Disease

Charcot-Marie-Tooth Disease Type 4D

About the Disease
Charcot-Marie-Tooth Disease, Type 4d, also known as charcot-marie-tooth disease type 4d, is related to hereditary sensory neuropathy and hereditary neuropathies. An important gene associated with Charcot-Marie-Tooth Disease, Type 4d is NDRG1 (N-Myc Downstream Regulated 1), and among its related pathways/superpathways are Glycerophospholipid biosynthesis and PI Metabolism. Affiliated tissues include tongue, bone and peripheral nerve, and related phenotypes are decreased motor nerve conduction velocity and distal lower limb muscle weakness

Common Targets
NDRG1 | REEP1

疾病靶点研报
Charcot-Marie-Tooth Disease Type 4D

Note: If you'd like to get a target analysis report for Charcot-Marie-Tooth Disease Type 4D, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Charcot-Marie-Tooth Disease Type 4D at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Prolymphocytic Leukemia | Azoospermia | Colon Adenoma | Encephalitis | Lymphomatoid Granulomatosis | 3C Syndrome | Spinocerebellar Ataxia Type 12 | Bietti Crystalline Dystrophy | Ollier Disease | Congenital Aniridia | Cantu Syndrome | Jaundice, Obstructive | Anorectal Fistula | Keratosis, Actinic | Leri Pleonosteosis | Nevus | Histiocytosis | Cartilage Disorders | Retinal Detachment | Ligneous Conjunctivitis | Isovaleric Acidemia | Cannabis Abuse | Sarcoma, Ewing | Proteasome-associated Autoinflammatory Syndrome 2 | CHOPS Syndrome | Leigh Syndrome | Granular Corneal Dystrophy Type 1 | Hypopituitarism | Hypospadias | Niemann-Pick Disease, Type C | Niemann-Pick Disease | Periventricular Nodular Heterotopia | Blau Syndrome | Camurati-Engelmann Disease | Malaria, Cerebral | Acute Tubular Necrosis | Myosin Storage Myopathy | Communication Disorders | Photosensitivity | Carcinoma, Small Cell | Thyrotoxic Periodic Paralysis | Juvenile Myoclonic Epilepsy | Alagille Syndrome | Cirrhosis | Ataxia-ocular Apraxia 2 | Usher Syndrome Type II | Autosomal Recessive Spastic Paraplegia Type 35 | Ophthalmia, Sympathetic | Chronic Mucocutaneous Candidiasis | Herpes Simplex Dermatitis | Thromboembolism | Familial Hypobetalipoproteinemia | Beare-Stevenson Syndrome | Kohlschutter-Tonz Syndrome | Glycogen Storage Disease Type 6 | Hyperacusis | Multicentric Carpotarsal Osteolysis Syndrome | Progressive Osseous Heteroplasia | HUPRA Syndrome | Chordoma | Ichthyosis, X-linked | Chronic Beryllium Disease | Perry Syndrome | Osteomalacia | Protein C Deficiency | Paronychia | Oligoastrocytoma | Pulmonary Capillary Hemangiomatosis | Lipoma | Myoclonic Epilepsy With Ragged Red Fibers | Glycogen Storage Disease Type 1b | Lipid Storage Diseases | Gastric Atrophy | Autoimmune Hemolytic Anemia | Hepatitis A | Renal Tubular Acidosis | Vascular Cognitive Impairment | Neutrophilia | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Ornithine Transcarbamylase Deficiency | Wiedemann-Steiner Syndrome | Chylothorax, Congenital | Borjeson-Forssman-Lehmann Syndrome | Lymphoma, Mantle Cell | Diamond-Blackfan Anemia | Opisthorchiasis | Neuromyelitis Optica | Aplastic Anemia | Metabolic Syndrome | Toxoplasmosis | Primary Carnitine Deficiency | Chediak-Higashi Syndrome | Sensorineural Hearing Loss | Shprintzen-Goldberg Syndrome | Cholesteryl Ester Storage Disease | Basal Ganglia Disease | Platelet Disorders | Gastroenteritis | Avian Influenza | Potocki-Shaffer Syndrome | Craniopharyngioma | Abetalipoproteinemia | Acute Coronary Syndrome | Lymphoproliferative Disorders | Trichothiodystrophy | Blue Nevus | Lymphopenia | Trichuriasis | Tenosynovial Giant Cell Tumor | Erythromelalgia | Chorea | Blepharitis | Schuurs-Hoeijmakers Syndrome | Gilbert Syndrome | Bladder Exstrophy | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Neurocutaneous Syndromes | Familial Retinal Arterial Macroaneurysm | Takayasu's Arteritis | Sertoli Cell-only Syndrome | Myositis, Focal | Encephalopathy, Glycine | Temtamy Preaxial Brachydactyly Syndrome | Marfan Syndrome | Diarrhea | Hereditary Elliptocytosis | Liver Failure, Acute Infantile | Geleophysic Dysplasia | Hyperthermia, Malignant | Osteitis | Hypersomnia | Cancer, Colon | Trismus-pseudocamptodactyly Syndrome | Diabetes Insipidus, Nephrogenic | Erectile Dysfunction | LRBA Deficiency | Cholangitis | Martsolf Syndrome | Budd-Chiari Syndrome | Alveolar Capillary Dysplasia | Bronchiectasis | Hypercalcemia | Antley-Bixler Syndrome | Atherosclerosis | Juvenile Myelomonocytic Leukemia | IgA Deficiency | B-cell Chronic Lymphocytic Leukemia | Phosphoglycerate Dehydrogenase Deficiency | Hyperekplexia | Otosclerosis | Agnathia-Otocephaly Complex | DOCK8 Immunodeficiency Syndrome | Dysequilibrium Syndrome | Ovarian Hyperstimulation Syndrome | Hypopigmentation | Bethlem Myopathy | Prolidase Deficiency | Tendinitis | Polycythemia Vera | Sponastrime Dysplasia | Persistent Mullerian Duct Syndrome | Anti-NMDA Receptor Encephalitis | Pseudohypoparathyroidism Type 1C | Nephrotic Syndrome | Diverticulitis | Lichen Planus | Leukodystrophies | Corneal Dystrophies, Hereditary | Sickle Cell Anemia | HELLP Syndrome | Chronic Myelomonocytic Leukemia | Swine Influenza | Osteogenesis Imperfecta | Pure Autonomic Failure | Neurodermatitis | Strabismus | Chronic Kidney Disease | Apraxia | Aneurysm, Abdominal Aortic | Pelizaeus-Merzbacher Disease | Myositis | Familial Mediterranean Fever | Hypertriglyceridemia | Pneumonia, Bacterial | Pontocerebellar Hypoplasia | Panniculitis | Coenzyme Q10 Deficiency | Neurocutaneous Melanocytosis | Cataract | Viral Meningitis | Glycogen Storage Disease Type 5 | Macrodactyly | Retinoschisis | 3-hydroxy-3-methylglutaric Aciduria | Tylosis With Esophageal Cancer | Lentigo | Neuromyotonia | Conjunctivitis, Allergic | Chorea-acanthocytosis | Majeed Syndrome | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Stuttering | Glioblastoma Multiforme | Tumoral Calcinosis | Low Phospholipid Associated Cholelithiasis | HANAC Syndrome | Motion Sickness | Wolman Disease | Hemochromatosis | Silver-Russell Syndrome | Brenner Tumor | Keratoconus | Mosaic Variegated Aneuploidy Syndrome 2 | Mitochondrial Cytopathy | DRESS Syndrome | Creatine Deficiency Syndrome | Klippel-Feil Syndrome | Blastoma, Pleuropulmonary | Meningococcal Meningitis | Anorexia Nervosa | Enterocolitis, Necrotizing | Hereditary Pyropoikilocytosis | Agoraphobia | Yellow Fever | B-cell Prolymphocytic Leukemia | Heart Failure | Anorchia | Asthma | Adenomatoid Tumor | Leber Hereditary Optic Neuropathy | Usher Syndrome Type IIC | Urea Cycle Disorder | Leukocyte Adhesion Deficiency Type 1 | Chondrodysplasia Punctata 2, X-linked Dominant | Vitamin B12 Deficiency | Nestor-Guillermo Progeria Syndrome | Fabry's Disease | Occipital Neuralgia | Mucolipidosis Type II | Van Der Knaap Disease | Charcot-Marie-Tooth Disease Type 4B1 | Chondromyxoid Fibroma | Glanzmann Thrombasthenia | Osteoporosis-pseudoglioma Syndrome | Borderline Personality Disorder | Neurofibroma | Sleep Apnea | Zellweger Syndrome | Optic Nerve Diseases | Inflammatory Joint Disease | Cabezas Syndrome | Asplenia | Crimean-Congo Hemorrhagic Fever | Osteosclerosis | Tardive Dyskinesia | Biotinidase Deficiency | Leiomyoma | Reye Syndrome | Chordoid Glioma | Vitreoretinal