Diabetic Retinopathy

About the Disease
Microvascular Complications of Diabetes 5, also known as diabetic retinopathy, is related to microvascular complications of diabetes 1 and type 1 diabetes mellitus. An important gene associated with Microvascular Complications of Diabetes 5 is PON1 (Paraoxonase 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are homeostasis/metabolism and cardiovascular system

Common Targets
IL10 | MTHFR | FLT3 | Superoxide dismutase (SOD) (nonspecified subtype) | Histone deacetylase (nonspecified subtype) | CA4 | SERPINF1 | NADPH Oxidase (nonspecified subtype) | TCF7L2 | Proteasome Complex | LINC02774 | RNLS | LRRC7 | IL18 | KCNJ11 | TNFSF4 | DCAF13 | GPR55 | Fibrinogen | ZNRF1 | CHN2 | CCR3 | SLC5A2 | G5243 | CNTN5 | CD19 | DDC | TRPC4 | KAZN | G7124 | BCL2L12 | NFS1 | CETP | HTR7 | G7422 | PASK | CYBA | PHACTR1 | G6647 | TNFRSF11B | Na+/H+ Exchanger (NHE) (nonspecified subtype) | LRP6 | Protein Phosphatase 2B | XRCC1 | CD248 | PALM2 | G114548 | Nuclear factor of activated T-cells (nonspecified subtype) | G6714 | TAFA5 | m-Calpain | BRCC3 | LPAR2 | G596 | LMO7 | CDH13 | EPHB2 | CAMK4 | G3576 | TBC1D32 | NGFR | KDR | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | ARL4C | DOC2B | MC1R | RRP1 | L-type voltage-dependent calcium channel complex | SSTR2 | SLC19A3 | HFE | NRARP | JAK2 | HAFML | CENPS-CORT | PRKCZ | SLC13A1 | CYSLTR1 | IL1B | Tyrosine-Protein Kinases Src (nonspecified subtype) | LINC00917 | ITGA2 | G6774 | ALOX5AP | LOC105377662 | IKBKB | PRKCG | MIR34A | G7015 | MIR137 | TXNRD2 | CMTM7 | Thyroid hormone receptor (nonspecified subtype) | ROMO1 | VEGFC | LPAR1 | OSCP1 | SPAM1 | SHANK2 | MYORG | Integrin alphavbeta3 (vitronectin) receptor | EPHX2 | ADIPOQ | HIF1A | Heat shock protein 90 (nonspecified subtype) | MYSM1 | ICAM4 | FZD4 | CASP10 | GCK | CTSS | PRKCA | G3569 | TXNIP | ROCK1 | CDT1 | DROSHA | Somatostatin receptor (nonspecified subtype) | APLNR | Folate Receptor (nonspecified subtype) | SGK1 | ADAMTS5 | HRH2 | SORT1 | TRPC5 | CTSL | ACE | CNR2 | LTA | CACNB2 | GRIK2 | SLC1A5 | PPARA | Protein Kinase B (PKB/Akt) (nonspecified subtype) | G3479 | AXL | TGFB1 | Matrix Metalloproteinase (MMP) (nonspecified subtype) | G1432 | Lipoxygenase (nonspecified subtype) | GH1 | ADIPOQ-AS1 | G1950 | Fibroblast growth factor (FGF) (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | Integrin Receptor (nonspecified subtype) | mTOR complex 1 | TXN2 | Protein kinase C (nonspecified subtype) | SYN3 | ADAM17 | LSMEM1 | LOC105369456 | HTRA1 | G7099 | ENG | ADORA2B | NF-kappaB (NFkB) | LOC100287329 | SCG3 | VSTM4 | TRPM8 | CABCOCO1 | HMGCR | COL5A1 | DHODH | Gap junction Connexin ( (nonspecified