Disease

Dysplastic Nevus

About the Disease
Dysplastic Nevus Syndrome, also known as familial atypical multiple mole melanoma syndrome, is related to ocular melanoma and acral lentiginous melanoma. An important gene associated with Dysplastic Nevus Syndrome is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Disease and Homology Directed Repair. The drugs Isotretinoin and Fenretinide have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
CDK6 | CDK4 | TOP1 | TYR | LOC105370627 | GPNMB | ICAM1 | NOD2 | PAX3 | GNAQ | CASP8 | VDR | G836 | PLA2G6 | ERVW-1 | DCT | NCOA6 | LURAP1L-AS1 | CCDC140 | CDH11 | LOC105369749 | PPP1R3C | G7015 | CLPTM1L | NF-kappaB (NFkB) | OCA2 | CDK10 | XRCC1 | MLH1 | CHEK2 | KIT | MIR196A2 | BAP1 | MAPK13 | G7124 | TYRP1 | GNMT | CLDN11 | G7157 | G673 | MC1R | G1029 | MYO7A

疾病靶点研报
Dysplastic Nevus

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