Noonan Syndrome

About the Disease
Noonan Syndrome 1, also known as noonan syndrome, is related to noonan syndrome with multiple lentigines and neurofibromatosis-noonan syndrome. An important gene associated with Noonan Syndrome 1 is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Simvastatin and Hormones have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and skin, and related phenotypes are ptosis and dysarthria

Common Targets
WDR5 | GH1 | BCR | TSGA10IP | LCK | G3845 | MAP2K7 | SOS2 | LZTR1 | LOC102724428 | PTPN1 | RASA2 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | SLC13A1 | HDAC7 | MLL1/MLL Complex | MAP3K8 | A2ML1 | CES1 | RAF1 | PDGFRA | SLC19A1 | PTPN9 | TRAPPC9 | G673 | KIT | VHL | RIT1 | KMT2A | NF1 | DDR1 | RETREG3 | LRP1 | CRBN | CBL | PTPN11 | MAP2K2 | LYN | SIK2 | TXNRD1 | SHOC2 | SPRY1 | ND4 | ABL1 | PPP1CB | SCN5A | FYN | SIK1 | PDGFRB | CSF1R | SPRED2 | BTK | NRAS | REEP5 | ND5 | NSUN2 | MRAS | HRAS | RRAS | Ras GTPase (nonspecified subtype) | PTPN6 | KDM6A | FGFR3 | NEB | SOS1 | COX1 | YES1 | HCK | CSK | DDR2 | ENKD1 | MAP2K1 | PTPN2 | HMGCR

Note: If you'd like to get a target analysis report for Noonan Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Noonan Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Lysosomal Acid Lipase Deficiency | Charcot-Marie-Tooth Disease Type 4D | Alstrom Syndrome | Glutathione Synthetase Deficiency | Parkinson's Disease | Epithelial-myoepithelial Carcinoma | Diabetes Insipidus | Hypoalbuminemia | Hashimoto Thyroiditis | Agoraphobia | Peeling Skin Syndrome Type B | Paternal Uniparental Disomy Of Chromosome 14 | Aceruloplasminemia | Noonan Syndrome-like Disorder With Loose Anagen Hair | Early Infantile Epileptic Encephalopathy | Diabetic Macular Edema | Cutaneous Mastocytosis | Hypertensive Retinopathy | Ileitis | Facioscapulohumeral Muscular Dystrophy Type 2 | Antithrombin III Deficiency | Epidermolysis Bullosa Simplex | Autosomal Recessive Congenital Ichthyosis | Hydrocephalus | Cancer, Brain | Choriocarcinoma | Congenital Fiber-type Disproportion Myopathy | Fuchs Dystrophy | Acrocallosal Syndrome | Osteoglophonic Dysplasia | Coronary Restenosis | Arthropathy | Hyperoxaluria | Endophthalmitis | Thrombocythemia, Essential | Adenoma, Villous | Diabetes Type 2 | Perry Syndrome | Chordoid Glioma | Chondromyxoid Fibroma | Xeroderma Pigmentosum | Cancer, Colon | Episodic Ataxia | Polycythemia | Periventricular Nodular Heterotopia | Cat Eye Syndrome | Multiple Sclerosis, Secondary Progressive | Nestor-Guillermo Progeria Syndrome | Hydronephrosis | Waardenburg Syndrome Type 2A | Delayed Sleep Phase Syndrome | Hoyeraal-Hreidarsson Syndrome | Borjeson-Forssman-Lehmann Syndrome | Hidradenitis Suppurativa | Ischemia | Specific Granule Deficiency | Disseminated Superficial Actinic Porokeratosis | Haim-Munk Syndrome | Schwannoma | Craniometaphyseal Dysplasia | Androgen Insensitivity | LRBA Deficiency | Focal Segmental Glomerulosclerosis | Hyperbilirubinemia | Infantile Liver Failure Syndrome 1 | Insulinoma | Carcinoma, Merkel Cell | DiGeorge Syndrome | Dengue Hemorrhagic Fever | Esophageal Motility Disorders | Vitreoretinal Degeneration, Snowflake Type | Hypohidrotic Ectodermal Dysplasia | Iron Metabolism Disorders | Atrioventricular Septal Defect | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Carcinoid Tumor | Sporadic Inclusion Body Myositis | Dupuytren Disease | Heterotopic Ossification | Astigmatism | Atelosteogenesis Type 1 | Lymphangioma | Oligoasthenoteratozoospermia | Persistent Truncus Arteriosus | Pyruvate Dehydrogenase Deficiency | Hyperhomocysteinemia | Waldenstrom Macroglobulinemia | Kashin-Beck Disease | Oculocutaneous Albinism Type 1 | Best Macular Dystrophy | Polymicrogyria | Peritonitis | Endometritis | Pontocerebellar Hypoplasia Type 2 | Hepatoblastoma | Adrenomyeloneuropathy | Steel Syndrome | Retinitis Pigmentosa 3 | Myeloid Leukemia | Perivascular Epithelioid Cell Tumor | Neurofibromatosis | Hypolipoproteinemia | Proteasome-associated Autoinflammatory Syndrome 2 | Cri-du-chat Syndrome | Cardiomyopathy, Dilated, 1L | Polyneuropathy | Angioedema | Vestibular Disease | Schindler Disease | Cranioectodermal Dysplasia | Amyotrophic Lateral Sclerosis, Juvenile | Walker-Warburg Syndrome | Acute Lung Injury | Localized Scleroderma | Bullous Pemphigoid | Chronic Beryllium Disease | Glomerulonephritis, Membranous | Bare Lymphocyte Syndrome | Fanconi Syndrome | Autoimmune Autonomic Ganglionopathy | Hereditary Pyropoikilocytosis | Hypocalcemia | Esophageal Carcinoma | Glomerulonephritis | Hereditary Sensory And Autonomic Neuropathy | Neuronal Ceroid Lipofuscinosis | Ataxia-ocular Apraxia 2 | Ectodermal Dysplasia | Benign Familial Pemphigus | Goiter | Diverticulitis | Plasma Cell Leukemia | Takenouchi-Kosaki Syndrome | Cysticercosis | Hydrops Fetalis | Hyperostosis | Paget's Disease Of The Breast | Osteomalacia | Leukoplakia | H Syndrome | Osteosclerosis | Macular Corneal Dystrophy Type 1 | Presbyopia | Colitis, Microscopic | Lafora Disease | Subcortical Band Heterotopia | Muir-Torre Syndrome | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Cohen Syndrome | Optic Atrophy 2 | Congenital Dysfibrinogenemia | Achondrogenesis | Hypophosphatasia | Retinal Vasculitis | Alkaptonuria | Galactosemia | Blepharoconjunctivitis | X-linked Acrogigantism | Exostoses | Diabetes Insipidus, Neurogenic | Fabry's Disease | Bulimia Nervosa | B-cell Chronic Lymphocytic Leukemia | Sialoadenitis | Amelogenesis Imperfecta | Short-chain Acyl-CoA Dehydrogenase Deficiency | Obesity, Morbid | Neuroblastoma | Aphasia | Corneal Dystrophy And Perceptive Deafness | Ellis-Van Creveld Syndrome | VACTERL/VATER Association | Leber Congenital Amaurosis | Pneumonia, Bacterial | Primary Carnitine Deficiency | Sotos Syndrome | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Cryptococcal Meningitis | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Lamellar Ichthyosis | T-cell Prolymphocytic Leukemia | Isobutyryl-CoA Dehydrogenase Deficiency | Nemaline Myopathy 8 | Crimean-Congo Hemorrhagic Fever | Carcinoid Syndrome | Meesmann Corneal Dystrophy | Pain | Chronic Granulomatous Disease | Anterior Segment Dysgenesis | Thyroid Hormone Resistance | Optic Nerve Hypoplasia, Bilateral | Thrombasthenia | Renal Failure | Congenital Hypofibrinogenemia | Autism Spectrum Disorders | Cherubism | Toxic Epidermal Necrolysis | Alveolar Capillary Dysplasia | Tumoral Calcinosis | Arteriovenous Malformations | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Acromesomelic Dysplasia | Histoplasmosis | Porphyria, Acute Intermittent | Cheilitis | Cenani-Lenz Syndactyly Syndrome | Jalili Syndrome | Knobloch Syndrome | Hyperbilirubinemia, Neonatal | Cyst | Hyperuricemia | Hemochromatosis Type 2 | Microphthalmia | Posterior Polar Cataract | Crisponi Syndrome | Cryptorchidism | Thrombotic Microangiopathy | Familial Dysautonomia | Familial Retinal Arterial Macroaneurysm | Nephritis, Interstitial | Joubert Syndrome 2 | Osteoporosis-pseudoglioma Syndrome | Hypertension, Pulmonary | Hereditary Inclusion Body Myopathy | Spondylometaphyseal Dysplasia | X-linked Creatine Transporter Deficiency | Alpha-1 Antitrypsin Deficiency | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Enhanced S-cone Syndrome | Lymphomatoid Granulomatosis | Agnathia-Otocephaly Complex | Skin Papilloma | Chylothorax, Congenital | Granular Corneal Dystrophy Type 1 | Eiken Syndrome | Spinocerebellar Ataxia Type 16 | Lattice Corneal Dystrophy Type 1 | Norrie Disease | Keratitis-ichthyosis-deafness Syndrome | Trigonocephaly | Lymphoma | Saethre-Chotzen Syndrome | Primary Hyperoxaluria Type 3 | Borderline Personality Disorder | Congenital Hereditary Endothelial Dystrophy Type II | Panniculitis | Familial Isolated Hyperparathyroidism | Polydactyly | Lymphoma, AIDS-related | Hypoplastic Left Heart Syndrome | Paraganglioma, Carotid Body | Cystitis | ADNP