Donnai-Barrow Syndrome

About the Disease
Donnai-Barrow Syndrome, also known as faciooculoacousticorenal syndrome, is related to lowe oculocerebrorenal syndrome and dent disease 1, and has symptoms including unspecified visual loss An important gene associated with Donnai-Barrow Syndrome is LRP2 (LDL Receptor Related Protein 2), and among its related pathways/superpathways are "Cobalamin (Cbl, vitamin B12) transport and metabolism" and BMP signaling in eyelid development. Affiliated tissues include heart, retina and brain, and related phenotypes are intellectual disability and global developmental delay

Common Targets
LRP2

Note: If you'd like to get a target analysis report for Donnai-Barrow Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Donnai-Barrow Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Kernicterus | Neurofibromatosis-Noonan Syndrome | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Urea Cycle Disorder | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Homocystinuria | Pulmonary Tuberculosis | Rash | Epidermolysis Bullosa Acquisita | Polyarteritis Nodosa | Basal Ganglia Disease, Biotin-responsive | Muir-Torre Syndrome | Eczema | Charcot-Marie-Tooth Disease Type 3 | Renal Tubular Dysgenesis | Metaphyseal Chondrodysplasia, Schmid Type | Osteonecrosis Of The Jaw | Amenorrhea | Tardive Dyskinesia | Leiomyoma | Hypertelorism | Sporadic Inclusion Body Myositis | Peroxisomal Disorder | Progressive Familial Intrahepatic Cholestasis Type 2 | Adenocarcinoma | Tyrosinemia | Vestibular Disease | Pseudohypoparathyroidism Type 1A | Tumoral Calcinosis | Lesch-Nyhan Syndrome | Conduct Disorder | Cold Agglutinin Disease | Stargardt Disease | Spinocerebellar Ataxia Type 31 | Neuroectodermal Tumors, Primitive | Pelvic Inflammatory Disease | Conjunctivitis | Juvenile Myelomonocytic Leukemia | Large Granular Lymphocytic Leukemia | Glaucomatocyclitic Crisis | Diabetes Insipidus, Neurogenic | Infectious Diarrhea | Anorchia | Yellow Fever | Sclerosing Cholangitis | Brooke-Spiegler Syndrome | Familial Hypobetalipoproteinemia | Progressive Myoclonic Epilepsy | Orthostatic Intolerance | Paraganglioma, Carotid Body | Shwachman-Bodian-Diamond Syndrome | Leiomyosarcoma | Tuberculosis | Oculopharyngeal Muscular Dystrophy | Rickets | L-2-Hydroxyglutaric Aciduria | Sickle Cell Disease | Treacher Collins Syndrome | Pyruvate Carboxylase Deficiency Disease | Methemoglobinemia Type IV | Babesiosis | Goldenhar Syndrome | Adenosine Deaminase 2 Deficiency | Multifocal Motor Neuropathy | Oculodentodigital Dysplasia | Iron Metabolism Disorders | Megaloblastic Anemia | Colitis, Collagenous | Thrombophilia | Birt-Hogg-Dube Syndrome | COACH Syndrome | Acrodysostosis | Chondrodysplasia Punctata 1, X-linked Recessive | Spinal Cord Diseases | Acanthosis Nigricans | Pancreatitis, Chronic | Corneal Dystrophies, Hereditary | Aceruloplasminemia | Liver Failure, Acute Infantile | Mabry Syndrome | Dominant Optic Atrophy | Hyperacusis | Adams-Oliver Syndrome | Osteoporosis | Vascular Cognitive Impairment | Hereditary Sensory And Autonomic Neuropathy | Chiari Malformation Type I | Leukoplakia | Familial Isolated Hyperparathyroidism | Castleman Disease | Nephritis, Interstitial | Corneal Edema | Marfan Syndrome | Keratocystic Odontogenic Tumor | Hereditary Multiple Exostoses | ICF Syndrome | Measles | Parkinson Disease 6, Autosomal Recessive Early-onset | Autosomal Recessive Spastic Paraplegia Type 75 | Hypoplastic Left Heart Syndrome | Lattice Corneal Dystrophy Type 1 | Histoplasmosis | Chromosome 16p11.2 Deletion Syndrome | Hypoglycemia | Arteriovenous Malformations | Asperger Syndrome | NGLY1 