Metabolic Syndrome

About the Disease
Abdominal Obesity-Metabolic Syndrome 1, also known as metabolic syndrome x, is related to mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome and nutritional deficiency disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Abdominal Obesity-Metabolic Syndrome 1 is MIR122 (MicroRNA 122), and among its related pathways/superpathways are Metabolism and IL-9 Signaling Pathways. The drugs Cilostazol and Captopril have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and adipocyte, and related phenotypes are hypertension and abdominal obesity

Common Targets
TNKS | SLC35D3 | SNCA | LDLR | SREBF1 | CDH13 | RARRES2 | SLC5A2 | KSR2 | SLC27A2 | LRP6 | CD36 | G3620 | UCP3 | PPIA | CETP | LPL | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | PASK | BDNF | INPPL1 | NF-kappaB (NFkB) | FNTA | MC1R | FFAR4 | GPBAR1 | MAD1L1 | PLCD1 | STEAP4 | G1026 | TGFB1 | GPR35 | PREP | HFE | MIPEP | VWF | AMP-activated protein kinase (AMPK) | FOLR2 | CDK6 | GPR119 | ASNS | PRC1 | IGF2R | TPCN1 | INSIG1 | PDK1 | MOGAT2 | GHRL | GHSR | ZPR1 | NISCH | SREBF2 | ATG7 | DCAF15 | SBNO2 | G7099 | SCAP | APOA4 | C22orf31 | GJA4 | MN1 | G59272 | CYP7A1 | NR1H2 | AQP10 | THRB | DGAT1 | ACE | FFAR1 | BPHL | APOA5 | LOC105375508 | PTGER3 | MIR488 | Glycogen phosphorylase (nonspecified subtype) | DAB2 | CYP21A2 | ADRA2B | ACP1 | CNR2 | LTA | MGAT2 | EPHX2 | GHRLOS | ADIPOQ | G4780 | NPC1L1 | CYP17A1 | PNPLA3 | PPARA | G3479 | AGT | MMP3 | CAMK2G | Alpha-2 Adrenergic receptors (nonspecified subtype) | THBS2 | IRS2 | DRD2 | ESR2 | GP1BA | BORCS7 | NR1H3 | PDK2 | GIP | HLA-B | SCD | MAP3K5 | DCUN1D1 | POMC | Serine palmitoyltransferase | TYR | GCK | COMT | APLNR | MTHFS | UGCG | ICAM4 | CDKAL1 | Casein kinase I (nonspecified subtype) | TRPM8 | CPT1A | BRD4 | PIP5K1B | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | GYPC | TXNIP | SLC22A12 | PEG3 | CCKBR | PDE10A | Cholesterol esterase (nonspecified subtype) | ABCG1 | HMGCR | PIM3 | ICAM1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | KHK | MAP3K11 | RAMP2 | ADORA2B | NOX4 | ADORA1 | NAPEPLD | LOC101928004 | CD14 | G23411 | SHBG | PDE9A | MTRR | AMP Deaminase (nonspecified subtype) | GALNT2 | ADIPOQ-AS1 | Liver Bile Transporters (LBAT) (nonspecified subtype) | LEP | PPID | PANK3 | SHROOM3 | CNR1 | CELF4 | ABCA1 | WRN | ANGPT2 | FRMD4A | TRPV2 | PPARG | SELENOS | CCN2 | DYRK1A | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | NPY2R | PCSK9 | GABA(A) receptor | NTRK3 | PTGIS | HSD11B1 | Reverse transcriptase (Telomerase) | ADD1 | TAS1R2 | HHIPL1 | G5595 | IAPP | APOC3 | SHC1 | GPX1 | CD38 | ITGB2 | TM6SF2 | TRPV1 | PSRC1 | PPARD | ULK4 | MTNR1B | PDK4 | RBMXL2 | ADRA2A | DPP4 | G2099 | TGFBR1 | UTS2R | Amylin receptor | G3605 | SELP | Casein kinase II (CKII) | INSR | G9429 | NEDD4 | PYGL | G3480 | ATP2B1 | GSTT1 | GIPR | ARAP1 | NTRK1 | PTPN1 | NPPA | IRAK4 | TNKS2 | AKR1B1 | MAPKAPK2 | ADH1B | ACHE | SERPINE1 | NPPA-AS1 | GSK3B | MC3R | ZMPSTE24 | ABCG5 | XDH | GCKR | FGFR1 | SOCS3 | CEP131 | PLG | PPP1R13L | USF1 | FABP5 | G836 | CAV1 | G3630 | ZBED3-AS1 | SLC6A19 | ST20-MTHFS | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | OPRD1 | ABHD6 | RPL9 | G7124 | TFAP2B | ZNF771 | APOA1-AS | Mitogen-Activated Protein Kinase (nonspecified subtype) | G4318 | NR3C1 | SMAD2 | JAZF1 | ADIPOR1 | WFS1 | ATP5F1E | NR1H4 | SLC10A1 | LIPC | ESRRA | SPATA5L1 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | LRP1 | HCRTR2 | Pyruvate dehydrogenase kinase (nonspecified subtype) | RAF1 | FGFR4 | GPX3 | G6PC1 | TPH2 | Trypsin (nonspecified subtype) | MTTP | AKR1C3 | STS | ZFPM2 | G367 | ABCG8 | GPR84 | ADAMTS9-AS2 | HDAC4 | KCNJ5 | GUCY1A1 | R3HDML | AFAP1 | KCNQ1OT1 | LEPR | HSD17B13 | RXRA | PRICKLE1 | ABCC8 | BRPF1 | TSTD1 | PNPLA2 | PDX1 | UBE2M | FASN | PIM1 | ATF3 | FLT3 | HNF1A | HPS1 | VDR | G5243 | PTPRN2 | AP-1 Transcription Factor Complex | Heat shock protein 70 (nonspecified subtype) | KCNQ1 | NOS3 | NUCB2 | SGMS2 | MMP2 | MTHFR | OLR1 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | LMNA | HSPA1A | HTR6 | CLK1 | STK4 | IGF2BP1 | COX6C | ENPEP | SLC34A1 | TFDP2 | MSTN | IL10 | PON1 | LANCL2 | DYRK1B | ENPP1 | LOC105376523 | ACACB | APOA1 | KDR | ROCK2 | SIRT5 | TP53INP1 | SLC5A1 | NMDA receptor | FURIN | KL | METAP2 | Fatty Acid Binding Protein (nonspecified subtype) | GAA | Cyclooxygenase (COX) (nonspecified subtype) | ADRB2 | HTR2A | PARPBP | NOS2 | LRP2 | GLP2R | PPP4R2 | C3 | AGTR1 | VHL | NOTCH2 | TRIB3 | SSTR5 | INS-IGF2 | SLC2A9 | LIPE | THPO | TRPA1 | Histone deacetylase (nonspecified subtype) | AGER | CFTR | MC4R | NPR1 | G7422 | LDHC | AGTR2 | ATF4 | HNF4A | SLC30A10 | Proteasome Complex | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | ACLY | APOB | SELENOP | SNTG2 | CYP19A1 | NQO1 | NID2 | CFH | NADPH Oxidase Complex | FTO | HCAR2 | IL6R | MRGPRX2 | CCL2 | F7 | PNLIP | STK4-DT | GRM4 | HTR2C | Retinoid RXR receptor (nonspecified subtype) | ADRA1B | IGF2BP2 | RETN | UCP1 | FABP4 | CALCR | HSPA1L | IDE | APOE | alpha-Amylase (nonspecified subtype) | ALOX5 | R3HDML-AS1 | CRP | CRBN | DOCK7 | MKKS | ENOX2 | ACACA | NNMT | MBOAT4 | CYP11B2 | CX3CR1 | LIMD2 | GLP1R | PPARGC1A | CHRNB2 | G8878 | IL1B | TGFBR2 | H19 | HLA-C | NADPH Oxidase (nonspecified subtype) | CLK2 | G7015 | GPR55 | FABP2 | IGF2 | PYY | G3569 | HNF1B | TRPM5 | LIPG | CLOCK | CHGA | G3576 | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | CDKN2D | FADS1 | BRAP | TCF7L2 | HMOX1 | Soluble guanylyl cyclase | CASC15 | LTF | MMP1 | AOC3 | G6714 | CST3 | MPO | B9D2 | MIR4761 | HLA-DQB1 | UCP2 | THADA | NTRK2 | TAS1R3 | PIM2 | SLC2A5 | G6774 | GCGR | HNMT | FASTKD3 | MICAL3 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | CYBA | SPP1 | TBXAS1 | ASGR1 | SIRT2 | KCNJ11

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