Chronic Myeloid Leukemia

About the Disease
Leukemia, Chronic Myeloid, also known as chronic myelogenous leukemia, is related to atypical chronic myeloid leukemia, bcr-abl1 negative and juvenile myelomonocytic leukemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia, Chronic Myeloid is ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways are Overview of interferons-mediated signaling pathway and VEGF Pathway (Tocris). The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related phenotypes are myeloproliferative disorder and splenomegaly

Common Targets
GSTP1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | G596 | CRBN | KDR | RASSF1 | YES1 | XRCC1 | G6714 | CTNNB1 | CAT | HCK | CYBA | DNA Methyltransferase (DNMT) (nonspecified subtype) | SOS1 | AURKA | G472 | CYP3A4 | ERCC5 | DNA-Directed DNA Polymerase Complex | FGR | ABL1 | SNCA | MYO15A | HSH2D | JAK2 | G3845 | SLC9A1 | SDC1 | Protein Phosphatase 2A | XPC | HLA-E | SOCS1 | MELK | SLC17A6 | IRF1 | MIR106B | UGT2A2 | G7015 | ASXL1 | Tyrosine-Protein Kinases Src (nonspecified subtype) | TFRC | SLIT2 | CSK | SLC22A1 | HMGCLL1 | BTK | MN1 | CTNNA1 | ETNK1 | CYP2D6 | Heat shock protein 90 (nonspecified subtype) | CYP2C19 | PARP9 | CCND2 | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | DNMT3A | MIR34A | KMT2C | IL2RA | CHEK1 | NPM1 | NF-kappaB (NFkB) | GFI1 | AURKB | AXL | Ephrin Receptor (nonspecified subtype) | CASP10 | Ribonucleoside-diphosphate reductase | LCK | Calcium channel (nonspecified subtype) | PSMB10 | GEMIN4 | GSTO1 | G598 | CD3 Complex (T Cell Receptor Complex) | G5133 | CHD5 | CSF1R | LOC102724428 | RRM2 | PRDM2 | SMC1A | KIT | HLA-G | RAD21 | TOP1 | SLAMF7 | CSF3R | G7852 | DDR2 | MIR3936HG | MAP2K1 | BCR | CYP1A1 | SEL1L3 | PIK3CD | DUSP21 | DEPP1 | CYP2C8 | DNA Topoisomerase II (nonspecified subtype) | DOCK4 | NR1I2 | CLEC12A | GCLC | G1029 | SLC22A8 | ABCC2 | GATA2 | PDGFRB | PPARD | SETBP1 | DPP4 | Tyrosine Kinase (nonspecified subtype) | G4170 | GSTO2 | PCBP1 | STAT5 (nonspecified subtype) | CYP11B1 | PPARG | SLC22A2 | ABCC9 | SOCS3 | NTRK1 | SERPINE1 | APAF1 | Heme Oxygenase (HO) (nonspecified subtype) | SLC10A1 | Interferon alpha/beta Receptor (nonspecified subtype) | G9429 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | BCL2A1 | DDX43 | BCL2L11 | MARK3 | MERTK | GSTT1 | DAPK1 | AURKC | MIR196B | FLT4 | TMC5 | G3630 | EPHB6 | PPP5C | GCLM | CD33 | MIR181A1 | DLX4 | IDH2 | PSMB2 | ERCC2 | IL1RAP | Transforming growth factor beta (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | SLC22A4 | MPL | FLT1 | FRK | CYP3A5 | G836 | CYP26B1 | TYRO3 | FGFR1 | ABCC8 | ARHGAP26 | BLK | G7157 | ROR1 | Heat shock protein 70 (nonspecified subtype) | TNFRSF17 | PAPPA | PTN | TEK | EPHA2 | SIK2 | TNK2 | DDR1 | IRF8 | G4193 | CYP2C9 | XRCC4 | PON1 | TNFRSF10D | MYB | FASLG | SRSF2 | Tubulin | NOX3 | LYN | CYP2B6 | SLC22A5 | ARHGAP45 | Histamine Receptor (HR) (nonspecified subtype) | MAP2K2 | SIK1 | PLK4 | RUNX1 | SH2B3 | VDR | HOXC9 | ALPK2 | FAS | SLCO1A2 | ABCA3 | WT1 | SMC3 | IFNG | HCN1 | G7124 | G2064 | NADPH Oxidase Complex | PHIP | RREB1 | ABCC1 | KMT2D | CYP1B1 | NQO1 | CREBBP | FLT3 | FYN | ABCC4 | SENP1 | PDGFRA | ANPEP | GSTM1 | HOXA4 | LTA4H | RET | MTHFR | VHL | ABCC3 | Proteasome Complex | AIDA | ALOX5 | SLCO1B3 | IFNAR2 | TOP2A | Histone deacetylase (nonspecified subtype) | G5243 | ULK1 | INPP5D | UGT2A1 | NUMB | CD19 | NADPH Oxidase (nonspecified subtype) | HOXA5 | CYP19A1 | VIRMA | G7422 | JAK3 | TNFSF4 | G238 | HMOX1 | GRB2

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