Dysplastic Nevus

About the Disease
Dysplastic Nevus Syndrome, also known as familial atypical multiple mole melanoma syndrome, is related to ocular melanoma and acral lentiginous melanoma. An important gene associated with Dysplastic Nevus Syndrome is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Disease and Homology Directed Repair. The drugs Isotretinoin and Fenretinide have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
CDK6 | CDK4 | TOP1 | TYR | LOC105370627 | GPNMB | ICAM1 | NOD2 | PAX3 | GNAQ | CASP8 | VDR | G836 | PLA2G6 | ERVW-1 | DCT | NCOA6 | LURAP1L-AS1 | CCDC140 | CDH11 | LOC105369749 | PPP1R3C | G7015 | CLPTM1L | NF-kappaB (NFkB) | OCA2 | CDK10 | XRCC1 | MLH1 | CHEK2 | KIT | MIR196A2 | BAP1 | MAPK13 | G7124 | TYRP1 | GNMT | CLDN11 | G7157 | G673 | MC1R | G1029 | MYO7A

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Congestive Heart Failure | Huntington's Disease-like 2 | Cavitary Optic Disc Anomalies | Urticaria | Thrombophilia | Spinocerebellar Ataxia Type 31 | Hepatic Steatosis | Gingivitis | Small Lymphocytic Lymphoma | Nephrocalcinosis | Pituitary Dwarfism | Glycogen Storage Disease Type 6 | McKusick Type Metaphyseal Chondrodysplasia | Peritonitis | Macular Corneal Dystrophy | Primary Progressive Aphasia | Dysmorphophobia | Angiosarcoma | Encephalopathy, Glycine | Congenital Tufting Enteropathy | Idiopathic Multicentric Castleman Disease | Primary Cutaneous Amyloidosis | Renpenning Syndrome | Familial Glucocorticoid Deficiency | Sengers Syndrome | Colitis, Lymphocytic | Cancer, Skin | Liddle Syndrome | Pulmonary Capillary Hemangiomatosis | Hypercalcemia | Osteopathia Striata With Cranial Sclerosis | Acute Leukemia | Glutaric Aciduria Type 1 | Trichorhinophalangeal Syndrome | Leukoplakia, Oral | Olmsted Syndrome | Glanzmann Thrombasthenia | Lymphedema | Pontocerebellar Hypoplasia | 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Syndrome | Prolidase Deficiency | Scapuloperoneal Spinal Muscular Atrophy | Stiff-man Syndrome | Gastric Atrophy | Hemochromatosis Type 2 | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Bursitis | Acquired Partial Lipodystrophy | Erysipelas | Synpolydactyly | Hepatitis E | Sarcoma | 3-methylglutaconic Aciduria Type I | Encephalopathy | Hypohidrotic Ectodermal Dysplasia, X-linked | Intracerebral Hemorrhage | Ulcerative Colitis | Hepatitis, Autoimmune | Sjogren Syndrome | Muir-Torre Syndrome | 3-methylglutaconic Aciduria Type IV | Cancer, Colon | Diabetes | Intestinal Tuberculosis | Endometrial Hyperplasia | Pneumonia, Viral | Waldenstrom Macroglobulinemia | Precocious Puberty | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Hermansky-Pudlak Syndrome | Eosinophilic Asthma | Pityriasis Rubra Pilaris | Diabetes Insipidus, Neurogenic | Maternally Inherited Diabetes And Deafness | Angina Pectoris | Papillorenal Syndrome | TARP Syndrome | Oculocutaneous 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