Hypothyroidism

About the Disease
Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and hypothyroidism, congenital, nongoitrous, 1. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Thyroid stimulating hormone (TSH) signaling pathway and Thyroid hormones production and peripheral downstream signaling effects. The drugs Nitroprusside and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and lymph node, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and homeostasis/metabolism

Common Targets
CYP3A4 | G29126 | DIO2 | THRB | DUOX2 | ACE | PHTF1 | Thyroid hormone receptor (nonspecified subtype) | PDE8B | TG | TRPM8 | TPO | IRS4 | TBL1X | G9429 | IGSF1 | SLC16A2 | SLC5A5 | PROP1 | CYP3A5 | G367 | ABCC8 | TSHR | NOS3 | G5243 | TRHR | PTPN22 | MTHFR | KDR | AGTR1 | WHRN | G7422 | SH2B3 | APOB | ABCB11 | Parathyroid Hormone Receptors (PTHR) (nonspecified subtype) | THRA | CHRNA1 | SHQ1

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Other Diseases

Proteasome-associated Autoinflammatory Syndrome 2 | Absence Epilepsy | Common Variable Immunodeficiency | Thyroid Dyshormonogenesis | Sarcoidosis, Pulmonary | Erythema Multiforme | Chloridorrhea, Congenital | Metanephric Adenoma | Behcet's Disease | Congenital Disorders Of Glycosylation | Tuberculosis | Arteriovenous Malformations | Hyperoxaluria | Spondyloarthritis | Retinitis | Arthritis, Gouty | Impetigo | Sertoli Cell-only Syndrome | Atelosteogenesis Type 1 | Mycosis Fungoides | Hypermethioninemia | Chronic Periodontitis | Hepatitis, Chronic | Acromicric Dysplasia | Papulopustular Rosacea | Anorectal Malformations | Glomerulonephritis, Membranoproliferative | Mitochondrial Myopathy | Autoimmune Disease | Epithelial-myoepithelial Carcinoma | Autosomal Recessive Bestrophinopathy | Intermittent Claudication | Thyrotoxic Periodic Paralysis | Retinal Vasculitis | Enlarged Vestibular Aqueduct | Insulinoma | Blepharo-cheilo-odontic Syndrome | Cutaneous Lupus Erythematosus | Hypertension, Portal | Posterior Polar Cataract | Congenital Hereditary Endothelial Dystrophy Type II | Hypervalinemia | Roberts Syndrome | Ocular Hypertension | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Cardiomyopathy, Hypertrophic | Carcinoma, Transitional Cell | Wolfram Syndrome 2 | Postpartum Depression | Keratitis | Diffuse Intrinsic Pontine Glioma | Meier-Gorlin Syndrome | Mitochondrial DNA Depletion Syndrome | Motion Sickness | Tinea | Dystonia-parkinsonism, X-linked | Cysticercosis | Rift Valley Fever | Glycogen Storage Disease Type 0 | Cataract | Coffin-Lowry Syndrome | Epidermolysis Bullosa Acquisita | Kearns-Sayre Syndrome | Smoldering Myeloma | Chorea | Alazami Syndrome | Adenoma, Pituitary | Conn Syndrome | Hypertension | Graft-versus-host Disease | Sorsby Fundus Dystrophy | Diabetes | Cryopyrin-associated Periodic Syndromes | Renal-hepatic-pancreatic Dysplasia | Colitis, Microscopic | Sensory Neuropathy | Vici Syndrome | Pulmonary Tuberculosis | Corticobasal Syndrome | Spondylosis | Personality Disorders | Hypereosinophilic Syndrome | Generalized Epilepsy With Febrile Seizures Plus | Thrombosis | Ovarian Sex Cord-stromal Tumor | Pneumonia, Mycoplasma | Perivascular Epithelioid Cell Tumor | Pituitary Stalk Interruption Syndrome | Juvenile Myelomonocytic Leukemia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Language Disorders | Megalencephaly | Microvillus Inclusion Disease | Dyslipidemia | Greig Cephalopolysyndactyly Syndrome | Hemochromatosis Type 1 | Retinal Dystrophy, Early-onset Severe | Panniculitis | Hepatitis | Camurati-Engelmann Disease | Spinocerebellar Ataxia Type 28 | Campomelic Dysplasia | Tremor | Ameloblastic Carcinoma | Proopiomelanocortin Deficiency | Fibrosis | Encephalocele | Dystonia | Multiple