Glomerulonephritis

About the Disease
Glomerulonephritis, also known as bright's disease, is related to c3 glomerulopathy and membranous nephropathy. An important gene associated with Glomerulonephritis is COL4A4 (Collagen Type IV Alpha 4 Chain), and among its related pathways/superpathways are Innate Immune System and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Mycophenolic acid and Leflunomide have been mentioned in the context of this disorder. Affiliated tissues include Kidney, heart and bone marrow, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Common Targets
ELANE | CFB | H4C16 | TYK2 | CDK4 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | IKBKB | C1S | IFNA13 | C5 | CFI | ESR2 | PLA2G4A | CFD | G7852 | IKZF1 | RPS6KA3 | CTSS | PIK3CD | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | PIK3CB | CDK5 | CFHR1 | G2099 | NR3C1 | ACHE | PDGFD | CDK9 | CCR2 | CXCR1 | SYK | G5743 | TGFBR1 | NTRK1 | PIK3CA | Guanylate cyclase (nonspecified subtype) | G4170 | GSK3B | TTK | CFHR3 | CDK6/Cyclin D1 | MAPK9 | MS4A1 | IL10 | ALDH1A1 | CCND3 | Phospholipase A2, Cytosolic (nonspecified subtype) | MMP2 | FLT3 | CHIA | G7422 | IL1B | NOS2 | PIM1 | CDK2/Cyclin A | G3569 | Janus Kinase (nonspecified subtype) | CR1 | CXCR2 | PTCHD3 | AGTR1 | Complement Complex | BDKRB1 | IFNAR1 | G7015 | JAK2 | NLRP3 Inflammasome | MIF | C3 | HPSE | JAK3 | JAK1 | C5AR1 | CFH | CDK6/Cyclin D3 | G114548 | CCL2 | Cyclin A (nonspecified subtype) | F2R | CYP11B2 | CDK1 | PIK3CG | G5347 | IFNAR2 | SIK3 | CDK7 | TGFB1 | TERC | CD46 | THBD | Phosphodiesterase (nonspecified subtype) | RORC | TLR1 | HIF1A | TLR8 | G595 | G7124 | PIM2 | CYBA | CDK4/Cyclin D1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CDK2 | G7157 | CSF1R | G5599 | NPHS1

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