Sleep Disorder

About the Disease
Sleep Disorder, also known as sleep disorders, is related to narcolepsy 1 and idiopathic hypersomnia, and has symptoms including back pain, cachexia and cyanosis. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are IL-9 Signaling Pathways and Peptide hormone metabolism. The drugs Tramadol and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are no effect and no effect

Common Targets
ADRA2C | GPR55 | G5243 | SCN5A | Glutamate Receptor Ionotropic AMPA Receptor | HTR7 | CACNA1H | GPR139 | HRH3 | PROKR2 | G114548 | CSNK1E | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | PDE4D | CACNA1B | HLA-DQB1 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | LDLR | KCNC1 | KDR | AURKA | AVPR1A | G1956 | ABL1 | GRM5 | BMAL1 | AANAT | Tyrosine-Protein Kinases Src (nonspecified subtype) | CHRM4 | MTNR1A | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | Gamma-Aminobutyric acid type B receptor | NPSR1 | MGLL | DRD4 | SLCO2B1 | AVPR1B | OPRM1 | ALOX12 | T-Type Calcium Channel | Alpha-2 Adrenergic receptors (nonspecified subtype) | GABRB2 | KCNC2 | CNR2 | GABRG2 | SIGMAR1 | CHRM1 | Casein kinase I (nonspecified subtype) | Calcium channel (nonspecified subtype) | HTR4 | HCRTR1 | KCNK2 | TYR | P2RX3 | CACNA1G | GRM2 | Protein kinase C (nonspecified subtype) | CLK4 | NF-kappaB (NFkB) | PDE9A | ADORA1 | CDK5 | Nicotinic alpha3beta4 Receptor | ADORA2B | SLC6A9 | TRPM8 | MAP3K14 | alpha-Adrenoceptor (nonspecified subtype) | NPY2R | TOP1 | HTR2B | Opioid receptor (nonspecified subtype) | SLC6A2 | HTR1A | HTR5A | DRD2 | MAPT-AS1 | CHRNA7 | UTS2R | CNR1 | BCHE | G4137 | MTNR1B | GABA(A) receptor | TRPV2 | ADRA2A | DYRK3 | HLA-DRB1 | DYRK1A | KCNQ Channels (K(v) 7) (nonspecified subtype) | OPRL1 | P2RX4 | Orexin receptor (nonspecified subtype) | K(ATP) Channel (nonspecified subtype) | ADORA2A | NPY5R | OXT | TRPV1 | Voltage-Gated Sodium Channel Complex | PTGDR | PTPN1 | XDH | ADORA3 | KCNK3 | TSPO | OPRD1 | GABRA1 | HCRTR2 | ACHE | VIPR2 | sigma Receptor (nonspecified subtype) | CSNK1A1 | PTGDR2 | NTRK1 | DRD1 | GSK3B | SOAT1 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | G9429 | LINC02210-CRHR1 | PDE1B | G2475 | FAAH | GNRHR | G3630 | GRM3 | Cryptochrome (nonspecified subtype) | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | Vasopressin Receptor (nonspecified subtype) | Sodium channel (nonspecified subtype) | PROKR1 | HTR6 | CRHR1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | KCNK9 | Mitogen-Activated Protein Kinase (nonspecified subtype) | GABRD | CLK1 | Transglutaminase (nonspecified subtype) | RBM39 | SLC6A1 | NQO2 | TMEM97 | AP-1 Transcription Factor Complex | MAPK10 | NR1D2 | DYRK1B | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | HTR1B | G196 | NR3C1 | TH | SCN9A | alpha1-Adrenoceptor (nonspecified subtype) | SLC6A4 | TACR1 | GABRA2 | HRH1 | IL2 | NR1D1 | NMDA receptor | SOAT2 | Histamine Receptor (HR) (nonspecified subtype) | SGMS1 | GHRHR | APP | SLCO1B1 | CASP1 | SLCO1A2 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | CSNK1D | NT5E | ADRA1B | DYRK2 | NOS2 | HTR2A | HTR2C | G4233 | VDR | TRPA1 | G5743 | CRHR2 | SLC29A1 | MCHR1 | TAAR1 | Potassium Channels (nonspecified subtype) | PRKCE | HTR1D | CLK2 | HRH4 | APOE | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | DRD3 | CHRM2 | ALOX5 | NLRP3 Inflammasome | SLC6A3 | OXTR | GABRA3 | FLT3 | G7124 | Proteasome Complex

