Osteoarthritis

About the Disease
Osteoarthritis, also known as osteoarthrosis, is related to cartilage disease and exostosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are ECM proteoglycans and Extracellular matrix organization. The drugs Fentanyl and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotype is limbs/digits/tail.

Common Targets
GPR55 | GCGR | Inositol Monophosphatase (nonspecified subtype) | G10413 | PIM2 | G5243 | Phosphodiesterase (nonspecified subtype) | G7422 | IL23R | SCN5A | BDKRB2 | TIMP3 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | HRH3 | YES1 | ENPP2 | PIK3CG | G114548 | JAK3 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | TNKS | MST1R | TNFRSF11B | P2RY1 | JAK1 | CCDC91 | NFKB1 | CDC42BPB | MAP2K4 | CACNA1B | ADAMTS7 | CYP3A4 | G6714 | ALPL | G596 | IL6ST | RUNX2 | Prostanoid Receptor (nonspecified subtype) | G3576 | KDR | COL18A1 | SNCA | PDGFB | RORC | DIO2 | TTR | CRBN | LCORL | ADAMTS6 | EPHB2 | EIF4A1 | Carbonic Anhydrase (nonspecified subtype) | ALDH1A2 | PTGES | MC1R | RAC1 | DIO3 | IL7 | ST14 | TLR3 | FAP | GBA1 | SPR | JAK2 | MEG3 | gamma-Secretase | IL1B | HFE | ITGA10 | Tachykinin Receptor (nonspecified subtype) | CLSTN2 | I-kappa-B-kinase (IKK) complex | ORAI1 | G6774 | EIF4F translation-initiation complex | MIR23A | IL1RN | Interleukin-1 (nonspecified subtype) | OPRK1 | SOST | CILP | SMO | PDE4B | COL6A4P1 | IKBKB | AKR1C2 | PLA2G4A | Phosphodiesterase IV (PDE4) (nonspecified subtype) | FGFR2 | TRPV4 | COL1A1 | G3569 | SLC17A3 | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | LPAR1 | OPRM1 | ROCK1 | GNG5 | Heat shock protein 90 (nonspecified subtype) | KCNQ3 | MIR155 | BTK | C5 | CTSS | CNR2 | BMP2 | ELANE | IL17RA | IMPA1 | ASAH1 | Hedgehog Protein (nonspecified subtype) | Mucin (nonspecified subtype) | MIR140 | MAPK11 | Folate Receptor (nonspecified subtype) | HRH2 | MMP3 | LTB4R2 | Casein kinase I (nonspecified subtype) | SGK1 | ADAMTS5 | ACE | MAP3K5 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | CTSL | Matrix Metalloproteinase (MMP) (nonspecified subtype) | IL-1 Receptor (nonspecified subtype) | Calcium channel (nonspecified subtype) | LRP5 | TUFT1 | AURKB | CHEK1 | G1432 | TGFB1 | AXL | LCK | MUTYH | RAMP2 | LOC102724428 | BGLAP | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | G842 | Protein kinase C (nonspecified subtype) | G1950 | G598 | CLK4 | Fibroblast growth factor (FGF) (nonspecified subtype) | MAOA | MMP12 | PIM3 | G7099 | MCF2L | NF-kappaB (NFkB) | TYK2 | CSF1R | G7295 | SGK2 | Nicotinic alpha3beta4 Receptor | ADAM17 | TRPM8 | Neurotrophic Factor (nonspecified subtype) | EIF4E | CHRNA9 | TNFSF11 | RAMP1 | SLC6A2 | DLG2 | P2RY11 | IKZF1 | Opioid receptor (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | IAPP | CDK9/Cyclin T1 | PIK3CB | EPHB4 | WSB1 | DDR2 | G23411 | MAP2K1 | Nicotinic alpha4beta2 receptor | Amylin receptor | ABCA1 | EIF4G1 | RAMP3 | CNR1 | DKK1 | Estrogen receptor (nonspecified subtype) | TGM2 | EIF4G2 | BRD4 | CCN2 | EIF2AK4 | Inhibitory kappaB Kinase (IKK) (nonspecified subtype) | DYRK1A | PIK3CD | GIPR | CCR2 | GNL3 | Casein kinase II (CKII) | DNA Topoisomerase II (nonspecified subtype) | TMSB4X | CDK9 | MC3R | TNKS2 | CD38 | KIF1C | IRAK4 | G142 | MAPKAPK2 | IHH | GLT8D1 | IL-6 receptor | SYK | HEXB | TRPV1 | PTCH1 | IL1R1 | TGFBR1 | Phospholipase A2, Cytosolic (nonspecified subtype) | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | F2 | G3605 | Voltage-Gated Sodium Channel Complex | G4170 | XDH | CAV1 | CCNT1 | ADORA3 | OPRD1 | PTGS1 | COL10A1 | CXCR3 | CLEC3B | ACHE | CASP8 | PRG4 | CALCA | PPARG | CSNK1A1 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | PTGDR2 | SOD3 | NTRK1 | GSK3B | Retinoid acid receptor (nonspecified subtype) | LIPC | FDPS | ANAPC13 | TBX5 | EPHA4 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | MERTK | PTGER4 | CDH2 | TNFRSF11A | CALCRL | OGA | TRPV3 | CTH | Aggrecanase (nonspecified subtype) | ADAM12 | FAAH | G3480 | CCR1 | GHR | G3630 | IL17F | CSF2 | SOX9 | Caspase (nonspecified subtype) | MMP13 | Sodium channel (nonspecified subtype) | LEPR | ABCC8 | G2099 | TYRO3 | PTPN4 | DACH2 | BDKRB1 | PDE2A | ADAMTS4 | TGFB2 | COL6A2 | Nicotinic alpha4beta4 receptor | EIF4G3 | Mitogen-Activated Protein Kinase (nonspecified subtype) | FGFR1 | G836 | GRM1 | CLK1 | ENPP1 | DOT1L | GJA1 | TPSB2 | Ikzf1 | EPHA2 | G4318 | AP-1 Transcription Factor Complex | SIK2 | CYSLTR2 | DYRK1B | APOA1 | Janus Kinase (nonspecified subtype) | NR3C1 | PTH1R | CTSK | ROCK2 | IL1A | MSR1 | DDR1 | PIM1 | P2RY14 | FLNB | AKR1B10 | SCN9A | ASIC1 | Gastric H+/K+-ATPase | SLC6A4 | Cyclooxygenase (COX) (nonspecified subtype) | MMP8 | Nicotinic alpha9alpha10 Receptor | NAAA | TIMP2 | C5AR1 | IL2 | GAA | NOX3 | LIPE | NMDA receptor | LYN | SMAD3 | UTRN | LTC4S | CTSB | MRGPRX2 | SIK1 | CASP1 | MIR1288 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | SULF1 | RUNX1 | MMP2 | ASTN2 | CALCR | Nicotinic alpha3beta2 receptor | MIR146A | MAPK7 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | USP33 | FAS | Neuronal acetylcholine receptor alpha2beta2 receptor | Collagenase (nonspecified subtype) | G367 | NOS2 | G4233 | VDR | P2RX7 | TRPA1 | G5743 | COL2A1 | Rho kinase (ROCK) (nonspecified subtype) | MMP14 | GSPT1 | CCL2 | PDE1A | TBK1 | NADPH Oxidase Complex | PITX1 | CHRNB2 | MIF | ABCC1 | DPP9 | TGFB3 | THRA | PIK3CA | FYN | GDF5 | CLK2 | TXK | S1PR1 | ABCC3 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | COL11A2 | IL-23 receptor complex | ALOX5 | ENOX2 | NLRP3 Inflammasome | CTSD | DHFR | SIK3 | GLP1R | HEXD | EN1 | AOC3 | LIPG | MTHFR | FLT3 | PTGER2 | ZNF678 | G7124 | H19 | HSD17B3 | IL10 | NGF | KCNQ2 | OSCAR | CDK1 | NADPH Oxidase (nonspecified subtype) | Nicotinic alpha1beta1deltagamma Receptor | NKAIN2 | CHST11

Note: If you'd like to get a target analysis report for Osteoarthritis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Osteoarthritis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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