Metabolic Syndrome

About the Disease
Abdominal Obesity-Metabolic Syndrome 1, also known as metabolic syndrome x, is related to mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome and nutritional deficiency disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Abdominal Obesity-Metabolic Syndrome 1 is MIR122 (MicroRNA 122), and among its related pathways/superpathways are Metabolism and IL-9 Signaling Pathways. The drugs Cilostazol and Captopril have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and adipocyte, and related phenotypes are hypertension and abdominal obesity

Common Targets
TNKS | SLC35D3 | SNCA | LDLR | SREBF1 | CDH13 | RARRES2 | SLC5A2 | KSR2 | SLC27A2 | LRP6 | CD36 | G3620 | UCP3 | PPIA | CETP | LPL | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | PASK | BDNF | INPPL1 | NF-kappaB (NFkB) | FNTA | MC1R | FFAR4 | GPBAR1 | MAD1L1 | PLCD1 | STEAP4 | G1026 | TGFB1 | GPR35 | PREP | HFE | MIPEP | VWF | AMP-activated protein kinase (AMPK) | FOLR2 | CDK6 | GPR119 | ASNS | PRC1 | IGF2R | TPCN1 | INSIG1 | PDK1 | MOGAT2 | GHRL | GHSR | ZPR1 | NISCH | SREBF2 | ATG7 | DCAF15 | SBNO2 | G7099 | SCAP | APOA4 | C22orf31 | GJA4 | MN1 | G59272 | CYP7A1 | NR1H2 | AQP10 | THRB | DGAT1 | ACE | FFAR1 | BPHL | APOA5 | LOC105375508 | PTGER3 | MIR488 | Glycogen phosphorylase (nonspecified subtype) | DAB2 | CYP21A2 | ADRA2B | ACP1 | CNR2 | LTA | MGAT2 | EPHX2 | GHRLOS | ADIPOQ | G4780 | NPC1L1 | CYP17A1 | PNPLA3 | PPARA | G3479 | AGT | MMP3 | CAMK2G | Alpha-2 Adrenergic receptors (nonspecified subtype) | THBS2 | IRS2 | DRD2 | ESR2 | GP1BA | BORCS7 | NR1H3 | PDK2 | GIP | HLA-B | SCD | MAP3K5 | DCUN1D1 | POMC | Serine palmitoyltransferase | TYR | GCK | COMT | APLNR | MTHFS | UGCG | ICAM4 | CDKAL1 | Casein kinase I (nonspecified subtype) | TRPM8 | CPT1A | BRD4 | PIP5K1B | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | GYPC | TXNIP | SLC22A12 | PEG3 | CCKBR | PDE10A | Cholesterol esterase (nonspecified subtype) | ABCG1 | HMGCR | PIM3 | ICAM1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | KHK | MAP3K11 | RAMP2 | ADORA2B | NOX4 | ADORA1 | NAPEPLD | LOC101928004 | CD14 | G23411 | SHBG | PDE9A | MTRR | AMP Deaminase (nonspecified subtype) | GALNT2 | ADIPOQ-AS1 | Liver Bile Transporters (LBAT) (nonspecified subtype) | LEP | PPID | PANK3 | SHROOM3 | CNR1 | CELF4 | ABCA1 | WRN | ANGPT2 | FRMD4A | TRPV2 | PPARG | SELENOS | CCN2 | DYRK1A | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | NPY2R | PCSK9 | GABA(A) receptor | NTRK3 | PTGIS | HSD11B1 | Reverse transcriptase (Telomerase) | ADD1 | TAS1R2 | HHIPL1 | G5595 | IAPP | APOC3 | SHC1 | GPX1 | CD38 | ITGB2 | TM6SF2 | TRPV1 | PSRC1 | PPARD | ULK4 | MTNR1B | PDK4 | RBMXL2 | ADRA2A | DPP4 | G2099 | TGFBR1 | UTS2R | Amylin receptor | G3605 | SELP | Casein kinase II (CKII) | INSR | G9429 | NEDD4 | PYGL | G3480 | ATP2B1 | GSTT1 | GIPR | ARAP1 | NTRK1 | PTPN1 | NPPA | IRAK4 | TNKS2 | AKR1B1 | MAPKAPK2 | ADH1B | ACHE | SERPINE1 | NPPA-AS1 | GSK3B | MC3R | ZMPSTE24 | ABCG5 | XDH | GCKR | FGFR1 | SOCS3 | CEP131 | PLG | PPP1R13L | USF1 | FABP5 | G836 | CAV1 | G3630 | ZBED3-AS1 | SLC6A19 | ST20-MTHFS | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | OPRD1 | ABHD6 | RPL9 | G7124 | TFAP2B | ZNF771 | APOA1-AS | Mitogen-Activated Protein Kinase (nonspecified subtype) | G4318 | NR3C1 | SMAD2 | JAZF1 | ADIPOR1 | WFS1 | ATP5F1E | NR1H4 | SLC10A1 | LIPC | ESRRA | SPATA5L1 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | LRP1 | HCRTR2 | Pyruvate dehydrogenase kinase (nonspecified subtype) | RAF1 | FGFR4 | GPX3 | G6PC1 | TPH2 | Trypsin (nonspecified subtype) | MTTP | AKR1C3 | STS | ZFPM2 | G367 | ABCG8 | GPR84 | ADAMTS9-AS2 | HDAC4 | KCNJ5 | GUCY1A1 | R3HDML | AFAP1 | KCNQ1OT1 | LEPR | HSD17B13 | RXRA | PRICKLE1 | ABCC8 | BRPF1 | TSTD1 | PNPLA2 | PDX1 | UBE2M | FASN | PIM1 | ATF3 | FLT3 | HNF1A | HPS1 | VDR | G5243 | PTPRN2 | AP-1 Transcription Factor Complex | Heat shock protein 70 (nonspecified subtype) | KCNQ1 | NOS3 | NUCB2 | SGMS2 | MMP2 | MTHFR | OLR1 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | LMNA | HSPA1A | HTR6 | CLK1 | STK4 | IGF2BP1 | COX6C | ENPEP | SLC34A1 | TFDP2 | MSTN | IL10 | PON1 | LANCL2 | DYRK1B | ENPP1 | LOC105376523 | ACACB | APOA1 | KDR | ROCK2 | SIRT5 | TP53INP1 | SLC5A1 | NMDA receptor | FURIN | KL | METAP2 | Fatty Acid Binding Protein (nonspecified subtype) | GAA | Cyclooxygenase (COX) (nonspecified subtype) | ADRB2 | HTR2A | PARPBP | NOS2 | LRP2 | GLP2R | PPP4R2 | C3 | AGTR1 | VHL | NOTCH2 | TRIB3 | SSTR5 | INS-IGF2 | SLC2A9 | LIPE | THPO | TRPA1 | Histone deacetylase (nonspecified subtype) | AGER | CFTR | MC4R | NPR1 | G7422 | LDHC | AGTR2 | ATF4 | HNF4A | SLC30A10 | Proteasome Complex | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | ACLY | APOB | SELENOP | SNTG2 | CYP19A1 | NQO1 | NID2 | CFH | NADPH Oxidase Complex | FTO | HCAR2 | IL6R | MRGPRX2 | CCL2 | F7 | PNLIP | STK4-DT | GRM4 | HTR2C | Retinoid RXR receptor (nonspecified subtype) | ADRA1B | IGF2BP2 | RETN | UCP1 | FABP4 | CALCR | HSPA1L | IDE | APOE | alpha-Amylase (nonspecified subtype) | ALOX5 | R3HDML-AS1 | CRP | CRBN | DOCK7 | MKKS | ENOX2 | ACACA | NNMT | MBOAT4 | CYP11B2 | CX3CR1 | LIMD2 | GLP1R | PPARGC1A | CHRNB2 | G8878 | IL1B | TGFBR2 | H19 | HLA-C | NADPH Oxidase (nonspecified subtype) | CLK2 | G7015 | GPR55 | FABP2 | IGF2 | PYY | G3569 | HNF1B | TRPM5 | LIPG | CLOCK | CHGA | G3576 | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | CDKN2D | FADS1 | BRAP | TCF7L2 | HMOX1 | Soluble guanylyl cyclase | CASC15 | LTF | MMP1 | AOC3 | G6714 | CST3 | MPO | B9D2 | MIR4761 | HLA-DQB1 | UCP2 | THADA | NTRK2 | TAS1R3 | PIM2 | SLC2A5 | G6774 | GCGR | HNMT | FASTKD3 | MICAL3 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | CYBA | SPP1 | TBXAS1 | ASGR1 | SIRT2 | KCNJ11

Note: If you'd like to get a target analysis report for Metabolic Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Metabolic Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Glioma | Macular Corneal Dystrophy Type 1 | Borjeson-Forssman-Lehmann Syndrome | Chronic Myelomonocytic Leukemia | Chondroma | Coffin-Lowry Syndrome | Tatton-Brown-Rahman Syndrome | Heart Septal Defects | Spinocerebellar Ataxia Type 40 | Fibrosarcoma | Chronic Granulomatous Disease | Splenomegaly | Li-Fraumeni Syndrome | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Thyroid Hormone Resistance | Chloridorrhea, Congenital | Hemochromatosis