Disease

Diabetes

About the Disease
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

Common Targets
HDAC6 | CDH13 | TLR8 | RUNX2 | KSR2 | CDK2 | Phosphodiesterase 6 (PDE6) (nonspecified subtype) | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | SLC27A2 | HRH3 | RPS6KA4 | HDAC2 | RORC | G3620 | KIT | PPIA | TRPC4 | HDAC10 | CETP | GPR139 | NF-kappaB (NFkB) | PRDX1 | APPL1 | G5599 | BTK | Protein Phosphatase 2A | ISLR | LPL | MIR541 | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | PASK | GSR | HIF1A | G595 | INPPL1 | MDH2 | PTPN2 | FFAR4 | Carbonic Anhydrase (nonspecified subtype) | TACR3 | MC1R | AVPR1A | GPBAR1 | SMO | G29126 | GPR88 | PTGES | GPR35 | AMP-activated protein kinase (AMPK) | SLC9A1 | DUSP3 | HFE | gamma-Secretase | Interleukin 17 (nonspecified subtype) | HSD17B2 | cAMP Phosphodiesterase (nonspecified subtype) | Prolyl 4-hydroxylase | GPR119 | Heat shock protein 90 (nonspecified subtype) | IL-15 receptor | SLC22A1 | SSTR2 | FOXO1 | PDE8A | CARM1 | SLC28A3 | TTR | GAPDH | CDK6 | PRMT6 | Carnitine O-Palmitoyltransferase 1 (CPT-1) (nonspecified subtype) | CSF1R | Integrin alphavbeta3 (vitronectin) receptor | IGF2R | RPS6KA2 | KISS1 | CD3 Complex (T Cell Receptor Complex) | MIR320A | IL37 | ALDH1A2 | G207 | TBC1D8 | KCNA3 | PDK1 | KCNN3 | MOGAT2 | ABHD11 | GHRL | CRTC2 | CISD2 | GBA1 | GHSR | CD81 | IFNA13 | Pyruvate Dehydrogenase Complex | SREBF2 | MKNK2 | GRM5 | GDF15 | NISCH | SLC18A2 | NR3C2 | ATP6V0A4 | Serine/Threonine Kinase (nonspecified subtype) | Serum/glucocorticoid regulated kinase (Sgk) (nonspecified subtype) | PTGR2 | ELANE | G7099 | AXL | TMPRSS15 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | L-type voltage-dependent calcium channel complex | CA5A | G5728 | CYP2C19 | MAX | PDE4B | CDK4 | Carnitine O-Palmitoyltransferase (CPT) (nonspecified subtype) | Phosphodiesterase IV (PDE4) (nonspecified subtype) | MIR23A | TOP1 | PRMT5 | HDAC8 | PRMT8 | LRBA | G59272 | IKBKB | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | DAO | THRB | NR1H2 | VEGFB | NOS1 | OPRK1 | DGAT1 | NR1I3 | CHRM4 | IL2RA | GLIS3 | FFAR1 | BMP4 | MTNR1A | ACE | Folate Receptor (nonspecified subtype) | AQP9 | CERT1 | CYSLTR1 | Interleukin-1 (nonspecified subtype) | ORAI1 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | I-kappa-B-kinase (IKK) complex | Cyclin-dependent kinase (nonspecified subtype) | ERO1A | SPHK2 | Glycogen phosphorylase (nonspecified subtype) | FKBP1A | NPM1 | SH2B1 | PTGER3 | COL1A1 | ADRA1A | Protein kinase C (nonspecified subtype) | AURKB | CHEK1 | KCNK18 | G7295 | OR12D3 | MIR488 | CNR2 | CA1 | IP6K2 | POR | AKR1C2 | MIR34A | PRKCA | NPY1R | IL17RA | ACP1 | IFNL3 | P4HA3 | PRKCG | ENTPD2 | Thyroid hormone receptor (nonspecified subtype) | MGAT2 | ADGRF5 | FCGRT | Hedgehog Protein (nonspecified subtype) | G598 | RPS6KA3 | EPHX2 | G4780 | FLG | PPARA | G1029 | ADIPOQ | PDE8B | GHRLOS | PTGIR | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | G1432 | PNPLA3 | NPC1L1 | EIF5A2 | T-Type Calcium Channel | IDH1 | Calcium channel (nonspecified subtype) | Somatostatin receptor (nonspecified subtype) | LCK | TYK2 | LanC-like proteins (nonspecified subtype) | AGT | CDKN2B | IKZF1 | DLAT | ALDH2 | PDGFRB | RUNX3 | CES2 | CYP8B1 | ALDH3A1 | ALOX12 | AVPR1B | MAP2K1 | HLA-DQA1 | CDC25C | KLB | DRD2 | MMP3 | ESR2 | mTOR complex 1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | CTSS | BRD2 | Phospholipase A2 (nonspecified subtype) | HMOX2 | FGF21 | GCK | NR1H3 | GP1BA | LOC102724428 | Calcium release-activated channel (CRAC) | DNA Topoisomerase II (nonspecified subtype) | MAP3K5 | TRPC5 | PDK2 | GH1 | DROSHA | HRH2 | SCD | G6352 | beta-Secretase (nonspecified subtype) | MIR574 | MT1A | GABRB2 | DGAT2 | GPR18 | CDK5 | CHRM1 | Lipoxygenase (nonspecified subtype) | Serine palmitoyltransferase | MAOA | TYR | SESN2 | GABRG2 | Steroid 5-alpha-Reductase (nonspecified subtype) | Mucin (nonspecified subtype) | CDK9/Cyclin T1 | SGK1 | DLD | PKLR | COMT | Matrix Metalloproteinase (MMP) (nonspecified subtype) | APLNR | UGCG | CDKAL1 | BCR | HDAC7 | CASR | PIK3CB | ANO1 | CPT1A | G142 | Estrogen receptor (nonspecified subtype) | C11orf65 | DHODH | USP19 | Casein kinase I (nonspecified subtype) | LOX | BRD4 | LEPROT | SORT1 | ENPP3 | PIK3CD | KEAP1 | Sodium-Glucose Cotransporter (SGLT) (nonspecified subtype) | PGR | HDAC5 | CEBPA | TXNIP | SLC22A12 | CTSL | CLEC14A | GATA6 | CCKBR | PDE10A | HMGCR | cGMP Phosphdiesterase (PDE) (nonspecified subtype) | HLA-DRB1 | HTR4 | ICAM1 | Cholesterol esterase (nonspecified subtype) | FFAR3 | HTR1A | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | SSTR3 | PIM3 | MKNK1 | HDAC3 | EIF2AK2 | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | G7157 | BACE2 | HCRTR1 | KHK | DBH | TNFSF13B | CLK4 | RPS6KB1 | ADORA2B | KCNK2 | SLC6A2 | MAP3K11 | NOX4 | RAMP2 | Actin related protein 2/3 complex | ADORA1 | ATP5IF1 | HDAC1 | G23411 | G2475 | CDK9 | GRM2 | HDAC11 | PDE9A | PTK6 | MAP3K8 | G1385 | KCNJ1 | NMU | ADIPOQ-AS1 | PPID | NR4A1 | CNR1 | AMP Deaminase (nonspecified subtype) | ARG1 | UQCRB | MAP3K14 | HTR2B | AMP-activated protein kinase alpha2beta1gamma1 | LEP | IL-2 receptor | MIR122 | PANK3 | POU5F1 | Neurotrophic Factor (nonspecified subtype) | S1PR2 | JUNB | ABCA1 | WEE1 | PPARG | CLU | G4609 | P2RY6 | PTPN9 | NR5A2 | SGK2 | NADH dehydrogenase (Complex I) | DYRK1A | DPP7 | AMP-activated protein kinase alpha1beta1gamma1 | NPY2R | BICC1 | NR1I2 | SELENOS | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | PCSK9 | GPR142 | GLIPR2 | Oxysterols receptor LXR (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | MIR379 | PDE6C | HSD11B1 | RBP4 | GABA(A) receptor | NTRK3 | PIK3C2A | PIEZO1 | Tyrosine Kinase (nonspecified subtype) | Reverse transcriptase (Telomerase) | FGA | PTCH1 | PYGB | REL | CCR2 | VCAM1 | CERS6 | RAMP1 | Gap junction Connexin ( (nonspecified subtype) | Adenylate Cyclase (nonspecified subtype) | TAS1R2 | PRKAG2 | G5595 | IAPP | AMP-activated protein kinase alpha2beta1gamma2 | P2RY11 | CASP8 | GPX1 | PGAM5-KEAP1-NRF2 Complex | Kir 3.1/3.2 | SHC1 | DPP4 | TTK | DPP8 | PTGS1 | CHRNA7 | G4170 | TRPV1 | KLRK1 | TM6SF2 | PPARD | CCNT1 | AVPR2 | SIRPA | ADRB3 | CREB3 | HPGD | CPT2 | JUND | G2099 | MTNR1B | VIPR1 | CA7 | Guanylate cyclase (nonspecified subtype) | INSR | ADRA2A | STK11 | NKX2-2 | PDK4 | SLC13A5 | BCHE | ADORA2A | SYK | Histone acetyltransferase (HAT) (nonspecified subtype) | Chaperone (nonspecified subtype) | Amylin receptor | TGFBR1 | PDPK1 | G9429 | MASP2 | G3605 | FLT1 | UTS2R | Casein kinase II (CKII) | GIPR | PRMT1 | PYGL | FABP3 | G3480 | NEU4 | SLC16A1 | CYP24A1 | EIF2AK4 | MT2A | ZAP70 | P2RY13 | PSMD14 | GSTT1 | PTPN1 | ITK | ANGPTL8 | KCNE1 | FFAR2 | BCKDHA | NPPA | NTRK1 | OXT | IRAK4 | TNKS2 | BSCL2 | MAPKAPK2 | RAPGEF4 | Inhibitory kappaB Kinase (IKK) (nonspecified subtype) | ACHE | AKT2 | C3AR1 | cAMP-Dependent protein kinase (PKA) | AKR1B1 | SLC29A3 | ERN2 | ADH1B | SLC22A2 | SMPD2 | Tubulin | SERPINE1 | CDK16 | FUCA1 | NPPA-AS1 | GSK3B | Sphingomyelin phosphodiesterase (nonspecified subtype) | KCNJ3 | F2 | IGFBP3 | Voltage-Gated Sodium Channel Complex | MC3R | XDH | MAP4K4 | CES1 | ENTPD3 | Lactate Dehydrogenase (LDH) | TIE1 | CASP2 | RORA | PIKFYVE | MPG | FGFR1 | G2309 | TNFRSF12A | SESN3 | CSNK2A2 | DICER1 | MAPK9 | SP110 | GUSB | G3630 | GRIN2A | Orexin receptor (nonspecified subtype) | MEN1 | PHKA1 | PLG | MAP4K1 | SSTR4 | G7124 | FABP5 | G836 | 15-Lipoxygenase (nonspecified subtype) | PCBD1 | PI4KA | PDIA4 | TLR2 | NPY5R | P4HB | OGT | PRKCD | SLC6A19 | IL-6 receptor | ALDH1A1 | ELAPOR1 | GABRB3 | NPY4R | CEBPB | PTP4A3 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | DHPS | ABCC9 | ABHD6 | ADORA3 | G4318 | K(ATP) Channel (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | NR3C1 | CYP2R1 | JAZF1 | WFS1 | QPCT | DNAJC3 | PTGER4 | CALCA | ADIPOR1 | FUCA2 | WWTR1 | KLF11 | MFN2 | NR1H4 | Heme Oxygenase (HO) (nonspecified subtype) | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | BACE1 | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | CXCR3 | DMGDH | LIPC | ESRRA | GABRA1 | POLG | ACP3 | APAF1 | MAP Kinase-Interacting Serine/Threonine-Protein Kinase (nonspecified subtype) | ADRB1 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | AMPD2 | HCRTR2 | Pyruvate dehydrogenase kinase (nonspecified subtype) | BCL9 | P2RY12 | KMT2A | G2033 | BCL2L11 | SLC19A2 | ADCY8 | G6PC1 | DRD1 | MTTP | TPH2 | Trypsin (nonspecified subtype) | G367 | STS | CHRM3 | GPR84 | PTGDR2 | CHUK | G4193 | G4233 | KDM1A | HDAC4 | XPO5 | QSOX1 | Sodium channel (nonspecified subtype) | TEK | STK17B | NPFFR2 | RAN | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | KCNJ5 | SOAT1 | LEPR | TIMP1 | Prostanoid TP receptor (nonspecified subtype) | GLUD1 | AKR1A1 | HSD17B13 | SST | ABCC8 | PIK3CA | HCAR1 | BLK | FAAH | G5743 | CYP3A5 | PTF1A | GHR | CALCRL | RXRA | CYP2J2 | PDE6D | CNDP1 | KLRC4-KLRK1 | TMEM219 | PIK3C3 | STK17A | FASN | IKZF3 | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | Caspase (nonspecified subtype) | PKM | CHIA | OGA | CDK2/Cyclin A | Glycylpeptide N-tetradecanoyltransferase (nonspecified subtype) | HNF1A | FLT3 | PIM1 | ADCYAP1R1 | CCR1 | CDK14 | IL1A | MLL/SET1 Complex | Integrin alphaLbeta2 (LFA-1) receptor | EPOR | ATF3 | VDR | G5243 | CTSC | FOXA2 | Heat shock protein 70 (nonspecified subtype) | SIK2 | BBOX1 | Carnitine O-palmitoyltransferase 2 (nonspecified subtype) | Serine protease (nonspecified subtype) | NOS3 | NEUROG3 | AP-1 Transcription Factor Complex | IL2 | ACMSD | LOXL2 | PRKCB | Leukotriene B4 receptor (LTB4-R) (nonspecified subtype) | LAMA2 | G196 | FBP1 | HSD11B2 | SGMS2 | MMP2 | MTHFR | CDC25A | FASLG | ADM | ESRRB | ADP/ATP Translocase (nonspecified subtype) | SCN1A | SLC6A4 | PTPRB | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | RORB | Poly [ADP-ribose] polymerase (nonspecified subtype) | TPH1 | ABHD5 | CLK1 | LMNA | STK4 | BRD3 | CDKN1B | HTR6 | Cytochrome P450 Enzymes (nonspecified subtype) | L-Type calcium channel (nonspecified subtype) | RPL31 | BRS3 | GRK5 | PROKR1 | Vasopressin Receptor (nonspecified subtype) | BDKRB1 | KCNJ6 | Janus Kinase (nonspecified subtype) | WT1 | Ikzf1 | CA2 | DOT1L | PTPN22 | S1PR5 | PDE5A | CA9 | MLYCD | FPR2 | MSTN | LANCL2 | SLC2A1 | ERN1 | ADIPOR2 | PDGFRA | PON1 | G1786 | DYRK1B | USP30 | PARP2 | ADH5 | Adenosine receptor (nonspecified subtype) | KDR | NQO2 | ENPP1 | TLR9 | SPHK1 | ACACB | APOA1 | SCN9A | SLC5A1 | Cannabinoid receptor (nonspecified subtype) | MYH6 | VRK1 | NMUR1 | ROCK2 | IFNAR1 | NOX3 | MAPK10 | HTR1B | SIRT5 | CCKAR | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | NMDA receptor | BCKDK | Phosphodiesterase 8 (nonspecified subtype) | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | PLIN1 | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | CXCL10 | G1956 | GAA | CTSK | FURIN | PLAU | STK25 | METAP2 | IFNG | ADRB2 | TOP2A | NPBWR1 | F2RL3 | ENTPD1 | AKR1B10 | Cyclooxygenase (COX) (nonspecified subtype) | SLC10A2 | NT5E | GLB1 | HTR2A | SIK1 | IKZF2 | RUNX1 | G3082 | HPSE | RAB5A | KCNJ8 | Gastric H+/K+-ATPase | DAGLA | NOS2 | PGF | PLA2G2D | NAMPT | CISD1 | EIF2AK3 | RXRB | PRKCQ | GLP2R | Myosin (nonspecified subtype) | AGTR1 | P2RY14 | SSTR5 | ESRRG | VHL | TRPA1 | CA5B | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | SPINK1 | PLA2G7 | TNFSF15 | CTRC | Cyclin A (nonspecified subtype) | CCR5 | APP | Mitochondrial pyruvate carrier complex (MPC) | Cytochrome P450 4A (nonspecified subtype) | SLC27A1 | Histone deacetylase (nonspecified subtype) | LIPE | AGER | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | CREBBP | Cyclin-dependent kinase inhibitor (nonspecified subtype) | MC4R | SGIP1 | IFNL4 | SEMA3A | CFTR | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | G7422 | PANK2 | FYN | GSTM1 | HNF4A | CMKLR1 