Overactive Bladder

About the Disease
Low Compliance Bladder, also known as overactive bladder, is related to interstitial cystitis and paine syndrome, and has symptoms including dysuria, urgency of micturition and prostatism. An important gene associated with Low Compliance Bladder is P2RX3 (Purinergic Receptor P2X 3), and among its related pathways/superpathways are Signal Transduction and Myometrial relaxation and contraction pathways. The drugs Propiverine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, smooth muscle and prostate.

Common Targets
Phosphodiesterase IV (PDE4) (nonspecified subtype) | CACNA1B | G7124 | CNR2 | TACR2 | P2X2/3 Receptor Complex | CACNA2D1 | Nicotinic alpha4beta2alpha5 Receptor | PDE4B | KCNA3 | CACNA2D2 | KCNAB2 | Nicotinic alpha6beta2alpha4beta2beta3 receptor | P2RX1 | Voltage-gated K(v) channel (nonspecified subtype) | Calcium channel (nonspecified subtype) | CHRM4 | Gamma-Aminobutyric acid type B receptor | Tachykinin Receptor (nonspecified subtype) | G1432 | TRPM8 | EPHX2 | PTGER3 | HTR1A | Lipoxygenase (nonspecified subtype) | TRPV4 | T-Type Calcium Channel | PTGIR | CHRM1 | KCNQ3 | TRPV1 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | P2RX3 | HSD11B1 | Neurotrophic Factor (nonspecified subtype) | KCNN4 | Voltage-Gated Sodium Channel Complex | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | CHRNA7 | G5743 | Nicotinic alpha3beta4 Receptor | ADRB3 | AVPR2 | Nicotinic alpha4beta2 receptor | Sodium channel (nonspecified subtype) | G367 | VDR | KCNE1 | OPRD1 | KCNC3 | PTGER4 | KCNA5 | K(ATP) Channel (nonspecified subtype) | CHRM3 | FAAH | CALCRL | PDE5A | KCNE3 | KCNQ1 | IL1B | ADRA1D | P2X Receptor (nonspecified subtype) | ROCK2 | KCNE4 | TACR1 | BDKRB1 | KCNE2 | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | GUCY2C | alpha1-Adrenoceptor (nonspecified subtype) | PTGER1 | P2RX2 | KCNS3 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | KCNH1 | ARHGEF10 | Potassium Channels (nonspecified subtype) | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | CHRNB2 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | Soluble guanylyl cyclase | CHRM2 | Neuronal acetylcholine receptor alpha2beta2 receptor | NGF | PDE4D | KCNQ2 | Nicotinic alpha1beta1deltaepsilon Receptor | TACR3 | OPRM1 | OPRK1

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