Disease

Charcot-Marie-Tooth Disease

About the Disease
Charcot-Marie-Tooth Disease, also known as hereditary motor and sensory neuropathy, is related to charcot-marie-tooth disease, axonal, type 2e and charcot-marie-tooth disease and deafness, and has symptoms including back pain, headache and pain. An important gene associated with Charcot-Marie-Tooth Disease is MPZ (Myelin Protein Zero), and among its related pathways/superpathways are Neural crest differentiation and Intracellular trafficking proteins involved in CMT neuropathy. The drugs Folic acid and Lipoic acid have been mentioned in the context of this disorder. Affiliated tissues include Peripheral Nervous System, spinal cord and brain, and related phenotypes are no effect and no effect

Common Targets
YARS1 | LITAF | GARS1 | FDXR | SIGMAR1 | AARS1 | GDF11 | TRPV4 | MIR4635 | Gamma-Aminobutyric acid type B receptor | TRIM2 | SPG11 | PMP2 | ZDHHC17 | PDXK | RBM19 | PMP22 | FGD4 | NFATC1 | NRG1 | DYNC1H1 | ATP1A1 | ZFYVE27 | HSD17B4 | TRNV | DGAT2 | MORC2 | DCTN2 | HDAC7 | MPZ | SAMD9L | ADRA2A | Heat Shock Protein 27 (Hsp27) (nonspecified subtype) | IMPA1 | MIR3134 | COA7 | ROPN1L | HADHB | MCM3AP | PRX | DNM2 | GNB4 | EGR2 | FXN | NMDA receptor | TXNL4A | CSMD1 | MTRFR | SARS1 | MCPH1 | MME | TRPA1 | HARS1 | ATAD3A | CSRP2 | NDRG1 | IGHMBP2 | BSCL2 | ZWILCH | PPP1R12A | GABRA1 | DNMBP | LRSAM1 | SUCLA2 | SEPSECS | IARS1 | CLCN1 | LOC100507053 | VAC14 | HSPB8 | HINT1 | CCDC28B | PENK-AS1 | MFN2 | PYGM | G9734 | G1786 | PNKP | PLEKHG5 | MTMR2 | RPS20 | FAM210B | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | C5orf34 | SACS | HK1 | CADM3 | MYH14 | FBXO38 | PIK3C3 | NKAIN3 | KIR2DL1 | SBF1 | DNAJB2 | DCTN1 | KARS1 | ARHGAP19 | SLC12A6 | FBLN5 | ANAPC1 | MSTN | SI | CCDC102B | MARS1 | NEFH | ARFGEF1 | SORD | AHNAK2 | FIG4 | HDAC6 | ARHGEF10 | NTRK2 | ADPRS | MFSD13A | GDAP1 | MYBL1 | HDAC2 | ACACA | MTPAP | BAG3 | SCO2 | NEFL | KIF1B | INF2 | ZNF236 | VEPH1 | SCN10A | LCTL | GPR17 | GJB1 | MARCHF6 | ADH1C | RAB7A | XKR4 | COX6A1 | CNTNAP1 | TRPV1 | NOTCH2NLC | MFN1 | SGPL1 | TFG | PDHB | AIFM1 | SH3TC2 | PPP1R15A

疾病靶点研报
Charcot-Marie-Tooth Disease

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