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | Chemokine receptor (nonspecified subtype) | AGTR2 | ALB | F11 | RFX6 | NPR1 | EGLN1 | Aurora Kinase (nonspecified subtype) | G3146 | PTPN11 | Proteasome Complex | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | ATF4 | GSTP1 | ACLY | NR1D1 | APOB | CYP19A1 | NMT1 | CASP1 | STING1 | Glycogen synthase (nonspecified subtype) | CTSB | GATA3 | UGT1A1 | Gap Junction Protein (nonspecified subtype) | Angiotensin receptor (AT) (nonspecified subtype) | FTO | P2RX7 | AKT3 | KLKB1 | DEFB1 | DHFR | FSTL3 | Glutathione S-Transferase (GST) (nonspecified subtype) | NADPH Oxidase Complex | SSTR1 | NQO1 | TLR6 | Nitric oxide synthase (NOS) (nonspecified subtype) | CREB5 | HCAR2 | Endothelin receptor (nonspecified subtype) | Imidazoline I2 receptor (I2) | SLC2A2 | SGMS1 | PNLIP | RAPGEF3 | IGF2BP2 | CCL2 | FOXO4 | GRM4 | HTR2C | RXRG | Retinoid RXR receptor (nonspecified subtype) | FABP4 | PCSK6 | G8678 | RETN | IRAK1 | UCP1 | CALCR | G2146 | PLCB1 | RXFP4 | IDE | CRY1 | DRD3 | TENT4B | alpha-Amylase (nonspecified subtype) | SLC30A8 | USP7 | NLRX1 | POLB | NPC1 | ALOX5 | NLRP3 Inflammasome | IL4 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | CRBN | GPR39 | Imidazoline I3 receptor (I3) | CDK1 | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | G596 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | NNMT | SIRT3 | DLL4 | GLP1R | TBK1 | ACACA | CHEK2 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | GABRA6 | DPP9 | MBOAT4 | JAK3 | SIAH2 | Potassium Channels (nonspecified subtype) | TRNL1 | CA3 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | PTPRC | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | CYP11B2 | PARL | REN | Rho kinase (ROCK) (nonspecified subtype) | MAOB | ALDH1A3 | OXTR | IL1B | Imidazoline receptor (nonspecified subtype) | CTNNB1 | CX3CR1 | G8878 | CRHR2 | JAK1 | DAGLB | PRKN | GPER1 | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | S1PR1 | PANK1 | MCHR1 | LINC01497 | TAAR1 | ABL1 | PGK1 | PRMT3 | NMUR2 | SLC1A2 | G7015 | P4HA2 | GPR55 | IKBKE | NEU3 | IP6K1 | NADPH Oxidase (nonspecified subtype) | CLK2 | G3569 | IL13 | THRA | PIK3CG | CBLB | HNF1B | TLR7 | HASPIN | CHRM2 | IFNAR2 | IL18 | PDHA2 | GRK6 | Transcription Factor TCF (nonspecified subtype) | SLC2A4 | CAMK1D | Melanocortin receptor (nonspecified subtype) | FBXW7 | LIPG | POLR1C | CHGA | G3576 | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | TCF7L2 | ODC1 | SIK3 | LY96 | FUT3 | SLC47A1 | G114548 | JAK2 | KCNN2 | FADS1 | HMOX1 | KISS1R | PPT1 | RPS6KA5 | GRIN2B | Soluble guanylyl cyclase | Vasopressin V1 Receptor (nonspecified subtype) | KCNB1 | MC5R | MMP1 | AOC3 | SLC6A5 | ONECUT1 | G6714 | AURKA | PDE3A | HLA-DQB1 | PTPN6 | Glutathione peroxidase (nonspecified subtype) | CXCL5 | alpha-Mannosidase (nonspecified subtype) | UCP2 | GLA | PTAFR | HSD17B3 | THADA | CST3 | MPO | RPS6KA1 | SCN5A | ELOVL6 | Superoxide dismutase (SOD) (nonspecified subtype) | IP6K3 | NTRK2 | ALOX15 | Epoxide Hydrolase (nonspecified subtype) | SIRT6 | TAS1R3 | GCGR | GRB2 | SLC27A4 | PLEKHH2 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | PIM2 | DNA-Directed DNA Polymerase Complex | Monoamine oxidase (MAO) (nonspecified subtype) | ADRA2C | G6647 | XBP1 | G6774 | HSP90B1 | SLC2A5 | MASTL | MFN1 | GSK3A | CGAS | Phosphodiesterase (nonspecified subtype) | MDM4 | PDE4D | SETD7 | PLA2G2A | Cytochrome bc1 complex | KCNJ11 | G5133 | CMKLR2 | CAPN10 | CYBA | PDHB | ENPP2 | PVT1 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | TBXAS1 | EDNRA | WNT5A | SIRT2 | HTR7 | SCN2A | Sphingosine kinase (nonspecified subtype) | CYP3A4 | ASGR1 | IER3IP1 | TJP2 | SLC5A2 | LDLR | SREBF1 | FAP | TNKS | NPY4R2 | CX3CL1 | CSNK1E

疾病靶点研报
Diabetes

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Dystrophy | Encephalitis, Tick-borne | Hereditary Coproporphyria | Pleural Tuberculosis | Atrial Septal Defect | Neuroendocrine Cancer | Malignant Peripheral Nerve Sheath Tumor | Lymphangiomatosis | Hyperparathyroidism, Primary | Pneumococcal Meningitis | Swine Influenza | Metatropic Dysplasia | Alkaptonuria | Cardiac Arrest | Pemphigoid | Thalassemia | Pendred Syndrome | 3-methylglutaconic Aciduria Type I | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Papulopustular Rosacea | Heroin Dependence | Liebenberg Syndrome | Postaxial Polydactyly | Avellino Corneal Dystrophy | Gastritis, Atrophic | Optic Nerve Diseases | Urea Cycle Disorder | Tumoral Calcinosis | Rhabdomyosarcoma | Lennox-Gastaut Syndrome | Kearns-Sayre Syndrome | Bernard-Soulier Syndrome | Currarino Syndrome | Carcinoma In Situ | Seizures-scoliosis-macrocephaly Syndrome | Pyruvate Decarboxylase Deficiency | Sporadic Inclusion Body Myositis | High Molecular Weight Kininogen Deficiency | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Syncope | Parkinsonism | Eclampsia | Familial Digital Arthropathy-brachydactyly | Osteoglophonic Dysplasia | Pseudo-pseudohypoparathyroidism | Congenital Dyserythropoietic Anemia Type 1 | Glutaric Aciduria Type 1 | Glycogen Storage Disease Type 3 | Generalized Epilepsy And Paroxysmal Dyskinesia | Splenomegaly | Metabolic Diseases | Congenital Fiber-type Disproportion Myopathy | Hypertension, Portal | Chondrodysplasia Punctata 1, X-linked Recessive | Smith-Lemli-Opitz Syndrome | Myasthenia Gravis | Farber Disease | Osteoarthritis | Trimethylaminuria | Lesch-Nyhan Syndrome | Schwartz-Jampel-Aberfeld Syndrome | Vitamin B12 Deficiency | CDKL5 Deficiency Disorder | Sarcoma | Pulmonary Sclerosing Hemangioma | Scleroderma | Klinefelter Syndrome | Cheilitis | Hypoalbuminemia | Non-bullous Congenital Ichthyosiform Erythroderma | Dyslipidemia | Pilomatrix Carcinoma | Creutzfeldt-Jakob Disease | Jaundice, Obstructive | Hepatitis | Hyperinsulinemia | Aarskog-Scott Syndrome | Hyperandrogenemia | Oguchi Disease-2 | Juvenile Myoclonic Epilepsy | Nemaline Myopathy | Corneal Ulcer | Pontocerebellar Hypoplasia | Insulin Resistance | Polyarteritis Nodosa | Epidermolysis Bullosa | Systemic Lupus Erythematosus | Protein S Deficiency | Anorchia | Ataxia-ocular Apraxia 2 | Blastomycosis | Acrodysostosis | Mumps | Marfan Syndrome | Raine Syndrome | Gastroenteritis, Eosinophilic | HANAC Syndrome | Guttate Psoriasis | Pneumonia, Viral | Occipital Neuralgia | Olmsted Syndrome | Conduct Disorder | Leri Pleonosteosis | Ellis-Van Creveld Syndrome | Cold-induced Sweating Syndrome | Silver-Russell Syndrome | Myelitis | Retinitis | Uremic Pruritus | Congenital Central Hypoventilation Syndrome | Sarcoidosis | Nicotine Dependence | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Autoimmune Hemolytic Anemia | Neurofibromatosis-Noonan Syndrome | Pseudomyxoma Peritonei | Wolfram Syndrome | Oculopharyngeal Muscular Dystrophy | Acral Lentiginous Melanoma | Lymphoma Lymphoblastic | Hemophagocytic Lymphohistiocytosis | Epidermolytic Ichthyosis, Annular | Bethlem Myopathy | Venous Insufficiency | Preaxial Polydactyly | Hypobetalipoproteinemias | Hypervalinemia | Juvenile Hyaline Fibromatosis | Macrophagic Myofasciitis | Chromosome 17q21.31 Deletion Syndrome | Huntington's Disease-like 2 | Apparent Mineralocorticoid Excess Syndrome | Muscle Wasting | Granular Corneal Dystrophy | Myelitis, Transverse | Arteriovenous Malformations | Migraine | Dupuytren Disease | Early Infantile Epileptic Encephalopathy 1 | Brachial Plexus Neuropathy | Parvovirus B19 Infection | Fatty Aldehyde Dehydrogenase Deficiency | Enterocolitis, Necrotizing | Agoraphobia | Cataplexy | Azoospermia | Portal Vein Thrombosis | Pleomorphic Xanthoastrocytoma | Nicotine Addiction | Kernicterus | Chorea | Congenital Aniridia | Microcephaly, Seizures, And Developmental Delay | Blastoma, Pleuropulmonary | Oculocutaneous Albinism | Stromal Corneal Dystrophy | Waldenstrom Macroglobulinemia | McLeod Syndrome | Pituitary Stalk Interruption Syndrome | Lactose Intolerance | Anencephaly | Stroke, Ischemic | Primary Pigmented Nodular Adrenocortical Disease | Toxic Epidermal Necrolysis | Pierson Syndrome | Alpha-mannosidosis | Melnick-Needles Syndrome | Turner's Syndrome | Cardiomyopathy, Hypertrophic | Blepharospasm | Ependymoma | Trichothiodystrophy | Mandibuloacral Dysplasia With Type A Lipodystrophy | Skin Papilloma | Juvenile Xanthogranuloma | Hypophosphatasia | Acrocallosal Syndrome | Congenital Disorders Of Glycosylation Type II | Giant Cell Glioblastoma | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Retinal Detachment | ACTH-independent Macronodular Adrenal Hyperplasia | Long QT Syndrome Type 3 | Dementia, Vascular | Multiple Epiphyseal Dysplasia | Tendinopathy | Leukoplakia | Blue Rubber Bleb Nevus Syndrome | Gray Platelet Syndrome | Leiomyoma | Chloridorrhea, Congenital | Neovascular Glaucoma | Plasma Cell Leukemia | Spinocerebellar Ataxia Type 1 | Neurofibrosarcoma | Fibromuscular Dysplasia | Myelofibrosis | Eczema | Phosphoglycerate Dehydrogenase