Spinocerebellar Ataxia Type 15

About the Disease
Spinocerebellar Ataxia 15, also known as sca15, is related to spinocerebellar ataxia 29 and spinocerebellar ataxia 5, and has symptoms including cerebellar ataxia, action tremor and static tremor. An important gene associated with Spinocerebellar Ataxia 15 is ITPR1 (Inositol 1,4,5-Trisphosphate Receptor Type 1), and among its related pathways/superpathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and PKC-gamma calcium signaling pathway in ataxia. Affiliated tissues include spinal cord, cerebellum and eye, and related phenotypes are hyperreflexia and gait ataxia

Common Targets
ITPR1

Note: If you'd like to get a target analysis report for Spinocerebellar Ataxia Type 15, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Spinocerebellar Ataxia Type 15 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Spinocerebellar Ataxia Type 1 | Erdheim-Chester Disease | Gastric Atrophy | Hyperlipidemia, Familial Combined | Schwannomatosis | Barrett Esophagus | Vulvovaginitis | Aspergillosis | Sclerosteosis | Dystonia Musculorum Deformans | Constipation | Hyperparathyroidism, Primary | Pituitary Dwarfism | DRESS Syndrome | Sensory Neuropathy | Sarcoma, Ewing | Syncope | Walker-Warburg Syndrome | Pulmonary Stenosis | Pterygium | Gray Platelet Syndrome | Syphilis | Metatropic Dysplasia | Pupil Disorders | Alopecia Totalis | Intestinal Obstruction | Sertoli Cell-only Syndrome | Muscular Dystrophy | Basal Cell Nevus Syndrome | Steel Syndrome | Chiari Malformation Type I | Waardenburg Syndrome Type 4 | Inborn Errors Of Metabolism | Dysferlinopathy | Seasonal Mood Disorder | Osteonecrosis Of The Jaw | Trichuriasis | Erectile Dysfunction | Kernicterus | Marinesco-Sjogren Syndrome | Retinal Detachment | Chronic Myelomonocytic Leukemia | Hypertension, Renal | Neonatal Progeroid Syndrome | Apert Syndrome | Kleine-Levin Syndrome | Myelitis, Transverse | Carcinoid Tumor | Familial Hypertrophic Cardiomyopathy | Spinocerebellar Ataxia Type 3 | Poikiloderma With Neutropenia | Esophageal Motility Disorders | Duodenal Atresia | Cushing Syndrome | Hereditary Inclusion Body Myopathy | Moyamoya Disease | Melanoma, Uveal | Benign Recurrent Intrahepatic Cholestasis 1 | Nicotine Dependence | ACTH-independent Macronodular Adrenal Hyperplasia | Glaucoma | Episodic Ataxia Type 1 | Fukuyama Congenital Muscular Dystrophy | 5-oxoprolinase Deficiency | Hydrocephalus | Beare-Stevenson Syndrome | Congestive Heart Failure | Ophthalmoplegia | Choroiditis | Alcoholism | Rickets | Hypogonadism | Norrie Disease | Myasthenia Gravis | Thymoma, Malignant | Lymphoma, AIDS-related | Binge Eating Disorder | Ophthalmia, Sympathetic | Paraganglioma, Carotid Body | Hypercalcemia | Atelosteogenesis Type 2 | IMAGe Syndrome | Mitochondrial DNA Depletion Syndrome 13 | Hemangioma | Multicentric Carpotarsal Osteolysis Syndrome | Keratitis | Diabetes Type 1 | Myocarditis | Schnitzler Syndrome | Delayed Sleep Phase Syndrome | Angiomyolipoma | Psoriasis | Congenital Aniridia | Gestational Trophoblastic Disease | Larsen Syndrome | Acute Tubular Necrosis | Japanese Encephalitis | Colitis, Microscopic | Sick Sinus Syndrome | Epidermal Nevus Syndrome | Optic Atrophy 2 | Esophagitis, Eosinophilic | High Molecular Weight Kininogen Deficiency | Polydactyly | Agranulocytosis | Adrenoleukodystrophy, X-linked | Spina Bifida | Carcinoma, Transitional Cell | Epicondylitis | Dermatomyositis | Macular Corneal Dystrophy Type 1 | Hodgkin Lymphoma | Intracranial Hypertension | Wolff-Parkinson-White Syndrome | Bruck Syndrome | Subcortical Band Heterotopia | Huntington's Disease | Pyruvate Dehydrogenase Deficiency | Narcolepsy | Antisocial Personality Disorder | Leukemia | Thanatophoric Dysplasia | Lymphangiomatosis | Progressive Osseous Heteroplasia | Atherosclerosis | Actinomycetoma | Okihiro Syndrome | Primary Familial Brain Calcification | Congenital Dysfibrinogenemia | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Syndactyly | Palsy, Cerebral | Colitis, Collagenous | Familial Episodic Pain Syndrome | Non-bullous Congenital Ichthyosiform Erythroderma | Argininosuccinic Aciduria | Bronchiectasis | Retinal Dystrophy | Congenital Central Hypoventilation Syndrome | Congenital Bilateral Absence Of Vas Deferens | Retinal Degeneration | Multiple Sclerosis, Primary Progressive | Autosomal Recessive Spastic Paraplegia Type 75 | Osteonecrosis | Smoldering Myeloma | Patent Ductus Arteriosus | Myoclonus-dystonia Syndrome | Bacterial Meningitis | Intellectual Disability, Autosomal Dominant 5 | Neuromuscular Disorders | Li-Fraumeni Syndrome | Neuroleptic Malignant Syndrome | Eiken Syndrome | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Hyperostosis | Herpes Genitalis | Sjogren Syndrome | Hypertension, Renovascular | Gitelman Syndrome | Fetal Alcohol Syndrome | Fowler's Syndrome | Amish Infantile Epilepsy Syndrome | Meniere's Disease | Endophthalmitis | Tendinitis | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Alpha-1 Antitrypsin Deficiency | Cystinuria | Hepatitis C, Chronic | Follicular Dendritic Cell Sarcoma | Paraganglioma | Nemaline Myopathy | Sepiapterin Reductase Deficiency | Diffuse Mesangial Sclerosis | Aicardi-Goutieres Syndrome | Fraser Syndrome | Microcephaly | Irritable Bowel Syndrome | Stroke | Mitochondrial DNA Depletion Syndrome | Coloboma | Motor Neuron Diseases | Nemaline Myopathy 8 | Goldenhar Syndrome | Lichen Planus | Lathosterolosis | Keratocystic Odontogenic Tumor | Keratitis-ichthyosis-deafness Syndrome | Presbyopia | Glaucoma, Congenital | Chediak-Higashi Syndrome | Neovascular Glaucoma | Cantu Syndrome | Sezary Syndrome | Porphyria Cutanea Tarda | Trimethylaminuria | Frontometaphyseal Dysplasia | Cryoglobulinemia | Meningioma | Donnai-Barrow Syndrome | Blastoma, Pleuropulmonary | Familial Thoracic Aortic Aneurysm | Pierpont Syndrome | Granular Corneal Dystrophy Type 1 | Persistent Hyperplastic Primary Vitreous | Demyelinating Diseases | Juvenile Myelomonocytic Leukemia | Proteasome-associated Autoinflammatory Syndrome 2 | Alopecia Areata | Congenital Hereditary Endothelial Dystrophy Type II | Congenital Absence Of Vas Deferens | Glomerulonephritis | Spinocerebellar Ataxia Type 40 | Congenital Stationary Night Blindness | Hyperlipidemia | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Melanocytic Nevus | Tenosynovial Giant Cell Tumor | NDH Syndrome | Myotonia | Pendred Syndrome | Crigler-Najjar Syndrome | Epidermolysis Bullosa Simplex, Localized | Acromesomelic Dysplasia | Sarcoma | Farber Disease | Schizophrenia | Stickler Syndrome | Encephalopathy, Ethylmalonic | Galactosemia | Autism Spectrum Disorders | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Fucosidosis | Waardenburg Syndrome | X-linked Acrogigantism | Acquired Partial Lipodystrophy | Osteogenesis Imperfecta Type III | Myopathy | Olmsted Syndrome | Familial Mediterranean Fever | Spinocerebellar Ataxia Type 10 | Cold-induced Sweating Syndrome | Thrombocytopenia | Epidermolytic Hyperkeratosis | IgA Nephropathy | Double Outlet Right Ventricle | Protein S Deficiency | Lattice Corneal Dystrophy Type 1 | Diabetes Insipidus, Neurogenic | Weill-Marchesani Syndrome | Asthma, Nocturnal | Perivascular Epithelioid Cell Tumor | Cenani-Lenz Syndactyly Syndrome | Myositis, Focal | Hypertension | Alazami Syndrome | Eccrine