Progressive Familial Intrahepatic Cholestasis Type 3

About the Disease
Cholestasis, Progressive Familial Intrahepatic, 3, also known as pfic3, is related to familial intrahepatic cholestasis and cholangitis, and has symptoms including diarrhea, icterus and pruritus. An important gene associated with Cholestasis, Progressive Familial Intrahepatic, 3 is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. Affiliated tissues include liver and spleen, and related phenotypes are splenomegaly and hepatomegaly

Common Targets
CDK2 | CDK5/p25 | Casein kinase I (nonspecified subtype) | ABCB4 | CDK5 | CDK9/Cyclin T1 | CDK9 | DYRK1A | CCNT1 | GSK3B | CDK2/Cyclin A | CLK1 | Cyclin A (nonspecified subtype) | CFTR

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