Holoprosencephaly

About the Disease
Holoprosencephaly, also known as holoprosencephaly sequence, is related to holoprosencephaly 9 and holoprosencephaly 7. An important gene associated with Holoprosencephaly is FGFR1 (Fibroblast Growth Factor Receptor 1), and among its related pathways/superpathways are Signal Transduction and Signaling by Hedgehog. Affiliated tissues include Primitive Streak, brain and eye, and related phenotypes are abnormal facial shape and holoprosencephaly

Common Targets
GLI2 | FAT1 | TGIF1 | SUFU | FGFR1 | SMC1A | PTCH1 | RAD21 | FGF8 | GAS1 | DISP1 | STIL | KMT2D | DLL1 | SHH | ZIC2 | SMC3 | PLCH1 | BOC | SIX3 | STAG2

Note: If you'd like to get a target analysis report for Holoprosencephaly, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Holoprosencephaly at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Spondylo-ocular Syndrome | Measles | Pseudohypoparathyroidism Type 1C | Rhinitis | Apert Syndrome | Thrombasthenia | Gastritis, Atrophic | Hennekam Lymphangiectasia-lymphedema Syndrome | Carney Triad | Fraser Syndrome | Periodic Limb Movement Disorder | Progressive External Ophthalmoplegia | Lathosterolosis | Ocular Surface Squamous Neoplasia | Tetanus | Astigmatism | Gilbert Syndrome | Lymphoma, B-cell | Epithelial-myoepithelial Carcinoma | Focal Cortical Dysplasia Type 2 | Vitelliform Macular Dystrophy | Meesmann Corneal Dystrophy | Alkaptonuria | Duodenal Atresia | Colitis, Collagenous | Hyper IgE Syndrome | Rubinstein-Taybi Syndrome | Anencephaly | Knobloch Syndrome | Pleomorphic Xanthoastrocytoma | Persistent Fetal Circulation | Acanthosis Nigricans | Sengers Syndrome | Systemic Lupus Erythematosus | Constipation | Hypervalinemia | Marinesco-Sjogren Syndrome | Prolidase Deficiency | Vulvovaginitis | Hyperostosis | Pierson Syndrome | Hemangioma | Hypersomnia | Congenital Stationary Night Blindness | Chudley-McCullough Syndrome | Chronic Lymphocytic Leukemia | Hemochromatosis Type 2 | Vestibular Disease | Tinea | Scleroderma, Diffuse | Intestinal Hypomagnesemia 1 | Angioedema, Hereditary | Pheochromocytoma | Familial Pheochromocytoma-paraganglioma | Emery-Dreifuss Muscular Dystrophy | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Renal Oncocytoma | Olmsted Syndrome | Hepatitis A | Cataplexy | Cellulitis | Burn-McKeown Syndrome | Methemoglobinemia Type IV | Cramp Fasciculation Syndrome | Acrodermatitis Enteropathica | Argininosuccinic Aciduria | Shprintzen-Goldberg Syndrome | Rotor Syndrome | Polymicrogyria | Lesch-Nyhan Syndrome | Tyrosine Hydroxylase Deficiency | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Retinal Dystrophy | Klinefelter Syndrome | Cone Dystrophy | Neurocutaneous Melanocytosis | Androgenic Alopecia | Periodontitis | Barrett Esophagus | Pulmonary Tuberculosis | Non-proliferative Diabetic Retinopathy | Pulmonary Vein Stenosis | LRBA Deficiency | Saethre-Chotzen Syndrome | Sclerosteosis 2 | Inflammatory Bowel Disease | Castleman Disease | X-linked Sideroblastic Anemia | Absence Epilepsy | Crouzon Syndrome With Acanthosis Nigricans | Trimethylaminuria | Polycystic Liver | Melanoma | Spinocerebellar Ataxia Type 20 | Thrombocythemia, Essential | Lymphangioleiomyomatosis | Thyroid Dysgenesis | Hypertension | Vitiligo | Anorectal Fistula | Hepatitis, Chronic | Dementia | Fowler's Syndrome | Giant Axonal Neuropathy | Pneumoconiosis | Senior-Loken Syndrome | Diabetic Encephalopathy | Ameloblastic Carcinoma | Hypertensive Nephropathy | Abetalipoproteinemia | Epidermolysis Bullosa Simplex, Generalized | Calcium Pyrophosphate Deposition Disease | Pyloric Stenosis, Infantile Hypertrophic | Amyotrophic Lateral Sclerosis, Juvenile | Usher