Intermittent Explosive Disorder

About the Disease
Intermittent Explosive Disorder, also known as explosive personality disorder, is related to pyromania and acute stress disorder. An important gene associated with Intermittent Explosive Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Class A/1 (Rhodopsin-like receptors) and G-protein signaling G-Protein alpha-i signaling cascades. The drugs Guanfacine and Naratriptan have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, amygdala and brain.

Common Targets
Voltage-Gated Sodium Channel Complex | SIGMAR1 | Sodium channel (nonspecified subtype) | OXT | SLC6A4 | NMDA receptor | Histone deacetylase (nonspecified subtype) | OXTR | AVPR1A | SLC6A2

Note: If you'd like to get a target analysis report for Intermittent Explosive Disorder, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Intermittent Explosive Disorder at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Hemangioendothelioma | Hyperbilirubinemia | Glucagonoma | ACTH-independent Macronodular Adrenal Hyperplasia | Aspartylglycosaminuria | Craniofacial Dysostosis | Lichen Sclerosus | Desmosterolosis | Hypertrophy | Heart Septal Defects | Tenosynovial Giant Cell Tumor | Anterior Segment Dysgenesis | Purpura | Spinocerebellar Ataxia Type 28 | Syndactyly | Osteoporosis, Postmenopausal | Hepatitis D | Myoclonus | Schaaf-Yang Syndrome | Neuromyotonia | Pyruvate Kinase Deficiency | Chorioretinitis | Osteomalacia | ADNP Syndrome | Autism Spectrum Disorders | Aphasia | Hemolytic Uremic Syndrome | Alveolar Capillary Dysplasia | Jalili Syndrome | Spinocerebellar Ataxia Type 6 | Cholesteryl Ester Storage Disease | Congenital Poikiloderma | Benign Familial Neonatal Convulsions | Periventricular Leukomalacia | Lysosomal Acid Lipase Deficiency | Glycogen Storage Disease Type 3 | Vertigo | Proctitis | Sensorineural Hearing Loss | Glioblastoma Multiforme | MELAS Syndrome | Charcot-Marie-Tooth Disease | Familial Hypobetalipoproteinemia | Specific Granule Deficiency | Pancreatitis, Chronic | Thyroid Dysgenesis | Schistosomiasis Mansoni | Contact Dermatitis | Kearns-Sayre Syndrome | Niemann-Pick Disease, Type B | Hyperferritinemia-cataract Syndrome | Mitochondrial Myopathy | Ocular Albinism Type 1 | Autosomal Recessive Spastic Paraplegia Type 35 | Pneumonia, Mycoplasma | Uterine Leiomyoma | Ornithine Transcarbamylase Deficiency | Oligoasthenoteratozoospermia | Jacobsen Syndrome | Familial Glucocorticoid Deficiency | Combined Pituitary Hormone Deficiency | Nail Disorder, Nonsyndromic Congenital | Nemaline Myopathy | Charcot-Marie-Tooth Disease, Type 2A | Subacute Sclerosing Panencephalitis | Retinopathy, Diabetic | Charcot-Marie-Tooth Disease, Type 1A | Hernia, Inguinal | Amish Infantile Epilepsy Syndrome | Retinitis Pigmentosa 3 | Cleidocranial Dysplasia | Glioblastoma | Kawasaki Disease | Spinocerebellar Ataxia Type 7 | Parkinson's Disease | Juvenile Polyposis | Milk Allergy | Acute Chest Syndrome | Renal Tubular Acidosis | Pseudohypoparathyroidism Type 1A | Growth Hormone Excess | Bacterial Meningitis | Relapsing Polychondritis | Xeroderma Pigmentosum | Gallstones | Waardenburg Syndrome Type 4 | Ollier Disease | Cohen Syndrome | Dengue Hemorrhagic Fever | Oculocutaneous Albinism Type 2 | 3-methylglutaconic Aciduria Type IV | Charcot-Marie-Tooth Disease Type 4 | Phosphoglycerate Dehydrogenase Deficiency | Meningeal Melanocytoma | Cholelithiasis | Cardiomyopathy, Restrictive | Angelman Syndrome | Potocki-Shaffer Syndrome | Pemphigus Vulgaris | Malonyl-CoA Decarboxylase Deficiency | Liver Failure, Acute Infantile | Carcinoid Tumor | Agoraphobia | Impulse Control Disorder | Multiple Sclerosis, Relapsing-remitting | Fuchs Dystrophy | Familial Digital Arthropathy-brachydactyly | Hepatitis