Progressive Myoclonic Epilepsy

About the Disease
Myoclonic Epilepsy of Unverricht and Lundborg, also known as progressive myoclonic epilepsy, is related to epilepsy, progressive myoclonic, 1b and progressive myoclonus epilepsy 7, and has symptoms including myoclonus and ataxia. An important gene associated with Myoclonic Epilepsy of Unverricht and Lundborg is CSTB (Cystatin B). The drugs Brivaracetam and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include brain, globus pallidus and cortex, and related phenotypes are limb ataxia and eeg with polyspike wave complexes

Common Targets
EPM2A | GPR37L1 | SMARCA1 | GBA1 | CACNA2D2 | KCNC1 | PKD1 | SLC7A6OS | NEU1 | LRBA | ADD3 | DUSP18 | G4851 | RRM1 | PNPLA7 | CERS1 | LMNB2 | SERPINI1 | PARD3B | ASAH1 | KCTD7 | GSTA1 | CHD2 | CLN6 | MT1F | TBC1D24 | SEMA6B | OPRL1 | TRAP1 | HELQ | MUC5B | NHLRC1 | MDM1 | CPEB2 | DHDDS | NUS1 | GSTP1 | SACS | SCN1A | GSTM1 | SCARB2 | TBC1D10A | TDRD6 | GPLD1 | COL6A2 | TRNI | ICA1L | NFAT5 | GOSR2 | MED1 | CD109 | SNTG2 | CES5A | ZNF598 | ALG10 | DMD | AFG3L2 | PRNP | CTBP2 | TGFBI | ALDH3B2

Note: If you'd like to get a target analysis report for Progressive Myoclonic Epilepsy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Progressive Myoclonic Epilepsy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pseudoachondroplasia | Intellectual Disability, Autosomal Dominant 5 | Colitis | Urethritis | Leukoplakia, Oral | Cornelia De Lange Syndrome | Macular Corneal Dystrophy | Corneal Dystrophies, Hereditary | Joubert Syndrome 2 | Osteogenesis Imperfecta Type III | Inflammatory Linear Verrucous Epidermal Nevus | Neurocutaneous Syndromes | Facioscapulohumeral Muscular Dystrophy Type 1 | Senior-Loken Syndrome | Obsessive-compulsive Disorder | Papillon-Lefevre Syndrome | Glutaric Aciduria Type 1 | Chronic Lymphocytic Leukemia | Sensorineural Hearing Loss | Familial Isolated Hyperparathyroidism | Splenomegaly | Angelman Syndrome | Choroideremia | Chronic Beryllium Disease | Gitelman Syndrome | Sulfite Oxidase Deficiency | Hypobetalipoproteinemias | Renal Tubular Acidosis | Erectile Dysfunction | Tibial Muscular Dystrophy | Congenital Lipoid Adrenal Hyperplasia | Bursitis | Antiphospholipid Syndrome | Papilledema | Epidermolysis Bullosa Simplex | Carcinoma In Situ | Erythematotelangiectatic Rosacea | Diabetes Insipidus, Neurogenic | Spinocerebellar Ataxia Type 16 | Hypertension, Essential | Uveitis, Anterior | Pneumoconiosis | Hepatitis B, Chronic | Nemaline Myopathy 10 | Hyperferritinemia-cataract Syndrome | Sepiapterin Reductase Deficiency | Pulmonary Sclerosing Hemangioma | Holoprosencephaly | Charcot-Marie-Tooth Disease Type 2T | Hypereosinophilic Syndrome | Hepatorenal Syndrome | Clouston Hidrotic Ectodermal Dysplasia | Protein C Deficiency | Progressive External Ophthalmoplegia | Tyrosinemia | Palsy, Cerebral | Systemic Mastocytosis | Nephropathy | Macular Corneal Dystrophy Type 1 | Porphyria, Acute Intermittent | Familial Hyperaldosteronism | Carey-Fineman-Ziter Syndrome | Arthritis, Psoriatic | Galloway-Mowat Syndrome | DOCK8 Immunodeficiency Syndrome | Sleep Apnea, Central | Hereditary Multiple Exostoses | Dyggve-Melchior-Clausen Disease | Dystonia | Follicular Dendritic Cell Sarcoma | Exfoliative Dermatitis | Learning Disability | Hypertension, Pulmonary | Spermatocele | Albinism | Pulmonary Stenosis | Osteosarcoma | Hemimegalencephaly | Gestational Trophoblastic Disease | Atelosteogenesis Type 1 | Congenital Heart Block | Low Phospholipid Associated Cholelithiasis | Campomelic Dysplasia | Mitochondrial Encephalomyopathy | Paroxysmal Kinesigenic Dyskinesia | Osteoarthritis | Congenital Bile Acid Synthesis Defect | Giant Axonal Neuropathy | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Greenberg Dysplasia | Glioblastoma | Cutaneous Angiosarcoma | Microtia | Kashin-Beck Disease | Urticaria | Pre-eclampsia | Pancreatitis | Autoimmune Disease | Acne | Acute Tubular Necrosis | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Lymphoma Lymphoblastic | Glaucoma, Congenital | Tenosynovial Giant Cell Tumor | Restrictive Dermopathy | Hereditary Neuropathy With Liability To Pressure Palsies | Van Der Knaap Disease | Blue Rubber Bleb Nevus Syndrome | Metabolic Diseases | Stroke | Anthrax | Congenital Poikiloderma | Placenta Previa | Dyskeratosis Congenita | Bronchiolitis | Orthostatic Intolerance | Chediak-Higashi Syndrome | Tyrosinemia Type 2 | Acute Myeloid Leukemia | Erythema Multiforme | Mosaic Variegated Aneuploidy Syndrome 2 | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Distal Spinal Muscular Atrophy | Sleep Disorder | Chondromyxoid Fibroma | Rubeosis Iridis | Episodic Ataxia Type 1 | Sick Sinus Syndrome 1 | Coffin-Siris Syndrome | Muir-Torre Syndrome | GAPO Syndrome | Early Infantile Epileptic Encephalopathy 28 | Asthma, Nocturnal | Gastrointestinal Disorders | Knobloch Syndrome | Spinocerebellar Ataxia Type 31 | Aldosterone Synthase Deficiency | Hemochromatosis Type 2 | Thrombophilia | Dengue Shock Syndrome | Small Lymphocytic Lymphoma | Hemorrhoids | Rift Valley Fever | Warsaw Breakage Syndrome | 5-oxoprolinase Deficiency | Subcortical Band Heterotopia | Subacute Sclerosing Panencephalitis | Atrioventricular Septal Defect | Myoclonus | Bulimia Nervosa | Neonatal Progeroid Syndrome | Agammaglobulinemia | Non-small Cell Lung Cancer | Nemaline Myopathy | Fanconi Anemia | Nail Disorder, Nonsyndromic Congenital | Keloid | Basal Ganglia Cerebrovascular Disease | Sclerosteosis 2 | Hydronephrosis | Polycythemia Vera | Alveolar Capillary Dysplasia | Gastroschisis | Pitt-Hopkins Syndrome | Niemann-Pick Disease, Type A | Chromosome 9q34.3 Deletion Syndrome | Rett Syndrome | Epilepsy | Keratosis, Seborrheic | Major Depression | Biotinidase Deficiency | Dysthymia | Atelosteogenesis Type 2 | Retinal Vasculitis | Graft-versus-host Disease | Erdheim-Chester Disease | Jalili Syndrome | Wolman Disease | Hemolytic Uremic Syndrome | Congenital Adrenal Hyperplasia 1 | Measles | Primary Familial Brain Calcification | Leukocyte Adhesion Deficiency | High Molecular Weight Kininogen Deficiency | Oculocutaneous Albinism Type 2 | Zellweger Syndrome | Neuroendocrine Cancer | Lymphangioleiomyomatosis | Castleman Disease | Melanoma | Haim-Munk Syndrome | Oligospermia | Mucolipidosis Type III | Focal Facial Dermal Dysplasia | Presbycusis | Charcot-Marie-Tooth Disease, Type 2A | Ependymoma | Vitiligo | Anorectal Malformations | Benign Recurrent Intrahepatic Cholestasis 1 | Congenital Central Hypoventilation Syndrome | Benign Familial Infantile Seizures | Purpura, Thrombotic Thrombocytopenic | Spinocerebellar Ataxia Type 17 | X-linked Sideroblastic Anemia | Sarcoma | Esophageal Adenocarcinoma | Meningococcal Meningitis | Optic Nerve Hypoplasia, Bilateral | Sclerosing Cholangitis | Pigment Dispersion Syndrome | Hemosiderosis | Fibromuscular Dysplasia | Neurodegeneration With Brain Iron Accumulation | Neuromyelitis Optica | Stargardt Disease | Heavy Chain Disease | Gastroenteritis, Eosinophilic | Kearns-Sayre Syndrome | Polymyalgia Rheumatica | Dyslipidemia | Fibrodysplasia Ossificans Progressiva | Endometrial Hyperplasia | Coronary Artery Disease | Pseudoexfoliation Syndrome | Paracoccidioidomycosis | Addison Disease | Lymphangiomatosis | Nicotine Dependence | Lymphopenia | Congenital Heart Defects | Primary Hyperoxaluria Type 3 | Progressive Familial Intrahepatic Cholestasis Type 2 | Encephalopathy, Hepatic | Pupil Disorders | Retinitis Pigmentosa 3 | Schizotypal Personality Disorder | Fucosidosis | 3-methylglutaconic Aciduria | Congenital Ichthyosiform Erythroderma | Microcephalic Primordial Dwarfism | Familial Episodic Pain Syndrome | Aneurysm, Abdominal Aortic | Azoospermia | Coffin-Lowry Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Impulse Control Disorder | Thyroiditis | Feingold Syndrome | Spondylocostal Dysostosis | Osteochondroma | Leber Hereditary Optic Neuropathy | Schuurs-Hoeijmakers Syndrome | Focal Cortical Dysplasia Type 2 | Anal Fissure | Blepharospasm | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Epithelial-myoepithelial Carcinoma | Schizencephaly | Fetal And Neonatal Alloimmune Thrombocytopenia | Thin Basement Membrane Disease | Hermansky-Pudlak Syndrome | Connective Tissue Disorders | Primary Torsion Dystonia | GNE Myopathy | Waardenburg Syndrome Type 1 | Glutaric Aciduria Type 2 | Sarcoma, Ewing | Parvovirus B19 Infection | Neurogenic Bladder | Chronic Myeloid Leukemia | Cholestasis, Intrahepatic | Usher Syndrome Type I | Werner's Syndrome | Erythrokeratodermia Variabilis | Ganglioglioma | Cyclic Vomiting Syndrome | Leukoplakia | Glycogen Storage Disease Type 3 | NGLY1 Deficiency | Myelofibrosis | Traboulsi Syndrome | Cataplexy | Uremic Pruritus | Yellow Fever | Wagner Disease | Kaposiform Hemangioendothelioma | Chondrodysplasia Punctata 1, X-linked Recessive | Sarcomatoid Carcinoma Of The Lung | Neural Tube Defect | Myopathy | Wolcott-Rallison Syndrome | Trichuriasis | Dystonia Musculorum Deformans | Fascioliasis | Spondyloperipheral Dysplasia | Osmotic Demyelination Syndrome | Arthropathy | Vasculitis | Smoldering Myeloma | Spinocerebellar Ataxia Type 8 | Hyperinsulinemia | Von Willebrand Disease | Hyper IgE Syndrome | Jacobsen Syndrome | Sjogren Syndrome | Hepatitis, Alcoholic | Prediabetes | Stomatitis | Preaxial Polydactyly | Waardenburg Syndrome Type 4 | Branchiootorenal Syndrome | Leukocyte Adhesion Deficiency Type 1 | Auriculocondylar Syndrome | Systemic Lupus Erythematosus | Milk Allergy | Filariasis | Hypercholesterolemia | Long QT Syndrome Type 1 | Cerebellofaciodental Syndrome | Sweet Syndrome | Hyperandrogenemia | Demyelinating Diseases | Cyst | Sick Sinus Syndrome | Nephrotic Syndrome Type 1 | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Vici Syndrome | Nail-Patella Syndrome | Lactose Intolerance | Situs Inversus | Impetigo | Juvenile Polyposis | Keratopathy | Cancer, Bladder | AIDS Dementia Complex | Myositis, Focal | Nicotine Addiction | Osteitis | Amelogenesis Imperfecta | Cysticercosis | Anorectal Fistula | B-cell Chronic Lymphocytic Leukemia | Spondyloepiphyseal Dysplasia Tarda, X-linked | Familial Cerebral Amyloid Angiopathy | Pulmonary Veno-occlusive Disease | Frontotemporal Dementia | Restless Legs Syndrome | Renal Medullary Carcinoma | Exocrine Pancreatic Insufficiency | Acrocallosal Syndrome | Optic Neuritis | Esophagitis, Eosinophilic | MIRAGE Syndrome | Cockayne Syndrome | Xeroderma Pigmentosum | PASLI Disease | Bipolar Disorder | Hypotrichosis Simplex | Inflammatory Myofibroblastic Tumor | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Norrie Disease | Neovascular Glaucoma | Hyperparathyroidism-jaw Tumor Syndrome | Reye Syndrome | Sengers Syndrome | Glutaric Aciduria Type 3 | Nestor-Guillermo Progeria Syndrome | C3 Glomerulopathy | Gout | Antisynthetase Syndrome | Paronychia | Phenylketonuria | Spinocerebellar Ataxia | Ectodermal Dysplasia | Snyder-Robinson Syndrome | Vitreoretinopathy, Proliferative | Pseudohypoparathyroidism Type 2 | Seborrheic Dermatitis | Neurofibroma | Dystrophy, Cone-rod | Autonomic Nervous System Disorders | Best Macular Dystrophy | Spondylocarpotarsal Synostosis Syndrome | Fukuyama Congenital Muscular Dystrophy | Lipoma | Periventricular Nodular Heterotopia | Atherosclerosis | Charcot-Marie-Tooth Disease Type 3 | Spinocerebellar Ataxia Type 40 | Osteogenesis Imperfecta Type IV | Schistosomiasis | Genee-Wiedemann Syndrome | Cutis Laxa | Hidradenitis Suppurativa | Mucolipidosis | Achromatopsia | Cutaneous Mastocytosis | Hepatic Steatosis | Hypopituitarism