Syndrome Type III | Oculocutaneous Albinism | Syndactyly | CHOPS Syndrome | Cancer, Prostate | Cat Eye Syndrome | Progressive Familial Intrahepatic Cholestasis Type 2 | Mood Disorder | Lymphedema | Angiosarcoma Of The Breast | Danon Disease | Cervicitis | Porokeratosis | Conn Syndrome | Ichthyosis, X-linked | Spinocerebellar Ataxia Type 21 | Discoid Lupus Erythematosus | Alpha-1 Antitrypsin Deficiency | Tibial Muscular Dystrophy | Nemaline Myopathy | Wolman Disease | Mitochondrial DNA Depletion Syndrome | Esthesioneuroblastoma | Tuberculosis | Dentinogenesis Imperfecta | Celiac Disease | Meningococcal Infections | Long QT Syndrome Type 3 | Adenylosuccinate Lyase Deficiency | Glucagonoma | Juvenile Xanthogranuloma | Esotropia | Pulmonary Alveolar Microlithiasis | Sickle Cell Anemia | HANAC Syndrome | Idiopathic Pulmonary Fibrosis | Herpes Genitalis | Trigonocephaly | Leukemia-lymphoma, Adult T-cell | Stargardt Disease | Methemoglobinemia | Familial Male-limited Precocious Puberty | Meniere's Disease | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Adrenomyeloneuropathy | Alzheimer Disease, Late Onset | Glycogen Storage Disease Type 3 | Hemorrhoids | Cockayne Syndrome | Amyloidosis | Peters-plus Syndrome | Esophageal Carcinoma | Schwannomatosis | Babesiosis | Sclerocornea | Lactose Intolerance | Epilepsy Of Infancy With Migrating Focal Seizures | Axenfeld-Rieger Syndrome | Cystinuria | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Heroin Dependence | Multiple Epiphyseal Dysplasia | Glycogen Storage Disease Type 1a | Pseudo-pseudohypoparathyroidism | Megaloblastic Anemia | Fibromyalgia | Lamellar Ichthyosis | Lyme Disease | Chitayat Syndrome | Familial Episodic Pain Syndrome | Hyperbilirubinemia | Epidermolysis Bullosa Dystrophica | Fuchs Dystrophy | Frontotemporal Dementia | Carpenter Syndrome | Thalassemia | Gitelman Syndrome | Spitzoid Melanoma | Menkes Disease | Carbonic Anhydrase VA Deficiency | Guttate Psoriasis | Cyst | Hernia, Inguinal | Stevens-Johnson Syndrome | Keratosis, Actinic | Noonan Syndrome-like Disorder With Loose Anagen Hair | Paraganglioma | Pure Autonomic Failure | Colitis, Microscopic | McCune-Albright Syndrome | Dermatitis | Pure Red Cell Aplasia | Prostatitis | Hyperparathyroidism-jaw Tumor Syndrome | Congenital Mirror Movements | Metabolic Diseases | Opisthorchiasis | Rheumatoid Arthritis | Waardenburg Syndrome Type 4 | Charcot-Marie-Tooth Disease Type 4B1 | Peeling Skin Syndrome Type B | Congenital Ichthyosiform Erythroderma | Progressive Myoclonic Epilepsy | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Agnathia-Otocephaly Complex | Choroideremia | Papulopustular Rosacea | Multiple Sclerosis | Neurofibromatosis Type 1 | Chorea | Spinocerebellar Ataxia Type 13 | Cheilitis | Restrictive Dermopathy | Craniosynostosis | Cholestasis, Intrahepatic | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Retinal Vasculitis | Large Granular Lymphocytic Leukemia | Blepharitis | Osteoglophonic Dysplasia | Holoprosencephaly | Hepatic Steatosis | Diabetic Neuropathy | Vitamin B12 Deficiency | Leiomyoma | Shwachman-Bodian-Diamond Syndrome | Polycystic Kidney, Autosomal Recessive | Autoimmune Disease | Epidermal Nevus Syndrome | Osteogenesis Imperfecta Type III | Pulmonary Sclerosing Hemangioma | Pseudomyxoma Peritonei | Nemaline Myopathy 10 | Viral Meningitis | Bone Marrow Necrosis | Craniometaphyseal Dysplasia | Chordoma | Hemophilia | Long QT Syndrome Type 2 | Congenital Stromal Corneal Dystrophy | Giant Cell Arteritis | Toxoplasmosis | Ectopia Lentis, Isolated, Autosomal Recessive | Infertility, Male | Cyclic Vomiting Syndrome | Lattice Corneal Dystrophy | Long QT Syndrome