglobinuria

About the Disease
Paroxysmal Nocturnal Hemoglobinuria, also known as marchiafava-micheli disease, is related to hemolytic anemia and budd-chiari syndrome. An important gene associated with Paroxysmal Nocturnal Hemoglobinuria is PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis Class A), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Warfarin and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and bone, and related phenotypes are abnormal erythrocyte enzyme level and hemolytic anemia

Common Targets
BRD4 | C1S | IDH1 | CFD | CFP | BRD2 | PKLR | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | PIGA | TET2 | IDH2 | Serine protease (nonspecified subtype) | Complement Complex | CR1 | BRD3 | C3 | MASP1 | C9 | PIGT | CFB | KLK7 | C5

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