Merkel Cell Carcinoma

About the Disease
Merkel Cell Carcinoma, also known as cutaneous neuroendocrine carcinoma, is related to skin carcinoma and skin benign neoplasm. An important gene associated with Merkel Cell Carcinoma is KRT20 (Keratin 20), and among its related pathways/superpathways are Signal Transduction and PI3K-Akt signaling pathway. The drugs Ipilimumab and Cemiplimab have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and brain, and related phenotypes are merkel cell skin cancer and cellular immunodeficiency

Common Targets
KDR | GH1 | mTOR complex 1 | G3845 | NCAM1 | HDAC3 | FLT3 | PTCH1 | TNC | NOTCH4 | RET | SSTR3 | G7015 | CTLA4 | G4193 | G7157 | PDGFRA | TLR9 | GRIN2A | TEK | CIT | RB1 | G673 | GPC3 | KIT | PIK3C2B | G472 | CD8 | mTOR complex 2 | LAMP1 | G7099 | EPHA2 | G5133 | G596 | TOP2A | ATOH1 | NOTCH2 | PRUNE2 | SSTR5 | G2146 | REG3A | SHH | G29126 | TLR7 | SSTR1 | G2475 | HDAC2 | ZNF837 | G925 | HRAS | PIK3CA | G1956 | G207 | G5243 | TLR8 | CD3 Complex (T Cell Receptor Complex) | GLI1 | PML | THOC5 | PPM1D | NOTCH3 | SSTR2 | Tubulin | DUSP2 | G4851 | HDAC1 | G4233

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