Acute Lymphocytic Leukemia

About the Disease
Leukemia, Acute Lymphoblastic, also known as acute lymphoblastic leukemia, is related to b-lymphoblastic leukemia/lymphoma and hematologic cancer, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia, Acute Lymphoblastic is PAX5 (Paired Box 5), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involvement in the immune response in sepsis. The drugs Epirubicin and Nicotine have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotype is acute lymphoblastic leukemia.

Common Targets
GOT1 | G10413 | CDK4/Cyclin D3 | STXBP5L | HNMT | CCDC190 | IQCE | SH3PXD2A | ACTB | KDR | MMP1 | FBXW7 | YES1 | GOT2 | ZC3HAV1 | WNT5A | XRCC1 | CDC7 | HAO1 | SLC27A2 | PTPRR | G6714 | KDM6A | NCOR1 | BHMT | MPO | KLHDC2 | MYNN | HCK | CTNNB1 | DNA Methyltransferase (DNMT) (nonspecified subtype) | ZNF791 | H4C3 | CEBPE | SIX2 | DDC | NT5C2 | SLX4 | ZNF488 | AURKA | G472 | CD36 | SULT1A1 | ERCC5 | DNA-Directed DNA Polymerase Complex | KLRC2 | CYP3A4 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | TUBG1 | FGR | LRRTM4 | ABL1 | KLK9 | Cyclin B (nonspecified subtype) | NBN | NAALADL1 | ACTA2 | JAK2 | G3845 | STN1 | PSMB5 | CNGA3 | DNASE1L3 | PTHLH | IL1B | TLR10 | PCDHGA12 | UBA2 | CSF3 | DUSP3 | XPC | COL18A1 | SDC1 | MIR323B | SLC28A3 | DYSF | TOX3 | KNL1 | ASNS | G3309 | GUK1 | FARS2 | MELK | ASB5 | SP4 | GSTM3 | CHGB | PRRT1 | DSCAML1 | CCBE1 | ADAMTS20 | GLB1L2 | TBC1D26 | ASB9 | TNPO3 | AKAP9 | AVPR1A | RAC1 | CDK13 | CDK2 | G3569 | FBN1 | ITPR3 | KCNA3 | CDCP1 | G7015 | SRRM3 | STIP1 | MIR412 | EVA1A | GSTM4 | SLC12A3 | ASXL1 | CHD1 | DDX51 | CSK | TFRC | MCU | COL4A5 | MYO9A | NCOR2 | CHST8 | MSH3 | COX3 | SNX27 | SLC28A1 | HFE | MAP4 | ATRNL1 | COL8A2 | DOCK11 | BTK | EXT2 | SMPD4 | MIR485 | ZNF860 | CIC | DGAT1 | GNAO1 | PRKCZ | HDAC2 | OR1Q1 | ZNF100 | GLIS3 | TWIST2 | AMOTL1 | PLOD2 | DDX10 | PDE4B | ABCC5 | Heat shock protein 90 (nonspecified subtype) | ZNF540 | GLRA4 | CTC1 | PHF6 | PPIF | CCDC40 | GATAD2B | SLC13A1 | BMAL2 | RARA | CDK5/p25 | NAE1 | CCND2 | FAT4 | MIR3117 | BMP4 | DNAH3 | BMP7 | TPMT | CDC73 | CUZD1 | SFMBT2 | PARD3B | G595 | DUSP6 | NCAM1 | PRDM1 | FAT1 | C5-OT1 | AGRN | RIMBP2 | FCHSD2 | GOLGA5 | MB | GRIA1 | PCDH19 | DUSP7 | THY1 | NPM1 | NRAS | CDK6 | IL19 | CHEK1 | C1QTNF12 | ATRX | CDA | ELK3 | NAT2 | TMED7-TICAM2 | SMIM24 | HS3ST4 | ILK | TGFB1 | RASGRP3 | FBXO2 | Folate Receptor (nonspecified subtype) | APCDD1 | NF-kappaB (NFkB) | DCXR | Protein Kinase B (PKB/Akt) (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | FKBP1A | AURKB | AXL | Ephrin Receptor (nonspecified subtype) | LEPROT | SLC36A4 | CCR4 | Ribonucleoside-diphosphate reductase | CAMTA1 | CASP10 | LIN7A | RTL9 | LCK | G7099 | GRM6 | TTLL4 | LINC00163 | CAPG | ETV6 | G598 | CLEC14A | CD3 Complex (T Cell Receptor Complex) | MIR15A | MITF | TYK2 | G5133 | CHD5 | RAPGEF4-AS1 | TBX21 | SALL1 | CSF1R | ND1 | FGF5 | LOC102724428 | SCGN | GSTO1 | BRD2 | EFCAB6 | CLASP2 | JMJD1C | TUBGCP6 | PRDM2 | RUNX3 | FRY | ADCK1 | GFPT1 | CEBPA | KIT | MAFIP | USP24 | SMC1A | PCDH17 | CDK4 | CDK5 | FRMPD1 | CDKN2B | IKZF1 | mTOR complex 1 | FOXB2 | G5728 | PTPRG | KCNK2 | MIR16-1 | MAOA | FBN2 | SLC6A15 | HLA-G | RAD21 | IL3RA | LGALS7 | HECA | CTNNAL1 | NUDT15 | EPB41L4A | CSF3R | DCK | MIR34B | TOP1 | HSFY1P1 | IL7R | TCF4 | FLT3LG | GREB1L | GALNT2 | CD2 | TWNK | WWOX | HLA-B | CDK9/Cyclin T1 | PDS5B | G7852 | OR6C74 | HSPE1 | SLC46A1 | TMTC1 | TAS2R46 | GP5 | DLC1 | GSTA4 | G4851 | PCDHGB4 | BRCA2 | STC1 | DDR2 | CD14 | AKAP5 | NAT1 | USP15 | PIK3R1 | MAP2K1 | BCR | CYP1A1 | DACH1 | MYOD1 | PTPN21 | DNAH5 | ATXN3 | EPPK1 | HLA-DRB1 | DNM2 | BRD4 | IGDCC4 | MUL1 | SCML1 | DRD2 | TPR | NUDT1 | GFRA1 | DNA Topoisomerase II (nonspecified subtype) | MEF2C | INHA | OGG1 | EHBP1 | SCRIB | HLA-L | Adenosine deaminase (nonspecified subtype) | IMPDH1 | ND2 | CDK9 | CNDP2 | PAN2 | WRN | ARID5B | PLXNA2 | XCR1 | G673 | TTK | MTRR | KAT6A | EYA4 | ADA | GRM7 | IRF4 | PICSAR | CDC123 | CHD7 | CLIC2 | XKR9 | CDKN2B-AS1 | TMEM120A | CD52 | ZNF516 | CDC27 | IL15 | DNAH6 | CD38 | SIRPA | FAM24B | XPO1 | PYGL | RBBP6 | HERC3 | CD22 | RIMS2 | CD8 | MSI1 | TUBB1 | ARAP1 | G1029 | GBP4 | ABCC2 | IGSF1 | PCYT1A | PRPF31 | MRRF | NHLRC1 | SYK | MIR34C | IL27 | PDGFRB | SLC22A8 | RANBP17 | GAS7 | HLA-DPA1 | PTPRK | BGN | CMSS1 | EPOP | NFATC4 | NKX6-1 | VPS39 | MSLN | HDAC1 | HLX | DNTT | ZNF569 | MIR612 | CCNT1 | RNPC3 | Tyrosine Kinase (nonspecified subtype) | ZNF570 | CREB3L1 | STIMATE | GSTO2 | EZH1 | SNORD114-2 | UGT1A6 | TRBV5-5 | UNC79 | G3605 | G4609 | TRIM24 | TMED7 | SLC26A11 | SLC19A1 | CYP11B1 | SOX5 | TYMSOS | SERTAD4 | CSMD1 | PRF1 | NDST1 | PTPRM | INHBA | EBF1 | MMP7 | PTK2B | PAX5 | ABCC9 | NEDD8-activating enzyme E1 | DNHD1 | NBEA | PYCARD | OSBPL6 | RPL10 | SYNDIG1 | CASP8 | RAD50 | STIL | JAG1 | ERCC3 | PCDHGA5 | OR2T3 | IL15RA | BLTP1 | PCLO | HLA-A | USP54 | ODAD2 | GSDMB | MTHFD1 | G9429 | MYBPHL | RYR2 | TICAM2-AS1 | MS4A1 | MST1L | BCL2A1 | CPEB4 | RHPN2 | NKAIN3 | FANCI | LINC02693 | DCST1 | MEN1 | G2475 | LRRTM2 | SLC9C2 | CD7 | COL4A2 | RPL15P20 | MEGF8 | COLEC12 | SRPRB | CDK1/Cyclin B | MIR618 | TLR2 | XRCC3 | GSTT1 | CXCL12 | PNP | GAB2 | INHBB | DAPK1 | MAML2 | TMLHE | SLC5A11 | CAPN1 | SACS | RAN | AFAP1 | AURKC | CDH11 | STK3 | EPHB6 | CBS | CCND3 | mTOR complex 2 | CLIC5 | POLR3B | RASSF8 | SAMD13 | CYP2J2 | CBL | CD33 | TGM4 | CDH2 | BRWD1 | SETD2 | AKR1C3 | RPL23A | INHBC | KIR2DL1 | KIF11 | GORASP2 | ESPL1 | ERCC2 | KMT2A | CYP26A1 | G2033 | PEPD | DET1 | SLC11A2 | ZNF331 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | MLL/SET1 Complex | Mitogen-Activated Protein Kinase (nonspecified subtype) | MIR195 | NSD2 | FRK | RAD51 | MPL | FLT1 | G836 | ARPC4 | CYP3A5 | RECK | alpha-beta T Cell Receptor Complex (TCR) | SLC2A14 | LAMA2 | NFIX | CD3E | H1-3 | ERICH3 | SOX9 | CDK2/Cyclin A | EEF1A2 | G7157 | BAIAP2L1 | BLK | ACTG1 | ROR1 | ADAP1 | TNFRSF13C | ZBTB46 | MIB2 | INSC | G4318 | ADAMTS4 | BCL2L2 | TRIM13 | NR3C1 | ITPA | ADAMTS17 | TLCD5 | PROM1 | POU2AF3 | RRP8 | IFT122 | CIB1 | POU2AF2 | STRN | SIK2 | PPFIA1 | PCDHB14 | GLIPR1L2 | ARHGAP9 | KCNQ1 | TEK | MLLT1 | USH2A | B2M | EPHA2 | DDR1 | FPGS | RSPO1 | RFX2 | ND4L | CLPP | SLC41A2 | USF3 | DTNA | USP11 | ZNF211 | PTGER1 | ERN1 | SCD5 | GTPBP4 | POLR2B | BMF | AFF3 | G4193 | REP15 | LMNB1 | ATP6 | BRD3 | CLDND2 | DTNB | NOS3 | IL2 | ACD | CAPN5 | KCNS3 | PRLR | LYPD1 | ITGB3 | SLCO3A1 | EPHA10 | FASLG | RPLP1 | CRLF2 | MAN2A1 | TRIO | PTGES2 | SCN9A | CACNA1A | ULK2 | OLFM3 | Tubulin | ACYP2 | TNFSF15 | LYN | MEIS1 | LOC105372327 | FYB2 | CHD4 | C14orf180 | SYT1 | USP49 | DKK4 | TTN | ARHGAP45 | MASP1 | CASP8AP2 | ATXN1 | NKX1-2 | MAP2K2 | MYO1G | SIK1 | KPNA3 | NELL1 | CDK6/Cyclin D3 | NBPF4 | MMP2 | SMC5 | HLA-DPB1 | LRRC32 | DNER | RAG1 | LRP2 | SMAD3 | SYNE1 | TLR9 | SLCO1B1 | CSPP1 | RUNX1 | Cyclin A (nonspecified subtype) | TENM4 | SH2B3 | ATP8 | NF1 | CHRNA6 | CTLA4 | LMO1 | TAP1 | LACTB2 | RPL23AP7 | CHP2 | EPHX1 | OR7C1 | APBA1 | TNRC6C | FAS | DCST2 | CLDN3 | WT1 | XRCC5 | METTL13 | PIK3CA | TLR6 | C6orf141 | TYMS | NOS2 | PIP4K2A | LRP1B | PRPH | CD47 | RNF150 | SYT5 | ADGRF2 | IFNG | SLCO1A2 | DLEU2 | ESM1 | IRAK1 | HTR3D | GATA3 | GGH | STARD9 | CCDC162P | NOTCH2 | USP6NL | G367 | G7124 | CCR5 | G672 | FSTL1 | ULBP1 | EGR3 | USP7 | G925 | ALB | PLPP1 | DDX3X | DTX1 | MIF | DCUN1D5 | CYP1B1 | NQO1 | FLT3 | ITCH | MST1 | FYN | SLC49A4 | CREBBP | BIRC5 | CLDN11 | TXNDC12 | PDGFRA | PTPN11 | LRCH1 | UGT1A1 | ABCC4 | HNF4G | NCAPG | SLC29A1 | GRN | GSTM1 | HOXA4 | PTPRC | ARSH | IL10 | CPM | TCL1A | FKBP1B | CDK12 | DHFR | MTHFR | CLCN6 | Proteasome Complex | RET | NUDT16 | TBC1D1 | ABCC3 | MIR196A2 | OR56B4 | ZNF182 | NAALADL2 | G2146 | ARID1A | APBB2 | DRD3 | FBXO11 | PER3 | CD5 | TOP2A | MTR | G5243 | TBL3 | APOE | Interleukin-7 receptor | THSD7A | PML | SLCO1C1 | ALG6 | CDK1 | REC8 | RUNDC3B | SETD3 | ARHGAP32 | OR2B11 | DSG2 | CD19 | ALDH1L1 | TRPC3 | FOXP3 | ATL1 | CIAO3 | DPEP1 | DVL1 | F8 | STC2 | RELN | PTPRO | PRPS1 | MYCBP2 | GABRA3 | USO1 | TP53BP2 | ND6 | ASRGL1 | G238 | JAK3 | OR5M10 | ODC1 | ETS1 | IL18 | SHMT1 | TNFSF4 | TUSC3 | CD226 | HLA-C | RAD51B | LHPP | JAK1 | DNAH10 | GRB2 | GRIN2B | RPL10AP3 | LYSMD2 | SSH3 | GSTP1 | G596 | DCC | NEB | OR4K1 | PAWR | G5347 | TSPEAR | MAMSTR | CHEK2 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | RABIF | NOM1 | FMN2 | MED12 | XBP1

Note: If you'd like to get a target analysis report for Acute Lymphocytic Leukemia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Acute Lymphocytic Leukemia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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