Deficiency | Malaria, Cerebral | Irritable Bowel Syndrome | Lung Diseases | Blastomycosis | Muckle-Wells Syndrome | Crohn's Disease | Hyperekplexia | Retinopathy, Diabetic | Thin Basement Membrane Disease | Encephalopathy | Gilbert Syndrome | Ataxia-ocular Apraxia 2 | Hypersensitivity Pneumonitis | Budd-Chiari Syndrome | Best Macular Dystrophy | Cirrhosis | Peritonitis | Adrenomyeloneuropathy | Muscular Dystrophy | Hyper IgE Syndrome | Postpartum Depression | Otopalatodigital Syndrome Type 2 | Hemophagocytic Lymphohistiocytosis | Desbuquois Syndrome | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Cold-induced Sweating Syndrome | Metachondromatosis | Subacute Sclerosing Panencephalitis | Seborrheic Dermatitis | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Hemolytic Uremic Syndrome | Exotropia | Spinocerebellar Ataxia Type 20 | Pachyonychia Congenita | Thrombophlebitis | Trimethylaminuria | Neurocysticercosis | Cone Dystrophy | Cryptorchidism | Cutaneous Angiosarcoma | Motion Sickness | Vici Syndrome | Patent Foramen Ovale | Johanson-Blizzard Syndrome | Japanese Encephalitis | Basal Ganglia Cerebrovascular Disease | Renal-hepatic-pancreatic Dysplasia | Hyperandrogenemia | Hypermethioninemia | Hyperinsulinemic Hypoglycemia | Greig Cephalopolysyndactyly Syndrome | Hereditary Hemorrhagic Telangiectasia Type 2 | Schwannomatosis | Osteoglophonic Dysplasia | Vitamin B12 Deficiency | Spinal And Bulbar Muscular Atrophy | Miyoshi Myopathy | Bainbridge-Ropers Syndrome | Arthropathy | Osteopathia Striata With Cranial Sclerosis | Follicular Dendritic Cell Sarcoma | Primary Aldosteronism | Thyroid Hormone Resistance | Anodontia | Dubin-Johnson Syndrome | Rhabdomyosarcoma, Embryonal | Anti-NMDA Receptor Encephalitis | Hypersomnia | Delayed Sleep Phase Syndrome | Galactosemia | Esthesioneuroblastoma | DiGeorge Syndrome | Small Lymphocytic Lymphoma | Fibromuscular Dysplasia | Dysequilibrium Syndrome | Meningitis | Retinal Detachment | Apparent Mineralocorticoid Excess Syndrome | Heimler Syndrome | Pilomatrix Carcinoma | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Parkinsonism | 3-methylglutaconic Aciduria | Hoyeraal-Hreidarsson Syndrome | Connective Tissue Disorders | Hypertension, Renovascular | Spondyloepiphyseal Dysplasia Tarda, X-linked | Thyroid Dyshormonogenesis | Pyoderma Gangrenosum | Microphthalmia | Leri-Weill Dyschondrosteosis | HANAC Syndrome | Fukuyama Congenital Muscular Dystrophy | Charcot-Marie-Tooth Disease Type 4 | Neurofibromatosis Type 1 | Thromboembolism | Cystitis | Angiomyolipoma | Haim-Munk Syndrome | Thalassemia, Beta | Heart Septal Defects | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Nephrocalcinosis | Sorsby Fundus Dystrophy | Metabolic Diseases | Schindler Disease | Neurofibromatosis | Brugada Syndrome 1 | KBG Syndrome | Hypotonia-cystinuria Syndrome | GATA2 Deficiency | Rheumatoid Arthritis | Hypokalemic Periodic Paralysis | Hydronephrosis | Desmosterolosis | Angioedema | Encephalocele | Astigmatism | Paroxysmal Nocturnal Hemoglobinuria | Osteogenesis Imperfecta Type I | Behcet's Disease | Trigonocephaly | Amelanotic Melanoma | Blepharophimosis Syndrome | Bronchitis, Chronic | Autosomal Recessive Spastic Paraplegia Type 54 | Pontocerebellar Hypoplasia Type 2 | Eccrine Porocarcinoma | Schistosomiasis Mansoni | Hepatic Adenomatosis | Congenital Bilateral Absence Of Vas Deferens | Hyperinsulinemia | Posterior Polar Cataract | Absence Epilepsy | Nephrotic Syndrome | Double Outlet Right Ventricle | Smith-Lemli-Opitz Syndrome | Primary Ovarian Insufficiency | Syncope | Asplenia | Neurotoxicity | Schistosomiasis | Cyclic Vomiting Syndrome | Stiff-man