Deficiency | Cervicitis | Ganglioneuroma | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Acute Lymphocytic Leukemia | Noonan Syndrome | Hemimegalencephaly | Chromosome 5q Deletion Syndrome | Intracranial Hypertension | Amelogenesis Imperfecta | H Syndrome | Dyggve-Melchior-Clausen Disease | HUPRA Syndrome | Scleritis | Pemphigus Foliaceus | Relapsing Polychondritis | Gerodermia Osteodysplastica | REM Sleep Behavior Disorder | Spinal Cord Diseases | Urethritis | Warsaw Breakage Syndrome | Cabezas Syndrome | Autonomic Nervous System Disorders | Stomatitis | Fanconi Syndrome | Major Depression | Hyperekplexia | Glaucoma | Gitelman Syndrome | Myofibrillar Myopathy | Bone Giant Cell Tumor | Hyperlipidemia Type V | Hepatitis E | Autoimmune Disease | Wolman Disease | Temtamy Preaxial Brachydactyly Syndrome | Craniofacial Dysostosis | Hennekam Lymphangiectasia-lymphedema Syndrome | Campomelic Dysplasia | Glioblastoma | Oligoastrocytoma | Usher Syndrome Type II | Tenosynovial Giant Cell Tumor | Infantile Nephropathic Cystinosis | Melanoma | Psoriasis | Benign Recurrent Intrahepatic Cholestasis 1 | CEDNIK Syndrome | Takayasu's Arteritis | Corneal Dystrophies, Hereditary | Reticular Dysgenesis | Presbyopia | Wiskott-Aldrich Syndrome | Hidradenitis Suppurativa | Ichthyosis | Inborn Errors Of Metabolism | Glutaric Aciduria Type 2 | 3-M Syndrome | Pyloric Stenosis, Infantile Hypertrophic | Gilbert Syndrome | Acute Chest Syndrome | Adenocarcinoma | Polycystic Kidney, Autosomal Recessive | Autism | McCune-Albright Syndrome | Hypothalamic Obesity | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Triple A Syndrome | Lassa Fever | Hyperuricemia | Neonatal Progeroid Syndrome | Common Variable Immunodeficiency | Progressive Myoclonic Epilepsy | Smith-Kingsmore Syndrome | Jalili Syndrome | Bartsocas-Papas Syndrome | Neurotoxicity | Gliosarcoma | Tetanus | Aneurysm, Abdominal Aortic | Pure Red Cell Aplasia | Rheumatic Heart Disease | Thrombotic Microangiopathy | Hypotension, Orthostatic | Kohlschutter-Tonz Syndrome | Diabetes Insipidus, Neurogenic | Meier-Gorlin Syndrome | Snyder-Robinson Syndrome | X-linked Sideroblastic Anemia | Acromegaly | Tremor | Congenital Sodium Diarrhea | Gout | Leishmaniasis, Cutaneous | Mucormycosis | Cystitis, Interstitial | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | ADNP Syndrome | Hemosiderosis | Malignant Fibrous Histiocytoma | Niemann-Pick Disease, Type A | Vertigo | Osteogenesis Imperfecta | Analgesia | Osteitis | Lymphopenia | Lipoma | Norrie Disease | Androgen Insensitivity | Hepatic Veno-occlusive Disease | Sclerocornea | Meningioma, Benign | Trichotillomania | Purpura, Thrombotic Thrombocytopenic | Asplenia | Patent Ductus Arteriosus | Menkes Disease | Stargardt Disease | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Loeys-Dietz Syndrome Type 4 | Paronychia | Progressive Familial Intrahepatic Cholestasis Type 2 | Evans Syndrome | Von Hippel-Lindau Disease