Note: If you'd like to get a target analysis report for Sleep Disorder, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Sleep Disorder at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Hypercalciuria | Generalized Epilepsy With Febrile Seizures Plus | Synovitis | Unverricht-Lundborg Syndrome | Chylothorax, Congenital | Inflammatory Joint Disease | Peutz-Jeghers Syndrome | Glycogen Storage Disease Type 0, Muscle | Hairy Cell Leukemia | Fibromuscular Dysplasia | Ichthyosis, X-linked | Trismus-pseudocamptodactyly Syndrome | Autosomal Recessive Spastic Paraplegia Type 54 | Riboflavin Transporter Deficiency Neuronopathy | Esophageal Carcinoma | Aromatic L-amino Acid Decarboxylase Deficiency | Congenital Myopathy | Low Phospholipid Associated Cholelithiasis | Chondrodysplasia Punctata 1, X-linked Recessive | Stromal Corneal Dystrophy | Smith-Magenis Syndrome | Lupus Erythematosus | MELAS Syndrome | Arthritis, Reactive | Acute Lung Injury | Progressive Familial Intrahepatic Cholestasis Type 3 | Pneumonia, Mycoplasma | Ameloblastic Carcinoma | Usher Syndrome Type III | Oculocutaneous Albinism Type 2 | Hartsfield Syndrome | Muckle-Wells Syndrome | L-2-Hydroxyglutaric Aciduria | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Diffuse Mesangial Sclerosis | Whipple's Disease | Amyotrophic Lateral Sclerosis, Juvenile | Schnyder Crystalline Corneal Dystrophy | Hypertension, Pulmonary | Intermittent Claudication | Bloom Syndrome | Aspartylglycosaminuria | Spermatocele | Wilson's Disease | GLUT1 Deficiency Syndrome | Conduct Disorder | Diabetic Macular Edema | Lymphoma | Alpha-1 Antitrypsin Deficiency | Thrombotic Microangiopathy | Subcortical Band Heterotopia | Anorectal Malformations | Jalili Syndrome | Skin Papilloma | Empyema | Migraine | Osteoarthritis | Corneal Ulcer | Proteasome-associated Autoinflammatory Syndrome 2 | Acromegaly | Bardet-Biedl Syndrome | Portal Vein Thrombosis | Early Infantile Epileptic Encephalopathy | Batten Disease | X-linked Charcot-Marie-Tooth Disease | Primary Erythromelalgia | Fucosidosis | Congenital Bilateral Absence Of Vas Deferens | Pseudoexfoliation Syndrome | Pineoblastoma | Anuria | Chronic Beryllium Disease | Aldosterone Synthase Deficiency | Trichomegaly | Macrophage Activation Syndrome | Coronary Artery Disease | Focal Dermal Hypoplasia | Torticollis | Parkinson's Disease | Persistent Mullerian Duct Syndrome | Fukuyama Congenital Muscular Dystrophy | Esophageal Motility Disorders | Chromosome 16p11.2 Deletion Syndrome | Choroideremia | Ovarian Sex Cord-stromal Tumor | Androgenic Alopecia | Cancer, Bladder | Nasodigitoacoustic Syndrome | Angioedema | Pearson Syndrome | Martsolf Syndrome | Autoimmune Polyendocrinopathy Syndrome Type I | Nephroblastoma | Obesity, Morbid | Liebenberg Syndrome | Acute Anterior Uveitis | Hyperparathyroidism, Secondary | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Mucolipidosis Type II | Greig Cephalopolysyndactyly Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Creutzfeldt-Jakob Disease | Giant Cell Glioblastoma | Coma | Chromosome 5q Deletion Syndrome | Erectile Dysfunction | Acromesomelic Dysplasia | Glycogen Storage Disease Type 9 | Sensorineural Hearing Loss | Bipolar Disorder | Congenital Myasthenic Syndrome | Ocular Surface Squamous Neoplasia | Chronic Lymphocytic Leukemia | Neonatal Progeroid Syndrome | Oligoasthenoteratozoospermia | Transcobalamin Deficiency | Skin Carcinoma | Specific Granule Deficiency | Congenital Nystagmus | Hypermetropia | Amblyopia | Plasma Cell Leukemia | Stuve-Wiedemann Syndrome | Joubert Syndrome 2 | Prader-Willi Syndrome | Blastoma, Pleuropulmonary | Holt-Oram Syndrome | Congenital Ichthyosiform Erythroderma | Saethre-Chotzen Syndrome | Cholangiocarcinoma | Spondyloarthritis | Glaucomatocyclitic Crisis | Blomstrand Osteochondrodysplasia | Pulmonary Veno-occlusive Disease | TARP Syndrome | Asthma, Exercise-induced | Spondyloepiphyseal Dysplasia Tarda, X-linked | Hemimegalencephaly | Congenital Absence Of Vas Deferens | Guillain-Barre Syndrome | Donnai-Barrow Syndrome | Spinocerebellar Ataxia Type 2 | Medulloblastoma | Gnathodiaphyseal Dysplasia | Takotsubo Cardiomyopathy | Varicocele | Retinal Dystrophy, Early-onset Severe | Ulcerative Colitis | Poretti-Boltshauser Syndrome | Cirrhosis | Cat Eye Syndrome | Pyloric Stenosis, Infantile Hypertrophic | Epithelioid Hemangioma | Cerebral Amyloid Angiopathy | Heimler Syndrome | Retinal Vasculitis | REM Sleep Behavior Disorder | Wolff-Parkinson-White Syndrome | Hypertrophy | Left Ventricular Noncompaction | Gastroenteritis, Eosinophilic | Obsessive-compulsive Disorder | Apert Syndrome | Hamartoma | Diabetes Insipidus | Personality Disorders | Uremia | Photosensitivity | Congenital Stationary Night Blindness | Fahr Disease | Pseudohermaphroditism | 5-oxoprolinase Deficiency | Agnathia-Otocephaly Complex | FG Syndrome | Agoraphobia | Barrett Esophagus | Rosacea | Giant Axonal Neuropathy | Neurofibroma, Plexiform | Carpal Tunnel Syndrome | Diffuse Intrinsic Pontine Glioma | Galloway-Mowat Syndrome | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Autoimmune Hemolytic Anemia | Lymphedema | Non-small Cell Lung Cancer | Muscular Dystrophy | Thanatophoric Dysplasia Type 1 | Usher Syndrome | Cannabis Abuse | Ligneous Conjunctivitis | Benign Recurrent Intrahepatic Cholestasis 1 | Gastritis, Atrophic | Congenital Fiber-type Disproportion Myopathy | Greenberg Dysplasia | Nephropathy | Osteogenesis Imperfecta Type II | Non-bullous Congenital Ichthyosiform Erythroderma | Hypotension, Orthostatic | C3 Glomerulonephritis | Spinal Muscular Atrophy | Progressive External Ophthalmoplegia | Analgesia | Zollinger-Ellison Syndrome | Neuromyelitis Optica | Heart Failure | Infantile Liver Failure Syndrome 1 | Intracranial Hypertension | Meier-Gorlin Syndrome | Thromboembolism | ICF Syndrome | B-cell Chronic Lymphocytic Leukemia | Priapism | 3C Syndrome | Tinea | Hypercholesterolemia, Familial | Rhabdoid Tumor | Macular Degeneration | Facioscapulohumeral Muscular Dystrophy Type 2 | Epidermolysis Bullosa Simplex, Localized | Chloridorrhea, Congenital | Neurofibromatosis | Relapsing Polychondritis | Autism Spectrum Disorders | Hypogonadism | Lymphangioma | Hashimoto Thyroiditis | Optic Neuropathy | Amenorrhea | Rhizomelic Chondrodysplasia Punctata | Hemophagocytic Lymphohistiocytosis | Hemophilia | Compartment Syndrome | Autosomal Recessive Congenital Ichthyosis | Absence Epilepsy | Hypobetalipoproteinemias | Stevens-Johnson Syndrome | Rash | Anodontia | Glomerulonephritis, Membranoproliferative | Dyslipidemia | Glomerulonephritis | LEOPARD Syndrome | Temporal Lobe Epilepsy | Central Pain Syndrome | Combined Malonic And Methylmalonic Acidemia | Retinal Degeneration | Hypercholesterolemia | Pyruvate Carboxylase Deficiency Disease | Long QT Syndrome Type 3 | Nijmegen Breakage Syndrome | Hyperandrogenemia | KBG Syndrome | Pseudohypoparathyroidism Type 1A | McCune-Albright Syndrome | Macular Corneal Dystrophy Type 1 | Glycogen Storage Disease Type 0 | Von Willebrand Disease | Pontocerebellar Hypoplasia