Juvenile Xanthogranuloma

About the Disease
Juvenile Xanthogranuloma, also known as multiple eruptive juvenile xanthogranuloma, is related to histiocytosis and cutaneous fibrous histiocytoma, and has symptoms including exanthema and pruritus. An important gene associated with Juvenile Xanthogranuloma is MLANA (Melan-A), and among its related pathways/superpathways are Innate Immune System and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Palbociclib and Mebendazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and liver, and related phenotypes are glaucoma and multiple cafe-au-lait spots

Common Targets
PTPN11

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