Hypothyroidism

About the Disease
Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and hypothyroidism, congenital, nongoitrous, 1. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Thyroid stimulating hormone (TSH) signaling pathway and Thyroid hormones production and peripheral downstream signaling effects. The drugs Nitroprusside and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and lymph node, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and homeostasis/metabolism

Common Targets
CYP3A4 | G29126 | DIO2 | THRB | DUOX2 | ACE | PHTF1 | Thyroid hormone receptor (nonspecified subtype) | PDE8B | TG | TRPM8 | TPO | IRS4 | TBL1X | G9429 | IGSF1 | SLC16A2 | SLC5A5 | PROP1 | CYP3A5 | G367 | ABCC8 | TSHR | NOS3 | G5243 | TRHR | PTPN22 | MTHFR | KDR | AGTR1 | WHRN | G7422 | SH2B3 | APOB | ABCB11 | Parathyroid Hormone Receptors (PTHR) (nonspecified subtype) | THRA | CHRNA1 | SHQ1

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