Isovaleric Acidemia

About the Disease
Isovaleric Acidemia, also known as isovaleric acid coa dehydrogenase deficiency, is related to carbonic anhydrase va deficiency, hyperammonemia due to and acyl-coa dehydrogenase deficiency, and has symptoms including lethargy, seizures and vomiting. An important gene associated with Isovaleric Acidemia is IVD (Isovaleryl-CoA Dehydrogenase), and among its related pathways/superpathways are Metabolism and Regulation of expression of SLITs and ROBOs. Affiliated tissues include bone marrow, bone and cortex, and related phenotypes are global developmental delay and metabolic acidosis

Common Targets
IVD | PANK3

Note: If you'd like to get a target analysis report for Isovaleric Acidemia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Isovaleric Acidemia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Retinoschisis | Schistosomiasis | Neuromyotonia | Amelogenesis Imperfecta | Hemangioendothelioma | Pleural Tuberculosis | Conn Syndrome | Muscular Dystrophy | Acute Leukemia | Purpura, Thrombotic Thrombocytopenic | Hemoglobinopathies | Papilloma | Hypoplastic Left Heart Syndrome | Arthritis, Gouty | Schizencephaly | Crohn's Disease | Alpers Syndrome | Alopecia Totalis | Mucolipidosis Type III | Esophageal Adenocarcinoma | Thanatophoric Dysplasia | GAPO Syndrome | Myelomeningocele | Spinocerebellar Ataxia Type 6 | Cardiospondylocarpofacial Syndrome | Ureteropelvic Junction Obstruction | Hereditary Elliptocytosis | Discoid Lupus Erythematosus | Hypertensive Retinopathy | Bloom Syndrome | Glomerulonephritis, Membranous | Metatropic Dysplasia | Scoliosis | Stroke | Pitt-Hopkins Syndrome | Congenital Generalized Lipodystrophy | Growth Hormone Excess | Myelitis | Combined Malonic And Methylmalonic Acidemia | 3-methylglutaconic Aciduria Type IV | Hypertension, Renovascular | Nanophthalmos | Crimean-Congo Hemorrhagic Fever | Familial Thoracic Aortic Aneurysm | Aplasia Cutis Congenita | Pseudoexfoliation Syndrome | Eczema | Chondrodysplasia Punctata | Raynaud Phenomenon | Pneumonia, Bacterial | Blue Rubber Bleb Nevus Syndrome | Waardenburg Syndrome Type 2 | Amish Infantile Epilepsy Syndrome | Atelosteogenesis Type 2 | Alcoholism | Waardenburg Syndrome Type 2E | Adenoma, Pituitary | Dementia, Vascular | 3-methylglutaconic Aciduria | Mannosidase Deficiency Diseases | Cholestasis, Intrahepatic | Endocarditis | Guttate Psoriasis | Rhabdoid Tumor | Pyruvate Decarboxylase Deficiency | Autosomal Recessive Spastic Paraplegia Type 75 | Frontotemporal Dementia | Scleroderma, Diffuse | Pancreatitis, Chronic | Myasthenia | Charcot-Marie-Tooth Disease Type 2E | Alagille Syndrome | Congenital Dyserythropoietic Anemia Type 1 | Myotonic Disorders | Glaucoma, Congenital | Parkinson Disease 6, Autosomal Recessive Early-onset | Pilomatrix Carcinoma | Chylothorax, Congenital | Chitayat Syndrome | Astigmatism | Vogt-Koyanagi-Harada Syndrome | WAGR Syndrome | Cirrhosis | Amebiasis | Rolandic Epilepsy | Trichotillomania | Depression | Wieacker-Wolff Syndrome | Placenta Previa | Syndactyly | Muscle Wasting | Myopia | Nicotine Dependence | Dystonia-parkinsonism, X-linked | Delirium | Spinocerebellar Ataxia Type 23 | Moyamoya Disease | Adenocarcinoma | Pure Autonomic Failure | Weill-Marchesani Syndrome | Metachromatic Leukodystrophy | Retinal Telangiectasia | Atrioventricular Septal Defect | Galloway-Mowat Syndrome | Tendinitis | Diabetes Insipidus | Chronic Myelomonocytic Leukemia | Pterygium | Schuurs-Hoeijmakers Syndrome | Aldosterone Deficiency | Congenital Dyserythropoietic Anemia Type 4 | Niemann-Pick Disease | Progressive Encephalopathy-optic Atrophy Syndrome | Tangier Disease | Pyruvate Dehydrogenase Deficiency | Alopecia | Infertility | Gestational Trophoblastic Disease | CREST Syndrome | Nail-Patella Syndrome | Klippel-Feil Syndrome | Primary Cutaneous Amyloidosis | Angiosarcoma Of The Breast | Bare Lymphocyte Syndrome | Platelet Disorders | Papulopustular Rosacea | C3 Glomerulopathy | Compartment Syndrome | Carbamoyl Phosphate Synthetase I Deficiency | Fowler's Syndrome | Sezary Syndrome | Multisystemic Smooth Muscle Dysfunction Syndrome | Hypersomnia | Fanconi Syndrome | Paraganglioma, Carotid Body | Spinocerebellar Ataxia Type 13 | Ectrodactyly | Neuroblastoma | Histoplasmosis | Cavitary Optic Disc Anomalies | Thyroid Hormone Resistance | Diabetes Gestational | Long QT Syndrome Type 1 | Personality Disorders | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Blepharospasm | Muckle-Wells Syndrome | Dermatitis | Hemangioma | Sleep Apnea | Lymphangioleiomyomatosis | Isobutyryl-CoA Dehydrogenase Deficiency | Lipid Storage Diseases | Vitreoretinopathy, Proliferative | Charcot-Marie-Tooth Disease Type 3 | Diabetes | Trigonocephaly | Progressive Familial Intrahepatic Cholestasis Type 1 | Mohr-Tranebjaerg Syndrome | Craniofrontonasal Syndrome | Lattice Corneal Dystrophy | Cataract | Neuroendocrine Cancer | Encephalitis, Tick-borne | Spastic Paraplegia Type 7 | Pneumothorax | Tuberculosis | Lymphangioma | Polydactyly | Kidney Stones | Epidermolysis Bullosa Simplex, Generalized | Shprintzen-Goldberg Syndrome | Myeloid Leukemia | Pelizaeus-Merzbacher Disease | Diffuse Intrinsic Pontine Glioma | Tyrosine Hydroxylase Deficiency | Progressive Myoclonic Epilepsy | Inborn Errors Of Metabolism | Fetal Akinesia Deformation Sequence | Delayed Sleep Phase Syndrome | Heart Failure | Papillon-Lefevre Syndrome | Fibrosis | Autonomic Nervous System Disorders | Optic Nerve Hypoplasia, Bilateral | Familial Hyperaldosteronism | Hypoglycemia | Charcot-Marie-Tooth Disease Type 4 | Facioscapulohumeral Muscular Dystrophy | Vitreoretinal Degeneration, Snowflake Type | Coenzyme Q10 Deficiency | Cryopyrin-associated Periodic Syndromes | Tyrosinemia Type 2 | IgA Deficiency | Lafora Disease | Uterine Leiomyoma | Porokeratosis | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Myoclonus | Glycogen Storage Disease Type 5 | Smith-Magenis Syndrome | Hypertension, Essential | Meier-Gorlin Syndrome | Cryoglobulinemia | Smith-Lemli-Opitz Syndrome | Vitamin K Deficiency | Cancer, Breast | Essential Fructosuria | Spinocerebellar Ataxia Type 15 | Autoimmune Polyendocrinopathy Syndrome Type I | Hypopigmentation | 3-hydroxy-3-methylglutaric Aciduria | Inflammatory Linear Verrucous Epidermal Nevus | Multiple Myeloma | 3-methylcrotonyl-CoA Carboxylase Deficiency | Retinitis Pigmentosa 3 | Tietze Syndrome | Sensorineural Hearing Loss | Neurodegeneration With Brain Iron Accumulation | Guanidinoacetate Methyltransferase Deficiency | Hypogonadism | D-2-Hydroxyglutaric Aciduria | Cornelia De Lange Syndrome | Pregnancy, Ectopic | Genee-Wiedemann Syndrome | Autosomal Recessive Congenital Ichthyosis | Mycosis Fungoides | Brachydactyly | B-cell Prolymphocytic Leukemia | Wilson's Disease | Neurofibroma, Plexiform | Sturge-Weber Syndrome | Pemphigus Foliaceus | Thromboembolism | Hydronephrosis | Gastroschisis | Gastroenteritis, Eosinophilic | Osteoporosis-pseudoglioma Syndrome | Saethre-Chotzen Syndrome | Sarcoma | Ganglioglioma | Tendinopathy | Tracheal Disorders | Congenital Poikiloderma | Joubert Syndrome 2 | Congenital Hereditary Endothelial Dystrophy Type II | Autonomic Neuropathy | Congenital Torticollis | Chronic Leukemia | Argininosuccinic Aciduria | Hemorrhoids | Retinopathy Of Prematurity | Angioedema, Hereditary | Yellow Fever | Protein C Deficiency | Retinal Coloboma | Cutaneous Lupus Erythematosus | Atelosteogenesis Type 1 | Cardiomyopathy, Dilated, 1L | Supravalvular Aortic Stenosis | B-cell Chronic Lymphocytic Leukemia | Lichen