Noonan Syndrome

About the Disease
Noonan Syndrome 1, also known as noonan syndrome, is related to noonan syndrome with multiple lentigines and neurofibromatosis-noonan syndrome. An important gene associated with Noonan Syndrome 1 is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Simvastatin and Hormones have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and skin, and related phenotypes are ptosis and dysarthria

Common Targets
WDR5 | GH1 | BCR | TSGA10IP | LCK | G3845 | MAP2K7 | SOS2 | LZTR1 | LOC102724428 | PTPN1 | RASA2 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | SLC13A1 | HDAC7 | MLL1/MLL Complex | MAP3K8 | A2ML1 | CES1 | RAF1 | PDGFRA | SLC19A1 | PTPN9 | TRAPPC9 | G673 | KIT | VHL | RIT1 | KMT2A | NF1 | DDR1 | RETREG3 | LRP1 | CRBN | CBL | PTPN11 | MAP2K2 | LYN | SIK2 | TXNRD1 | SHOC2 | SPRY1 | ND4 | ABL1 | PPP1CB | SCN5A | FYN | SIK1 | PDGFRB | CSF1R | SPRED2 | BTK | NRAS | REEP5 | ND5 | NSUN2 | MRAS | HRAS | RRAS | Ras GTPase (nonspecified subtype) | PTPN6 | KDM6A | FGFR3 | NEB | SOS1 | COX1 | YES1 | HCK | CSK | DDR2 | ENKD1 | MAP2K1 | PTPN2 | HMGCR

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Cutis Laxa