Porocarcinoma | Thin Basement Membrane Disease | Megalencephaly | Cluster Headache | Uremia | Nance-Horan Syndrome | Bullous Pemphigoid | Ischemia | Primary Ovarian Insufficiency | Renal Failure | Intermittent Explosive Disorder | Creutzfeldt-Jakob Disease | Nail-Patella Syndrome | Histoplasmosis | Cataract | Apraxia | Osteomyelitis | Seminoma | Leber Hereditary Optic Neuropathy | Swine Influenza | Heart Failure | Nicotine Addiction | Optic Nerve Hypoplasia, Bilateral | Autoimmune Disease | Ornithine Transcarbamylase Deficiency | Spinal Cord Diseases | Liver Failure | Cri-du-chat Syndrome | Lafora Disease | Emery-Dreifuss Muscular Dystrophy | Hereditary Hemorrhagic Telangiectasia | Ulcerative Colitis | Anal Fissure | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Lymphedema-distichiasis Syndrome | Mohr-Tranebjaerg Syndrome | Lactose Intolerance | Succinic Semialdehyde Dehydrogenase Deficiency | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Hepatic Veno-occlusive Disease | Usher Syndrome Type II | Tyrosine Hydroxylase Deficiency | Cancer, Prostate | Myeloid Leukemia | Urea Cycle Disorder | Pulmonary Sclerosing Hemangioma | Heterotaxy | Systemic Mastocytosis | Cardiomyopathy, Restrictive | Danon Disease | Hemorrhagic Disorders | Arrhythmogenic Right Ventricular Cardiomyopathy | Cellulitis | Aarskog-Scott Syndrome | Non-Hodgkin Lymphoma | Nephrotic Syndrome | Hyperprolactinemia | Trismus-pseudocamptodactyly Syndrome | Crohn's Disease | Benign Hereditary Chorea | Polymicrogyria | Borderline Personality Disorder | Primary Aldosteronism | Smith-Kingsmore Syndrome | Tetanus | Diabetes Insipidus | Reflex Epilepsy | IgA Deficiency | Kallmann Syndrome | Graft-versus-host Disease | Cardiofaciocutaneous Syndrome | Ganglioneuroma | Arterial Tortuosity Syndrome | Carcinoma, Merkel Cell | Charcot-Marie-Tooth Disease Type 4D | Burn-McKeown Syndrome | Sponastrime Dysplasia | Personality Disorders | Takenouchi-Kosaki Syndrome | Cancer, Bladder | Congenital Lipoid Adrenal Hyperplasia | Meningioma, Benign | Noonan Syndrome | Lentigo | Relapsing Polychondritis | Graves Disease | Thrombocythemia, Essential | Charcot-Marie-Tooth Disease Type 2E | Focal Segmental Glomerulosclerosis | Congenital Generalized Lipodystrophy | Combined Malonic And Methylmalonic Acidemia | Bernard-Soulier Syndrome | Renal Hypomagnesemia 3 | Ehlers-Danlos Syndrome | Postpoliomyelitis Syndrome | Geleophysic Dysplasia | Juvenile Polyposis | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Transthyretin-related Amyloidosis | Dyggve-Melchior-Clausen Disease | Chanarin-Dorfman Syndrome | Tibial Muscular Dystrophy | Sarcoma, Endometrial Stromal | Central Retinal Artery Occlusion | Bicuspid Aortic Valve | Measles | Postaxial Polydactyly | Cocaine-Related Disorders | Hypercholesterolemia | Colon Adenoma | Fibromuscular Dysplasia | Encephalocele | Blue Nevus | Coma | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Polycystic Kidney, Autosomal Dominant | Nephrotic Syndrome Type 1 | Melanoma, Malignant | Blepharitis | Cherubism | Yellow Fever | Neutropenia | Amblyopia | Costello Syndrome | Chondrodysplasia Punctata | Communication Disorders | Gilbert Syndrome | Exostoses | Primary Lateral Sclerosis | Hepatic Adenomatosis | Neuronal Ceroid Lipofuscinosis | Hemangioblastoma | Spinocerebellar Ataxia Type 15 | Congenital Stromal Corneal Dystrophy | Hepatopulmonary Syndrome | Hereditary Sensory Neuropathy Type 1 | Shprintzen-Goldberg Syndrome | Cutis Laxa | Cardiomyopathy, Peripartum | Vascular Calcification | Congenital Adrenal Hyperplasia | Peutz-Jeghers Syndrome | Odonto-onycho-dermal Dysplasia | Xeroderma Pigmentosum Variant Type