Allergic Conjunctivitis

About the Disease
Allergic Conjunctivitis, also known as perennial allergic conjunctivitis, is related to vernal keratoconjunctivitis and giant papillary conjunctivitis. An important gene associated with Allergic Conjunctivitis is HRH1 (Histamine Receptor H1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Hyaluronic acid and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and thymus, and related phenotypes are homeostasis/metabolism and immune system

Common Targets
IL13 | Phosphodiesterase (nonspecified subtype) | MRGPRX1 | CCR3 | TLR7 | Protein Phosphatase 2B | PPIA | JAK3 | PDE4D | JAK1 | GPR35 | CCN1 | Integrin alpha4beta1 (VLA-4) receptor | PDK1 | JAK2 | IL1B | Cyclophilins (nonspecified subtype) | ORAI1 | CYSLTR1 | Interleukin-1 (nonspecified subtype) | IL1RN | PDE4B | G3620 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | SIGLEC8 | FKBP1A | HRH2 | IL-1 Receptor (nonspecified subtype) | PPP3R2 | SLC22A12 | FPR1 | PDE10A | G7099 | PPID | PPP3CC | alpha-Adrenoceptor (nonspecified subtype) | NTSR2 | ICAM1 | MAP3K19 | CCL11 | TRPV2 | TSLP | IgE Receptors (nonspecified subtype) | SYK | PTGDR | Prostanoid TP receptor (nonspecified subtype) | PTGDR2 | Immunoglobulin E (IgE) | PTGER4 | PDE6D | Integrin alphaLbeta2 (LFA-1) receptor | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | G3630 | PTGER1 | TEK | NR3C1 | PPP3CB | HRH1 | CMKLR1 | IL2 | Histamine Receptor (HR) (nonspecified subtype) | PPP3R1 | ARHGEF2 | Nitric oxide synthase (NOS) (nonspecified subtype) | IL-13 receptor | CFTR | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | PTGFR | IFNG | Rho kinase (ROCK) (nonspecified subtype) | MIF | HRH4 | PTAFR | CMA1 | PDE3A | IL4 | IL10 | G7124

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