Merkel Cell Carcinoma

About the Disease
Merkel Cell Carcinoma, also known as cutaneous neuroendocrine carcinoma, is related to skin carcinoma and skin benign neoplasm. An important gene associated with Merkel Cell Carcinoma is KRT20 (Keratin 20), and among its related pathways/superpathways are Signal Transduction and PI3K-Akt signaling pathway. The drugs Ipilimumab and Cemiplimab have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and brain, and related phenotypes are merkel cell skin cancer and cellular immunodeficiency

Common Targets
KDR | GH1 | mTOR complex 1 | G3845 | NCAM1 | HDAC3 | FLT3 | PTCH1 | TNC | NOTCH4 | RET | SSTR3 | G7015 | CTLA4 | G4193 | G7157 | PDGFRA | TLR9 | GRIN2A | TEK | CIT | RB1 | G673 | GPC3 | KIT | PIK3C2B | G472 | CD8 | mTOR complex 2 | LAMP1 | G7099 | EPHA2 | G5133 | G596 | TOP2A | ATOH1 | NOTCH2 | PRUNE2 | SSTR5 | G2146 | REG3A | SHH | G29126 | TLR7 | SSTR1 | G2475 | HDAC2 | ZNF837 | G925 | HRAS | PIK3CA | G1956 | G207 | G5243 | TLR8 | CD3 Complex (T Cell Receptor Complex) | GLI1 | PML | THOC5 | PPM1D | NOTCH3 | SSTR2 | Tubulin | DUSP2 | G4851 | HDAC1 | G4233

Note: If you'd like to get a target analysis report for Merkel Cell Carcinoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Merkel Cell Carcinoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Tonsillitis | Okihiro Syndrome | Fanconi Syndrome | Genitopatellar Syndrome | Idiopathic Multicentric Castleman Disease | Pseudoachondroplasia | Fetal Akinesia Deformation Sequence | 3-methylglutaconic Aciduria Type I | Osteoporosis | Hereditary Mixed Polyposis Syndrome | Dysgerminoma | Vulvovaginitis | Rift Valley Fever | Sarcosinemia | Tangier Disease | Meniere's Disease | Cataract | Larsen Syndrome | Gastritis, Atrophic | Protein C Deficiency | Shprintzen-Goldberg Syndrome | Autosomal Recessive Bestrophinopathy | Ollier Disease | Epidermolysis Bullosa Simplex | Neurocutaneous Melanocytosis | Hereditary Coproporphyria | Melanoma | Feingold Syndrome | Ventricular Septal Defect | Erythrokeratodermia Variabilis | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Chronic Kidney Disease | Facioscapulohumeral Muscular Dystrophy | Kaposiform Hemangioendothelioma | X-linked Creatine Transporter Deficiency | Pulmonary Alveolar Microlithiasis | Carney Triad | Lymphoma, AIDS-related | Crigler-Najjar Syndrome | Urofacial Syndrome | Acute Leukemia | Hyperlipidemia | Hypoparathyroidism | Meningitis | Teratozoospermia | Optic Nerve Diseases | Oligoasthenoteratozoospermia | Alveolar Capillary Dysplasia | Long QT Syndrome Type 1 | Neurofibrosarcoma | Gastritis | Lichen Sclerosus | Erythromelalgia | Pseudohypoparathyroidism Type 2 | Conjunctivitis, Allergic | Hepatic Steatosis | Heart Block | Iron Deficiency Anemia | Distal Myopathy | Thymoma, Malignant | Hodgkin Lymphoma | Chromosome 16p11.2 Deletion Syndrome | Osteogenesis Imperfecta Type I | Hemosiderosis | Gyrate Atrophy Of The Choroid And Retina | Celiac Disease | Alagille Syndrome | Budd-Chiari Syndrome | Congenital Bile Acid Synthesis Defect | Congenital Hereditary Endothelial Dystrophy Type I | VACTERL Association | Demyelinating Diseases | Prostatitis | Carbamoyl Phosphate Synthetase I Deficiency | Persistent Hyperplastic Primary Vitreous | Leukocyte Adhesion Deficiency | Cancer, Prostate | Stroke, Ischemic | Oculopharyngeal Muscular Dystrophy | Wiskott-Aldrich Syndrome | Cold-induced Sweating Syndrome | Immunoproliferative Disorders | Epidermolysis Bullosa Acquisita | Vertebrobasilar Insufficiency | Hypocalcemia | Waardenburg Syndrome Type 4A | Skin Carcinoma | Otopalatodigital Syndrome Type 2 | Colitis | Sickle Cell Disease | Superficial Spreading Melanoma | Cohen Syndrome | Nephritis, Interstitial | Porphyria Cutanea Tarda | Werner's Syndrome | Histoplasmosis | ACTH-independent Macronodular Adrenal Hyperplasia | Bleeding Disorder Due To CalDAG-GEFI Deficiency | CEDNIK Syndrome | Anorectal Malformations | Hypotrichosis Simplex | Pulmonary Alveolar Proteinosis | Genee-Wiedemann Syndrome | 3C Syndrome | Pierson Syndrome | Endophthalmitis | Benign Familial Pemphigus | Diabetes Insipidus, Nephrogenic | Situs Inversus | Pyruvate Decarboxylase Deficiency | Vascular Cognitive Impairment | Cartilage Disorders | Sarcoma, Alveolar Soft Part | Cryptococcal Meningitis | Hyperlipidemia, Familial Combined | Myofibrillar Myopathy | Giant Cell Arteritis | Pitt-Hopkins Syndrome | Craniofrontonasal Syndrome | Anosmia, Congenital | Primary Sclerosing Cholangitis | Dysplastic Nevus | Acute Chest Syndrome | Hypertension, Pulmonary | Jawad Syndrome | Stroke, Hemorrhagic | Neural Tube Defect | Familial Thoracic Aortic Aneurysm | Pantothenate Kinase-associated Neurodegeneration | CREST Syndrome | Polycystic Kidney, Autosomal Recessive | Ischemia | Multiple Sclerosis, Relapsing-remitting | Glycogen Storage Disease Type 0 | Polymyositis | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Cutaneous T-cell Lymphoma | Mitochondrial DNA Depletion Syndrome | Bronchiectasis | Bronchitis, Chronic | Hyperkalemic Periodic Paralysis | Adenomyosis | Auriculocondylar Syndrome | Empyema | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Galloway-Mowat Syndrome | Multiple Epiphyseal Dysplasia | Corticobasal Syndrome | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Sarcoma, Ewing | Motor Neuron Diseases | Distal Myopathy 2 | Multiple System Atrophy | Restless Legs Syndrome | Gynecomastia | Early Infantile Epileptic Encephalopathy | Mitochondrial Myopathy | Angiosarcoma | Discoid Lupus Erythematosus | Blood Protein Disorders | Sclerosteosis | Gastroenteritis, Eosinophilic | Neutropenia | Pemphigoid | Osteogenesis Imperfecta Type V | Astrocytoma, Anaplastic | Leukodystrophies | Cystinuria | Vasculitis | Scoliosis | Bare Lymphocyte Syndrome | Intellectual Disability, Autosomal Dominant 5 | Congenital Aniridia | Ureteropelvic Junction Obstruction | Saethre-Chotzen Syndrome | Waardenburg Syndrome Type 4 | Myotonia | Basal Ganglia Disease, Biotin-responsive | Histiocytic Sarcoma | PHARC Syndrome | Kindler Syndrome | Spinocerebellar Ataxia Type 10 | Stroke | Chorea-acanthocytosis | Corneal Dystrophies, Hereditary | Tricho-hepato-enteric Syndrome | Waldenstrom Macroglobulinemia | Hepatopulmonary Syndrome | Desmosterolosis | Leri Pleonosteosis | Progressive Familial Intrahepatic Cholestasis Type 1 | Anti-glomerular Basement Membrane Disease | Localized Scleroderma | Congenital Tufting Enteropathy | Tumoral Calcinosis | Williams Syndrome | Sick Sinus Syndrome | Nemaline Myopathy | Arrhythmogenic Right Ventricular Cardiomyopathy | Pityriasis Rubra Pilaris | Primary Familial Brain Calcification | Lymphoma Lymphoblastic | Pigment Dispersion Syndrome | Hypersomnia | Coloboma | Congenital Adrenal Hyperplasia | Oculocutaneous Albinism Type 1 | Addison Disease | Hidradenitis Suppurativa | Trichomegaly | Scabies | Hypophosphatasia | Autosomal Recessive Spastic Paraplegia Type 54 | Primary Hyperoxaluria | Withdrawal Syndrome | Kaposi Sarcoma | Myotonic Disorders | Renal Hypomagnesemia 3 | Porencephaly | Macrophagic Myofasciitis | Lichen Planus | Fahr Disease | Huntington's Disease | Chiari Malformation Type I | Basan Syndrome | Neurofibromatosis | Conduct Disorder | Major Depression | Bethlem Myopathy | Vitamin B12 Deficiency | Stomatitis | Hereditary Spherocytosis | Alpha-thalassemia Myelodysplasia Syndrome | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | MELAS Syndrome | VACTERL/VATER Association | Retinal Vasculitis | Hypotonia-cystinuria Syndrome | Donnai-Barrow Syndrome | Emery-Dreifuss Muscular Dystrophy | Charcot-Marie-Tooth Disease Type 2E | Blue Rubber Bleb Nevus Syndrome | Glomerulonephritis, Membranous | Hemochromatosis Type 1 | Adenylosuccinate Lyase Deficiency | Choroiditis | Carpal Tunnel Syndrome | Anodontia | Juvenile Xanthogranuloma | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Cholelithiasis | Pneumococcal Meningitis | Esophageal Carcinoma | LEOPARD Syndrome | Phenylketonuria II | Spondylosis | Stargardt Disease | Fundus Albipunctatus | Rhabdomyosarcoma, Embryonal | Mabry Syndrome | Dermatitis | Alpers Syndrome | Hyperostosis | Waardenburg Syndrome Type 2 | Trichothiodystrophy | Hyperinsulinemia | Sponastrime Dysplasia | Tyrosinemia Type 1 | Proctitis | Long QT Syndrome Type 3 | Mountain Sickness | Macular Degeneration | Miyoshi Myopathy | Jacobsen Syndrome | Hydrops Fetalis | Barrett Esophagus | Glycogen Storage Disease Type 9 | Multiple Sclerosis, Chronic Progressive | Charcot-Marie-Tooth Disease, Type 2 | Choriocarcinoma | Pierpont Syndrome | Thrombocythemia, Essential | Spitzoid Melanoma | Gliosarcoma | Batten Disease | Leri-Weill Dyschondrosteosis | Hemolytic Uremic Syndrome, Atypical | Spinocerebellar Ataxia Type 3 | Actinomycetoma | Tylosis With Esophageal Cancer | Porphyria, Acute Intermittent | Vertigo | Congenital Myasthenic Syndrome | Leishmaniasis, Cutaneous | Primary Progressive Aphasia | Intermittent Claudication | Coffin-Lowry Syndrome | Seizures | Charcot-Marie-Tooth Disease Type 2T | Charcot-Marie-Tooth Disease Type 4E | Congenital Sodium Diarrhea | Thrombophlebitis | Rheumatoid Arthritis | T-cell Chronic Lymphocytic Leukemia | Down Syndrome | Hepatoblastoma | Congenital Disorders Of Glycosylation | Polycystic Kidney, Autosomal Dominant | Cardiomyopathy, Restrictive | Lennox-Gastaut Syndrome | Analgesia | Lymphomatoid Granulomatosis | Gastroschisis | Wolfram Syndrome | Sporadic Hemiplegic Migraine | Clouston Hidrotic Ectodermal Dysplasia | Wieacker-Wolff Syndrome | Chronic Enteropathy Associated With SLCO2A1 Gene | Osteopetrosis | Plasmacytoma | Preaxial Polydactyly | Varices | Renal Hypouricemia | Schuurs-Hoeijmakers Syndrome | Fucosidosis | Cenani-Lenz Syndactyly Syndrome | Lymphopenia | Portal Vein Thrombosis | Dysequilibrium Syndrome | Mucolipidosis Type IV | Smith-Magenis Syndrome | Congenital Bilateral Absence Of Vas Deferens | Osteoarthritis | Pseudohypoaldosteronism | Glomerulonephritis, Membranoproliferative | Metabolic Syndrome | Polyneuropathy | Allan-Herndon-Dudley Syndrome | Spitz Nevus | Hereditary Inclusion Body Myopathy | Agnathia-Otocephaly Complex | Asplenia | Glioblastoma Multiforme | Retinal Diseases | Antithrombin III Deficiency | Premenstrual Syndrome | Myopia | Brooke-Spiegler Syndrome | Christianson Syndrome | Cerebral Amyloid Angiopathy | Ocular Hypertension | Walker-Warburg Syndrome | Mixed Connective Tissue Disease | Malignant Fibrous Histiocytoma | Congenital Muscular Dystrophy | Babesiosis | Sturge-Weber Syndrome | Olmsted Syndrome | Hyperglycemia | Pemphigus | Cancer, Colon | CHARGE Syndrome | Dystrophy, Cone-rod | Mucolipidosis Type II | Pontocerebellar Hypoplasia Type 2 | Campomelic Dysplasia | DNA Ligase IV Deficiency | Neuroectodermal Tumors, Primitive | Tuberculosis | Gerstmann-Straussler-Scheinker Syndrome | B-cell Prolymphocytic Leukemia | Cholestasis, Intrahepatic | Hypermetropia | Hypercalcemia | Spinal Muscular Atrophy Type 2 | Oligoastrocytoma | Osteogenesis Imperfecta Type II | Keratoacanthoma | Partington Syndrome | Usher Syndrome | Diamond-Blackfan Anemia | Leiomyosarcoma | Waardenburg Syndrome Type 1 | Anorchia | Pneumonia, Mycoplasma | Carcinoid Tumor | Anorexia Nervosa | Cutaneous Mastocytosis | Usher Syndrome Type III | Spinal Muscular Atrophy | Hyperacusis | Diabetes Type 1 | Hepatitis, Alcoholic | Cardiofaciocutaneous Syndrome | IgA Nephropathy | Spinocerebellar Ataxia Type 16 | Azoospermia | Plasma Cell Leukemia | Sorsby Fundus Dystrophy | Chronic Periodontitis