B, Chronic | Synpolydactyly | Christianson Syndrome | Treacher Collins Syndrome | Avian Influenza | Pituitary Stalk Interruption Syndrome | Galactosialidosis | Early Infantile Epileptic Encephalopathy 28 | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Cheilitis | Keratoconus | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Necrotizing Autoimmune Myopathy | Pierre Robin Syndrome | Aplasia Cutis Congenita | Kallmann Syndrome | Pierpont Syndrome | Episodic Ataxia Type 1 | Fundus Albipunctatus | Infertility | NDH Syndrome | Spinocerebellar Ataxia Type 20 | Microphthalmia | Idiopathic Pulmonary Fibrosis | Hyperostosis | Asthma, Exercise-induced | Alazami Syndrome | Neuroleptic Malignant Syndrome | Perivascular Epithelioid Cell Tumor | Sandhoff Disease | Jawad Syndrome | Non-small Cell Lung Cancer | Carbamoyl Phosphate Synthetase I Deficiency | Focal Segmental Glomerulosclerosis | Craniometaphyseal Dysplasia | Myocarditis | Gastroenteritis | Aromatic L-amino Acid Decarboxylase Deficiency | Primary Torsion Dystonia | Primary Sclerosing Cholangitis | Eccrine Porocarcinoma | Basal Ganglia Disease | Pseudohermaphroditism | Mycosis Fungoides | Fatty Aldehyde Dehydrogenase Deficiency | Aneurysm, Abdominal Aortic | Nanophthalmos | Osteoglophonic Dysplasia | Niemann-Pick Disease | Hyperuricemia | Pompe Disease | Leukemia-lymphoma, Adult T-cell | Exostoses | Scabies | Corneal Dystrophy And Perceptive Deafness | Oculocutaneous Albinism Type 4 | Cherubism | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Cellulitis | Allan-Herndon-Dudley Syndrome | Diastrophic Dysplasia | Lassa Fever | Adenocarcinoma | Dysequilibrium Syndrome | Sleep Disorder | Benign Hereditary Chorea | Tyrosinemia Type 1 | Angiomyolipoma | Parapsoriasis | Parkinson Disease 6, Autosomal Recessive Early-onset | Diabetes | Hereditary Xerocytosis | Prune Belly Syndrome | Cutis Laxa | Tularemia | Aicardi-Goutieres Syndrome | Skin Carcinoma | Polycythemia Vera | Atrioventricular Septal Defect | Barakat Syndrome | Congenital Generalized Lipodystrophy | Hypercholesterolemia, Familial | Cluster Headache | Optic Nerve Diseases | Spinocerebellar Ataxia Type 31 | Angioedema, Hereditary | 3-hydroxy-3-methylglutaric Aciduria | Urofacial Syndrome | Familial Isolated Hyperparathyroidism | Apraxia | Congenital Hereditary Endothelial Dystrophy Type II | Acrocallosal Syndrome | Rheumatoid Arthritis | Arthritis, Psoriatic | Perry Syndrome | Encephalopathy, Hepatic | Zimmermann-Laband Syndrome | Crouzon Syndrome With Acanthosis Nigricans | Oculodentodigital Dysplasia | Renal Tubular Dysgenesis | Scapuloperoneal Spinal Muscular Atrophy | Tracheal Disorders | Osteonecrosis | Brenner Tumor | Pantothenate Kinase-associated Neurodegeneration | Neurogenic Bladder | Transcobalamin Deficiency | Peritonitis | GM2-gangliosidosis AB Variant | Exfoliative Dermatitis | Prolidase Deficiency | Down Syndrome | Retinoschisis | Osteogenesis Imperfecta | Myoclonus-dystonia Syndrome | Hemochromatosis Type 2 | T-cell Prolymphocytic Leukemia | Hereditary Pyropoikilocytosis | Duodenal Atresia | Anxiety Disorders | Dystonia Musculorum Deformans | Neural Tube Defect | Schwannoma | Bartsocas-Papas Syndrome | Schizophrenia | Colitis, Collagenous | Learning Disability | Cannabis Abuse | Retinal Dystrophy, Early-onset Severe | Glomerulonephritis | Analgesia | Axenfeld-Rieger Syndrome | Gynecomastia | LMNA-related Congenital Muscular Dystrophy | Polycystic Ovary Syndrome | Pierson Syndrome | Methemoglobinemia Type IV | Extramammary Paget's Disease | D-2-Hydroxyglutaric Aciduria | GNE Myopathy | Chromosome 9q34.3 Deletion Syndrome | Hemolytic Uremic Syndrome, Atypical | Van Der Knaap Disease | Hypersensitivity Pneumonitis | Pachyonychia Congenita | HIBCH Deficiency | Primary Progressive Nonfluent Aphasia | Optic Nerve Hypoplasia, Bilateral | Blau Syndrome | Polyneuropathy | Asphyxia Neonatorum | Supravalvular Aortic Stenosis | MIRAGE Syndrome | Glutaric Aciduria Type 1 | Vascular Calcification | Congenital Stationary Night Blindness | Lymphedema-distichiasis Syndrome | Schizotypal Personality Disorder | Angiosarcoma Of The Breast | Carpenter Syndrome | Chronic Beryllium Disease | Congenital Bile Acid Synthesis Defect | Situs Inversus | Pontocerebellar Hypoplasia | Cartilage Disorders | Anthrax | Diabetic Nephropathy | Burn-McKeown Syndrome | Asthma, Nocturnal | Trigonocephaly | Familial Mediterranean Fever | Stargardt Disease | Obesity | Keratosis | Liver Failure | Tinea Versicolor | Schindler Disease | Erythematotelangiectatic Rosacea | Influenza | Peeling Skin Syndrome, Acral Type | Loeys-Dietz Syndrome Type 4 | Glycogen Storage Disease Type 1a | Hereditary Neuropathy With Liability To Pressure Palsies | Retinitis Pigmentosa | Inflammatory Joint Disease | Acrodermatitis | Lyme Disease | Vitelliform Macular Dystrophy | Ulcerative Colitis | Sclerocornea | Keratitis | Primary Cutaneous Amyloidosis | Meesmann Corneal Dystrophy | Hereditary Multiple Exostoses | Congenital Ichthyosiform Erythroderma | Cocaine-Related Disorders | Depression | Silicosis | Long QT Syndrome Type 1 | Conduct Disorder | Glutathione Synthetase Deficiency | Lactose Intolerance | Oculocutaneous Albinism Type 1 | Postaxial Polydactyly | Trichothiodystrophy | Coloboma | Sporadic Hemiplegic Migraine | Haim-Munk Syndrome | Epidermodysplasia Verruciformis | Onchocerciasis | Interstitial Lung Diseases | Usher Syndrome Type IIC | Neurofibroma, Plexiform | Erectile Dysfunction | Glycogen Storage Disease Type 0 | Hyperekplexia | Hypokalemia | Nephritis, Interstitial | Intestinal Tuberculosis | Multisystemic Smooth Muscle Dysfunction Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Osteochondrosis | Acute Anterior Uveitis | Charcot-Marie-Tooth Disease Type 4E | Cyclic Vomiting Syndrome | Graves Disease | Ichthyosis | Cenani-Lenz Syndactyly Syndrome | Poirier-Bienvenu Neurodevelopmental Syndrome | Schizophrenia, Paranoid | Heroin Dependence | Hepatitis A | Meningococcal Meningitis | Williams Syndrome | Pycnodysostosis | Neurocutaneous Syndromes | Renal Medullary Carcinoma | Tendinopathy | Basal Ganglia Disease, Biotin-responsive | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Neurocysticercosis | Glaucoma, Congenital | Hypertension, Renal | Cousin Syndrome | Multifocal Motor Neuropathy | Spinocerebellar Ataxia Type 1 | Gastritis | Keratocystic Odontogenic Tumor | Systemic Mastocytosis | Neutrophilia | Bullous Pemphigoid | Myocardial Infarction | Central Retinal Artery Occlusion | Hyperuricemic Nephropathy, Familial Juvenile | Eating Disorder | Pelizaeus-Merzbacher Disease | Congenital Dyserythropoietic Anemia Type 4 | Gliosarcoma | Zygomycosis | Mitochondrial DNA Depletion Syndrome | Mohr-Tranebjaerg Syndrome | Uveitis, Anterior | Synovitis | Lathosterolosis | Prader-Willi Syndrome | VACTERL/VATER Association | Carcinoma, Small Cell | Cutaneous Lupus Erythematosus | 3-methylglutaconic Aciduria Type I | Hypoparathyroidism | Costello Syndrome | Warsaw Breakage Syndrome | Eiken Syndrome | Myelomeningocele | Hepatitis C, Chronic | Protein S Deficiency | Intermittent Claudication | Priapism | Bone Giant Cell Tumor | Muckle-Wells Syndrome | Alexander Disease | Usher Syndrome Type III | Thrombophlebitis | GAPO Syndrome | ICF Syndrome | Cryoglobulinemia | Viral Meningitis | Methylmalonic Acidemia | Spondyloarthritis | Chronic Granulomatous Disease, X-linked | Bainbridge-Ropers Syndrome | Benign Recurrent Intrahepatic Cholestasis 1 | Epidermolysis Bullosa Simplex, Dowling-Meara Type