Dentinogenesis Imperfecta

About the Disease
Dentinogenesis Imperfecta, also known as hereditary opalescent dentin, is related to dentinogenesis imperfecta 1 and osteogenesis imperfecta, type v. An important gene associated with Dentinogenesis Imperfecta is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Collagen chain trimerization. Affiliated tissues include Tooth, bone and skin, and related phenotypes are pulp obliteration and grayish enamel

Common Targets
COL1A1 | COL1A2 | DSPP

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