Type 2 | Epiphyseal Chondrodysplasia, Miura Type | Bartter Syndrome | Cervicitis | Filariasis | Acrodermatitis | WAGR Syndrome | Hypolipoproteinemia | Bronchitis | Treacher Collins Syndrome | Paget's Disease Of The Breast | Multifocal Motor Neuropathy | Rickets | Crimean-Congo Hemorrhagic Fever | Peyronie's Disease | Primary Hyperoxaluria Type 1 | Hashimoto Thyroiditis | Hypertrophy | Hereditary Folate Malabsorption | Uterine Leiomyoma | Babesiosis | Asthma, Exercise-induced | Renal Medullary Carcinoma | Spinal Muscular Atrophy Type 2 | Charcot-Marie-Tooth Disease Type 2D | Basal Ganglia Disease | Congenital Heart Defects | Metabolic Syndrome | Bullous Pemphigoid | Glycogen Storage Disease Type 0 | Branchiootorenal Syndrome | Lentigo | Maple Syrup Urine Disease | Focal Cortical Dysplasia Type 2 | Epidermodysplasia Verruciformis | Erysipelas | Cutaneous Mastocytosis | Heterotopic Ossification | Neutrophilia | Adenoma, Pleomorphic | Communication Disorders | Stuve-Wiedemann Syndrome | Nemaline Myopathy | Optic Nerve Hypoplasia, Bilateral | Alexander Disease | Esotropia | Anodontia | Wolcott-Rallison Syndrome | Congenital Adrenal Hyperplasia 1 | Anorectal Fistula | Diabetes Insipidus, Nephrogenic | IMAGe Syndrome | Aplasia Cutis Congenita | Interstitial Lung Diseases | Microphthalmia, Syndromic 7 | Eczema | Pyloric Stenosis, Infantile Hypertrophic | Exostoses | Spinal Muscular Atrophy | Parvovirus B19 Infection | Anal Fissure | Perry Syndrome | TARP Syndrome | Mucormycosis | Episodic Ataxia Type 2 | Glaucoma | Leiomyosarcoma | Restless Legs Syndrome | Robinow Syndrome | Giant Cell Glioblastoma | Congenital Afibrinogenemia | Globozoospermia | Lymphedema | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Cancer, Brain | Spinocerebellar Ataxia Type 17 | Muir-Torre Syndrome | Argininosuccinic Aciduria | Uveitis, Anterior | Viral Meningitis | Emery-Dreifuss Muscular Dystrophy | Myoclonic Epilepsy With Ragged Red Fibers | Neutropenia | Progressive Familial Intrahepatic Cholestasis | Exocrine Pancreatic Insufficiency | Cohen Syndrome | Blue Nevus | Cartilage Disorders | Galloway-Mowat Syndrome | Fatty Aldehyde Dehydrogenase Deficiency | Cerebellofaciodental Syndrome | Pulmonary Sclerosing Hemangioma | Cellulitis | Ameloblastic Carcinoma | Episodic Ataxia | Granuloma Annulare | Fuchs Dystrophy | Myelodysplasia | Gastroenteritis, Eosinophilic | Knobloch Syndrome | Anencephaly | Auriculocondylar Syndrome | Leri-Weill Dyschondrosteosis | Brachial Plexus Neuropathy | Impulse Control Disorder | Familial Male-limited Precocious Puberty | Alstrom Syndrome | Schnitzler Syndrome | Allan-Herndon-Dudley Syndrome | Autism Spectrum Disorders | Campomelic Dysplasia | Congenital Nephrotic Syndrome | Multisystemic Smooth Muscle Dysfunction Syndrome | Lipid Storage Myopathy | Nephritis, Interstitial | Autoimmune Hemolytic Anemia | Meconium Ileus | Noonan Syndrome | 3-methylglutaconic Aciduria | Oculodentodigital Dysplasia | Meningeal Melanocytoma | Retinal Detachment | Familial Exudative Vitreoretinopathy | Cranial Nerve Disease | Tangier Disease | Hyperkeratosis | Craniolenticulosutural Dysplasia | Keratosis, Seborrheic | Wolff-Parkinson-White Syndrome | Insulin Resistance | Glomerulonephritis | Polyneuropathy | Cancer, Colon | Pain | Stromal Corneal Dystrophy | Lewy Body Dementia | Osteosclerosis | Generalized Epilepsy And Paroxysmal Dyskinesia | Frontotemporal Dementia | Centronuclear Myopathy | Chronic Kidney Disease | Purpura, Thrombotic Thrombocytopenic | Creutzfeldt-Jakob Disease | Systemic Lupus Erythematosus | Heavy Chain Disease | Evans Syndrome | Haim-Munk Syndrome | Neuromyotonia | Woodhouse-Sakati Syndrome | Transient Bullous Dermolysis Of The Newborn | Osteogenesis Imperfecta Type II | HANAC Syndrome | Demyelinating Diseases | Eccrine Porocarcinoma | Mitochondrial Myopathy | Azoospermia | Primary Ovarian Insufficiency | Porphyria Cutanea Tarda | Urea Cycle Disorder | Eating Disorder | Hydronephrosis | Tardive Dyskinesia | Pulmonary Alveolar Proteinosis | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Carcinoma, Signet Ring Cell | Malaria, Cerebral | Intestinal Obstruction | Nager Acrofacial Dysostosis | Cryptosporidiosis | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Pancreatitis, Chronic | Waardenburg Syndrome | Thin Basement Membrane Disease | Mycosis Fungoides | Progressive Encephalopathy-optic Atrophy Syndrome | Acute Leukemia | Extramammary Paget's Disease | Polycystic Ovary Syndrome | Marshall-Smith Syndrome | Reye Syndrome | Anthrax | Currarino Syndrome | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Congenital Hereditary Endothelial Dystrophy Type II | Gnathodiaphyseal Dysplasia | Hypokalemia | Uveitis | Androgen Insensitivity | Hodgkin Lymphoma | Hyperprolactinemia | Colitis, Lymphocytic | Congenital Dyserythropoietic Anemia Type 1 | Multiple Hamartoma Syndrome | Waardenburg Syndrome Type 2E | Low Tension Glaucoma | Zygomycosis | Heart Block | Varicocele | Anorectal Malformations | Hemangioendothelioma | Hereditary Spherocytosis | Pitt-Hopkins Syndrome | Spitzoid Melanoma | Basal Ganglia Cerebrovascular Disease | Binge Eating Disorder | Dyslipidemia | Ebstein Anomaly | Epidermolysis Bullosa Simplex, Generalized | Congenital Poikiloderma | Endometrial Hyperplasia | Cardiomyopathy, Restrictive | Avian Influenza | T-cell Chronic Lymphocytic Leukemia | Retinoblastoma | Pearson Syndrome | Impetigo | Familial Advanced Sleep Phase Syndrome | Ovarian Hyperstimulation Syndrome | Congenital Disorders Of Glycosylation | Arteriosclerosis | Carpenter Syndrome | Feingold Syndrome | Carcinoma, Squamous Cell | Tinea Versicolor | Hyperparathyroidism, Secondary | Hydrops Fetalis | Blepharitis | Smoldering Myeloma | Acute Lung Injury | Hypohidrotic Ectodermal Dysplasia | Neuronal Ceroid Lipofuscinosis | PASLI Disease | Schwannoma | Pterygium | Hydrocephalus, Normal Pressure | Oculopharyngeal Muscular Dystrophy | Pilomatrix Carcinoma | Hyperkalemic Periodic Paralysis | Trichomegaly | Acute Tubular Necrosis | Congenital Torticollis | Celiac Disease | Hemolytic Uremic Syndrome | Myosin Storage Myopathy | Erythrokeratodermia Variabilis | Jawad Syndrome | Preaxial Polydactyly | Rhizomelic Chondrodysplasia Punctata | Parkinson's Disease | Chronic Enteropathy Associated With SLCO2A1 Gene | Giant Cell Arteritis | Hyperuricemic Nephropathy, Familial Juvenile | Micropenis | Spinocerebellar Ataxia Type 42 | Ovarian Sex Cord-stromal Tumor | Neurotoxicity | Best Macular Dystrophy | Diabetes Type 1 | Neuroectodermal Tumors, Primitive | Bethlem Myopathy | Mannosidase Deficiency Diseases | Keratoconjunctivitis | Methemoglobinemia | Focal Dermal Hypoplasia | Saul-Wilson Syndrome | Obsessive-compulsive Disorder | Ornithine Transcarbamylase Deficiency | Sweet Syndrome | Poretti-Boltshauser Syndrome | Tonsillitis | Mood Disorder | Acromesomelic Dysplasia | Pigment Dispersion Syndrome | Plasma Cell Dyscrasia | Osteoporosis | Kabuki Syndrome 2 | Hypertensive Retinopathy | Hypertension, Renal | Oligodendroglioma | Hypersomnia | Amenorrhea | Primary Sclerosing Cholangitis | Neurofibromatosis | Chromosome 9q34.3 Deletion Syndrome | Dystrophy, Cone-rod | Progressive External Ophthalmoplegia | Down Syndrome | Enterocolitis, Necrotizing | Cystinosis | Twin-to-twin Transfusion Syndrome | Malaria | Hypodontia | Coffin-Siris Syndrome | Bietti Crystalline Dystrophy | Schuurs-Hoeijmakers Syndrome | Antisynthetase Syndrome | Uremia | Choriocarcinoma | Citrullinemia | Carcinoma, Merkel Cell | Disseminated Intravascular Coagulation | Behcet's Disease | Primary Lateral Sclerosis | Primary Progressive Nonfluent Aphasia | Liver Failure, Acute Infantile | Wolman Disease | Amblyopia | Non-bullous Congenital Ichthyosiform Erythroderma | Pulmonary Alveolar Microlithiasis | Paracoccidioidomycosis | Papilledema | Hypocalcemia | Huntington's Disease | Endometritis | Amyloidosis | Retinal Coloboma | Hypervalinemia | Cockayne Syndrome | Osteoglophonic Dysplasia | Familial Retinal Arterial Macroaneurysm | Isovaleric Acidemia | Rett Syndrome | Non-small Cell Lung Cancer | Klinefelter Syndrome | Inborn Errors Of Metabolism | Adenylosuccinate Lyase Deficiency | Liddle Syndrome | Placenta Previa | Benign Hereditary Chorea | Galactosialidosis | NGLY1 Deficiency | Sporadic Hemiplegic Migraine | Thrombophilia | Tetanus | Becker Muscular Dystrophy | Hemochromatosis | Aldosterone Deficiency | Facioscapulohumeral Muscular Dystrophy Type 2 | Meniere's Disease | Multiple Myeloma | Primary Hyperoxaluria | Dupuytren Disease | Craniopharyngioma | Blomstrand Osteochondrodysplasia | Focal Facial Dermal Dysplasia | Mountain Sickness | Eosinophilic Asthma | Pneumoconiosis | Encephalopathy, Glycine | Thanatophoric Dysplasia | Sensorineural Hearing Loss | Dwarfism | Vitamin K Deficiency | Osteosarcoma | Tendinopathy | Polyradiculopathy | Cantu Syndrome | Spasticity | Prolactinoma | Sarcoidosis | Spinocerebellar Ataxia Type 16 | Von Willebrand Disease | Aromatic L-amino Acid Decarboxylase Deficiency | Lassa Fever | Endocarditis | NDH Syndrome | Paraganglioma, Carotid Body | Osteogenesis Imperfecta Type VI | Craniometaphyseal Dysplasia | Hennekam Lymphangiectasia-lymphedema Syndrome | Keratopathy | Poirier-Bienvenu Neurodevelopmental Syndrome | Lymphoproliferative Disease, X-linked | Irritable Bowel Syndrome | Protein C Deficiency | Thrombotic Microangiopathy | Microtia | Myoclonus | Schwannomatosis | Vitelliform Macular Dystrophy | Necrotizing Autoimmune Myopathy | Glycogen Storage Disease Type 9 | Chronic Periodontitis | Intermittent Claudication