Myeloma | Leigh Syndrome | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | H Syndrome | Hermansky-Pudlak Syndrome | Epidermolysis Bullosa Dystrophica | HELLP Syndrome | Persistent Mullerian Duct Syndrome | Hypocalcemia | Apraxia | Spinal Muscular Atrophy Type 3 | Myelitis, Transverse | REM Sleep Behavior Disorder | B-cell Prolymphocytic Leukemia | Charcot-Marie-Tooth Disease Axonal Type 2N | Moyamoya Disease | LRBA Deficiency | Methylmalonic Aciduria And Homocystinuria, CblC Type | Huntington's Disease-like 2 | Spinocerebellar Ataxia Type 17 | Senior-Loken Syndrome | Protein C Deficiency | Compartment Syndrome | Celiac Disease | Hyperinsulinemia | Riboflavin Transporter Deficiency Neuronopathy | Renal Tubular Dysgenesis | Aromatic L-amino Acid Decarboxylase Deficiency | Leukemia-lymphoma, Adult T-cell | Pituitary Dwarfism | Bone Marrow Necrosis | Neurofibrosarcoma | Hepatic Veno-occlusive Disease | Leber Congenital Amaurosis | Hypohidrotic Ectodermal Dysplasia | Babesiosis | Hyperthyroidism | Aicardi-Goutieres Syndrome | Pyruvate Kinase Deficiency | Exfoliative Dermatitis | Disseminated Superficial Actinic Porokeratosis | Aspartylglycosaminuria | Multiple Sclerosis, Primary Progressive | Sulfite Oxidase Deficiency | Farber Disease | Sweet Syndrome | Dysplastic Nevus | Spinocerebellar Ataxia Type 2 | Addison Disease | Monilethrix | Swine Influenza | Sarcoma | Amyloidosis | Stargardt Disease | Periventricular Nodular Heterotopia | Pure Red Cell Aplasia | Peritonitis | Palmoplantar Keratoderma | Aarskog-Scott Syndrome | Seborrheic Dermatitis | Fukuyama Congenital Muscular Dystrophy | Ichthyosis | Sleep Disorder | Ileitis | Porphyria, Variegate | Colorectal Adenoma | Pterygium | Hidradenitis Suppurativa | Adenoid Cystic Carcinoma | Craniolenticulosutural Dysplasia | Panuveitis | Lymphopenia | Gastritis, Atrophic | Chronic Mucocutaneous Candidiasis | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Dementia | Pulmonary Alveolar Proteinosis | Hypercalciuria | Mucolipidosis Type IV | Diabetic Nephropathy | Urea Cycle Disorder | Hyperammonemia | Ameloblastoma | Nasodigitoacoustic Syndrome | Marinesco-Sjogren Syndrome | 3-M Syndrome | Acanthosis Nigricans | Hereditary Elliptocytosis | T-cell Leukemia | Agammaglobulinemia | Familial Pheochromocytoma-paraganglioma | Autosomal Recessive Spastic Paraplegia Type 35 | Fibronectin Glomerulopathy | Potocki-Shaffer Syndrome | Myocardial Infarction | Multisystemic Smooth Muscle Dysfunction Syndrome | Hypertensive Retinopathy | Angiosarcoma Of The Breast | Cold Agglutinin Disease | Coronary Heart Disease | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Schamberg Disease | Neuroectodermal Tumors, Primitive | Transcobalamin Deficiency | Down Syndrome | Esophageal Motility Disorders | Alopecia | Graves Disease | Tyrosine Hydroxylase Deficiency | Nicotine Addiction | Tyrosinemia Type 1 | Hydrocephalus, Normal Pressure | Common Cold | Crimean-Congo Hemorrhagic Fever | ICF Syndrome | Pseudoachondroplasia | Hereditary Mixed Polyposis Syndrome | Influenza | Dwarfism | Early Infantile Epileptic Encephalopathy 4 | Ornithine Transcarbamylase Deficiency | Spitzoid Melanoma | Hemophagocytic Lymphohistiocytosis | Niemann-Pick Disease, Type C | Porphyria Cutanea Tarda | Agoraphobia | Polyomavirus Nephropathy | Chediak-Higashi Syndrome | Noonan Syndrome-like Disorder With Loose Anagen Hair | Meckel-Gruber Syndrome | Primary Hyperoxaluria | Neovascular Glaucoma | Heart Block | Cantu Syndrome | Skin Fragility-woolly Hair Syndrome | Hyperlipidemia, Familial Combined | Renal Failure | Trichomegaly | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Spinal And Bulbar Muscular Atrophy | Congenital Muscular Dystrophy | Vitamin B12 