Disease

Creutzfeldt-Jakob Disease

About the Disease
Creutzfeldt-Jakob Disease, also known as variant creutzfeldt-jakob disease, is related to frontotemporal lobar degeneration with tdp43 inclusions, grn-related and prion disease, and has symptoms including back pain, headache and hemiparesis. An important gene associated with Creutzfeldt-Jakob Disease is PRNP (Prion Protein), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Neuroscience. The drugs Coal tar and Quinacrine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related phenotypes are dementia and neuronal loss in central nervous system

Common Targets
G7157 | COX3 | INPP4B | BCHE | Neurotrophic Factor (nonspecified subtype) | ND1 | LOC105370819 | NMDA receptor | GRIA1 | CYTB | NOS2 | STX6 | AGTR1 | VHL | CRBN | ND2 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | APOE | KCNQ Channels (K(v) 7) (nonspecified subtype) | COL4A2 | ND3 | BACE1 | GRM8 | APP | PDIA4 | EPOR | ND4 | ATP6 | AMP-activated protein kinase (AMPK) | ERN1 | GRIN2B | PLA2G2D | G7124 | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | ND4L | ND5 | PPARGC1A | ATP8 | Tubulin | ACHE | SNCA | DPF3 | PRNP | L3MBTL1 | COX1 | PLA2G2A | ND6 | G23411 | CFAP20DC-DT | MACROD2 | TMEM232 | COX2 | MIR646HG | MTMR7 | MYO5C | NF-kappaB (NFkB)

疾病靶点研报
Creutzfeldt-Jakob Disease

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