Degeneration, Snowflake Type | Hypercalciuria | Incontinentia Pigmenti | Tangier Disease | Melnick-Needles Syndrome | Hereditary Inclusion Body Myopathy | Fontaine Progeroid Syndrome | AIDS | Cancer, Prostate | Alopecia Totalis | N-acetylglutamate Synthase Deficiency | Cold Agglutinin Disease | Whipple's Disease | Hypervalinemia | Combined Malonic And Methylmalonic Acidemia | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Obsessive-compulsive Disorder | Pseudohypoaldosteronism | Pre-eclampsia | Hepatitis E | Spinocerebellar Ataxia Type 17 | Traboulsi Syndrome | Beckwith-Wiedemann Syndrome | Fanconi Anemia | Leukemia-lymphoma, Adult T-cell | Aldosterone Deficiency | Retinal Dystrophy, Early-onset Severe | Primary Biliary Cholangitis | Epilepsy, Generalized | Neurofibroma, Plexiform | Hyperostosis | Congenital Mirror Movements | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Iron Overload | Nijmegen Breakage Syndrome | Pseudomyxoma Peritonei | Oculocutaneous Albinism Type 1 | Rhabdomyosarcoma | Corneal Edema | Alazami Syndrome | Meier-Gorlin Syndrome | Sturge-Weber Syndrome | Focal Cortical Dysplasia Type 2 | Hepatitis C, Chronic | Hereditary Sensory Neuropathy Type 1 | VACTERL Association | Batten Disease | Costello Syndrome | Pleomorphic Xanthoastrocytoma | Personality Disorders | Leishmaniasis, Cutaneous | Left Ventricular Noncompaction | Hepatitis | Papulopustular Rosacea | Hyperinsulinemia | Congenital Generalized Lipodystrophy | Poikiloderma With Neutropenia | Williams Syndrome | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Hydrocephalus, Normal Pressure | Kaposi Sarcoma | Astigmatism | Fukuyama Congenital Muscular Dystrophy | Pouchitis | Postpoliomyelitis Syndrome | Coronary Artery Disease | Scoliosis | Periodontitis | SAPHO Syndrome | Spondyloarthritis | Prolactinoma | Aicardi-Goutieres Syndrome | Parkinsonism | Corneal Ulcer | Cardiac Arrest | Dyggve-Melchior-Clausen Disease | Phenylketonuria II | Papilledema | Cutaneous Lupus Erythematosus | Ectrodactyly | Spinocerebellar Ataxia Type 23 | Schizencephaly | Retinal Degeneration | Hyperphenylalaninemia | REM Sleep Behavior Disorder | Parkinson Disease 6, Autosomal Recessive Early-onset | Spinal Muscular Atrophy Type 2 | Spinal Muscular Atrophy Type 3 | Hypoplastic Left Heart Syndrome | Primrose Syndrome | Angiosarcoma | Disseminated Intravascular Coagulation | Patent Foramen Ovale | Giant Cell Glioblastoma | Acute Generalized Exanthematous Pustulosis | Hypotrichosis Simplex | Delirium | Myocarditis | Postaxial Polydactyly | Myofibromatosis | X-linked Myotubular Myopathy | Danon Disease | Behavioral Variant Of Frontotemporal Dementia | Diabetic Neuropathy | Retinal Telangiectasia | Amish Infantile Epilepsy Syndrome | Epidermolysis Bullosa Simplex, Generalized | Porphyria, Variegate | Non-proliferative Diabetic Retinopathy | Campomelic Dysplasia | Pineoblastoma | Meningioma, Benign | Nicotine Dependence | Anxiety Disorders | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Hyperbilirubinemia, Neonatal | Osteoporosis | Sorsby Fundus Dystrophy | Preaxial Polydactyly | Lymphedema-distichiasis Syndrome | DNA Ligase IV Deficiency | Syndactyly | COACH Syndrome | Urolithiasis | Adrenoleukodystrophy, X-linked | Carey-Fineman-Ziter Syndrome | Colitis | Neuronal Ceroid Lipofuscinosis | Muscular Dystrophy | Cerebral Cavernous Malformations | L-2-Hydroxyglutaric Aciduria | Charcot-Marie-Tooth Disease | Thrombocythemia, Essential | AIDS Dementia Complex | Antithrombin III Deficiency | Omenn Syndrome | Wagner Disease | Vaginitis | Hidradenitis Suppurativa | Usher Syndrome Type III