Type 2 | Babesiosis | Postpartum Depression | Cocaine-Related Disorders | Erythema Nodosum | Alpha-mannosidosis | Dystonia-parkinsonism, X-linked | Senior-Loken Syndrome | Encephalopathy, Hepatic | Marshall-Smith Syndrome | Coenzyme Q10 Deficiency | Osteomalacia | Tuberculous Meningitis | Splenomegaly | Anorchia | Iron Metabolism Disorders | Sensory Neuropathy | Reye Syndrome | Fatty Aldehyde Dehydrogenase Deficiency | Osteonecrosis | Congenital Dyserythropoietic Anemia Type 4 | Pigment Dispersion Syndrome | Adenoma, Pituitary | Sclerosteosis 2 | Lafora Disease | Familial Cerebral Amyloid Angiopathy | Hereditary Hemorrhagic Telangiectasia Type 2 | Antley-Bixler Syndrome | Lipid Metabolism Disorders | Familial Hemiplegic Migraine | Heavy Chain Disease | Aplasia Cutis Congenita | Costello Syndrome | Rubeosis Iridis | Polyarteritis Nodosa | Charcot-Marie-Tooth Disease Type 2E | Chordoid Glioma | Spinocerebellar Ataxia Type 10 | Pericarditis | Retinitis | Kleine-Levin Syndrome | Usher Syndrome Type IIC | Tremor | Syphilis | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Microphthalmia | Hyperbilirubinemia | Anal Fissure | Trigonocephaly | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Cluster Headache | Prostatitis | Exocrine Pancreatic Insufficiency | Spinocerebellar Ataxia Type 23 | Myofibromatosis | Sarcoidosis, Pulmonary | Canavan Disease | Histiocytic Sarcoma | Neuroectodermal Tumors, Primitive | Renal Oncocytoma | Spinocerebellar Ataxia Type 15 | Idiopathic Multicentric Castleman Disease | Dermatofibrosarcoma | Tricho-hepato-enteric Syndrome | Milk Allergy | Multiple Myeloma | Harlequin Ichthyosis | Moyamoya Disease | Cone Dystrophy | Basan Syndrome | Auriculocondylar Syndrome | Hennekam Lymphangiectasia-lymphedema Syndrome | Geleophysic Dysplasia | Tyrosinemia | Spinocerebellar Ataxia Type 20 | Primary Biliary Cholangitis | Thymoma, Malignant | Evans Syndrome | Depression | Stickler Syndrome | Common Cold | Warsaw Breakage Syndrome | Chronic Enteropathy Associated With SLCO2A1 Gene | Glutaric Aciduria Type 2 | Ichthyosis Bullosa Of Siemens | Haim-Munk Syndrome | Spinocerebellar Ataxia Type 27 | Charcot-Marie-Tooth Disease Type 4E | Neuroma | Spondylosis | Glycogen Storage Disease | Pulmonary Sclerosing Hemangioma | Hydrolethalus Syndrome | Allan-Herndon-Dudley Syndrome | Hereditary Mixed Polyposis Syndrome | Melanocytic Nevus | Still Disease | Epidermodysplasia Verruciformis | Ebstein Anomaly | Cryptosporidiosis | Hyperphenylalaninemia | Toxoplasmosis | 3-methylglutaconic Aciduria Type I | Keratoconus | Panic Disorder | Waardenburg Syndrome Type 2E | Gastrointestinal Disorders | Wolfram Syndrome 2 | Jawad Syndrome | Charcot-Marie-Tooth Disease Type 3 | Congenital Heart Defects | Familial Exudative Vitreoretinopathy | Fascioliasis | Nestor-Guillermo Progeria Syndrome | Porokeratosis | Dysfibrinogenemia | Schistosomiasis | Pregnancy, Ectopic | Peyronie's Disease | Keratitis-ichthyosis-deafness Syndrome | Diabetes Type 1 | Hypodontia | Carbamoyl Phosphate Synthetase I Deficiency | Tic Disorder | Limb Girdle Muscular Dystrophy | Liddle Syndrome | Chronic Mucocutaneous Candidiasis | Overactive Bladder | 3-methylcrotonyl-CoA Carboxylase Deficiency | Hemangioma | Vici Syndrome | Colitis, Lymphocytic | T-cell Chronic Lymphocytic Leukemia | Adenomyosis | Focal Cortical Dysplasia Type 2 | Hypercalcemia | Meckel-Gruber Syndrome | Stomatitis | Stargardt Disease | Cataplexy | Salla Disease | Familial Isolated Hyperparathyroidism