Anti-glomerular Basement Membrane Disease

About the Disease
Goodpasture Syndrome, also known as anti-glomerular basement membrane disease, is related to rapidly progressive glomerulonephritis and pulmonary hemosiderosis. An important gene associated with Goodpasture Syndrome is COL4A3 (Collagen Type IV Alpha 3 Chain), and among its related pathways/superpathways are Extracellular matrix organization and Non-integrin membrane-ECM interactions. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and bone, and related phenotypes are respiratory insufficiency and proteinuria

Common Targets
HLA-DRB1

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