Type 1 | Pyelonephritis | Amish Infantile Epilepsy Syndrome | Adenoid Cystic Carcinoma | Aicardi-Goutieres Syndrome | Waardenburg Syndrome Type 4A | Kohlschutter-Tonz Syndrome | Hypogonadism | Basal Ganglia Disease, Biotin-responsive | Congenital Muscular Dystrophy | Lichen Sclerosus | Waardenburg Syndrome Type 2 | Sorsby Fundus Dystrophy | Scapuloperoneal Spinal Muscular Atrophy | Neurodegeneration With Brain Iron Accumulation | Otitis Media | Tuberculous Meningitis | Myositis, Focal | Congenital Primary Aphakia | Acute Chest Syndrome | Acute Lung Injury | DRESS Syndrome | Familial Hypobetalipoproteinemia | Isovaleric Acidemia | Granular Corneal Dystrophy Type 1 | Toxic Epidermal Necrolysis | Angiosarcoma | Seizures-scoliosis-macrocephaly Syndrome | Enterocolitis, Necrotizing | Keratoconjunctivitis | Ureteropelvic Junction Obstruction | Benign Hereditary Chorea | Paraplegia | Primary Erythromelalgia | Diabetes Gestational | Acute Motor Axonal Neuropathy | IMAGe Syndrome | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Adenoma, Pleomorphic | Pierre Robin Syndrome | Trichorhinophalangeal Syndrome | Oculopharyngeal Muscular Dystrophy | Graves Disease | Myopathy | Huntington's Disease | Ophthalmia, Sympathetic | Reticular Dysgenesis | Congenital Myopathy | Smoldering Myeloma | Achromatopsia | Paget's Disease Of The Breast | Tinea Versicolor | Lymphoproliferative Disorders | Sporadic Inclusion Body Myositis | Cholesteryl Ester Storage Disease | Primary Hyperoxaluria Type 1 | Proopiomelanocortin Deficiency | Glycogen Storage Disease Type 1 | Coloboma | Wilson's Disease | Metachondromatosis | Cardiofaciocutaneous Syndrome | Lafora Disease | Proteus Syndrome | Retinal Diseases | Malaria | Encephalopathy, Hepatic | Anti-glomerular Basement Membrane Disease | 3-methylglutaconic Aciduria Type I | Myofibrillar Myopathy | Hemophagocytic Lymphohistiocytosis | Coronary Heart Disease | Blastomycosis | Globozoospermia | Motor Neuron Diseases | Pulmonary Capillary Hemangiomatosis | Schindler Disease | Glutaric Aciduria Type 1 | Synpolydactyly | Polyradiculopathy | Ulcerative Colitis | Low Phospholipid Associated Cholelithiasis | Mixed Connective Tissue Disease | Ellis-Van Creveld Syndrome | Incontinentia Pigmenti | Hyperuricemia | Proximal Symphalangism | Hypotonia-cystinuria Syndrome | ACTH-independent Macronodular Adrenal Hyperplasia | Short-chain Acyl-CoA Dehydrogenase Deficiency | Spermatocele | Prolactinoma | Delayed Sleep Phase Syndrome | Colitis | Histoplasmosis | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Cardiomyopathy, Peripartum | Hydronephrosis | Ichthyosis | Primary Aldosteronism | Pseudohypoparathyroidism Type 1A | Neurocysticercosis | Treacher Collins Syndrome | Gingivitis | Schizophrenia | Disseminated Superficial Actinic Porokeratosis | Pulmonary Alveolar Proteinosis | Synovitis | Acute Kidney Injury | Donnai-Barrow Syndrome | Azoospermia | Idiopathic Multicentric Castleman Disease | Paronychia | Polycythemia Vera | Renal Failure | Hypolipoproteinemia | Triphalangeal Thumb-polysyndactyly Syndrome | Personality Disorders | Triple A Syndrome | Hemorrhagic Disorders | Cryoglobulinemia | Guanidinoacetate Methyltransferase Deficiency | Hashimoto Thyroiditis | Spinocerebellar Ataxia Type 14 | Chronic Granulomatous Disease, X-linked | Primary Lateral Sclerosis | Acrodermatitis | Medulloblastoma | Pontocerebellar Hypoplasia | Blastoma, Pleuropulmonary | Benign Familial Neonatal Convulsions | Tracheal Disorders | Thin Basement Membrane Disease | Spondylocostal Dysostosis | Chromosome 5q Deletion Syndrome | Oligoastrocytoma | Nephropathy | Methylmalonic Acidemia | Allergic Contact Dermatitis