Deficiency | Mumps | Chylothorax, Congenital | Malaria, Cerebral | Scleroderma, Diffuse | Scapuloperoneal Myopathy, X-linked Dominant | Epidermodysplasia Verruciformis | Lamellar Ichthyosis | Oculodentodigital Dysplasia | Asplenia | Hypertension, Pulmonary | Keratoconus | Stromal Corneal Dystrophy | Angiosarcoma | Astigmatism | Histiocytosis | Cervical Dystonia | Creutzfeldt-Jakob Disease | Hyperferritinemia-cataract Syndrome | Infantile Nephropathic Cystinosis | 5-oxoprolinase Deficiency | Behavioral Variant Of Frontotemporal Dementia | Metachromatic Leukodystrophy | Cartilage Disorders | Chorea-acanthocytosis | Hypertrophy | Nephrotic Syndrome | Alagille Syndrome | Coffin-Siris Syndrome | Reticular Dysgenesis | Hepatorenal Syndrome | Hereditary Spastic Paraplegia | Otitis Media | Ichthyosis, X-linked | Anti-glomerular Basement Membrane Disease | Pleural Tuberculosis | Chromosome 17q21.31 Deletion Syndrome | Carotid Artery Disease | Toxic Epidermal Necrolysis | Polydactyly | Corneal Edema | Harlequin Ichthyosis | Hypolipoproteinemia | Primary Sclerosing Cholangitis | Amenorrhea | Glioblastoma Multiforme | TARP Syndrome | Premature Ejaculation | Pure Autonomic Failure | Sclerocornea | Cerebral Amyloid Angiopathy | Keratopathy | Chronic Lymphocytic Leukemia | Phosphoglycerate Dehydrogenase Deficiency | Acute Lung Injury | Gastroenteritis | Cerebrotendinous Xanthomatosis | Motor Neuron Diseases | Medulloblastoma | Loeys-Dietz Syndrome Type 4 | Anosmia, Congenital | Metaphyseal Chondrodysplasia, Schmid Type | Kashin-Beck Disease | Poretti-Boltshauser Syndrome | Polycythemia | Osteoporosis | Hyperglycemia | Epicondylitis | Schwartz-Jampel-Aberfeld Syndrome | Pouchitis | Dystonia Musculorum Deformans | Antithrombin III Deficiency | Cardiac Sarcoidosis | Encephalopathy, Ethylmalonic | Pompe Disease | Ventricular Septal Defect | Constipation | Diabetes Gestational | Metatropic Dysplasia | Multicentric Carpotarsal Osteolysis Syndrome | Mucolipidosis Type III | Trichorhinophalangeal Syndrome | Porphyria | Granular Corneal Dystrophy | Tardive Dyskinesia | Ellis-Van Creveld Syndrome | Vulvovaginitis | GM2-gangliosidosis AB Variant | Melnick-Needles Syndrome | Kabuki Syndrome | Renal Hypouricemia | VEXAS Syndrome | Myhre Syndrome | Osteoglophonic Dysplasia | Optic Neuropathy, Anterior Ischemic | Neurofibromatosis Type 1 | Geleophysic Dysplasia | Myoclonic Atonic Epilepsy | Polyradiculopathy | Heavy Chain Disease | Rhabdoid Tumor | Hemolytic Anemia | Mandibuloacral Dysplasia With Type A Lipodystrophy | Myopathy | Basal Ganglia Cerebrovascular Disease | Cancer, Breast | Porphyria, Acute Intermittent | Smith-Magenis Syndrome | Pineoblastoma | Brachial Plexus Neuropathy | Schizophrenia | Macular Corneal Dystrophy Type 1 | Cholecystitis | Donnai-Barrow Syndrome | Precocious Puberty | Cystinosis | Diffuse Mesangial Sclerosis | Chiari Malformation Type I | Usher Syndrome Type I | Waardenburg Syndrome Type 2E | Hypoalbuminemia | Infantile Neuroaxonal Dystrophy | Dermatomyositis | Inborn Errors Of Metabolism | Esophagitis | Sleep Apnea | Astrocytoma | Pheochromocytoma | Argininosuccinic Aciduria | Membranous Nephropathy | Gingivitis | Peripheral Neuropathy | Osteonecrosis Of The Jaw | Mountain Sickness | Aspergillosis | Acute Myeloid Leukemia | Microcephalic Primordial Dwarfism | Giant Cell Glioblastoma | Transient Bullous Dermolysis Of The Newborn | Osteogenesis Imperfecta Type III | Li-Fraumeni Syndrome | Centronuclear Myopathy | 3-hydroxy-3-methylglutaric Aciduria | Fibromuscular Dysplasia | Hypophosphatasia | Charcot-Marie-Tooth Disease Type 2T | Pontocerebellar Hypoplasia | Optic Neuritis | Spinocerebellar Ataxia | Focal Dermal Hypoplasia | Ovarian Hyperstimulation Syndrome