Sclerosus | Fetal Alcohol Syndrome | Bladder Exstrophy | Esophageal Motility Disorders | LRBA Deficiency | Left Ventricular Noncompaction | Cri-du-chat Syndrome | Cold Agglutinin Disease | McCune-Albright Syndrome | Avellino Corneal Dystrophy | T-cell Prolymphocytic Leukemia | Pseudomyxoma Peritonei | Cancer, Lung | Walker-Warburg Syndrome | Atherosclerosis | Meleda Disease | Keratopathy | Bethlem Myopathy | Spinocerebellar Ataxia Type 21 | Fascioliasis | Insulin Resistance | Glioblastoma Multiforme | Waardenburg Syndrome Type 2A | Early Infantile Epileptic Encephalopathy 13 | Oculocutaneous Albinism Type 4 | Craniometaphyseal Dysplasia | Branchiootorenal Syndrome | Hennekam Lymphangiectasia-lymphedema Syndrome | Cystinuria | Leber Congenital Amaurosis | Protein S Deficiency | Carcinoma In Situ | Diamond-Blackfan Anemia | Meconium Ileus | Pulmonary Capillary Hemangiomatosis | Congenital Hereditary Endothelial Dystrophy Type I | Alexander Disease | Spondyloepiphyseal Dysplasia Tarda, X-linked | Juvenile Hyaline Fibromatosis | Exotropia | Ectopia Lentis, Isolated, Autosomal Recessive | Glycogen Storage Disease Type 0, Muscle | Dysmorphophobia | Joubert Syndrome | Distal Myopathy | Takotsubo Cardiomyopathy | Fibromuscular Dysplasia | Retinoblastoma | Congenital Ichthyosiform Erythroderma | Peeling Skin Syndrome Type B | Anal Fissure | Zygomycosis | Beckwith-Wiedemann Syndrome | Myosin Storage Myopathy | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Diabetic Encephalopathy | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Otopalatodigital Syndrome Type 2 | Reye Syndrome | Lassa Fever | Necrotizing Autoimmune Myopathy | Lipid Storage Myopathy | Irritable Bowel Syndrome | Liver Failure, Acute Infantile | Iron Metabolism Disorders | Lysosomal Acid Lipase Deficiency | Amblyopia | Paternal Uniparental Disomy Of Chromosome 14 | T-cell Lymphoma, Subcutaneous Panniculitis-like | Keratitis-ichthyosis-deafness Syndrome | Hemochromatosis Type 2 | Glycogen Storage Disease Type 6 | Tic Disorder | Congenital Fiber-type Disproportion Myopathy | Aphasia | Autism Spectrum Disorders | Chondrodysplasia Punctata 2, X-linked Dominant | Osteogenesis Imperfecta Type V | Thrombotic Microangiopathy | Absence Epilepsy | Porphyria, Variegate | Orotic Aciduria | Kearns-Sayre Syndrome | Biotinidase Deficiency | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Bronchitis, Chronic | Hepatitis, Alcoholic | Lateral Meningocele Syndrome | Congenital Dysfibrinogenemia | Noonan Syndrome-like Disorder With Loose Anagen Hair | Enterocolitis, Necrotizing | Thyroid Dysgenesis | Cheilitis | Pfeiffer Syndrome | Trichorhinophalangeal Syndrome | Costello Syndrome | Vascular Calcification | Brachial Plexus Neuropathy | Non-epidermolytic Palmoplantar Keratoderma | Fatty Aldehyde Dehydrogenase Deficiency | Duchenne Muscular Dystrophy | Congenital Sodium Diarrhea | Microcephaly | Papilledema | Primary Erythromelalgia | Osteogenesis Imperfecta Type IV | Dysferlinopathy | Waardenburg Syndrome Type 1 | Blau Syndrome | Giant Axonal Neuropathy | Crigler-Najjar Syndrome | Bipolar Disorder | Agranulocytosis | Cutis Laxa | Sclerosteosis | Dermatomyositis | Early Infantile Epileptic Encephalopathy 28 | Cholelithiasis | Hyperandrogenemia | Sponastrime Dysplasia | Evans Syndrome | Intellectual Disability, Autosomal Dominant 5 | Xeroderma Pigmentosum | Neurogenic Bladder | Hyperuricemic Nephropathy, Familial Juvenile | Leishmaniasis, Cutaneous | ICF Syndrome | Necrobiosis Lipoidica | Hyperferritinemia-cataract Syndrome | Johanson-Blizzard Syndrome | Familial Hypobetalipoproteinemia | Seasonal Mood Disorder | Fibrillation, Atrial | Primrose Syndrome | Camurati-Engelmann Disease | Liebenberg Syndrome | Lentigo | Pseudohermaphroditism | Lymphangiomatosis