subtype) | EPHB4 | MTHFD2 | GLO1 | TRAP1 | SMYD4 | KIT | DRD2 | SMAD7 | ICAM1 | G7852 | PRMT1 | SH3BP4 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | Integrin alpha5beta1 (VLA-5) receptor | EIF2AK4 | LDB3 | EPO | CCN2 | CNR1 | SELP | TRPV2 | ANGPT2 | SEPTIN9 | PRKCH | Integrin alphavbeta5 receptor | SOD2 | INSR | KIAA0825 | PLXDC2 | LOC101928273 | PPARD | EIF5A | ELAVL1 | DPP4 | G142 | LINC01249 | AKR1B1 | GRIK3 | Reverse transcriptase (Telomerase) | PRKCD | POSTN | PTP4A3 | MALRD1 | SLC25A32 | HMGA1 | MFN2 | SSTR4 | Tyrosine Kinase (nonspecified subtype) | NRP1 | TRPV1 | TGFBR1 | PDGFRB | RYR2 | XDH | SERPINE1 | PTPN1 | SRPK1 | ADORA3 | G4609 | ACVR1 | CXCR3 | ACVRL1 | PALM2AKAP2 | PPARG | ACKR3 | Kallikrein (nonspecified subtype) | CAPN1 | Platelet-Derived Growth Factor (PDGF) (nonspecified subtype) | P2X Receptor (nonspecified subtype) | CXCL12 | FOLH1 | LRRC4 | beta-Adrenoceptor (nonspecified subtype) | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | NTRK1 | LPAR4 | AKR1C3 | SGF29 | CEP135 | mTOR complex 2 | PEBP4 | EPOR | G2475 | GHR | G3480 | SERPINF2 | Integrin alphaLbeta2 (LFA-1) receptor | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | SST | HNF1A | FRK | PTPRB | BDKRB1 | G3630 | L-Type calcium channel (nonspecified subtype) | IFIH1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | SORD | HPX | APEX1 | GJA1 | SLC2A1 | Poly [ADP-ribose] polymerase (nonspecified subtype) | FPR2 | PRKCB | ITGB3 | SLMAP | FLT1 | CYSLTR2 | TMEM217 | CDK8 | TEK | G4318 | GMFB | PTK7 | SLC5A1 | CA2 | PLA2G7 | NOS3 | MRPL14 | LINC02741 | F11 | ROCK2 | MIR126 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | METAP2 | Focal Adhesion Kinases (FAK) (nonspecified subtype) | SEMA3A | GAA | TSHZ1 | SSTR5 | NOX3 | PRKCQ | HPSE | Gap Junction Protein (nonspecified subtype) | Endothelin receptor (nonspecified subtype) | Integrin alphavbeta1 | LYN | NR3C1 | CREB5 | UCP1 | PDE5A | LHFPL3 | KLKB1 | AGTR1 | MIR9-3 | ESM1 | LMO2 | AGER | SSTR1 | TRNL1 | NPC1 | FMN1 | RPE65 | PORCN | MMP2 | GALR2 | CD47 | Tubulin | HS6ST3 | BFSP2 | Integrin alpha2beta1 (VLA-2) receptor | VDR | NOS2 | ARHGAP22 | G4233 | CCL2 | TRPA1 | IFNG | NADPH Oxidase Complex | CYP11B2 | G2064 | PRKCE | CCR5 | IRS1 | PTGFR | Melanocortin receptor (nonspecified subtype) | Rho kinase (ROCK) (nonspecified subtype) | LOC105372760 | Glutathione peroxidase (nonspecified subtype) | MIRLET7B | GAS6 | S1PR1 | Defensin (nonspecified subtype) | DHFR | MC5R | PDGFRA | ANXA2 | mu-Calpain (calpain 1) | RHOA | UCP2 | FGF2 | GLP1R | AOC3 | CAPN2 | Soluble guanylyl cyclase | EDIL3 | LOC100506023 | TMEM94 | F12 | CDK19

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