Stroke

About the Disease
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

Common Targets
CXADR | F12 | KCNQ2 | GCGR | Monoamine oxidase (MAO) (nonspecified subtype) | CASZ1 | CA4 | CDK7 | LOC105375175 | SH3PXD2A | CDK1 | TCF7L2 | GRIN2B | FLT3 | GSK3A | ACTB | CUBN | ADRA2C | ALOX15 | RPS6KA4 | IL4 | MTHFR | NADPH Oxidase (nonspecified subtype) | Fibrinogen | Superoxide dismutase (SOD) (nonspecified subtype) | CYP19A1 | GSTP1 | HMOX1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | Histone deacetylase (nonspecified subtype) | TBXAS1 | GPR55 | SLC29A2 | BDKRB2 | SLC5A2 | NT5C2 | CHEK2 | SCN2A | SIRT2 | FUT6 | Serine/threonine-protein kinase (PAK) (nonspecified subtype) | GJB2 | HTR7 | MAS1L | ADK | Prostaglandin EP Receptor (nonspecified subtype) | ITGAM | Glutamate Receptor Ionotropic AMPA Receptor | LINC01394 | CETP | PHACTR1 | CASP7 | LPL | MLKL | F9 | P2RY1 | Proteasome Complex | RGS7 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | ENPP2 | AK8 | PIK3CG | SLC9A1 | DUSP3 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | JAK3 | MMUT | G5243 | G6647 | EDNRA | VWF | CACNA1B | P2RX1 | TAFA5 | G5599 | MPO | NTRK2 | SLC28A3 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | PDE4D | G6714 | TLR7 | KCNAB2 | IL10 | CSF3 | m-Calpain | Cyclin B (nonspecified subtype) | ILF3 | JAK1 | GHRL | GAPDH | PMF1 | CISD2 | Kainate Receptor (GluR) (nonspecified subtype) | Integrin alpha4beta1 (VLA-4) receptor | AURKA | DTL | CDH13 | G3309 | Protein Phosphatase 2A | SCN10A | HPS4 | Calpain (nonspecified subtype) | IFNB1 | G114548 | Integrin alphaMbeta2 (MAC-1) Receptor | LDLR | ABCD4 | RORC | SLC12A3 | NOTCH3 | AVPR1A | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | C1S | FKBP4 | CRBN | PDK1 | Voltage-gated K(v) channel (nonspecified subtype) | GRIN2C | PREP | BDNF | GRIK1 | PTGES | P2Y purinoceptor (nonspecified subtype) | RYR1 | KDR | gamma-Secretase | G1956 | DGAT1 | SRR | KCNA3 | GRM5 | TLR8 | GRIN1 | L-type voltage-dependent calcium channel complex | Cyclophilins (nonspecified subtype) | EPHB3 | Serine/Threonine Kinase (nonspecified subtype) | SYNE2 | Glycogen phosphorylase (nonspecified subtype) | AQP4 | PTGER3 | CCNH | G7124 | NPY1R | CDK2 | KCNK18 | Kir 3.1/3.4 | Tyrosine-Protein Kinases Src (nonspecified subtype) | NOS1 | ACP1 | JAK2 | Cyclin-dependent kinase (nonspecified subtype) | AHCY | NDUFB6 | GNB3 | LRRK2 | ALOX5AP | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | Interleukin-1 (nonspecified subtype) | CSK | NR3C2 | IKBKB | CDK5/p25 | NR1H2 | OPRK1 | STRIP1 | ADRA2B | FLG | RPS6KA3 | CYP2C19 | KCND3 | VKORC1 | PDK2 | IPO11 | PDE4B | AVPR1B | MGLL | beta-Secretase (nonspecified subtype) | HDAC6 | HMOX2 | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | AMP-activated protein kinase (AMPK) | LPAR1 | ADIPOQ | LOC105377732 | Phospholipase A2 (nonspecified subtype) | EGR1 | G3620 | Integrin alphavbeta3 (vitronectin) receptor | RTN4 | CTNNA2 | KCNQ3 | KYNU | ICAM4 | EPHX2 | ALOX12 | G1/S-specific cyclin-E (nonspecified subtype) | CD320 | HDAC5 | T-Type Calcium Channel | GABRB2 | MAPK11 | COL4A1 | SCD | SDC2 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CYP17A1 | G6774 | BTK | CALM1 | HIF1A | APLNR | C5 | NPM1 | HDAC7 | ROCK1 | OPRM1 | SDC4 | Heat shock protein 90 (nonspecified subtype) | SCARB1 | Casein kinase I (nonspecified subtype) | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | CLYBL | VIP | GABRG2 | CIRBP | IGFBP1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | CTSL | MMP3 | SIGMAR1 | AURKB | NR1H3 | CHRM1 | ACE | DSG3 | CDK6 | GRIK2 | ATP5IF1 | G3479 | CARD9 | KCNJ1 | Ribonucleoside-diphosphate reductase | GRIN2D | AMP Deaminase (nonspecified subtype) | MAP3K11 | RAMP2 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | IL1B | PTPRG | Phospholipase C (nonspecified subtype) | GRIA2 | KCNK2 | ALDH2 | NOX4 | G842 | LCK | FKBP1A | Alcohol Dehydrogenase (nonspecified subtype) | PPARA | CNR2 | Calcium channel (nonspecified subtype) | F3 | CDKN2B | GRM2 | FPR1 | G5728 | Lipoxygenase (nonspecified subtype) | G1432 | CSF3R | MMP12 | P2RX3 | S1PR4 | alpha-Secretase (nonspecified subtype) | Matrix Metalloproteinase (MMP) (nonspecified subtype) | NFATC2 | PDE10A | TYR | SGK2 | CDK5 | Glutamate Transporter (nonspecified subtype) | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | SMPD1 | CHRNA9 | G3569 | SLC9A3 | KCNN4 | POU5F1 | HTRA1 | Nicotinic alpha3beta4 Receptor | KEAP1 | SLC6A9 | NPY2R | PRPF8 | PANX1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | IAPP | Protein kinase C (nonspecified subtype) | ESR2 | ADORA2B | TYK2 | NTSR2 | PIK3CB | MTRNR2L8 | ANXA4 | APOC3 | CDK9/Cyclin T1 | alpha-Adrenoceptor (nonspecified subtype) | Opioid receptor (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | F10 | DDR2 | Chloride channel (nonspecified subtype) | PCSK9 | AVPR2 | RNF213 | Neurotrophic Factor (nonspecified subtype) | ADORA1 | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | Adenylate Cyclase (nonspecified subtype) | ZFHX3 | TRPM8 | PRKAG2 | Guanylate cyclase (nonspecified subtype) | HTR1A | HTR2B | LOC105375977 | PGAM5-KEAP1-NRF2 Complex | Amylin receptor | VCAM1 | HMGCR | G4780 | KIT | MAP2K1 | MAOA | VIPR1 | G23411 | UTS2R | Nicotinic alpha4beta2 receptor | SCN4A | TCN1 | NPPA | DRD2 | NF-kappaB (NFkB) | CA7 | NPPA-AS1 | Sphingomyelin phosphodiesterase (nonspecified subtype) | KCNE1 | SMPD2 | NR1I2 | Integrin alpha5beta1 (VLA-5) receptor | KCNJ3 | CDKN2B-AS1 | GIPR | LOC100507053 | ARHGEF7 | CHRNA7 | EDNRB | CASP4 | DYRK3 | ITGA4 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | ITGB2 | ABCA1 | G4137 | C3AR1 | PGR | BORCS7-ASMT | ICAM1 | CELSR2 | SH3YL1 | S1PR3 | G7852 | C10orf88 | G5595 | BCHE | KCNC3 | KCNQ Channels (K(v) 7) (nonspecified subtype) | DYRK1A | ZAP70 | TRPV2 | Estrogen receptor (nonspecified subtype) | CASP2 | PRKCH | ADRA2A | cAMP-Dependent protein kinase (PKA) | MMAA | LOC101928272 | GABA(A) receptor | SLC6A11 | SOD2 | CDK9 | CNR1 | Orexin receptor (nonspecified subtype) | CES1 | DLG4 | MAPK9 | HSD11B1 | IGFBP3 | TREM2 | PPARD | RORA | Interleukin-12 (IL-12) | G1029 | PYCARD | Anandamide membrane transporter (AMT) | HERC2 | G581 | GRIK3 | GABRB3 | 15-Lipoxygenase (nonspecified subtype) | DPP4 | TRPC6 | PLAT | GRM8 | CPB2 | G142 | KCNA5 | MIR210 | TCN2 | FOLR3 | PRKCD | MFN2 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | Tyrosine Kinase (nonspecified subtype) | PLG | NRP1 | BOLL | AKT2 | CAV1 | GRIN2A | EYS | Cysteine Protease (nonspecified subtype) | LHCGR | MAG | CCNT1 | RYR2 | KCNK3 | HDAC1 | P2RY12 | AKR1B1 | Pyruvate dehydrogenase kinase (nonspecified subtype) | ADORA2A | RTEL1 | GUCY1A1 | QSOX1 | CYP2R1 | TGFBR1 | TSPO | F2 | BACE1 | CASP8 | G9734 | COL4A2 | ADRB1 | SMARCA4 | FOXF2 | Heme Oxygenase (HO) (nonspecified subtype) | Trypsin (nonspecified subtype) | Voltage-Gated Sodium Channel Complex | KCNJ5 | TRPV1 | WDR12 | CXCR3 | CHRM3 | sigma Receptor (nonspecified subtype) | ADORA3 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | OPRD1 | SERPINE1 | CBS | NADSYN1 | PDE4C | IPO11-LRRC70 | STK17A | Kallikrein (nonspecified subtype) | Prostanoid TP receptor (nonspecified subtype) | LIPC | EPHA4 | XDH | KCNE3 | CCR9 | P2X Receptor (nonspecified subtype) | BCAT1 | FOLH1 | LRRC4 | CAPN1 | GCLM | Peptidylprolyl Isomerase (nonspecified subtype) | LPAR4 | CALCRL | GSTT1 | CDK1/Cyclin B | beta-Adrenoceptor (nonspecified subtype) | GSK3B | LINC02210-CRHR1 | ADCYAP1R1 | TRPM2 | NTRK1 | TRPM7 | PTGS1 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | CYP26A1 | STS | PTPN1 | MIR195 | ACHE | KCNE4 | NUAK Family SNF1-like Kinase (nonspcified subtype) | ABCC6 | PDE6D | PPARG | NR1H4 | PDE1B | Elastase (nonspecified subtype) | EDN1 | EPOR | HDAC4 | CYP26B1 | Solute carrier family 29 member (nonspecified subtype) | Actin (nonspecified subtype) | FLT4 | GRM3 | G3480 | SOX9 | SST | MMP13 | GGT1 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | FBXW7-AS1 | HSPA1A | Serine protease (nonspecified subtype) | ABCC8 | PTPRB | ADH5 | CRHR1 | Caspase (nonspecified subtype) | FAAH | KDM1A | CHI3L1 | G2099 | RORB | KCNE2 | PDE2A | CHRM5 | HTR6 | CLK1 | G3630 | TXNRD1 | FGFR1 | ENPP1 | GABRD | Sodium channel (nonspecified subtype) | SORD | GABRA5 | SERPINA1 | GRM1 | Heat shock protein 70 (nonspecified subtype) | L-Type calcium channel (nonspecified subtype) | KCNQ1 | GJA1 | CDK2/Cyclin A | CCNE1 | Cannabinoid receptor (nonspecified subtype) | CCKAR | LIMASI | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | F2RL3 | CORIN | Adenosine receptor (nonspecified subtype) | FLT1 | SIK2 | G836 | TMEM97 | Poly [ADP-ribose] polymerase (nonspecified subtype) | FASN | ITGB3 | BRSK1 | CYP4F2 | MAPK10 | Mitochondrial pyruvate carrier complex (MPC) | Mitogen-Activated Protein Kinase (nonspecified subtype) | KCNS3 | FPR2 | DYRK1B | FLNB | PON1 | Janus Kinase (nonspecified subtype) | HTR1B | SRSF2 | GC | ADAMTS2 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | PLA2G7 | MAGI1 | EIF2AK3 | Chemokine receptor (nonspecified subtype) | EGLN1 | G4318 | PLAU | Aurora Kinase (nonspecified subtype) | alpha-6 beta-2 Nicotinic receptor | TH | CA2 | PDE4A | MASP1 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | Nicotinic alpha9alpha10 Receptor | MAS1 | G196 | NOS3 | CDK5RAP3 | KCNH1 | F11 | GABRA2 | Angiotensin receptor (AT) (nonspecified subtype) | PARK7 | Cyclooxygenase (COX) (nonspecified subtype) | ADRB2 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | Complement Complex | CDK2/Cyclin E | CDK7/Cyclin H | alpha1-Adrenoceptor (nonspecified subtype) | LIPE | G7157 | ROCK2 | Imidazoline I2 receptor (I2) | F2R | Endothelin receptor (nonspecified subtype) | SLC6A4 | CYP4A11 | LYN | FUT2 | SH2B3 | LINC01492 | MAP2K2 | CTSB | KLKB1 | GAA | PNLIP | ANK2 | AGTR2 | FABP4 | NOX3 | PDE5A | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | CALCR | IL2 | Cyclin-dependent kinase inhibitor (nonspecified subtype) | CASP1 | GRM4 | Gamma-glutamyl transferase (nonspecified subtype) | 5-Hydroxytryptamine Receptor (nonspecified subtype) | APP | LOC100505841 | GPR39 | WDFY4 | APOB | NMDA receptor | AGTR1 | ND5 | CASP6 | DYRK2 | PARP2 | alpha-Amylase (nonspecified subtype) | AGER | C3 | Cyclin A (nonspecified subtype) | NAMPT | Nitric oxide synthase (NOS) (nonspecified subtype) | GPR182 | MIA3 | NT5E | GABRA6 | Ryanodine receptor (nonspecified subtype) | Glutamate Receptor Ionotropic (nonspecified subtype) | TRDMT1 | MMP2 | TUB | LRCH1 | Collagenase (nonspecified subtype) | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | GRK2 | Protein phosphatase-1 | NR3C1 | FAS | NMUR2 | MMP14 | G367 | SLC29A1 | G8878 | SLC2A4 | SERPING1 | KRR1 | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | G4233 | PDE1A | GPR17 | CCL2 | CYP27B1 | ABCC4 | REN | CRP | LPAR3 | PRKCE | HTR2A | TAAR1 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | CX3CR1 | SLC8A1 | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | CYP11B2 | LOC101928635 | CHRNB2 | NADPH Oxidase Complex | SLC1A2 | FYN | TRPA1 | LOC105377134 | Melanocortin receptor (nonspecified subtype) | VDR | LTA4H | LOC105372798 | GSTM1 | Glutathione peroxidase (nonspecified subtype) | ZDHHC6 | NOS2 | Potassium Channels (nonspecified subtype) | P2RX7 | RIPK1 | STING1 | Vasoactive intestinal polypeptide receptor (VIP-R) (nonspecified subtype) | Rho kinase (ROCK) (nonspecified subtype) | DRD3 | PDE7A | Epoxide Hydrolase (nonspecified subtype) | CHRM2 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | KCNB1 | GOLGB1 | CMA1 | ALOX5 | UCP2 | LIPG | CCR5 | MASTL | GYPA | G5743 | RHOA | TRPM3 | PDGFRA | PI3 | MFN1 | RET | G2146 | VHL | FGF2 | AOC3 | mu-Calpain (calpain 1) | DHFR | MAOB | NGF | HAAO | ADAMTS12 | PTAFR | Soluble guanylyl cyclase | SLC6A3 | CAPN2 | GLP1R | PTGER2 | NLRP3 Inflammasome | KMO

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