Syndrome | Tricho-hepato-enteric Syndrome | Charcot-Marie-Tooth Disease Type 4D | Panic Disorder | Erythematotelangiectatic Rosacea | Dermatitis Herpetiformis | Familial Dysautonomia | Avellino Corneal Dystrophy | Cardiomyopathy, Hypertrophic | Rolandic Epilepsy | Carotid Artery Disease | Inflammatory Myofibroblastic Tumor | Atopic Dermatitis | Bipolar Disorder | Perivascular Epithelioid Cell Tumor | Common Cold | Mevalonate Kinase Deficiency | Strabismus | Hypohidrotic Ectodermal Dysplasia | Retinopathy Of Prematurity | Raine Syndrome | Uveitis | Borderline Personality Disorder | Anencephaly | Hamartoma | Erysipelas | Hypertension | DICER1 Syndrome | Beare-Stevenson Syndrome | Charcot-Marie-Tooth Disease, Type 2A | Chronic Leukemia | Creutzfeldt-Jakob Disease | Hereditary Spastic Paraplegia | Cardiospondylocarpofacial Syndrome | Panuveitis | Zimmermann-Laband Syndrome | Primary Familial Brain Calcification | Lactose Intolerance | Renal Hypomagnesemia 3 | Thymoma, Malignant | Retinoblastoma | Waardenburg Syndrome Type 4 | Adenomatoid Tumor | Synovitis | Bullous Pemphigoid | Spitz Nevus | Intermittent Explosive Disorder | Rubeosis Iridis | Oguchi Disease-2 | Agammaglobulinemia | Keratoconus | Milk Allergy | Methemoglobinemia | Malignant Peripheral Nerve Sheath Tumor | Transient Bullous Dermolysis Of The Newborn | Micropenis | Noonan Syndrome-like Disorder With Loose Anagen Hair | Retinal Telangiectasia | Niemann-Pick Disease, Type B | Prolymphocytic Leukemia | Epicondylitis | Hyperuricemia | Cholelithiasis | Neuromuscular Disorders | Coronary Heart Disease | Hemolytic Uremic Syndrome, Atypical | Hypogonadism | Acute Chest Syndrome | Succinic Semialdehyde Dehydrogenase Deficiency | Cherubism | Canavan Disease | Spinocerebellar Ataxia Type 15 | Chronic Kidney Disease | Lipoma | Porokeratosis | DRESS Syndrome | Rheumatic Heart Disease | Achondrogenesis | Cancer, Breast | Okihiro Syndrome | Trachoma | Gaucher Disease | AIDS Dementia Complex | Hyperhomocysteinemia | Otitis Externa | Adenoma, Pituitary | Keratoconjunctivitis | Sepiapterin Reductase Deficiency | Proteus Syndrome | Muscle Wasting | Charcot-Marie-Tooth Disease Type 4E | Schizophrenia, Paranoid | Kearns-Sayre Syndrome | Pfeiffer Syndrome | 3-methylglutaconic Aciduria Type IV | Cystinosis | Diabetes Type 1 | Batten Disease | Skin Papilloma | Schizencephaly | Leukocyte Adhesion Deficiency | Communication Disorders | Cystitis, Interstitial | Fucosidosis | Cutis Laxa | Recurrent Respiratory Papillomatosis | Pulmonary Veno-occlusive Disease | Cutaneous T-cell Lymphoma | Charcot-Marie-Tooth Disease Type 2E | Oral Lichen Planus | Juvenile Hyaline Fibromatosis | Aldosterone Synthase Deficiency | Congenital Hereditary Endothelial Dystrophy Type II | Urofacial Syndrome | 3-M Syndrome | Glycogen Storage Disease Type 1b | Gyrate Atrophy Of The Choroid And Retina | Borjeson-Forssman-Lehmann Syndrome | Potocki-Shaffer Syndrome | Angiodysplasia | Leigh Syndrome | Focal Cortical Dysplasia Type 2 | Mucolipidosis Type II | Craniometaphyseal Dysplasia | Creatine Deficiency Syndrome | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Hemangioma | Benign Familial Neonatal Convulsions | PHARC Syndrome | Silicosis | Meningococcal Infections | Charcot-Marie-Tooth Disease Type 2D | Gerstmann-Straussler-Scheinker Syndrome | Coronary Artery Disease | Acute Kidney Injury | Liddle Syndrome | Vasculitis | Scleroderma, Diffuse | Leukoplakia, Oral | Mucolipidosis | Ebstein Anomaly | Pulverulent Zonular Cataract | Usher Syndrome Type I | Paraplegia | Coronary Restenosis | Myotonic Disorders | Fibrosis | Scleroderma | Gynecomastia | Tetraplegia