Osteonecrosis

About the Disease
Osteonecrosis, also known as bone necrosis, is related to osteonecrosis of the jaw and osteomyelitis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Osteonecrosis is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Signal Transduction and Extracellular matrix organization. The drugs Pentoxifylline and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related phenotypes are homeostasis/metabolism and growth/size/body region

Common Targets
SLC35E4 | ACHE | STEAP4 | FAT1 | G23411 | G4318 | PTGIR | TRPV4 | BAZ2A | ACP1 | IL1B | G7124 | G7422 | DIP2A | CCDC192 | GNG7 | MMP2 | CYP2C8 | ZFHX3 | G7157 | GRM7 | NF-kappaB (NFkB) | GSTP1 | LINC01428 | EPG5 | CASC17 | EBF1 | CHIA | BCL2L11 | DNAH12 | SPEG | TLE4 | GRID2 | XRCC1 | PLEKHH1 | CABIN1 | S100B | COL20A1 | NR1D2 | HIF1A | ANK2 | ENOX2 | USH1C | CTBP1 | Phosphodiesterase (nonspecified subtype) | ERCC5 | LINC01495 | BRCA2 | COL22A1 | APRT | Integrin alpha4beta1 (VLA-4) receptor | TRPV1 | GRM5 | AMPD1

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