Castleman Disease

About the Disease
Castleman Disease, also known as angiofollicular ganglionic hyperplasia, is related to multicentric castleman disease and polyclonal hypergammaglobulinemia. An important gene associated with Castleman Disease is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Thalidomide and Zanubrutinib have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone marrow and bone, and related phenotypes are fatigue and anemia

Common Targets
HSP90AB1 | MS4A1 | Casein kinase II (CKII) | MEFV | IL6R | TNFRSF1A | G3569 | G3320

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