Gout

About the Disease
Gout, also known as gouty arthritis, is related to tubulointerstitial kidney disease, autosomal dominant, 1 and phosphoribosylpyrophosphate synthetase superactivity, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Gout is DARS2 (Aspartyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Drug ADME. The drugs Allopurinol and Febuxostat have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and skin, and related phenotypes are no effect and no effect

Common Targets
ALOX15 | MLXIP | CARD8 | FGF18 | NIPAL1 | ASGR1 | CGAS | Asialoglycoprotein Receptor (ASGPR) (nonspecified subtype) | CNTN5 | TLR7 | G114548 | PIK3CG | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | LOC107986623 | Prostaglandin EP Receptor (nonspecified subtype) | SLC28A2 | CTNNB1 | G3576 | CARM1 | CRBN | IL37 | UBE2Q2 | PLXDC1 | Protein Phosphatase 2A | CNIH2 | PRMT6 | OVOL1 | ALDH16A1 | Carbonic Anhydrase (nonspecified subtype) | TLR8 | SLC16A9 | CASP5 | IL1B | COX3 | PDZK1 | PRMT8 | MYD88 | SLC22A1 | LOC105373585 | PRPSAP1 | IL1RN | Interleukin-1 (nonspecified subtype) | G3620 | MTX1 | G3569 | KALRN | SLC17A3 | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | EPHX2 | ALOX12 | IL17RA | H4C5 | TXNIP | ACAD10 | ACE | IL-1 Receptor (nonspecified subtype) | G1432 | AGMAT | SLC22A12 | NINJ1 | MAP3K11 | ALDH2 | TYR | MAOA | G7099 | NF-kappaB (NFkB) | TYK2 | ALPK1 | SLC2A6 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | NAT1 | TNFSF11 | CD14 | ASH1L | SHLD2 | HMGCR | IKZF1 | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | COMT | PIK3CB | AADACL2-AS1 | G23411 | PRKAG2 | ICAM1 | HYKK | LOC105371356 | GABA(A) receptor | BCHE | TRPV2 | PRMT1 | PIK3CD | CASP4 | GUSB | IRAK4 | GCKR | TRNA | AKR1B1 | 15-Lipoxygenase (nonspecified subtype) | TRPV1 | MUC1 | DNAJC16 | MALRD1 | IL1R1 | XDH | G3605 | SLC22A2 | TRIM46 | SLC17A4 | PTGS1 | ACHE | PPARG | SLC17A1 | HPRT1 | PTGDR2 | GLUD1 | LOC107984526 | PNP | PTGER4 | G9429 | DAPK1 | TLR2 | AKR1C3 | CTSC | G3480 | G3630 | IL17F | Leukotriene B4 receptor (LTB4-R) (nonspecified subtype) | SERPINH1 | NRXN2 | NAA25 | CARMIL1 | ABCC8 | PTPRN2 | ZBTB46 | FPR2 | Ikzf1 | G4318 | NR3C1 | PIBF1 | A1CF | CD160 | IL1A | BCAS3 | P2RY14 | AKR1B10 | IKZF2 | BAZ1B | SLC2A9 | Cyclooxygenase (COX) (nonspecified subtype) | IL2 | GAA | Neurotensin receptor (nonspecified subtype) | NOX3 | R3HDM2 | PPARGC1B | LRP2 | CASP1 | HPSE2 | PNLIP | 5-Hydroxytryptamine Receptor (nonspecified subtype) | MMP2 | Tubulin | MIR3142HG | NOS2 | P2RX7 | G5743 | VDR | LOC105379030 | KRR1 | IFNG | IRAK1 | HNF4G | PRMT3 | NADPH Oxidase Complex | ABCC1 | ABCC4 | PIK3CA | LTA4H | CUX2 | RIPK1 | NUDT17 | GRK6 | Melanocortin receptor (nonspecified subtype) | ABCC3 | NLRP3 Inflammasome | ATXN2 | DNA-Dependent Protein Kinase (DNA-PK) | GLP1R | G7124 | PRPS1 | FLT3 | IL10 | LOC105375069 | IL4 | MIR4761 | SLC22A11 | PRKG2 | NADPH Oxidase (nonspecified subtype) | ACSM2B | HLF

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