Disease

Diffuse Intrinsic Pontine Glioma

About the Disease
Diffuse Midline Glioma, H3 K27m-Mutant, also known as diffuse intrinsic pontine glioma, is related to glioblastoma and brain stem glioma. An important gene associated with Diffuse Midline Glioma, H3 K27m-Mutant is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Gene expression (Transcription) and Metabolism of proteins. The drugs Prednisone and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and pons, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
H3-3A | HDAC2 | G29126 | TPM3 | G5728 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | Cyclin-dependent kinase (nonspecified subtype) | ATRX | BMI1 | DRD2 | LCK | PDGFRB | CDK9/Cyclin T1 | G7157 | G2475 | HDAC3 | HDAC1 | CDK9 | CCNT1 | Tubulin | STAT5 (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | ACVR1 | PIK3CA | KDM1A | H3C3 | FLT3 | TGFB2 | KDR | Janus Kinase (nonspecified subtype) | CLPP | G1956 | Histone deacetylase (nonspecified subtype) | BIRC5 | Cyclin-dependent kinase inhibitor (nonspecified subtype) | BMPR1A | DRD3 | G238 | MAPK7 | CD276 | JAK2 | H3C2 | PPM1D | G6774 | G5133 | HDAC6

疾病靶点研报
Diffuse Intrinsic Pontine Glioma

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