Syndrome | Microphthalmia, Syndromic 7 | Melanoma | Seborrheic Dermatitis | Papillon-Lefevre Syndrome | Primary Cutaneous Amyloidosis | Hypersensitivity Pneumonitis | Keratopathy | Ornithine Transcarbamylase Deficiency | Gastrointestinal Disorders | Congestive Heart Failure | Non-bullous Congenital Ichthyosiform Erythroderma | Congenital Lipoid Adrenal Hyperplasia | Diastrophic Dysplasia | Blomstrand Osteochondrodysplasia | Myoclonic Epilepsy With Ragged Red Fibers | Polyarteritis Nodosa | Mohr-Tranebjaerg Syndrome | Dystonia Musculorum Deformans | Adenosine Deaminase Deficiency | Myelitis, Transverse | Nager Acrofacial Dysostosis | WAGR Syndrome | Meningeal Melanocytoma | LEOPARD Syndrome | Peripheral Neuropathy | Malnutrition | Alpers Syndrome | Chiari Malformation Type I | Multicystic Renal Dysplasia | Glycogen Storage Disease Type 1a | AIDS Dementia Complex | Polycystic Liver | Takotsubo Cardiomyopathy | Lymphoproliferative Disease, X-linked | Familial Episodic Pain Syndrome | Bacterial Meningitis | Hereditary Coproporphyria | Pineoblastoma | Allan-Herndon-Dudley Syndrome | Greenberg Dysplasia | Niemann-Pick Disease, Type C | Progressive Myoclonic Epilepsy | Cerebral Amyloid Angiopathy | Desbuquois Syndrome | Bone Giant Cell Tumor | Schizoaffective Disorder | Intestinal Tuberculosis | Cramp Fasciculation Syndrome | Iron Overload | Vitamin K Deficiency | Fibronectin Glomerulopathy | Epidermolytic Ichthyosis, Annular | Bone Marrow Necrosis | Ghosal Syndrome | Myelitis | Overactive Bladder | Pachyonychia Congenita | Acrodermatitis Enteropathica | Duodenal Atresia | Blue Rubber Bleb Nevus Syndrome | Glycogen Storage Disease Type 9 | Diabetes Type 1 | Nevus | Enterocolitis, Necrotizing | Wolff-Parkinson-White Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | Lyme Disease | Methylmalonic Aciduria And Homocystinuria, CblC Type | Pigment Dispersion Syndrome | Hepatic Steatosis | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Urofacial Syndrome | Adenoma, Pituitary | Pelizaeus-Merzbacher Disease | Renal Tubular Dysgenesis | Lesch-Nyhan Syndrome | Spina Bifida | Kabuki Syndrome | Ligneous Conjunctivitis | Chediak-Higashi Syndrome | Lymphoma, Mantle Cell | Holt-Oram Syndrome | Mixed Connective Tissue Disease | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Stroke, Hemorrhagic | Micropenis | Iron Deficiency Anemia | Progressive External Ophthalmoplegia | Tinea Versicolor | Endometrial Hyperplasia | Myelomeningocele | Rickets | Syndactyly | Cerebellar Ataxia, Cayman Type | Astrocytoma, Anaplastic | Chromosome 17q21.31 Deletion Syndrome | Mitochondrial DNA Depletion Syndrome | Chronic Leukemia | Spondyloarthritis | Guanidinoacetate Methyltransferase Deficiency | Fucosidosis | Primary Lateral Sclerosis | Hemolytic Anemia | Diabetic Neuropathy | 3-hydroxy-3-methylglutaric Aciduria | Charcot-Marie-Tooth Disease Type 3 | Primary Progressive Nonfluent Aphasia | Juvenile Myelomonocytic Leukemia | Protein S Deficiency | Yellow Fever | Stevens-Johnson Syndrome | Dubin-Johnson Syndrome | Rash | Nicotine Dependence | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Neutropenia | HIBCH Deficiency | Renpenning Syndrome | Nephrotic Syndrome Type 1 | Familial Exudative Vitreoretinopathy | Arrhythmogenic Right Ventricular Cardiomyopathy | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Sponastrime Dysplasia | Eclampsia | Gout | Sarcoidosis | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Inflammatory Linear Verrucous Epidermal Nevus | Thin Basement Membrane Disease | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Dowling-Degos Disease | Sarcoma, Alveolar Soft Part | Macrophage Activation Syndrome | Acne Vulgaris | MIRAGE Syndrome | Angiodysplasia | Tay-Sachs Disease | Lymphoma, B-cell | Erdheim-Chester Disease | Adenomyosis | Celiac Disease | Epicondylitis | Osteogenesis Imperfecta Type IV | Esthesioneuroblastoma | Gynecomastia | Heavy Chain Disease | Hypermethioninemia