Angina Pectoris

About the Disease
Angina Pectoris, also known as prinzmetal's variant angina, is related to polycythemia vera and intermittent claudication, and has symptoms including other and unspecified angina pectoris An important gene associated with Angina Pectoris is EDN1 (Endothelin 1), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Candesartan cilexetil and Amiodarone have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and bone marrow, and related phenotypes are homeostasis/metabolism and muscle

Common Targets
SLC9A1 | cAMP Phosphodiesterase (nonspecified subtype) | CNR1 | RYR1 | COMT | KCNN3 | EPHX2 | P2RY1 | MAOA | G142 | SLC18A2 | Alpha-2 Adrenergic receptors (nonspecified subtype) | Carnitine O-Palmitoyltransferase 1 (CPT-1) (nonspecified subtype) | MTNR1A | G5243 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | PTGER3 | Lipoxygenase (nonspecified subtype) | GUCY2D | PKMYT1 | PTGIR | HMGCR | P2RY2 | ACHE | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | T-Type Calcium Channel | G1956 | ADORA1 | APLNR | G23411 | HTR2B | NPY1R | CTSS | ALOX12 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | Voltage-Gated Sodium Channel Complex | Phospholipase A2 (nonspecified subtype) | ADORA2B | CES2 | CACNA1G | G1/S-specific cyclin-E (nonspecified subtype) | F2 | FPR1 | TGFBR1 | CTSL | PPID | ADORA2A | DBH | CALM1 | Sodium channel (nonspecified subtype) | F10 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | alpha-Adrenoceptor (nonspecified subtype) | KDR | XDH | Neurotrophic Factor (nonspecified subtype) | AKR1B1 | cGMP Phosphdiesterase (PDE) (nonspecified subtype) | NOS3 | PTPN1 | CHRNA7 | Tyrosine Kinase (nonspecified subtype) | PCSK9 | G2064 | CACNA1C | NFATC2 | S1PR2 | SLC9A3 | GSK3B | ATP5IF1 | HPGD | Guanylate cyclase (nonspecified subtype) | BCHE | SERPINE1 | ADRB3 | EDNRB | SELP | NR5A2 | G836 | WEE1 | AMP Deaminase (nonspecified subtype) | OPRD1 | Adenylate Cyclase (nonspecified subtype) | SCN4A | UTS2R | Integrin alphavbeta5 receptor | ADORA3 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | ADA | RYR2 | PLG | PDE5A | HTR2A | Adenosine deaminase (nonspecified subtype) | ADRB1 | G7422 | NPPA | K(ATP) Channel (nonspecified subtype) | MME | TSPO | 15-Lipoxygenase (nonspecified subtype) | PRKCD | SMPD2 | beta-Adrenoceptor (nonspecified subtype) | IL-6 receptor | CXCR3 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | AGTR1 | Elastase (nonspecified subtype) | P2RY12 | CALCRL | Prostanoid TP receptor (nonspecified subtype) | G7124 | STS | HRH1 | NF-kappaB (NFkB) | CPB2 | ADRB2 | RAD51 | SCN9A | Cysteine Protease (nonspecified subtype) | SLC4A8 | VHL | CCNE1 | L-Type calcium channel (nonspecified subtype) | CFTR | PDE2A | SCN1A | CCR9 | Complement Complex | FPR2 | CDK2/Cyclin A | NLRP3 Inflammasome | CR1 | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | alpha1-Adrenoceptor (nonspecified subtype) | Poly [ADP-ribose] polymerase (nonspecified subtype) | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | G114548 | S1PR5 | CRBN | BBOX1 | LPAR4 | Integrin alpha2beta3 Receptor | GRK5 | Adenosine receptor (nonspecified subtype) | F11 | OLR1 | AGTR2 | PLAU | Nitric oxide synthase (NOS) (nonspecified subtype) | APP | MLYCD | CTSK | ECE1 | C5AR1 | CYSLTR2 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | NPR1 | PLA2G2D | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | Adrenoceptor (nonspecified subtype) | Potassium Channels (nonspecified subtype) | F2R | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | Cyclin A (nonspecified subtype) | Myosin (nonspecified subtype) | Angiotensin receptor (AT) (nonspecified subtype) | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | PLA2G7 | CDK2/Cyclin E | Endothelin receptor (nonspecified subtype) | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | Soluble guanylyl cyclase | SCN5A | Rho kinase (ROCK) (nonspecified subtype) | CDK1 | SERPING1 | FGF2 | ACAA2 | REN | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | FGFR2 | ACACA | 3-Ketoacyl-CoA Thiolase (3-KAT) (nonspecified subtype) | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | PI3 | HIF1A | ACE | PTAFR | OPRM1 | CMA1 | EDNRA | Phosphodiesterase (nonspecified subtype) | SLC8A1 | ALOX15 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | ELANE | HRH3 | TBXAS1 | ECE2 | SELE | Bradykinin receptor (nonspecified subtype) | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | SCN2A | LDLR | PDGFRB | PLA2G2A | CDK2 | DRD2 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | NR3C2 | CACNA1H | CETP | BDKRB2 | G2475 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | KCNH2 | GPR35 | GSK3A | Integrin alphavbeta3 (vitronectin) receptor | Calcium channel (nonspecified subtype) | Sphingosine kinase (nonspecified subtype) | CACNA1B | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | L-type voltage-dependent calcium channel complex | CASP7 | PPARG | Protein kinase C (nonspecified subtype) | Protein Kinase B (PKB/Akt) (nonspecified subtype) | F9

Note: If you'd like to get a target analysis report for Angina Pectoris, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Angina Pectoris at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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